Olesia

RESEARCH, TEACHING, or OTHER INTERESTS

General Medicine, Pulmonary and Respiratory Medicine

Scopus Publications

ARTIFICIAL VENTILATION OF THE LUNGS IN THE NEONATAL PERIOD: LONG-TERM OUTCOMES




Morphology of intracoronary thrombi and its prognosis in young and older patients after STEMI
Dmytro Besh and Olesia Besh
Danylo Halytskyi Lviv National Medical University
The article presents the features of the morphologic structure of intracoronary thrombi and the prognosis of acute ST segment elevation myocardial infarction (STEMI) in patients of different age groups.
 Methods: Histological analysis of the aspirated intracoronary clots was performed in 97 patients with STEMI. The patients were divided into two groups: 11 patients aged under 44 (young group) and the remaining older than 45 (older group). The short-term prognosis was determined by: ST-segment resolution, achievement of good coronary flow, myocardial blush, indices of myocardial contractility, and QS wave formation on ECG. The study’s endpoints determined the long-term prognosis: The onset or worsening of angina symptoms, coronary revascularization (PCI or CABG), AMI, and death.
 Results: Elderly patients were substantially more likely to have a history of coronary artery disease, as well as angina attacks, or their equivalents, at rest a few days before the onset of STEMI and arterial hypertension. Dyslipidemia was significantly more common in young patients. Formation of microchannels within the thrombi was significantly more common among older patients. Achieving the target quality of microcirculation was substantially more frequent among young patients (p=0.007). The long-term prognosis was better in young patients due to the lower prevalence of the combined endpoint.
 Conclusions: Elderly patients were more likely to have intracoronary thrombi with microchannel formation, indicating a longer duration of the thrombotic process. The long-term prognosis after STEMI was significantly better in young patients.


EFFICACY OF PRIMARY REHABILITATION MEASURES ASSOCIATED WITH THE DEVELOPMENT OF RECURRENT BRONCHIAL OBSTRUCTION SYNDROME IN YOUNG CHILDREN WITH RESPIRATORY DISORDERS IN NEONATAL PERIOD
Oksana Matsyura, Lesya Besh, Olena Borysiuk, Olesia Besh, Marta Kondratyuk, Olena Sorokopud, and Svitlana Zubchenko
ALUNA
The aim: To improve primary prophylactic measures associated with the development and progression of recurrent bronchial obstruction syndrome in young children, who had suffered respiratory disorders in neonatal period. Materials and methods: Algorithm of primary prophylactic measures implied adequate balanced nutrition, sanation of living conditions, restriction of contact with infectious agents, sanation of chronic foci of infection, systematic training and general fitness. The investigation included 160 young children (1 day – 3 years of age). The basic group (n=80) involved children, who had experienced respiratory disorders in neonatal period and received appropriate respiratory therapy (artificial ventilation and / or spontaneous breathing with continuous positive airway pressure and supply of free oxygen), control group – children, who did not have respiratory disorders and respiratory therapy (n=80). Results: Conducted investigation throughout 12-month monitoring enabled to record the development of recurrent bronchial obstruction syndrome in 43 children (respectively, 30 – 37.50% patients of the basic group versus 13 – 16.25% of control group; p 0.05), could not be obtained. Conclusions: Comparative analysis within groups did not show a reliable difference in the development of recurrent bronchial obstruction syndrome in children (р>0.05), which can be explained by partial following of doctor’s recommendations. There is the need in further study of the issue involving more patients for a longer period of monitoring.


Food Hypersensitivity in Children Aged 0–3 Years of the Lviv Region in Ukraine: A Cross-Sectional Study
Oksana Matsyura, Lesya Besh, Olena Borysiuk, Taras Gutor, Andriana Malska, Oksana Kovalska, Olesia Besh, Olena Sorokopud, and Sandor G. Vari
Frontiers Media SA
Aim: To determine the prevalence and to estimate factors associated with food hypersensitivity in young children of the Lviv region in Ukraine.Methods: A prospective cross-sectional survey study was conducted between 2016 and 2017 in the Lviv region of Ukraine. A specially designed questionnaire about food hypersensitivity of young children developed and validated by M. J. Flokstra-de Blok was used after translation into the Ukrainian language. The questionnaire included 34 questions, grouped into general and detailed information. Parents of children aged 0–3 years were asked to complete the questionnaire at pre-schools and medical institutions.Results: Among 4,500 distributed questionnaires, 3,214 (71%) were completed and processed. Parents reported that 25% of their young children had food hypersensitivity. According to the survey the most common agents involved in food hypersensitivity in young children were cow's milk (34%), egg (28%), and wheat (24%). Hypersensitivity to milk occurred in 50% of children in the age group of 1–2 years. Regional differences associated with food hypersensitivity were also found. Namely, in the Carpathians, there was more hypersensitivity to fish (27%) and honey (22%) than in other regions, while hypersensitivity to soy was detected mostly in Lviv City residents (8.5%). Unknown causes of food hypersensitivity were highly reported (34%) in the Carpathians.Conclusion: Prevalence and some distinctiveness of food hypersensitivity revealed in four geographic and climate zones as well as in Lviv City have a considerable practical use for formulation of recommendations for children with food hypersensitivity.


Translation, adaptation, and initial validation of the Food Allergy Quality of Life Questionnaire - Parent Form (0-12 years) in Ukrainian language
Oksana Matsyura, Anna Menshykova, Lesya Besh, Taras Gutor, Oksana Kovalska, Olesya Besh, Olena Sorokopud, Natalia Lukyanenko, and Bertine Flokstra-de Blok
Termedia Sp. z.o.o.
Aim of the study: The objective of this study was aimed at the translation, adaption, and initial validation of the Food Allergy Quality of Life Questionnaire – Parent Form (FAQLQ-PF) (0–12 years) into Ukrainian language. Material and methods: Sixty patients with cow’s milk allergy and their parents were involved in the study. The FAQLQ-PF translated into Ukrainian language and the Ukrainian version of the Food Allergy Independent Measure (FAIM) were used. Forward and backward translations were done. One independent Ukrainian translator produced forward translations, and 2 other bilingual translators worked on the backward translation according to the World Health Organization guidelines. Construct validity of the Ukrainian FAQLQ-PF (U-FAQLQ-PF) was checked by calculating correlation coefficients between FAIM and U-FAQLQ-PF. The internal consistency was assessed using Cronbach’s alpha coefficient and corrected item-total correlations. Confirmatory factor analysis was used to test the originally proposed 3-factor structure with our data. Results: Feasibility of the U-FAQLQ-PF was 100%, all questionnaires were fully completed by the parents. The total U-FAQLQ-PF scores correlated significantly with the total FAIM. The factor analysis resulted in 3 factors that confirmed the original ones. All the factors had strong loadings from 0.575 to 0.840. Cronbach alphas were 0.72 for the total U-FAQLQ-PF and 0.76–0.84 for its subscales. Corrected item-total correlation was between 0.27 and 0.67 for the total U-FAQLQ-PF, but for each subscale it was > 0.300. Cronbach`s alpha was not increased for the scale and subscales after deletion of any item. Conclusions: The Food Allergy Quality of Life Questionnaire – Parent Form (0–12 years) in Ukrainian language has satisfactory validity and reliability and can be used to improve the management of children with food allergies and in clinical trials.


HYPERSENSITIVITY REACTIONS to FOOD ADDITIVES in PEDIATRIC PRACTICE: TWO CLINICAL CASES




Eczema herpeticum in an infant - A case report
Lesya Besh, , Oksana Matsyura, Olesya Besh, Olga Troyanovska, Svitlana Zubchenko, Zoryana Slyuzar, Sergei Gerasimov, Anna Menshikova, Khrystyna Lishchuk-Yakymovych,et al.
Medical Communications Sp. z.o.o.
Eczema herpeticum is a chronic dermatosis with erosive and ulcerative lesions of the skin in children of a predominantly young age. The clinical case presented in this article shows the severe course of herpesvirus infection combined with atopic dermatitis in a 5-month infant. A rash in the form of vesicles and pustules throughout the body with a predominant localisation on the skin of the face, the scalp, neck, and chest was found in the course of the examination of the child. Influence of infections on the course of allergic processes is an ambiguous and complicated issue. It has been proved that an infection can contribute to the development of allergies and exacerbate the course of already existing allergic inflammation. In recent years, an increasing number of studies have shown the preventive effect of infection on the development of allergic pathology in children, especially during the first years of life.


ALLERGY TO HYPOALLERGENIC METALS