@international.ufg.br
Biology
Federal University of Goias
Acute lymphoblastic leukemia (ALL) is a type of cancer that affects lymphocyte-producing cells in the bone marrow. Its diagnosis and treatment require a multidisciplinary approach, involving chemotherapy, radiotherapy, bone marrow transplantation and supportive care. MicroRNAs (miRNAs) are small non-coding RNA molecules that play a crucial role in regulating gene expression. MiRNAs have been explored as therapeutic targets in cancer treatment. They can be used to restore the function of tumor suppressor miRNAs or inhibit the activity of oncogenic miRNAs. Its unregulated expression in the body represents continuity of the disease. Recently, miRNAs from tumor cells have been detected circulating in the blood of cancer patients, representing a new opportunity to use miRNAs in blood as an early predictor of cancer, and as a marker of response to therapy and disease prognosis. The treatment of ALL based-on miRNAs by the SUS can bring significant benefits, by becoming an option in the availa