Katrin Streckfuss-Bomeke

Scopus Publications

Chamber-specific chromatin architecture guides functional interpretation of disease-associated Cis-regulatory elements in human cardiomyocytes
S. Haydar, R. Bednarz, P. Laurette, I. Sobitov, N. Díaz i Pedrosa, et al.
Nature Communications, 2026
Cis- regulatory elements (CREs) are noncoding DNA regions regulating cell-type-specific gene expression programs by interacting with distal gene promoters. Here, we aim to decode the function and spatial organization of CRE-promoter interactions in human cardiomyocytes. We analyzed the epigenome and chromatin interactions of human male atrial, ventricular, and failing cardiomyocytes. Atrial and ventricular cardiomyocytes harbored chamber-specific CRE-promoter interactions modulating gene expression as confirmed by functional epigenetic silencing. These CRE-promoter interactions explain the distinct contribution of non-coding genetic variants to atrial and ventricular diseases, such as dilated cardiomyopathy and arrhythmias. We dissected the prototypic KCNJ2 locus, encoding a potassium channel associated with ventricular arrhythmia susceptibility. Functional epigenetic silencing confirmed that CREs, harboring QT-duration-associated genetic risk factors, modulate KCNJ2 gene expression levels, alter KCNJ2-dependent channel currents, and affect cardiomyocyte repolarization. The presented human CM-specific chromatin interaction analysis provides key insights into regulatory mechanisms and aids in interpreting genetic risk factors.
Enhancing KLF15 activity in cardiomyocytes: a novel approach to prevent pathological reprogramming and fibrosis via nuclease-deficient dCas9VPR
Eric Schoger, Rosa Kim, Federico Bleckwedel, Tomas Peralta, Laura Priesmeier, et al.
Signal Transduction and Targeted Therapy, 2026
Transcriptional activity perturbation holds promise for selectively modulating harmful transcriptional networks, but its therapeutic potential remains largely unexplored. We employed a network-based analysis of single-cell heart transcriptomes to identify transcription factor activities linked to pathological cardiomyocytes in vivo. This analysis revealed that transcriptional activity of Krüppel-like factor 15 (KLF15) exhibited the most significant change in pathological cardiomyocytes, characterized by less effective repression of disease-associated genes in stressed hearts, which correlated with reduced KLF15 expression. To restore KLF15 activity, we utilized CRISPR/nuclease-dead (d)Cas9-based transcriptional enhancement (CRISPRa) in cardiomyocytes, which effectively abolished fetal reprogramming by simultaneously suppressing pathological gene expression and restoring metabolic homeostasis under sustained stress conditions. Furthermore, we identified a novel cell-nonautonomous anti-fibrotic effect mediated by cardiomyocyte-fibroblast crosstalk, and revealed the contribution of KLF15-dependent Alpha-2-glycoprotein 1, zinc-binding (AZGP1) regulation in this process. We also elucidated the upstream mechanisms of KLF15 regulation, highlighting its role as a cell-specific downstream target of the broad TGF-β canonical signaling pathway, along with its downstream-dependent mechanisms in human cardiomyocytes. Finally, to enhance the therapeutic potential of this approach, we engineered and validated an adeno-associated viral (AAV) vector with a small CRISPRa system for endogenous regulation in human cardiomyocytes suitable for clinical applications. Overall, we elucidated a regulatory circuit involving TGF-β, KLF15, and AZGP1, which coordinates critical pathological responses through cellular crosstalk between cardiomyocytes and fibroblasts. Importantly, we demonstrated the efficacy of CRISPRa as an epigenetic intervention restoring a critical transcriptional function disrupted in non-genetic heart failure. This approach provides a promising blueprint for future adaptation targeting additional non-hereditary pathologies.
Generation of pluripotent stem cell line (IPWi001-A) and a corresponding CRISPR/Cas9 modified isogenic rescue control (IPWi001-A-1) from a patient with arrhythmia-induced cardiomyopathy harboring a KCNQ1 truncating mutation
Meike Anders, Stefanie Hoppe, Hanna Eberl, Sabine Rebs, Aylin Seedorf, et al.
Stem Cell Research, 2026
Models of the human heart for biomedical research: Opportunities and challenges
Katrin Streckfuss‐Bömeke, Laura C. Zelarayán, Renate B. Schnabel, Nicolle Kränkel, Christoph Maack, et al.
Physiological Reports, 2026
Model systems that mimic human cardiac structure and function are essential for the development of novel diagnostics and effective treatments for cardiovascular diseases. While non‐human vertebrate models, from zebrafish to pig, remain vital to cardiovascular research, the translatability of findings to human patients is often limited. Therefore, animal experiments should be supplemented with human model systems, including human induced pluripotent stem cell‐derived cells, 3D engineered constructs, and last but not least, native tissue preparations and isolated primary cardiomyocytes. However, while human myocardium remains the gold standard, human heart tissue – and particularly tissue from control hearts–remains scarce, and its use in research is generally restricted to settings where tissue has been excised from diseased or failing hearts. While it is in principle possible to use tissue from rejected non‐failing donor hearts that cannot be transplanted, legal hurdles (e.g., in Germany) can restrict the use of non‐transplanted donor organs in research. Given the challenges associated with accessing and using human tissue in biomedical research, an integrated strategy towards combining non‐human vertebrate models, in silico models, and human tissue‐derived models is recommended, enhancing the chances of successful research and development, and helping bridge the gap between preclinical and clinical research.
Cardiac arrhythmias—Cellular mechanisms, consequences and challenges in the diagnostics using human models
Katrin Streckfuß-Bömeke, Christoph Maack, Samuel Sossalla
Herz, 2026
A human-on-human assay for detecting anti-myocardial antibodies in patients with myocardial disease
Anne Auer, Johanna Siegel, Stasa Janjatovic, Margarete Heinrichs, Stefan Störk, et al.
Frontiers in Immunology, 2026
Adaptive immune responses, particularly the production of anti-myocardial antibodies, have been implicated as critical mediators in myocardial healing and remodeling following myocardial infarction (MI), acute myocarditis (Myo), and heart failure (HF). However, current methods for detecting heart-reactive antibodies in patients are insufficient, as most rely on heart tissue slices from primates or other species. These approaches pose technical, logistical, and ethical challenges, including the risk of false negative results due to lack of inter-species cross-reactivity. To address these limitations, we developed a human cell-based assay to screen for patient-derived serum or plasma reactivity against human cardiomyocytes differentiated from induced pluripotent stem cells (iPSC-CMs). This human-on-human test system can detect cardiomyocyte-specific immunoglobulins present in patient plasma by applying indirect immunofluorescence staining, followed by convenient visualization through either confocal microscopy or standard widefield systems available in clinical laboratories. Overall, this approach provides a physiologically relevant and ethically responsible model for rapid, accurate testing of anti-myocardial antibodies across various clinical settings, thus offering accessible tools to stratify patients with myocardial disease according to their adaptive immune response status.
Deregulation of m6A-RNA methylation impairs adaptive hypertrophic response and drives maladaptation via mTORC1-S6K1-hyperactivation and autophagy impairment
Karthika Annamalai, Soniya Dilliker, Eric Buchholz, Ricardo Castro-Hernández, Nikita Panyam, et al.
Cell Communication and Signaling, 2025
Impaired Atrial Mitochondrial Calcium Handling in Patients With Atrial Fibrillation
Julius Ryan D. Pronto, Fleur E. Mason, Eva A. Rog-Zielinska, Funsho E. Fakuade, Donata Bülow, et al.
Circulation Research, 2025
BACKGROUND: Mitochondrial calcium (Ca 2+ ) is a key regulator of cardiac energetics by stimulating the tricarboxylic acid cycle during elevated workload. Atrial fibrillation (AF) is associated with a reduction in cytosolic Ca 2+ transient amplitude, but its effect on mitochondrial Ca 2+ handling and cellular redox state has not been explored. METHODS: Cardiac myocytes isolated from patient-derived right atrial biopsies were subjected to workload transitions using patch-clamp stimulation and β-adrenergic stimulation (isoproterenol). In conjunction, nicotinamide adenine dinucleotide (phosphate)/flavin adenine dinucleotide (NAD[P]H/FAD) autofluorescence, cytosolic and mitochondrial [Ca 2+ ] were monitored using epifluorescence microscopy. Sarcoplasmic reticulum and mitochondria were imaged using electron microscopy and tomography and stimulated emission depletion microscopy. The effects of the mitochondrial Ca 2+ uptake enhancer ezetimibe on proarrhythmic activity in atrial myocytes and on AF burden in patients were investigated. RESULTS: Mitochondrial Ca 2+ accumulation during increased workload was blunted in AF, and was associated with impaired regeneration of nicotinamide adenine dinucleotide and flavin adenine dinucleotide. Nanoscale imaging revealed spatial disorganization of sarcoplasmic reticulum and mitochondria, associated with microtubule destabilization. This was confirmed in human induced pluripotent stem cell–derived cardiac myocytes, where treatment with the microtubule destabilizer nocodazole displaced mitochondria and increased proarrhythmic Ca 2+ sparks, which were rescued by MitoTEMPO. Ezetimibe also reduced the occurrence of arrhythmogenic Ca 2+ release events both in AF myocytes and nocodazole-treated human induced pluripotent stem cell–derived cardiac myocytes. Retrospective patient analysis also revealed a reduced AF burden in patients on ezetimibe treatment. CONCLUSIONS: Mitochondrial Ca 2+ uptake and accumulation are impaired in atrial myocytes from patients with AF. The disturbed spatial association between sarcoplasmic reticulum and mitochondria driven by destabilized microtubules may underlie impaired Ca 2+ transfer in AF. Enhancing mitochondrial Ca 2+ uptake potentially protects against arrhythmogenic events.
Arrhythpy: an automated tool to quantify and classify arrhythmias in Ca2+ transients of iPSC-cardiomyocytes
Karim Ajmail, Charlotte Brand, Thomas Borchert, Benjamin Meder, Sabine Rebs, et al.
American Journal of Physiology Heart and Circulatory Physiology, 2025
Arrhythmias in calcium transients are easy to detect by human perception. However, quantifying these arrhythmias in a computer-readable manner remains challenging. To address this, we developed Arrhythpy, an automated tool that measures arrhythmias in iPSC-derived cardiomyocytes by analyzing Ca2+ transients. Unlike other tools, Arrhythpy directly evaluates arrhythmia levels. It effectively monitors arrhythmias in healthy and diseased iPSC-CMs, including dilated cardiomyopathy and Takotsubo syndrome. Arrhythpy’s flexible framework suits varied cell types and measurement techniques.
Atrial fibrillation in end-stage heart failure: Cellular mechanisms behind CASTLE-HTx
Maria Knierim, Nico Hartmann, Wiebke Maurer, Steffen Pabel, Simon Sedej, et al.
European Journal of Heart Failure, 2025
Mechano-energetic uncoupling in heart failure
Dunja Aksentijevic, Simon Sedej, Jeremy Fauconnier, Melanie Paillard, Mahmoud Abdellatif, et al.
Nature Reviews Cardiology, 2025
Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function
Melanie Paillard, Mahmoud Abdellatif, Ioanna Andreadou, Christian Bär, Luc Bertrand, et al.
European Journal of Heart Failure, 2025
Update on preclinical models of cancer therapy-related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (HFA) of the ESC, the ESC Council of Cardio-Oncology, and the ESC Working Group on Cellular Biology of the Heart
Alessandra Ghigo, Pietro Ameri, Aarti Asnani, Edoardo Bertero, Rudolf A. de Boer, et al.
European Journal of Heart Failure, 2025
Opportunities and challenges for the use of human samples in translational cardiovascular research: a scientific statement of the ESC Working Group on Cellular Biology of the Heart, the ESC Working Group on Cardiovascular Surgery, the ESC Council on Basic Cardiovascular Science, the ESC Scientists of Tomorrow, the European Association of Percutaneous Cardiovascular Interventions of the ESC, and the Heart Failure Association of the ESC
Sean M Davidson, Ioanna Andreadou, Charalambos Antoniades, Jozef Bartunek, Cristina Basso, et al.
Cardiovascular Research, 2025
In Vitro Simulation of Hemodialysis Reveals Hemodialysis-Associated Pro-Arrhythmic Effects in a Human Cardiomyocyte Model
Thomas Körtl, Niklas Hankowitz, Laura Stengel, Oliver Pfeuffer, Dominic Riedl, et al.
Journal of the American Society of Nephrology, 2025
State of the art and perspectives of gene therapy in heart failure. A scientific statement of the Heart Failure Association of the ESC, the ESC Council on Cardiovascular Genomics and the ESC Working Group on Myocardial & Pericardial Diseases
Sophie Van Linthout, Konstantinos Stellos, Mauro Giacca, Edoardo Bertero, Antonio Cannata, et al.
European Journal of Heart Failure, 2025
Methamphetamine-induced cardiotoxicity: in search of protective transcriptional mechanisms
Kristin Annawald, Katrin Streckfuss-Bömeke, Thomas Meyer
Herz, 2024
Generation of a heterozygous Calsequestrin 2 F189L iPSC line (UMGi158-B) by CRISPR/Cas9 genome editing to investigate the cardiac pathophysiology of Takotsubo Syndrome and Catecholaminergic Polymorphic Ventricular Tachycardia
Gideon Syed Ali, Sabine Rebs, Hanna Eberl, Clarissa Zinke, Daniela Hübscher, et al.
Stem Cell Research, 2024
Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner
Zaher ElBeck, Mohammad Bakhtiar Hossain, Humam Siga, Nikolay Oskolkov, Fredrik Karlsson, et al.
Nature Communications, 2024
Cellular calcium handling and electrophysiology are modulated by chronic physiological pacing in human induced pluripotent stem cell-derived cardiomyocytes
Maria Knierim, Thea Bommer, Michael Paulus, Dominic Riedl, Sarah Fink, et al.
American Journal of Physiology Heart and Circulatory Physiology, 2024
Physiologists as medical scientists: An early warning from the German academic system
Katrin Streckfuss‐Bömeke, Nicolle Kränkel, Christoph Maack, Renate B. Schnabel, Laura C. Zelarayán, et al.
Physiological Reports, 2024
Simulation of cardiac arrhythmias in human induced pluripotent stem cell-derived cardiomyocytes
Thea Bommer, Maria Knierim, Julia Unsöld, Dominic Riedl, Laura Stengel, et al.
Plos One, 2024
Generation of a pluripotent stem cell line (UMGi270-A) and a corresponding CRISPR/Cas9 modified isogenic control (UMGi270-A-1) from a patient with sudden onset dilated cardiomyopathy harboring a FLNC p.R2187P mutation
Wiebke Maurer, Sabine Rebs, Steffen Köhne, Hanna Eberl, Bernd Wollnik, et al.
Stem Cell Research, 2024
NaV1.8 as Proarrhythmic Target in a Ventricular Cardiac Stem Cell Model
N. Hartmann, M. Knierim, W. Maurer, N. Dybkova, Florian Zeman, et al.
International Journal of Molecular Sciences, 2024
The challenges of research data management in cardiovascular science: a DGK and DZHK position paper—executive summary
Sabine Steffens, Katrin Schröder, Martina Krüger, Christoph Maack, Katrin Streckfuss-Bömeke, et al.
Clinical Research in Cardiology, 2024
Generation of an RBM20-mutation-associated left-ventricular non-compaction cardiomyopathy iPSC line (UMGi255-A) into a DCM genetic background to investigate monogenetic cardiomyopathies
Hanna Eberl, Sabine Rebs, Stefanie Hoppe, Farbod Sedaghat-Hamedani, Elham Kayvanpour, et al.
Stem Cell Research, 2024
Electrophysiological and calcium-handling development during long-term culture of human-induced pluripotent stem cell-derived cardiomyocytes
Fitzwilliam Seibertz, Henry Sutanto, Rebekka Dülk, Julius Ryan D. Pronto, Robin Springer, et al.
Basic Research in Cardiology, 2023
Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome
Ilona Kutschka, Edoardo Bertero, Christina Wasmus, Ke Xiao, Lifeng Yang, et al.
Basic Research in Cardiology, 2023
Atrial fibrillation-Associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: A novel pathway for antiarrhythmic therapy development
Fitzwilliam Seibertz, Tony Rubio, Robin Springer, Fiona Popp, Melanie Ritter, et al.
Cardiovascular Research, 2023
An interferon gamma response signature links myocardial aging and immunosenescence
DiyaaElDin Ashour, Sabine Rebs, Panagiota Arampatzi, Antoine-Emmanuel Saliba, Jan Dudek, et al.
Cardiovascular Research, 2023
Molecular and Functional Relevance of NaV1.8-Induced Atrial Arrhythmogenic Triggers in a Human SCN10A Knock-Out Stem Cell Model
Nico Hartmann, Maria Knierim, Wiebke Maurer, Nataliya Dybkova, Gerd Hasenfuß, et al.
International Journal of Molecular Sciences, 2023
Large-scale microRNA functional high-throughput screening identifies miR-515-3p and miR-519e-3p as inducers of human cardiomyocyte proliferation
Harsha V. Renikunta, Katina Lazarow, Yiqi Gong, Praphulla Chandra Shukla, Vanasa Nageswaran, et al.
Iscience, 2023
Moving toward gender equity in the cardiology and cardiovascular research workforce in Germany: a report from the German Cardiac Society
Carolin Lerchenmüller, Laura Zelarayan, Katrin Streckfuss-Bömeke, Maria Rubini Gimenez, Renate Schnabel, et al.
European Heart Journal Open, 2023
A novel single-cell RNA-sequencing approach and its applicability connecting genotype to phenotype in ageing disease
Orr Shomroni, Maren Sitte, Julia Schmidt, Sabnam Parbin, Fabian Ludewig, et al.
Scientific Reports, 2022
Tachycardiomyopathy entails a dysfunctional pattern of interrelated mitochondrial functions
Michael G. Paulus, Kathrin Renner, Alexander G. Nickel, Christoph Brochhausen, Katharina Limm, et al.
Basic Research in Cardiology, 2022
Reduction of A-to-I RNA editing in the failing human heart regulates formation of circular RNAs
Karoline E. Kokot, Jasmin M. Kneuer, David John, Sabine Rebs, Maximilian N. Möbius-Winkler, et al.
Basic Research in Cardiology, 2022
Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients
Luis Peter Haupt, Sabine Rebs, Wiebke Maurer, Daniela Hübscher, Malte Tiburcy, et al.
Basic Research in Cardiology, 2022
Atrial Fibrillation Burden Specifically Determines Human Ventricular Cellular Remodeling
Thomas Körtl, Thea Stehle, Dominic Riedl, Johanna Trausel, Sabine Rebs, et al.
Jacc Clinical Electrophysiology, 2022
Genotype Complements the Phenotype: Identification of the Pathogenicity of an LMNA Splice Variant by Nanopore Long-Read Sequencing in a Large DCM Family
Farbod Sedaghat-Hamedani, Sabine Rebs, Elham Kayvanpour, Chenchen Zhu, Ali Amr, et al.
International Journal of Molecular Sciences, 2022
Generation of homozygous Nav1.8 knock-out iPSC lines by CRISPR Cas9 genome editing to investigate a potential new antiarrhythmic strategy
Wiebke Maurer, Nico Hartmann, Loukas Argyriou, Samuel Sossalla, Katrin Streckfuss-Bömeke
Stem Cell Research, 2022
Effects of Atrial Fibrillation on the Human Ventricle
Steffen Pabel, Maria Knierim, Thea Stehle, Felix Alebrand, Michael Paulus, et al.
Circulation Research, 2022
A quantitative RT-PCR protocol to adapt and quantify RBM20-dependent exon splicing of targets at the human locus
Sabine Rebs, Tjark Alexander Buchwald, Katrin Streckfuss-Bömeke
STAR Protocols, 2022
A roadmap for the characterization of energy metabolism in human cardiomyocytes derived from induced pluripotent stem cells
Giulia Emanuelli, Anna Zoccarato, Christina M. Reumiller, Angelos Papadopoulos, Mei Chong, et al.
Journal of Molecular and Cellular Cardiology, 2022
SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy
Jes-Niels Boeckel, Maximilian Möbius-Winkler, Marion Müller, Sabine Rebs, Nicole Eger, et al.
Genomics Proteomics and Bioinformatics, 2022
Cardiomyocyte protein O-GlcNAcylation is regulated by GFAT1 not GFAT2
Adam A Nabeebaccus, Sharwari Verma, Anna Zoccarato, Giulia Emanuelli, Celio XC. Santos, et al.
Biochemical and Biophysical Research Communications, 2021
Identification of SCN5a p.C335R variant in a large family with dilated cardiomyopathy and conduction disease
Farbod Sedaghat-Hamedani, Sabine Rebs, Ibrahim El-Battrawy, Safak Chasan, Tobias Krause, et al.
International Journal of Molecular Sciences, 2021
Detrimental proarrhythmogenic interaction of Ca2+/calmodulin-dependent protein kinase II and NaV1.8 in heart failure
Philipp Bengel, Nataliya Dybkova, Petros Tirilomis, Shakil Ahmad, Nico Hartmann, et al.
Nature Communications, 2021
Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations
Andrey Fomin, Anna Gärtner, Lukas Cyganek, Malte Tiburcy, Izabela Tuleta, et al.
Science Translational Medicine, 2021
Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells
Yelena Sargsyan, Uta Bickmeyer, Christine S Gibhardt, Katrin Streckfuss-Bömeke, Ivan Bogeski, et al.
Life Science Alliance, 2021
Generation and cardiac differentiation of an induced pluripotent stem cell line from a patient with arrhythmia-induced cardiomyopathy
Sabine Rebs, Jakob Beier, Loukas Argyriou, Tillmann Schill, Gerd Hasenfuss, et al.
Stem Cell Research, 2021
Telomerase therapy attenuates cardiotoxic effects of doxorubicin
Shambhabi Chatterjee, Teresa Hofer, Alessia Costa, Dongchao Lu, Sandor Batkai, et al.
Molecular Therapy, 2021
Pluripotent stem cell‐derived mesenchymal stem cells show comparable functionality to their autologous origin
Mark Jakob, Mario Hambrecht, Jennifer L. Spiegel, Julia Kitz, Martin Canis, et al.
Cells, 2021
Long-term effects of empagliflozin on excitation-contraction-coupling in human induced pluripotent stem cell cardiomyocytes
Steffen Pabel, Florian Reetz, Nataliya Dybkova, Orr Shomroni, Gabriela Salinas, et al.
Journal of Molecular Medicine, 2020
Nox4 regulates InsP3 receptor-dependent Ca2+ release into mitochondria to promote cell survival
Matteo Beretta, Celio XC Santos, Chris Molenaar, Anne D Hafstad, Chris CJ Miller, et al.
EMBO Journal, 2020
High-throughput analysis for the identification of viral infections in ps-iPSCs
Daniela Hübscher, Katrin Streckfuss-Bömeke
Biospektrum, 2020
Generation of pluripotent stem cell lines and CRISPR/Cas9 modified isogenic controls from a patient with dilated cardiomyopathy harboring a RBM20 p.R634W mutation
Sabine Rebs, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Benjamin Meder, Katrin Streckfuss-Bömeke
Stem Cell Research, 2020
Dysferlin links excitation-contraction coupling to structure and maintenance of the cardiac transverse-axial tubule system
Julia Hofhuis, Kristina Bersch, Stefan Wagner, Cristina Molina, Funsho E Fakuade, et al.
Europace, 2020
Non-Human Primate iPSC Generation, Cultivation, and Cardiac Differentiation under Chemically Defined Conditions
Michael Stauske, Ignacio Rodriguez Polo, Wadim Haas, Debbra Yasemin Knorr, Thomas Borchert, et al.
Cells, 2020
CRISPLD1: a novel conserved target in the transition to human heart failure
Sara Khadjeh, Vanessa Hindmarsh, Frederike Weber, Lukas Cyganek, Ramon O. Vidal, et al.
Basic Research in Cardiology, 2020
Generation of iPSC-lines from two independent Takotsubo syndrome patients with recurrent Takotsubo events
Daniela Hübscher, Sabine Rebs, Wiebke Maurer, Jelena R. Ghadri, Ralf Dressel, et al.
Stem Cell Research, 2020
Inhibition of NaV1.8 prevents atrial arrhythmogenesis in human and mice
Steffen Pabel, Shakil Ahmad, Petros Tirilomis, Thea Stehle, Julian Mustroph, et al.
Basic Research in Cardiology, 2020
Radiation-induced sensitivity of tissue-resident mesenchymal stem cells in the head and neck region
Jennifer L. Spiegel, Mario Hambrecht, Vera Kohlbauer, Frank Haubner, Friedrich Ihler, et al.
Head and Neck, 2019
The functional consequences of sodium channel NaV1.8 in human left ventricular hypertrophy
Shakil Ahmad, Petros Tirilomis, Steffen Pabel, Nataliya Dybkova, Nico Hartmann, et al.
Esc Heart Failure, 2019
miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity
Shashi Kumar Gupta, Ankita Garg, Petros Avramopoulos, Stefan Engelhardt, Katrin Streckfuss-Bömeke, et al.
Molecular Therapy, 2019
A high-throughput method as a diagnostic tool for HIV detection in patient-specific induced pluripotent stem cells generated by different reprogramming methods
Daniela Hübscher, Sabine Rebs, Luis Haupt, Thomas Borchert, Celina Isabell Guessoum, et al.
Stem Cells International, 2019
Empagliflozin directly improves diastolic function in human heart failure
Steffen Pabel, Stefan Wagner, Hannah Bollenberg, Philipp Bengel, Árpád Kovács, et al.
European Journal of Heart Failure, 2018
Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart
Nataliya Dybkova, Shakil Ahmad, Steffen Pabel, Petros Tirilomis, Nico Hartmann, et al.
Cardiovascular Research, 2018
Clinical nuclear medicine tracers: Easy metabolic assays in stem cell research and cardiac disease?
Katrin Streckfuss-Bömeke
International Journal of Cardiology, 2018
Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy
Farbod Sedaghat-Hamedani, Jan Haas, Feng Zhu, Christian Geier, Elham Kayvanpour, et al.
European Heart Journal, 2017
Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes
Katrin Streckfuss-Bömeke, Malte Tiburcy, Andrey Fomin, Xiaojing Luo, Wener Li, et al.
Journal of Molecular and Cellular Cardiology, 2017
Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy
Thomas Borchert, Daniela Hübscher, Celina I. Guessoum, Tuan-Dinh D. Lam, Jelena R. Ghadri, et al.
Journal of the American College of Cardiology, 2017
Generation of a KLF15 homozygous knockout human embryonic stem cell line using paired CRISPR/Cas9n, and human cardiomyocytes derivation
Claudia Noack, Luis Peter Haupt, Wolfram-Hubertus Zimmermann, Katrin Streckfuss-Bömeke, Laura Cecilia Zelarayán
Stem Cell Research, 2017
Sensing Cardiac Electrical Activity with a Cardiac Myocyte-Targeted Optogenetic Voltage Indicator
Mei-Ling Chang Liao, Teun P. de Boer, Hiroki Mutoh, Nour Raad, Claudia Richter, et al.
Circulation Research, 2015
Patient-specific iPS cells and their application in heart research
Katrin Streckfuß-Bömeke, Lukas Cyganek
Biospektrum, 2015
Human induced pluripotent stem cells are targets for allogeneic and autologous natural killer (NK) cells and killing is partly mediated by the activating NK receptor DNAM-1
Vanessa Kruse, Carina Hamann, Sebastian Monecke, Lukas Cyganek, Leslie Elsner, et al.
Plos One, 2015
Ca2+/calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca2+ leak in human ischaemic and dilated cardiomyopathy
Thomas H. Fischer, Jörg Eiringhaus, Nataliya Dybkova, Anna Förster, Jonas Herting, et al.
European Journal of Heart Failure, 2014
Efficient generation of hepatic cells from multipotent adult mouse germ-line stem cells using an OP9 co-culture system
Katrin Streckfuss-Bömeke, Jörg Jende, I-Fen Cheng, Gerd Hasenfuss, Kaomei Guan
Cellular Reprogramming, 2014
Comparative study of human-induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes, and skin fibroblasts
Katrin Streckfuss-Bömeke, Frieder Wolf, Azadeh Azizian, Michael Stauske, Malte Tiburcy, et al.
European Heart Journal, 2013
Cardiolipin deficiency affects respiratory chain function and organization in an induced pluripotent stem cell model of Barth syndrome
Jan Dudek, I-Fen Cheng, Martina Balleininger, Frédéric M. Vaz, Katrin Streckfuss-Bömeke, et al.
Stem Cell Research, 2013
A feedback circuit between transcriptional activation and self-destruction of Gcn4 separates its metabolic and morphogenic response in diploid yeasts
Britta Herzog, Katrin Streckfuss-Bömeke, Gerhard H. Braus
Journal of Molecular Biology, 2011
Pluripotent stem cells are highly susceptible targets for syngeneic, allogeneic, and xenogeneic natural killer cells
Ralf Dressel, Jessica Nolte, Leslie Elsner, Peter Novota, Kaomei Guan, et al.
FASEB Journal, 2010
Degradation of Saccharomyces cerevisiae transcription factor Gcn4 requires a C-terminal nuclear localization signal in the cyclin Pcl5
Katrin Streckfuss-Bömeke, Florian Schulze, Britta Herzog, Eva Scholz, Gerhard H. Braus
Eukaryotic Cell, 2009
Generation of functional neurons and glia from multipotent adult mouse germ-line stem cells
Katrin Streckfuss-Bömeke, Alla Vlasov, Swen Hülsmann, Dongjiao Yin, Karim Nayernia, et al.
Stem Cell Research, 2009
The Saccharomyces homolog of mammalian RACK1, Cpc2/Asc1p, is required for FLO11-dependent adhesive growth and dimorphism
Oliver Valerius, Malte Kleinschmidt, Nicole Rachfall, Florian Schulze, Sarai López Marín, et al.
Molecular and Cellular Proteomics, 2007

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