Aldoushy Mahdy
@faculty of science
Associated Prof of Aquatic Ecology, Zoology Department
Al-Azhar University
RESEARCH, TEACHING, or OTHER INTERESTS
Aquatic Science, Animal Science and Zoology, Environmental Science, Ecology
Scopus Publications
Scopus Publications
Fahd M. Abdelkarem, Hamdy K. Assaf, Yaser A. Mostafa, Aldoushy Mahdy, Modather F. Hussein, Samir A. Ross, and Nesma M. Mohamed
Royal Society of Chemistry (RSC)
Chemical analyses of the sea urchin Clypeaster humilis yielded twelve compounds including; a new sulfonic acid derivative (7R) tridec-1-en-7-yl hydrogen sulphate (1), pyridine-3-yl methane sulfonate (2), boldine (12), and nine known compounds (3–11).
Ahmed E. A. Badrey, Mohamed F. El-Sawy, Aldoushy Mahdy, Mahmoud M. S. Farrag, Werner Kloas, and Alaa G. M. Osman
Springer Science and Business Media LLC
Mohamed A. Tammam, Omnia Aly, Florbela Pereira, Aldoushy Mahdy, and Amr El-Demerdash
Elsevier BV
Aya Abd-Elkader, El Sayed A.E. Hamed, Aldoushy Mahdy, and Soha Shabaka
Elsevier BV
Mohamed A. Tammam, Florbela Pereira, Omnia Aly, Mohamed Sebak, Yasser M. Diab, Aldoushy Mahdy, and Amr El-Demerdash
Royal Society of Chemistry (RSC)
The present study investigates multiple interactions of a series of marine steroids with glutathione-S-transferase (GST) and Cu–Zn human superoxide dismutase (Cu–ZnSOD) enzymes, in order to reveal insights into the process of hepatoprotection.
Yasmine A. M. Hassan, Ahmed E. A. Badrey, Alaa G. M. Osman, and Aldoushy Mahdy
Springer Science and Business Media LLC
AbstractThe present study described the most recent findings concerning the abundance and distribution of plastic in water, sediment, and fauna in the Nile River of Upper Egypt as an interesting research point. The findings revealed that plastics were abundant in the water, sediments, fish, and crayfish throughout the sites. The Nagaa Hammadi site has the highest abundance of meso- and macroplastics in its water and sediment. African catfish had the highest abundance of meso- and macroplastics compared to the other species, while Nile tilapia had no meso- or macroplastics in its alimentary canal or gills in all sites. The Edfu site has the highest abundance of mesoplastics in the alimentary canals of African catfish, while the Nagaa Hammadi site has the highest abundance of mesoplastics in the gills, and macroplastics appeared only in the alimentary canal of African catfish from the El-wasta site. Only mesoplastics were found in the crayfish’s alimentary canal, with the Nagaa Hammadi site having the highest abundance. No macroplastics were detected in the crayfish’s gills or alimentary canal. Additionally, this work lets us understand how plastics behave in freshwater environments, and it is a step toward decision-makers taking appropriate measures to reduce their risk.
Rashad E.M. Said, Amani Fitori, Ali El Fituri, and Aldoushy Mahdy
Uniwersytet Gdanski
Biodiversity in the Mediterranean Sea has not yet been fully explored. There has been very little research on molluscs along the Libyan coast. An individual of the chromodoridid nudibranch Felimare picta (Philippi, 1836) was encountered during scuba diving at the Lido resort near the Tobruk baybasin. The sample was carefully transported to the lab in seawater, photographed, and identified. The current study revealed that Felimare picta was recorded for the first time on the Libyan coast. Despite Felimare picta being rather common in many Mediterranean regions, records of it on the southern Mediterranean coasts are extremely rare or absent.It may be concluded that this study represents not only the southernmost record of Felimare picta in the Mediterranean but also the first record of the species in Libya.
Mohamed A. Tammam, Maria G. Daskalaki, Nikolaos Tsoureas, Ourania Kolliniati, Aldoushy Mahdy, Sotirios C. Kampranis, Christos Tsatsanis, Vassilios Roussis, and Efstathia Ioannou
MDPI AG
The chemical investigation of the organic extract of the red alga Laurencia majuscula collected from Hurghada reef in the Red Sea resulted in the isolation of five C15 acetogenins, including four tricyclic ones of the maneonene type (1–4) and a 5-membered one (5), 15 sesquiterpenes, including seven lauranes (6–12), one cuparane (13), one seco-laurane (14), one snyderane (15), two chamigranes (16, 17), two rearranged chamigranes (18, 19) and one aristolane (20), as well as a tricyclic diterpene (21) and a chlorinated fatty acid derivative (22). Among them, compounds 1–3, 5, 7, 8, 10, 11 and 14 are new natural products. The structures and the relative configurations of the isolated natural products have been established based on extensive analysis of their NMR and MS data, while the absolute configuration of maneonenes F (1) and G (2) was determined on the basis of single-crystal X-ray diffraction analysis. The anti-inflammatory activity of compounds 1, 2, 4–8, 10, 12–16, 18 and 20–22 was evaluated by measuring suppression of nitric oxide (NO) release in TLR4-activated RAW 264.7 macrophages in culture. All compounds, except 6, exhibited significant anti-inflammatory activity. Among them, metabolites 1, 4 and 18 did not exhibit any cytostatic activity at the tested concentrations. The most prominent anti-inflammatory activity, accompanied by absence of cytostatic activity at the same concentration, was exerted by compounds 5 and 18, with IC50 values of 3.69 μM and 3.55 μΜ, respectively.
Ahmed Salah-Tantawy, Aldoushy Mahdy, Mahmoud A. Dar, Shuh-Sen Young, and Abdelbaset M. A. Abdelreheem
Uniwersytet Gdanski
The purpose of this study was to assess the north coasts of the Egyptian Red Sea, including Ras Gharieb, Hurghada, Safaga and Qusier, by evaluating the heavy metal pollution in seawater and benthic flora and fauna in the winter and summer of 2016. The concentrations of heavy metals (Fe, Mn, Zn, Cu, Ni, Cd and Pb) were analysed with an atomic absorption spectrophotometer. The results revealed that the Fe levels in the seawater ranged from 7.86 and 27.95 µg l-1, while the Zn concentrations fell between 1.83 and 5.63 µg l-1. In contrast, the recorded values of Mn, Cu, Ni, Pb and Cd in the seawater were minimal at the study sites. Regarding the biota samples, Porifera species were more adaptable than others to an accumulation of most metals in their tissues. Furthermore, seaweeds and seagrasses demonstrated remarkable adaptation in highly polluted regions, especially those with high turbidity, landfilling, sedimentation and high eutrophication rates – much more than the benthic fauna. Our research highlights the critical need for strict regulation of metal emissions in these coastal regions.
Aldoushy Mahdy, Rashad E.M. Said, Mostafa A. Khaled, and Ali A. Abdelsalam
Elsevier BV
Ahmed Salah-Tantawy et al.
Egypts Presidential Specialized Council for Education and Scientific Research
This study investigated the Spatio-temporal variations in the physicochemical properties of the surface seawater along the northern Red sea. 41 seawater samples were gathered from Ras Gharieb, Hurghada, Safaga, and Qusier cities to measure conservative (temperature, DO, salinity, pH) parameters. In parallel, non-conservative parameters (ammonia, phosphorous, nitrite, nitrate) were analyzed via a colorimetric-spectrophotometer instrument. Our findings revealed that physical parameters fluctuated between 19.01 ± 0.75 - 35.01 ± 0.47 ºC, 5.05 ± 0.54 - 11.70 ± 1.06 mg/l, 39.81 ± 0.35 - 42.31 ± 0.50 ‰, and 8.10 ± 0.14 - 8.50 ± 0.44 for temperature, DO, salinity, and pH, respectively. While chemical parameters ranged from 0.12 ± 0.06 to 1.53 ± 0.20 mg/l for ammonia, BDL to 1.71 ± 0.23 mg/l for phosphorous, BDL to 1.38 ± 0.05 mg/l for nitrite, and 0.09 ± 0.06 to 4.50 ± 1.22 mg/l for nitrate. Statistically, no discernible variation was detected among different seasons for all measurements except temperature, DO, and phosphorous ( P < 0.05). In addition, Pearson’s correlation analysis showed some positive or negative relationships between temperature and salinity (r = 0.75), salinity and pH (r = 0.50), temperature and phosphate (r = 0.70), salinity and phosphate (r = 0.73), nitrite and nitrate (r = 0.71), temperature and DO (r = - 0.73), DO and phosphate (r = - 0.50), pH and ammonia (r = - 0.71), as well as phosphate and nitrate (r = -0.55). These results indicate that physico-chemical properties should be taken into account during the development of management strategies to protect the Egyptian marine environment, especially in the Red sea areas.
Mohamed Talaat et al.
Egypts Presidential Specialized Council for Education and Scientific Research
The current study was organized to determine the abundance and distribution status of the seaweed community in two Red Sea locations in order to assist decision-makers in managing natural resources, particularly the macroalgal community. During summer, autumn of 2017, and winter, spring of 2018, seaweed species were collected seasonally by snorkeling in the intertidal zone at two sites: a mangrove forest 17 km south of Safaga
Ahmed Ghallab et al.
Egypts Presidential Specialized Council for Education and Scientific Research
The northern Red Sea has a variety of habitats especially coral reefs (Ghallab et al., 2020) and an abundance and diversity of seagrass (Mahdy et al., 2020). The diversity of ecosystems in Hurghada gains the attraction of ecotourism, where the activities of diving, snorkeling, fishing and a lot of daily tripsand safari boats are found (Ghallab et al., 2020, Mahdy et al., 2020). Seagrass is a unique group of flowering plants that have been adapted to exist fully immersed in the sea, providing numerous significant environmental services to marine environment (Costanza et al., 1997). For climate and food security, seagrass ecosystems possess a global significance, but they remain rather unknown and on the periphery of marine conservation (Duarte et al., 2008). Six main global challenges are encountering seagrass conservation, among which the followings ARTICLE INFO ABSTRACT Article History: Received: Jan. 14, 2022 Accepted: Jan. 27, 2022 Online: March 2, 2022 _______________
MOHAMED A.W.S. EBEAD, HUSSEIN N.M. HUSSEIN, HASSANIEN GOMAA, MOHAMED ABDELMOTTALEB, and ALDOUSHY MAHDY
UNS Solo
Abstract. Ebead MAS, Hussein HNM, Gomaa H, Abdelmottaleb M, Mahdy A. 2022. The relationship between seagrass abundance, distribution and the abiotic factors in Big Gifton and Abu Minqar islands, Red Sea, Egypt. Biodiversitas 23: 2295-2303. Seagrass communities represent spatially complex and biomass-producing systems. The current research aims to understand the relationship between the abundance and distribution of seagrass communities and the abiotic factors in Big Gifton Island and Abu Minqar Island, Red Sea, Egypt. Seasonal seagrass samples were collected during 2019-2020 using line-transect and quadrat techniques. Canonical Correspondence Analysis was used to determine the effect of environmental factors on the occurrence and abundance of seagrass species. Three seagrass species, i.e., Halophila stipulacea, Halodule uninervis, and Halophila ovalis were recorded in the two islands. The most dominant seagrass species in both locations was H. stipulacea, which accounted for 54% in Big Gifton and 45% in Abu Minqar Island, while H. uninervis and H. ovalis were less numerous, with a percentage cover of 23 and 24%; and 8 and 5% in Big Gifton and Abu Minqar island, respectively. Halophila stipulacea was highest in the winter season with a percentage of 62 % and lowest in the spring (47%) in Big Gifton, whereas it was highest in the spring (62%) and lowest in the winter (47%) on Abu Minqar Island (22%). Statistical analysis showed highly significant differences between both sites and seasons in terms of conductivity, total dissolved solids, salinity, and the presence of H. uninervis and H. ovalis. On the other hand, there were non-significant differences between both sites and seasons in terms of temperatures, dissolved oxygen, oxidation-reduction potential, nitrite, nitrate, ammonia, phosphorus and the presence of H. stipulacea. Throughout the year, Big Gifton had a higher mean phosphate value than Abu Minqar Island and this may be related to the highest abundance of H. stipulacea in Big Gifton Island. The findings of this study may aid decision-makers in the management of natural resources, particularly the seagrass beds of Big Gifton and Abu Minqar Island.
H. O. Ahmed, A. Mahdy, S. A. M. Nasser, K. F. Abd El-Wakeil, A. H. Obuid-Allah, and M. M. Hassan
FapUNIFESP (SciELO)
Abstract In the present study, the biochemical composition of some Echinodermata (Holothuroidea, Echinoidea) from the Red Sea, Egypt was investigated. The results showed that the highest percentage of saturated fatty acids (SFA) was in Holothuria nobilis and the lowest percentage was recorded in Holothuria scabra. The highest percentage of monounsaturated fatty acids (MUFA) was recorded in Pearsonothuria graeffei while the lowest percentage was recorded in Holothuria atra. The highest percentage of polyunsaturated fatty acids (PUFA) was recorded in Holothuria nobilis and the lowest percentage was recorded in Holothuria atra. The highest percentage of omega-3 fatty acids was recorded in Stichopus hermanni however, the lowest percentage was recorded in Diadema setosum. The highest percentage of omega-6 fatty acids was recorded in Bohadschia vitiensis where, the lowest percentage was recorded in Holothuria atra. In addition, nonessential amino acid (NEAA) glycine were the highest in all species and serine was the lowest while Essential amino acid (EAA) arginine was the highest and cysteine was the lowest. All of the NEAA recorded highest concentrations in S. hermanni except proline. The recorded essential amino acids were histidine, isoleucine, phenylalanine, and leucine. The latter was high in Pearsonothuria graeffei. Tyrosine, valine, threonine, and arginine were high in Stichopus hermanni. The present study proved that sea cucumbers has great nutritional value.
Fahd M. Abdelkarem, Ezz-Eldin K. Desoky, Alaa M. Nafady, Ahmed E. Allam, Aldoushy Mahdy, Ahmed Ashour, and Kuniyoshi Shimizu
Informa UK Limited
Abstract In our promising project toward discovery of secondary metabolites with potential anticancer activity against human cervical cancer, seven marine organisms were screened for their cytotoxic activity against HeLa cancer cell line using MTT colorimetric assay. The crude extract of the outer shell of Diadema setosum showed promising activity with 88.02% inhibition at a concentration 250 µg/ml. Chromatographic investigation of the Ethyl acetate fraction, which is the main contributor to the activity (IC50= 43.1 ± 5.94 µg/ml), led to isolation of five compounds. Structures of the isolates (1-5) were elucidated by 1 D and 2 D NMR spectroscopy and HR-ESI-MS analysis. 5α,8α-epidioxycholest-6-en-3β ol (2) and 5α,8α-epidioxycholest-6,9(11)-en-3β ol (3) showed the highest cytotoxic activity with IC50 values 12.1 ± 2.74 µg/ml and 21.8 ± 6.32 µg/ml, respectively. Epidioxy steroids with cholestane nucleus could be a prospective candidate for the development of drugs for treatment of human cervical cancer. Graphical Abstract
Amani Fitori, Aldoushy Mahdy, Rashad E.M. Said, and Ali Al-Faturi
Elsevier BV
Aldoushy Mahdy et al.
Egypts Presidential Specialized Council for Education and Scientific Research
Zooplankton communities at the Gulf of Suez were investigated during the current study and their abundance was correlated with the physicochemical parameters of the area. The goal of the study was to estimate the distribution and abundance of zooplankton taxa under various habitat stressors and update the ecological database of the study area. The study recorded 39 species of zooplankton in 16 taxa with a total abundance of 66300 organisms across all investigated sites. The organisms were distributed between holoplankton that recorded approximately 55560 organisms (84.2 %) and meroplankton which recorded approximately 10740 organisms (15.8 %). The most abundant groups were Copepoda 52340 organisms (78.9 %), larval stages (11%) and Maxillopoda (3 %). While, Anthomedusea, Leptomeduea, and Pteropods were rarely recorded. Among the surveyed sites, Zafarana recorded the highest abundance (23537 Organisms) with a percentage of 63 of the total zooplankton populations, whereas the lowest site in abundance was Port-Tewfik which recorded (6656 organisms), represented a percentage of 10 % of the total populations. The current work showed that copepods recorded a significant difference in spatial distribution, while copepods, dissolved oxygen, water temperature, and total dissolved solids differed significantly at temporal distribution.
Ahmed Ghallab et al.
Egypts Presidential Specialized Council for Education and Scientific Research
1; Egyptian Environmental Affairs Agency, Manager of Red Sea Northern Protected Islands, Egypt 2; Zoology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt. 3; Marine Science Department, Faculty of Science, Suez Canal University, Ismailia, Egypt 4; Zoology Department, Faculty of Science, Al-Azhar University, Assiut Branch, Assiut, Egypt. * Corresponding Author: ahmedghallab968@yahoo.com
Aldoushy Mahdy, Ahmed Ghallab, Hashem Madkour, and Alaa Osman
Egypts Presidential Specialized Council for Education and Scientific Research
The Red Sea is one of the world's most significant deposits of marine biodiversity. These marine resources, particularly coral reefs, have gained tourist interest in a way that tourist activities are predominant along the Egyptian Red Sea coasts. Thus, tourism has developed considerably in recent years, making a major contribution to the Egyptian ARTICLE INFO ABSTRACT Article History: Received: Jan. 19, 2021 Accepted: Feb. 5, 2021 Online: Feb. 17, 2021 _______________
Fahd M. Abdelkarem, Ezz-Eldin K. Desoky, Alaa M. Nafady, Ahmed E. Allam, Aldoushy Mahdy, Ahmed Ashour, Gamal A. Mohamed, Tomofumi Miyamoto, and Kuniyoshi Shimizu
Informa UK Limited
Abstract Two new polyhydroxylated steroids, 3β-acetoxy-gorgost-5α,6β,11α-triol (3) and (23 R) methylergosta-20-ene-3β,5α,6β,17α-tetrol (4), together with three known gorgosteroid compounds, gorgost-3β, 5α,6β,11α- tetrol (1), 11α-acetoxy-gorgost- 3β,5α, 6β- triol (2), and gorgost-5 (E) ene-3-β-ol (5), as well as batyl alcohol (6), were isolated from the Egyptian soft coral Heteroxenia fuscescens. The structures of these compounds were elucidated based on NMR spectroscopic analyses, HR-FAB-MS, and comparisons with published data. The cytotoxic activities of the fractions and compounds were evaluated against MCF-7 cancer cell lines using MTT colorimetric assay. Compounds 2 and 4 showed moderate cytotoxic activity, with IC50 values equal to 33.2 and 25.1 µM, respectively, in comparison with the IC50 of 5-fluorouracil 18.7 µM. GRAPHICAL ABSTRACT
A. Mahdy, G. Abu El-Kheir, Abdullah S. Gohar, and Maher I. El-Soughier
Informa UK Limited
ABSTRACT Basilosauridae are aquatic Archaeoceti whales, included larger Basilosaurus isis and smaller Dorudon atrox in the middle to upper Eocene Gehannam and Birket Qaroun formations (38–36.5 Ma) of Wadi El-Hitan, Fayoum, Egypt. In this study, 123 specimens of Basilosauridae are discovered from Gehannam and Birket Qaroun formations. B. isis and D. atrox are represented by 116 and 7 specimens, respectively. Gehannam Fm is more productive than Birket Qaroun Fm (86 vs 37 specimens). Preservation and taphonomy of specimens recorded from Birket Qaroun are better than those of Gehannam according to their articulation, completeness, abrasion, and weathering. Comparison between D. atrox and recent odontocetes whales’ Orcinus orca reveals several similarities, for example aquatic habitat, Basilosauridae predatory behaviour, and skull bones arrangement in a usual mammalian pattern. However, D. atrox lacks the cranial telescoping of skull and echolocation capability of O. orca. D. atrox has a fluke like O. orca, but lacks a caudal peduncle like this seen in O. orca. O. orca lacks the hindlimb that occurs in D. atrox. D. atrox was smaller than O. orca; both of them inhabit shallow water and feed on fish and squid but with different mechanisms.
Mohamed A. Tammam, Lucie Rárová, Marie Kvasnicová, Gabriel Gonzalez, Ahmed M. Emam, Aldoushy Mahdy, Miroslav Strnad, Efstathia Ioannou, and Vassilios Roussis
MDPI AG
Six new (1, 2, 6, 8, 13, and 20) and twenty previously isolated (3–5, 7, 9–12, 14–19, and 21–26) steroids featuring thirteen different carbocycle motifs were isolated from the organic extract of the soft coral Sinularia polydactyla collected from the Hurghada reef in the Red Sea. The structures and the relative configurations of the isolated natural products have been determined based on extensive analysis of their NMR and MS data. The cytotoxic, anti-inflammatory, anti-angiogenic, and neuroprotective activity of compounds 3–7, 9–12, 14–20, and 22–26, as well as their effect on androgen receptor-regulated transcription was evaluated in vitro in human tumor and non-cancerous cells. Steroids 22 and 23 showed significant cytotoxicity in the low micromolar range against the HeLa and MCF7 cancer cell lines, while migration of endothelial cells was inhibited by compounds 11, 12, 22, and 23 at 20 µM. The results of the androgen receptor (AR) reporter assay showed that compound 11 exhibited the strongest inhibition of AR at 10 µM, while it is noteworthy that steroids 10, 16, and 20 displayed increased inhibition of AR with decreasing concentrations. Additionally, compounds 11 and 23 showed neuroprotective activity on neuron-like SH-SY5Y cells.
Zeynep Ersoy, Ulrike Scharfenberger, Didier L. Baho, Tuba Bucak, Tõnu Feldmann, Josef Hejzlar, Eti E. Levi, Aldoushy Mahdy, Tiina Nõges, Eva Papastergiadou,et al.
Wiley
AbstractSubmerged macrophytes are of key importance for the structure and functioning of shallow lakes and can be decisive for maintaining them in a clear water state. The ongoing climate change affects the macrophytes through changes in temperature and precipitation, causing variations in nutrient load, water level and light availability. To investigate how these factors jointly determine macrophyte dominance and growth, we conducted a highly standardized pan‐European experiment involving the installation of mesocosms in lakes. The experimental design consisted of mesotrophic and eutrophic nutrient conditions at 1 m (shallow) and 2 m (deep) depth along a latitudinal temperature gradient with average water temperatures ranging from 14.9 to 23.9°C (Sweden to Greece) and a natural drop in water levels in the warmest countries (Greece and Turkey). We determined percent plant volume inhabited (PVI) of submerged macrophytes on a monthly basis for 5 months and dry weight at the end of the experiment. Over the temperature gradient, PVI was highest in the shallow mesotrophic mesocosms followed by intermediate levels in the shallow eutrophic and deep mesotrophic mesocosms, and lowest levels in the deep eutrophic mesocosms. We identified three pathways along which water temperature likely affected PVI, exhibiting (a) a direct positive effect if light was not limiting; (b) an indirect positive effect due to an evaporation‐driven water level reduction, causing a nonlinear increase in mean available light; and (c) an indirect negative effect through algal growth and, thus, high light attenuation under eutrophic conditions. We conclude that high temperatures combined with a temperature‐mediated water level decrease can counterbalance the negative effects of eutrophic conditions on macrophytes by enhancing the light availability. While a water level reduction can promote macrophyte dominance, an extreme reduction will likely decrease macrophyte biomass and, consequently, their capacity to function as a carbon store and food source.