Ali Awadallah Saeed
@nu.edu.sd
Department of Pharmacology and therapeutics
National University, Sudan
RESEARCH, TEACHING, or OTHER INTERESTS
General Pharmacology, Toxicology and Pharmaceutics, Research and Theory
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Osama Mohamed Ibrahim, Nadia Al Mazrouei, A. A. Elnour, Rana Ibrahim, Derar H. Abdel-Qader, Rowida Mohamed El Amin Ibrahim Hamid, Vineetha Menon, Ali Awadallah Saeed, Sami Fatehi Abdalla, Fahad T. Alsulami,et al.
Public Library of Science (PLoS)
Background Drug-related problems (DRPs) significantly threaten the safety of the elderly. In order to improve pharmacists’ ability to minimize these events, novel educational interventions that consider the current challenges in clinical practice are crucial. Objectives The primary objective is to assess the impact of two unique educational interventions on pharmacists’ ability to identify DRPs. Method A total of 127 community pharmacies in the United Arab Emirates (UAE) were recruited and randomly allocated to one of three arms using a 1:1:1 allocation ratio. While a series of clinical case scenarios (N = 24) related to elderly care were established and validated and sent to pharmacists in Active Group A over a 3-month period, lengthy research articles focused on medication safety in elderly were emailed to pharmacists in Active Group B. The control group pharmacist received no intervention. Then, pharmacists self-reported the number, categories, and severity of DRPs and pharmacist recommendations. Results The incidence of DRPs identified by pharmacists was 10.8% in Active Group A, 2.0% in the Control Group (p = 0.011), and 3.8% in Active Group B (p = 0.014). A significant difference was observed in the proportion of DRP types between Active Group A and the Control Group. The most common DRPs in Active Group A were avoidable medication (14.7%) and untreated disease (9.2%). Pharmacists in Active Group A (37.2%) and Active Group B (32.3%) most commonly intervened by recommending the cessation of medication, while the most common intervention in the Control Group was recommending a decrease in dose (29.8%). The mean cost reduction per patient was highest in Active Group A (31.3 ±11.8 $), followed by Active Group B (20.8 ±8.6 $) and the Control Group (19.6 ±9.5 $). The mean time needed to resolve a DRP was shortest in Active Group A (7.3 ±3.5 minutes), followed by Active Group B (9.8 ±4.2 minutes) and the Control Group (9.8 ±5.7 minutes). Conclusion Using WhatsApp to deliver clinical scenarios was effective in improving pharmacists’ ability to identify and address DRPs in elderly patients, resulting in faster resolution and higher cost savings.
Ali Awadallah Saeed, Omer A. Gibreel, Ayman B. Mousa, Saeed M. Omer, Abdallateif Alkhair Omer, Intisar A. M. A. Elalawy, and Ahmed Hassan Fahal
Public Library of Science (PLoS)
Background Snakebite statistics in Sudan are lacking despite the high estimated burden of the problem. One study in Sudan reported the presence of 17 medically significant snakes belonging to three major families: Burrowing asps, Elapidae, and Viperidae. These snakes usually become abundant during and after the rainy season, and most snakebite victims are farm workers. This study was set out based on the observed snakebite management, poor outcomes and lack of information on the healthcare provider’s knowledge of this serious, deadly medical and health condition in snakebite-endemic regions of Sudan. Materials and methods In August 2022, a descriptive cross-sectional survey was conducted involving 394 medical and healthcare providers in snakebite-endemic regions of Sudan (Gaddarif, Sinnar, Khartoum, and Kassala). A validated questionnaire was used. It consisted of seven sections addressing the study population demographic characteristics, knowledge of snakes, snakebites, and their management. Data analysis used various statistical tests using Microsoft Excel and the Statistical Package for Social Sciences (SPSS) version 20 (IBM SPSS Inc., Chicago, IL) was done. Results Among the 394 participants (44.7% males, 53.3% females), 58.1% demonstrated adequate knowledge of snakes, and 45.3% exhibited adequate knowledge of snakebites. A mere 25.9% received training in snakebite management, with 60.4% possessing adequate knowledge in this domain. Only 14% expressed high confidence in managing snakebites, and 40.9% reported having protocols for snakebite management at their health facilities. Conclusion The study highlighted the inadequacy of healthcare providers’ knowledge in snakebite-endemic areas in Sudan regarding snakes, snakebites and snakebites management. Urgent interventions, such as intensive continuing professional education and training, are essential to address this neglected medical and health problem.
Abuelnor Mohammed, Azza Ramadan, Asim Ahmed Elnour, Ali Awadallah Ali Mohamed Saeed, Nadia Al Mazrouei, Fahad T. Alsulami, Yousef Saeed Alqarni, Vineetha Menon, Abdulla Al Amoodi, and Sami Fatehi Abdalla
Wiley
AbstractAimsThe study aimed to evaluate the potential benefits of luteolin treatment in Huntington's disease (HD), an inherited progressive neurodegenerative disorder.MethodsHD N171‐82Q transgenic and WT mice received luteolin or vehicle for treatment at 6 weeks of age. The mice's body weight changes and survival rates were monitored throughout the study, and a series of motor functional tests were conducted. Serum level of the marker NfL was also determined. Immunohistochemical staining and western blotting were utilized to assess the expression of huntingtin aggregates.ResultsLuteolin treatment enhanced survival and prevented weight loss in HD mice compared to the vehicle‐treated HD group. Furthermore, the luteolin‐treated HD mice exhibited enhanced motor coordination and balance and significantly reduced motor dysfunction. Also, luteolin decreased serum NfL levels in HD mice. Notably, the accumulation of huntingtin aggregates was significantly reduced in the brain's cortex, hippocampus, and striatum of luteolin‐treated HD mice compared to the vehicle‐treated HD group.ConclusionLuteolin holds promise as a therapeutic agent for improving survival outcomes, managing motor dysfunction, and reducing huntingtin aggregates in HD. The findings are of significance as currently, there are no approved therapeutic interventions that reverse HD pathology or slow down its progression.
Ahmed Hassan Fahal, Eiman Siddig Ahmed, Ahmed Hussein Mahmoud, and Ali Awadella Saaed
Public Library of Science (PLoS)
Mycetoma profoundly affects marginalised communities, especially in impoverished and remote areas with limited access to healthcare. This chronic and debilitating inflammatory disease highlights the typical issues of neglected tropical diseases (NTDs), such as insufficient attention, funding, and resources, which perpetuate neglect and suffering. Patients often delay seeking medical help, leading to advanced disease stages, severe complications, and lasting disabilities. The lack of medical infrastructure and skilled healthcare professionals worsens the situation, causing delays in diagnosis and inadequate treatment. Engaging affected communities in tailored interventions is essential to tackle these challenges, promote collaboration, raise awareness, and mobilise resources to improve healthcare access and enhance diagnostic and treatment capabilities. Since 1991, the Mycetoma Research Center (MRC) at the University of Khartoum, Sudan, has led community engagement initiatives aimed at improving the quality of life for mycetoma-affected individuals through education, advocacy, and local collaboration. In this communication, the MRC shares its extensive experience in community engagement to benefit mycetoma-affected communities.
Azza Ramadan, Abuelnor Mohammed, Asim Ahmed Elnour, Adel Sadeq, Nadia Al Mazrouei, Maisoun Alkaabi, Khalid Awad Al-Kubaisi, Semira Abdi Beshir, Vineetha Menon, Abdulla AlAmoodi,et al.
Elsevier BV
Ahmed Hassan Fahal, Kannan Omer Ahmed, Ali Awadallah Saeed, Abdalla Omer Elkhawad, and Sahar Mubarak Bakhiet
Public Library of Science (PLoS)
1 Mycetoma Research Center, University of Khartoum, Khartoum, Sudan, 2 Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, University of Gezira, Wad Medani, Gezira state, Sudan, 3 Department of Pharmacology, Faculty of Pharmacy, The National University, Khartoum, Sudan, 4 Department of Pharmacology, Faculty of Pharmacy, University of Medical Sciences and Technology, Khartoum, Sudan, 5 Department of Molecular biology, Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan