Emmanuel Saviour Saheed

@kwasu.edu.ng

Research Assistant, Department of Biochemistry
Kwara State University

Emmanuel Saviour Saheed


                           Download Compact PDF  
https://researchid.co/emmysaviour
Emmanuel is a dedicated Biochemist and Molecular Biologist with a passion for discovery and cross-cultural engagement, excelling in dynamic, multidisciplinary team environment

I am curious to understand the roles of proteins in pathophysiology. My previous research have given me the basic information that targeted protein (membrane receptors, enzymes, ion channels and transporter proteins) are innovative methods of drug discovery.

During my undergraduate years I conducted a research titled Effect of phenolic and alkaloid extract of Senna occidentalis leaf on the oxidative status of the heart in high fat-diet streptozotocin-induced type 2 diabetic Wistar rats. This experience made me understand that biomarkers, protein folding and interactions play significant roles in mechanisms leading to healthy and diseased states.

I want to conduct a translational research where I can use my findings to pave way for innovate therapies to bring hope to countless lives suffering from cancer

EDUCATION

BSc. Biochemistry, Kwara State University, Malete, Nigeria.

Associate Degree in Science, Ahmadu Bello University, Zaria, Nigeria.

RESEARCH, TEACHING, or OTHER INTERESTS

Cancer Research, Biochemistry, Genetics and Molecular Biology, Cell Biology, Structural Biology

FUTURE PROJECTS

Cancer Biology, Molecular Biology, Structural Biology, and Computational Biology

Cancer is a disease caused by uncontrollable division of abnormal cells within the body leading to the damage of body tissue. The fusion of the divided abnormal cells leads to the formation of tumor. Overtime the tumor grows bigger at the site of formation and moves to other parts of the body, this process is known as metastasis. Cancer is a complex and life-threatening disease which has killed and keeps killing millions of people around the world. Bioactive compounds are chemical substances derived from plants and certain food. Previous research has made it known that specific bioactive compounds posses anticancer properties. Considering all aforementioned facts, I am fascinated to conduct an interdisciplinary research to understand the cellular and molecular pathways that occurs from the onset of cancer to metastasis. I am also interested to discover novel and effective anticancer bioactive compounds.


Applications Invited
Fully Funded Biomedical Sciences (Cancer Biology) PhD Program
3

Scopus Publications

36

Scholar Citations

2

Scholar h-index

2

Scholar i10-index

Scopus Publications

  • Effect of Phenolic and Alkaloid Extract of Senna Occidentalis Leaf on the Oxidative Status of the Heart in High Fat‑Diet Streptozotocin‑Induced Type 2 Diabetic Wistar Rats
    Emmanuel Saviour Saheed, Mutiat A. Abdulkareem, Fehintoluwa Celestina Adeleke
    World Journal of Traditional Chinese Medicine, 2025
    Objective: This research examined the effects of extracts (alkaloid and phenolic) from the leaves of Senna occidentalis on the oxidative status of heart in Wistar rats fed high-fat diets and induced with streptozotocin. Type 2 diabetes was established in the rats by injecting 35 mg/kg of streptozotocin intraperitoneally. Materials and Methods: Forty-three experimental rats were randomly categorized into seven groups of six rats each, with Group 1 as control group, which comprised seven rats. The remaining groups were as follows: group 2 (untreated diabetic rats), Group 3 (metformin-treated diabetic rats), Group 4 (phenolic extract-treated diabetic rats), Group 5 (alkaloids extract-treated diabetic rats), Group 6 (high-dose phenolic extract-treated diabetic rats), and Group 7 (high-dose alkaloids extract-treated diabetic rats). Results: The activity levels of various biochemical factors such as catalase, superoxide dismutase, glutathione-S-transferase, glutathione peroxidase, glutathione, and malondialdehyde were assessed to determine antioxidant status. Conclusions: The findings of this study demonstrated that the phenolic and alkaloid extracts from S. occidentalis possess antioxidant properties and show promise in the management of type 2 diabetes.
  • Mycoremediation: A biobased approach toward environmental sustainability
    Abiodun Oladipo, Victoria Alabi, Saad Muse, Onomen Ehizojie, Emmanuel Saheed, et al.
    Management of Mycorrhizal Symbiosis for Mycoremediation and Phytostabilization, 2025
  • Genetic factors and the role of pancreatic amylase in the pathogenesis of type 2 diabetes
    Mutiat A. Abdulkareem, Bunmi A. Owolabi, Emmanuel S. Saheed, Remilekun F. Aromolaran, Rukayat M. Bashiru, et al.
    Egyptian Journal of Medical Human Genetics, 2024
    This review article gives an insight into the genetic factors and the role of pancreatic amylase in type 2 diabetes (T2D). Diabetes is a non-communicable, multifactorial, heritable, complex, and irreversible disease of public health burden with a global prevalence rate of 6.28%, about 6% in sub-Saharan Africa, and 1.7% in Nigeria. T2D is recognized as the ninth leading cause of mortality worldwide. This disease is yet to be diagnosed in a significant number of people who live with it in underdeveloped and developing countries like Nigeria due to the lack of free or subsidized access to health care, especially medical checkups, inadequate health facilities, government policies, and negligence. Consequently, undiagnosed cases of T2D have contributed to the prevalence of this disease and its comorbidities -hypertension and chronic kidney disease. Obesity, age, race and ethnicity, inactivity, family history, underlying illness, and unhealthy diets are prominent undisputable predisposing factors of T2D. Pancreatic amylase is a type of amylase produced in the pancreas, known to hydrolyze starch and prone to mutations, but most of the genetic components, causative polymorphisms, and affected genes are yet unknown. Even as insulin secretion is found to be influenced by the loci, the causation of T2D cannot be inferred. Pancreatic amylase was observed to be the most relevant digestive enzyme, whose role is to bind to glycoprotein N-glycan to activate starch digestion. In a malfunctioning pancreas, little or no insulin is generated to keep the blood glucose at an appropriate level, thereby resulting in T2D.

RECENT SCHOLAR PUBLICATIONS

  • Effect of Phenolic and Alkaloid Extract of Senna Occidentalis Leaf on the Oxidative Status of the Heart in High Fat-Diet Streptozotocin-Induced Type 2 Diabetic Wistar Rats
    ES Saheed, MA Abdulkareem, FC Adeleke
    World Journal of Traditional Chinese Medicine 11 (2), 219-224 , 2025
    2025
    Citations: 2
  • Mycoremediation: A biobased approach toward environmental sustainability
    Management of Mycorrhizal Symbiosis for Mycoremediation and … , 2025
    2025
  • Immunotherapeutic treatment for metastatic prostate cancer: a review of recent clinical trials
    TA Jumah, DU Chijioke, OD Babalola, OJ Amaechi, FC Adeleke, ...
    Avicenna Journal of Medical Biochemistry 12 (2), 144-161 , 2024
    2024
    Citations: 1
  • Anticancer Potentials of bioactive compounds in some locally available spices in Nigeria
    ES Saheed
    Discover Plants 1 (1), 49 , 2024
    2024
    Citations: 2
  • Mechanism of the Warburg effect and its role in breast cancer immunotherapy
    ES Saheed, RF Aromolaran, AD Atoyebi, FC Adeleke, AI Otuyalo, ...
    Discover Medicine 1 (1), 110 , 2024
    2024
    Citations: 10
  • Genetic factors and the role of pancreatic amylase in the pathogenesis of type 2 diabetes
    MA Abdulkareem, BA Owolabi, ES Saheed, RF Aromolaran, RM Bashiru, ...
    Egyptian Journal of Medical Human Genetics , 2024
    2024
    Citations: 21

MOST CITED SCHOLAR PUBLICATIONS

  • Genetic factors and the role of pancreatic amylase in the pathogenesis of type 2 diabetes
    MA Abdulkareem, BA Owolabi, ES Saheed, RF Aromolaran, RM Bashiru, ...
    Egyptian Journal of Medical Human Genetics , 2024
    2024
    Citations: 21
  • Mechanism of the Warburg effect and its role in breast cancer immunotherapy
    ES Saheed, RF Aromolaran, AD Atoyebi, FC Adeleke, AI Otuyalo, ...
    Discover Medicine 1 (1), 110 , 2024
    2024
    Citations: 10
  • Effect of Phenolic and Alkaloid Extract of Senna Occidentalis Leaf on the Oxidative Status of the Heart in High Fat-Diet Streptozotocin-Induced Type 2 Diabetic Wistar Rats
    ES Saheed, MA Abdulkareem, FC Adeleke
    World Journal of Traditional Chinese Medicine 11 (2), 219-224 , 2025
    2025
    Citations: 2
  • Anticancer Potentials of bioactive compounds in some locally available spices in Nigeria
    ES Saheed
    Discover Plants 1 (1), 49 , 2024
    2024
    Citations: 2
  • Immunotherapeutic treatment for metastatic prostate cancer: a review of recent clinical trials
    TA Jumah, DU Chijioke, OD Babalola, OJ Amaechi, FC Adeleke, ...
    Avicenna Journal of Medical Biochemistry 12 (2), 144-161 , 2024
    2024
    Citations: 1
  • Mycoremediation: A biobased approach toward environmental sustainability
    Management of Mycorrhizal Symbiosis for Mycoremediation and … , 2025
    2025

INDUSTRY EXPERIENCE

Rajab limited pharmaceutical Industry, Ilorin, Kwara State
Internship (Quality Control Officer)

1. I performed laboratory analyses of raw materials for drug production as well as intermediate and finished products.

2. I engaged in lab rotation in different units of the organization and documented all records of analytical results.

3. I carried out water analyses on the water to be used for drug production and monitored the industrial effluent treatment at regular intervals.

SOCIAL, ECONOMIC, or ACADEMIC BENEFITS

1. Ambassador of the Nigerian Society of Biochemistry Students (NSBS), Kwara State University (2018-2019).

2. Best Graduating Student Centre for Entrepreneurship
Enterprise Creation and Skills Acquisition Programme, Kwara State University (2018-2019).

3. Outstanding performance in Social Entrepreneurship, Kwara State University (2018).