V G Abilash
@vit.ac.in
ASSISTANT PROFESSOR SENIOR, DEPARTMENT OF BIO-MEDICAL SCIENCES, SBST, VIT
VELLORE INSTITUTE OF TECHNOLOGY
RESEARCH INTERESTS
GENETICS, MOLECULAR BIOLOGY, PHARMACOLOGY, TOXICOLOGY AND REPRODUCTIVE BIOLOGY
Scopus Publications
Scopus Publications
Kaviyarasi Renu, Vishnu Priya Veeraraghavan, and Abilash Valsala Gopalakrishnan
Elsevier BV
Mahalaxmi Iyer, Ajay Elangovan, Ramya Sennimalai, Harysh Winster Suresh Babu, Saranya Thiruvenkataswamy, Jayalakshmi Krishnan, Mukesh Kumar Yadav, Abilash Valsala Gopalakrishnan, Arul Narayanasamy, and Balachandar Vellingiri
Elsevier BV
Uddesh Ramesh Wanjari and Abilash Valsala Gopalakrishnan
Springer Science and Business Media LLC
Sayanti Mandal, Santosh Kumar Gupta, Mimosa Ghorai, Manoj Tukaram Patil, Protha Biswas, Manoj Kumar, Radha, Abilash Valsala Gopalakrishnan, Vikas Moreshwar Mohture, Md. Habibur Rahman,et al.
Springer Science and Business Media LLC
Shatakshi Mitra, Protha Biswas, Anupriya Bandyopadhyay, Vijaykumar Shivaji Gadekar, Abilash Valsala Gopalakrishnan, Manoj Kumar, Radha, and Samapika Nandy
Springer Science and Business Media LLC
Shalaka S. Ramgir, Sivakumar Annamalai, and V. G. Abilash
Springer Science and Business Media LLC
Uddesh Ramesh Wanjari and Abilash Valsala Gopalakrishnan
Springer Science and Business Media LLC
Mahalaxmi Iyer, Uttpal Anand, Saranya Thiruvenkataswamy, Harysh Winster Suresh Babu, Arul Narayanasamy, Vijay Kumar Prajapati, Chandan Kumar Tiwari, Abilash Valsala Gopalakrishnan, Elza Bontempi, Christian Sonne,et al.
Elsevier BV
Anirban Goutam Mukherjee, Kaviyarasi Renu, Abilash Valsala Gopalakrishnan, Vishnu Priya Veeraraghavan, Sathishkumar Vinayagam, Soraya Paz-Montelongo, Abhijit Dey, Balachandar Vellingiri, Alex George, Harishkumar Madhyastha,et al.
MDPI AG
The authors would like to make the following corrections to the published paper [...]
Anirban Goutam Mukherjee, Abilash Valsala Gopalakrishnan, and Amitava Mukherjee
Elsevier BV
Ajay Elangovan, Bhawna Dahiya, Laxmi Kirola, Mahalaxmi Iyer, Priyanka Jeeth, Sakshi Maharaj, Nikki Kumari, Vikas Lakhanpal, Tanja Maria Michel, K.R.S. Sambasiva Rao,et al.
Elsevier BV
Anirban Goutam Mukherjee and Abilash Valsala Gopalakrishnan
Springer Science and Business Media LLC
Chandramohan Govindasamy, Khalid S. Al-Numair, Mohammed A. Alsaif, Abilash Valsala Gopalakrishnan, and Raja Ganesan
Elsevier BV
Manisha Parthasarathy, Vijayadharshini Seenivasan, Sangeetha Nithiyanandam, Ramkumar Katturajan, Deepak Haraganahalli Bhasakarmurthy, Raja Ganesan, Abilash Valsala Gopalakrishnan, Sheikh F. Ahmad, and Sabina Evan Prince
Bentham Science Publishers Ltd.
Background:: Methotrexate (MTX) is a widely used medication for treating various conditions, including skin infections, inflammatory diseases, autoimmune disorders, and malignancies. However, prolonged and extreme use of MTX can lead to detrimental effects on multiple organs. Green Chiretta (GC) is a traditional medicinal plant known for its anti-inflammatory, antioxidant, and immunostimulatory properties. Objective:: The objective of this study is to examine the antioxidant potential of GC through in-vitro analysis and to assess the potential protective effects of aqueous leaf extracts of GC against MTXinduced cardiac and spleen toxicity. Methods:: In-vitro antioxidant activity was assessed by measuring total phenolic content, DPPH, catalase and peroxidase activity. We divided rats into five groups (n=6), and after the study, rats were euthanized and the levels of antioxidants (SOD, CAT & GSH) and lipid peroxidase (MDA), as well as histopathology modification of the heart and spleen tissues were examined. Results:: Our study's findings highlight the superiority of the aqueous GC extract's antioxidant capacity relative to other solvents (ethanol and methanol). Moreover, the aqueous GC extract's administration to rats yielded significant progress in antioxidant levels (Superoxide dismutase, catalase, glutathione), a reduction in lipid peroxidation (MDA), and the restoration of cardiac and spleen histoarchitecture against MTX-induced toxicity. These results collectively emphasize the extract's potential as a valuable therapeutic option against oxidative stress and tissue damage. Conclusion:: The present study revealed that the aqueous GC extract demonstrated its protective efficacy against MTX-induced cardio and spleen toxicity in Wistar albino rats
Anila Venugopal, Mahalaxmi Iyer, Arul Narayanasamy, T. Ravimanickam, Abilash Valsala Gopalakrishnan, Mukesh Kumar Yadav, Nachimuthu Senthil Kumar, and Balachandar Vellingiri
Springer Science and Business Media LLC
Shaika Shanbagh, Santosh Gopikrishna Gadde, Rohit Shetty, Stephane Heymans, V.G. Abilash, Shyam S. Chaurasia, and Arkasubhra Ghosh
Elsevier BV
Kaviyarasi Renu, Anirban Goutam Mukherjee, Abilash Valsala Gopalakrishnan, Uddesh Ramesh Wanjari, Sandra Kannampuzha, Reshma Murali, Vishnu Priya Veeraraghavan, Sathishkumar Vinayagam, Soraya Paz-Montelongo, Alex George,et al.
Elsevier BV
Reshma Murali and Abilash Valsala Gopalakrishnan
Springer Science and Business Media LLC
Dhivya Venkatesan, Mahalaxmi Iyer, Neethu Raj, Abilash Valsala Gopalakrishnan, Arul Narayanasamy, Nachimuthu Senthil Kumar, and Balachandar Vellingiri
Springer Science and Business Media LLC
Balachandar Vellingiri, Kiruthika Balasubramani, Mahalaxmi Iyer, Neethu Raj, Ajay Elangovan, Kwonwoo Song, Han‐Cheol Yeo, Namitha Jayakumar, Masako Kinoshita, Ravimanickam Thangarasu,et al.
Wiley
AbstractParkinson's disease (PD) is a complex condition that is significantly influenced by oxidative stress and inflammation. It is also suggested that telomere shortening (TS) is regulated by oxidative stress which leads to various diseases including age‐related neurodegenerative diseases like PD. Thus, it is anticipated that PD would result in TS of peripheral blood mononuclear cells (PBMCs). Telomeres protect the ends of eukaryotic chromosomes preserving them against fusion and destruction. The TS is a normal process because DNA polymerase is unable to replicate the linear ends of the DNA due to end replication complications and telomerase activity in various cell types counteracts this process. PD is usually observed in the aged population and progresses over time therefore, disparities among telomere length in PBMCs of PD patients are recorded and it is still a question whether it has any useful role. Here, the likelihood of telomere attrition in PD and its implications concerning microglia activation, ageing, oxidative stress, and the significance of telomerase activators are addressed. Also, the possibility of telomeres and telomerase as a diagnostic and therapeutic biomarker in PD is discussed.
Kaviyarasi Renu, Haritha Myakala, Rituraj Chakraborty, Sharmishtha Bhattacharya, Asmita Abuwani, Mariyam Lokhandwala, Balachandar Vellingiri, and Abilash Valsala Gopalakrishnan
Wiley
AbstractAlcohol consumption has been linked to numerous negative health outcomes although it has some beneficial effects on moderate dosages, the most severe of which being alcohol‐induced hepatitis. The number of people dying from this liver illness has been shown to climb steadily over time, and its prevalence has been increasing. Researchers have found that alcohol consumption primarily affects the brain, leading to a wide range of neurological and psychological diseases. High‐alcohol‐consumption addicts not only experienced seizures, but also ataxia, aggression, social anxiety, and variceal hemorrhage that ultimately resulted in death, ascites, and schizophrenia. Drugs treating this liver condition are limited and can cause serious side effects like depression. Serine‐threonine kinases, cAMP protein kinases, protein kinase C, ERK, RACK 1, Homer 2, and more have all been observed to have their signaling pathways disrupted by alcohol, and alcohol has also been linked to epigenetic changes. In addition, alcohol consumption induces dysbiosis by changing the composition of the microbiome found in the gastrointestinal tract. Although more studies are needed, those that have been done suggest that probiotics aid in keeping the various microbiota concentrations stable. It has been argued that reducing one's alcohol intake may seem less harmful because excessive drinking is a lifestyle disorder.
Dhivya Venkatesan, Mahalaxmi Iyer, Arul Narayanasamy, Abilash Valsala Gopalakrishnan, and Balachandar Vellingiri
Springer Science and Business Media LLC
Anupriya Bandyopadhyay, Tuyelee Das, Samapika Nandy, Synudeen Sahib, Subham Preetam, Abilash Valsala Gopalakrishnan, and Abhijit Dey
Springer Science and Business Media LLC
Pragya Bradu, Antara Biswas, Chandralekha Nair, Salini Sreevalsakumar, Megha Patil, Sandra Kannampuzha, Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Kaviyarasi Renu, Balachandar Vellingiri,et al.
Springer Science and Business Media LLC
Arunraj Namachivayam and Abilash Valsala Gopalakrishnan
Elsevier BV