New Insights from the Expression of the Mismatch Repair System in Pituitary Neuroendocrine Tumors Francesca Carbonara, Francesca Gianno, Tiziana Feola, Francesco Mancinelli, Dario De Alcubierre, Mariana Moroni, Eleonora Lucantonio, Antonietta Arcella, Alba Di Pardo, Roberta Morace, Andrea M. Isidori, Stefano Gambardella, Vincenzo Esposito, Marie-Lise Jaffrain-Rea Endocrine Pathology, 2026 Although defects in the mismatch repair (MMR) system have been occasionally reported in aggressive/metastatic pituitary neuroendocrine tumors (PitNETs), the potential role of MMR dysregulation in pituitary tumorigenesis is largely unknown. This study aimed to evaluate the expression of the four key MMR components in a large series of PitNETs. MMR gene expression was studied by RT-qPCR in 127 tumors (54 PIT1, 51 SF1, 22 TPIT), and semi-quantitative immunohistochemistry (score 0-12) in selected cases (n=46). MSH2/6 and MLH1 promoters methylation was studied in 96 tumors. Except for MLH1, tumor lineage of origin was the most significant factor influencing MMR transcripts (P=0.005, <0.001 and 0.039 for MSH2/6 and PMS2, respectively), the highest levels being observed in SF1 tumors. Within subgroups, MMR transcripts were significantly lower in large/invasive PIT1 and in functioning TPIT tumors. MSH2 promoter methylation was occasionally associated with reduced MSH2 expression. Global loss of MSH6 (score 0), defining MMR deficiency, was observed in a single silent lactotroph PitNET, unrelated to the Lynch's syndrome. Near global loss involving MSH6, MSH2 or PMS2 (score 1) was observed in 5 tumors (1 lactotroph, 1 SF1, 3 TPIT). MMR mutations were excluded in 4/5 cases but 2 had LOH at MSH2/MSH6 loci. Heterogeneous immunostaining for any MMR (score 2-4) was also observed in 15 cases. In conclusion, MMR deficiency was rarely observed (2.2%) but reduced MMR expression could be found, especially in functioning corticotroph and invasive lactotroph tumors. The molecular mechanisms and prognostic significance of such findings would deserve further investigation.
Surgical treatment of recurrent glioblastoma: a multicenter perspective from the Italian society of neurosurgery (SINch®) and a systematic review Pier Paolo Panciani, Tamara Ius, Giuseppe Lombardi, Nicola Montemurro, Alessandro Agnoletti, Roberto Altieri, Giuseppe M. V. Barbagallo, Michela Buglione, Giuseppe Catapano, Luigi Maria Cavallo, Francesco Certo, Domenico d’Avella, Luca Denaro, Giuseppe Maria Della Pepa, Lucio De Maria, Vincenzo Esposito, Antonio Fioravanti, Diego Garbossa, Elisabetta Marton, Rossella Merli, Giovanni Nodari, Alessandro Olivi, Alessandro Frati, Fabrizio Pignotti, Giovanni Raffa, Fabio Raneri, Giovanni Sabatino, Teresa Somma, Francesco Guerrini, Giannantonio Spena, Stefano Telera, Cesare Tomasi, Gianluca Trevisi, Luca Zanin, Marco Maria Fontanella, Filippo Flavio Angileri Neurosurgical Review, 2026
Uncertainty-aware semi-supervised learning for neurosurgical navigation Francesco Nitti, Silvia Seoni, Alberto Morello, Lorenzo Dolci, Amedeo Piazza, Vincenzo Esposito, Luigi Rosito, Diego Garbossa, Fabio Cofano, Abdulkadir Sengur, Massimo Salvi Applied Soft Computing, 2026 Accurate, real-time segmentation of anatomical structures during neurosurgical procedures can support intraoperative orientation. One of the most significant challenges in this domain is developing robust segmentation models with limited annotated data while maintaining clinical reliability. This work addresses how semi-supervised learning can leverage both labeled and unlabeled data, while ensuring the dependability crucial for clinical applications where even small segmentation errors can have significant consequences. Methods: We present a novel uncertainty-aware semi-supervised framework for neurosurgical scene segmentation. Our approach introduces Semantic Spatial Uncertainty (SSU), a metric that quantifies prediction reliability by analyzing spatial consistency across multiple stochastic forward passes using Monte Carlo Dropout. The framework employs class-specific calibration with adaptive thresholds that continuously refine through iterative pseudo-labeling, effectively counteracting dataset imbalance. Results: Our method achieves significant improvements for clinically critical classes, with relative gains in Dice Similarity Coefficient of +40% for tumors, +15% for middle cerebral artery and +14% for aneurysm. Unlike traditional uncertainty measures, SSU captures uncertainty even for structures with high perimeter-to-area ratios, demonstrating strong correlation with segmentation quality (Pearson coefficient -0.85) without requiring ground truth. Our approach also outperforms intensive data augmentation (even at 200% synthetic samples) and maintains effectiveness across multiple architectures, demonstrating its architecture-agnostic advantages . Conclusion: By reframing annotation scarcity as an uncertainty quantification problem, our approach provides a practical solution for medical image segmentation in data-constrained environments. This segmentation framework offers potential applications beyond neurosurgery to other computer vision segmentation tasks with limited labeled data. Code is available at https://github.com/nittifra/ua-ssl-neuro • Novel Spatial Uncertainty metric guides semi-supervised neurosurgical segmentation • Class-specific calibration ensures reliable pseudo-labeling with adaptive thresholds • Major gains for rare classes (+40% Dice for tumors, +14% for aneurysms) • Outperforms data augmentation and generalizes across different architectures • Real-time speed (3ms/frame) enables practical intraoperative use
Ageing and pituitary neuroendocrine tumours (PitNETs): from bench to bedside Dario De Alcubierre, Francesca Carbonara, Tiziana Feola, Francesca Gianno, Giuseppe Minniti, Vincenzo Esposito, Marie-Lise Jaffrain-Rea Endocrine Related Cancer, 2026 Graphical Abstract Abstract The prevalence of pituitary neuroendocrine tumours (PitNETs) in elderly people (≥65 years old) is raising with life expectancy. Despite an increasing incidental detection on neuroimaging for unrelated conditions, a large majority are macrotumours (≥1 cm) and mass effects are frequent, in particular visual defects. Clinically non-functioning PitNETs are the most prevalent (about 75%), and a majority are gonadotrophs. The clinical presentation of functioning PitNETs differ from younger patients and include somatotroph tumours – often intrasellar with mild acromegaly, prolactinomas – often large and invasive, and rare corticotroph and uncommon thyrotroph tumours. Such epidemiological characteristics likely reflect different biological features as compared with PitNETs diagnosed in younger patients. Epigenetic alterations are more frequent than mutations, whereas cell senescence and age-related changes in immune surveillance and feedback mechanisms from ageing target organs may play an underestimated role. Endocrinological changes associated with ageing and concomitant pathological conditions should be considered as relevant confounding factors for diagnosis. In particular, ocular diseases may mask visual defects, progressive symptoms of hypopituitarism may be misinterpreted as ageing, and peripheral physiological (menopause) or pathological dysfunction or drugs given for other diseases can alter pituitary hormone secretion. Mild hypersecretion should be searched for in clinically non-functioning cases, as it may significantly impact on clinical management. Multidisciplinary evaluation is necessary to define personalized therapeutic goals, and where indicated, surgery should be performed by experienced pituitary surgeons. The development of innovative diagnostic and prognostic markers would usefully support the clinical management and follow-up of PitNETs in elderly patients.
Life-Threatening Radiation Necrosis After Complete Response to Pembrolizumab in a Patient With a Metastatic Silent PIT1 Pituitary Neuroendocrine Tumor (PitNET) Dario De Alcubierre, Tiziana Feola, Francesca Gianno, Monica Verrico, Francesca Carbonara, Eugenio Venditti, Andrea M. Isidori, Vincenzo Esposito, Giuseppe Minniti, Marie‐Lise Jaffrain-Rea Journal of Immunotherapy, 2026 Metastatic pituitary neuroendocrine tumors (metPitNETs) are rare neoplasms with limited therapeutic options. Temozolomide is the first-line therapy, but primary or secondary resistance frequently occurs. Immune checkpoint inhibitors (ICIs) are emerging as a promising second-line option; however, clinical experience remains limited. We report the long-term follow-up of a 62-year-old male patient who received pembrolizumab (PBZ) treatment for a silent metPitNET derived from the PIT1 lineage after multiple surgical and radiation therapies and temozolomide failure. PBZ was proposed based on extensive PD‐L1 expression by tumor cells. A remarkable clinical, radiologic, and metabolic response was soon observed, progressively leading to complete disease remission after 21 months of treatment, with moderate immune-related adverse events. However, an unexpected rapid neurological deterioration occurred, due to the progression of a pseudotumoral temporal radionecrosis surrounded by an impressive vasogenic oedema, requiring emergency neurosurgery 7 weeks after PBZ withdrawal. The temporal mass had progressively developed on a previous small temporal metastasis treated through stereotactic radiosurgery, the corresponding area was hypometabolic at 18 FDG PET-CT imaging, and histopathologic examination confirmed extensive radionecrosis and the absence of residual tumor cells. This is the first documented complete response to ICI in a PIT1-derived metPitNET. However, this remarkable response was complicated by the severe evolution of a brain radionecrosis, probably favoured by long-term PBZ. This case underscores the need for multidisciplinary expertise to differentiate treatment effects from neoplastic progression and to carefully follow-up the patients for potentially severe late treatment-related complications. It also questions the optimal duration of treatment in responsive cases.
Anti-seizure prophylaxis in brain tumors: An Italian survey among epileptologists Elena Pasini, Giada Pauletto, Marta Maschio, Roberto Michelucci, and Epilepsia Open, 2026 In order to elucidate any differences in the therapeutic approach in patients with epilepsy affected by cerebral tumors, we conducted a brief survey to Italian epileptologists (neurologists and neurosurgeons) affiliated with the Italian League Against Epilepsy (LICE). Epilepsy is the most common symptom associated with cerebral tumors, occurring in the 35%–75% of cases. The incidence is even higher in low-grade tumors, although it may also be influenced by tumor size, location and protein expression.1 According to ILAE guidelines, a diagnosis of epilepsy in the presence of a consistent cerebral lesion requires at least only a single ictal event in order to justify initiation of anti-seizure medication (ASM), whereas the prophylactic use of ASMs in seizure-naïve brain tumor is not recommended.2 Similarly, according to SNO (the Italian Neurohospitalist Society) and EANO (European Association of Neuro-Oncology) practice guidelines; there is no evidence to support the routine prescription of ASM in the perioperative or postoperative period.3 Finally, in recent years, many studies have focused on the hypothetical anti-epileptogenic effect of ASMs, although promising data have so far been limited to preclinical studies.4-6 In addition, available guidelines and literature revisions suggest the prescription of newer drugs in order to avoid interactions and reduce side effects.3 In the real-world clinical practice, however, adherence to these recommendations is often inconsistent. This may be due to variations in healthcare organization, institutional protocols, and individual prescribing habits. Our survey was a cross-sectional study targeting experienced epileptologists routinely involved in the management of tumor-related epilepsy. The aim was to identify the gap between current guidelines and real-world therapeutic approaches for patients with epilepsy and primary brain tumors in Italy. The survey consisted of six items (full text in Table 1). The first four were multiple-choice questions with closed responses, whereas the last two were open-ended. The survey data collection and analysis were performed using Microsoft Excel software. Only epileptologists belonging to a qualified center for the treatment of brain tumor patients were invited to participate. The survey was distributed in February 2023 with a span of 14 day window for completion. A total of 57 LICE members answered the survey (see the Figure 1 for a geographical representation of participating centers). The first question explored the attitude to introduce an ASM in High-Grade Gliomas (HGG) after a first seizure. Fifty-two epileptologists (91.2%) confirmed the attitude to introduce an ASM after the first seizure. Two (3.5%) preferred to wait for a second seizure, one (1.8%) decided on EEG results basis, and two (3.5%) chose not to initiate treatment at all. The second question explored the therapeutic attitude in HHG without seizures. Twenty-seven epileptologists (47.4%) reported not prescribing prophylactic therapy, 17 (29.8%) deferred the decision to the neurosurgeon, 8 (14%) introduced therapy during the perioperative period to prevent symptomatic postcraniotomy seizures and 5 (8.8%) prescribed long-term prophylaxic ASMs. The third question asked about ASM duration after a single seizure at HGG onset. Most responders (48, the 84.2%) favored long-term therapy, while 9 (15.8%) recommended withdrawal after the perioperative or radiotherapy phase. The fourth question concerned the diagnostic pathways of Low-Grade Gliomas (LGG)/Long-Term Epilepsy-Associated Tumors (LEAT). Forty respondents (70.2%) preferred a tailored surgery after appropriate diagnostic investigations or referred the patient to an epilepsy surgery center. Twelve (21.1%) decided upon a quick surgery without prior epileptological evaluation and 5 (8.8%) chose for the medical therapy until pharmacoresistance emerged. The final two questions explored preferred ASMs for HHG and LGG/LEAT patients. For HHG, first-line treatment was levetiracetam (43, 75.4%) followed by lacosamide (7, 12.3%) and valproate. Second-line choices were lacosamide (31, 54.4%), levetiracetam (9, 15.8%) and valproate (4, 7.0%). Third-line options included valproate (10, 17.5%), lacosamide (8, 14.0%) and perampanel (7, 12.3%). For LGG/LEAT, first-line treatment was levetiracetam (34, 59.6%), followed by lacosamide (10, 17.5%) and carbamazepine (7, 12.3%). Second-line choices were lacosamide (25, 43.9%), levetiracetam (19.3%) and carbamazepine (8, 14.0%). Third-line treatments were equally distributed among lacosamide (10, 17.5%), oxcarbazepine (9, 15.8%) and carbamazepine (7, 12.3%) (see Figure 2 for full details). This brief survey assessed the current therapeutic attitudes of Italian epileptologists regarding ASM management in patients with brain tumors. First, the results confirm the alignment of the epileptologists to ILAE and neuro-oncological guidelines for the treatment of the first seizure in the contest of brain tumors, reflecting awareness of the high risk of seizure recurrence. ASM initiation after a single seizure remains widely accepted among specialists. However, the management of seizure-naïve HGG remains controversial. Despite guideline recommendations against prophylactic treatment, nearly half of the responders seem to prefer ASM prophylaxis, at least temporarily, or defer the decision to the neurosurgeon. This tendency is likely driven by a desire to prevent early postoperative seizures, as suggested in studies of postcraniotomy seizures following traumatic brain injury.7 Regarding long-term prophylaxis, despite a lack of demonstrated benefit, this practice persists, likely due to the paucity of robust, well-designed trials and the historical use of older ASMs. Considering the high incidence of seizures in cerebral tumors (at the onset or during the course), as well as the ease of handling new drugs, prospective controlled trials are urgently needed to evaluate ASM prophylaxis, with attention to quality of life and healthcare costs. When a cerebral tumor presents with one or more seizures, the duration of therapy is debated, but most responders (85%) seem to favor long-term ASM therapy. Since tumors are an on-going developing pathology, one could opt for a lifelong therapy. Nevertheless, 15.8% of the interviewed declared that they withdraw therapy after the perioperative/radiotherapy phase, possibly viewing the seizures as acute symptomatic rather than indicative of chronic epilepsy. Concerning the therapeutic management of patients with LGG/LEATs, over 70% of the respondents favored tailored surgery aimed at both seizure control and histological diagnosis. Indeed, patients affected by LGG/LEATs show a high incidence of drug-resistant epilepsy despite a relatively low risk of oncological progression. For this reason, the epilepsy must be taken into account as the main problem for the patient's quality of life and deserves a specific neurosurgical approach, consisting of tailored surgery, sometimes preceded by a long-term video-EEG monitoring. In this study, the choice of an epilepsy surgery approach was probably influenced by the preponderance of epileptologists over neurosurgeons who answered the survey. This underscores the need for a national network to share case management and promote interdisciplinary decision-making. Concerning the pharmacological choices in these patients, levetiracetam and lacosamide emerged, as expected, as the most widely used drugs for prophylaxis in both HGG and LGG/LEATs. Their favorable pharmacokinetic and pharmacodynamic profiles—minimal drug interactions, good tolerability, and high efficacy—make them the preferred options. The third-line use of valproate in HGG likely reflects historical interest in its potential antitumor effects, while the inclusion of perampanel may relate to its potential modulation of glutamatergic neurotransmission.8 Despite the existence of several consensus statements and guidelines, this survey confirmed a significant variability in the therapeutic approach of these patients and further supports the need of prospective controlled trials to better define standardized treatment strategies. EP: conceptualization; formal analysis; data curation; writing original draft. MR: conceptualization; methodology; supervision; validation; visualization; review & editing. PG: conceptualization; methodology; supervision; review & editing. MM: conceptualization; review & editing. The authors have nothing to report. None of the authors has something to disclose. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. Umberto Aguglia, Cinzia Costa, Giuseppe Didato, Vincenzo Esposito, Enrico Franceschi, Anna Teresa Giallonardo, Angela La Neve, Marta Maschio, Giada Pauletto, Flavio Villani, Paolo Vitali, Matteo Martinoni, Marta Piccioli. The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
Perioperative Management of Chronic Subdural Hematoma Under Antithrombotic Therapy: A Multicenter Analysis of 679 Patients Giuseppe Corazzelli, Maria Rosaria Scala, Luigi Sigona, Ioana Maftei, Ciro Mastantuoni, Sergio Corvino, Valentina Cioffi, Francesco Corazzelli, Gautam Maharajan, Settimio Leonetti, Rosario Barbato, Francesco Ricciardi, Paolo Di Russo, Gennaro De Rosa, Maria Sacco, Nicola Gorgoglione, Valentina Pizzuti, Giandomenico Petrella, Alessandro D'Elia, Giuseppe Catapano, Salvatore Di Colandrea, Plinio Cirillo, Sergio Paolini, Vincenzo Esposito, Gualtiero Innocenzi, Antonio Bocchetti, Raffaele de Falco Neurosurgery, 2026 BACKGROUND AND OBJECTIVES: Management of chronic subdural hematoma (cSDH) in elderly patients receiving antithrombotic therapy remains heterogeneous, and surgical evacuation is often delayed allowing partial pharmacological washout despite limited supporting evidence. The aim of this study was to determine whether a structured perioperative pathway permits safe evacuation of cSDH as soon as logistically feasible, without awaiting drug washout, and to evaluate differences in recurrence probability and timing across antiplatelet, anticoagulant, and nonantithrombotic cohorts. METHODS: A multicenter retrospective analysis was conducted on consecutive elderly patients treated through a shared perioperative management. Patients were stratified into antiplatelet therapy (Group A, n = 199), anticoagulant therapy (Group B, n = 254), and no antithrombotic therapy (Group C, n = 226). Early recurrence rates were compared using predefined ±10% equivalence margins. Independent predictors of recurrence probability were identified using multivariate logistic regression analysis, and determinants of recurrence timing were assessed with Cox proportional hazards model. RESULTS: Early recurrence occurred in 9.0% of Group A, 11.8% of Group B, and 13.7% of Group C, with no significant differences among groups. Equivalence testing confirmed that recurrence rates met predefined equivalence criteria across all pairwise comparisons. Mean time to recurrence differed significantly ( P = .023), with earlier recurrence in antiplatelet-treated patients. In the multivariate logistic regression model, postoperative length of stay was the only independent predictor of recurrence probability ( P < .001). In the Cox model, antiplatelet therapy (hazard ratio 3.387, P < .001) and a history of stroke (hazard ratio 2.726, P = .034) independently influenced recurrence timing, whereas pharmacological status did not increase recurrence incidence. Complication rates were comparable across groups, and no thromboembolic events were observed. CONCLUSION: A shared perioperative pathway allowed cSDH evacuation as soon as logistically feasible while maintaining comparable early recurrence rates across antiplatelet, anticoagulant, and nonantithrombotic groups, despite differences in time to recurrence. Distinct predictors of recurrence probability and timing support the feasibility and clinical relevance of immediate surgical treatment within a coordinated perioperative framework.
Evaluating the role of gross total resection in primary spinal cord glioblastoma: evidence from a multicenter cohort and meta-analysis Giuseppe Corazzelli, Sergio Corvino, Luigi Sigona, Valentina Cioffi, Francesco Ricciardi, Maria Rosaria Scala, Cristina Mancarella, Ciro Mastantuoni, Anthony Kevin Scafa, Francesco de Falco, Valentina Pizzuti, Alessandro D’Elia, Settimio Leonetti, Salvatore Di Colandrea, Giuseppe Catapano, Antonio Bocchetti, Sergio Paolini, Vincenzo Esposito, Gualtiero Innocenzi, Raffaele de Falco Journal of Neuro Oncology, 2025
Trends in epilepsy surgery in Italy before and after the COVID-19 pandemic: A nationwide study Giuseppe Didato, Federico Vigevano, Laura Tassi, Renzo Guerrini, Marco de Curtis, Luca De Palma, Giancarlo Di Gennaro, Lino Nobili, Matteo Martinoni, Stefano Meletti, Domenica Battaglia, Elisabetta Cesaroni, Roberta Vittorini, Laura Grisotto, Giuseppe d'Orsi, Robertino Dilena, Valeria Pingue, Antonio Nardone, Federica Ranzato, Claudio Zucca, Paolo Bonanni, Pietro Mattioli, Gianpiero Tamburrini, Michela Quintiliani, Michele Luzi, Roberto Trignani, Francesca Torta, Giovanni Morana, Matteo Pugnaghi, Anna Elisabetta Vaudano, Francesca Bisulli, Elena Pasini, Alessandro Consales, Giulia Nobile, Vincenzo Esposito, Pier Paolo Quarato, Elena Freri, Carlo Efisio Marras, Flavio Giordano, Veronica Pelliccia, Laura Castana, Nicola Specchio, Umberto Costantino, Mauro Pluderi, Michele Rizzi, Diana Polo, Stefania Zambrano, Alberto Danieli, Flavio Villani, Carmen Barba, and Epilepsia, 2025
Comprehensive Surgical Management of Thoracic Schwannomas: A Retrospective Multicenter Study on 98 Lesions Giuseppe Corazzelli, Sergio Corvino, Maria Marvulli, Valentina Cioffi, Alessandro D'Elia, Vincenzo Meglio, Roberto Tafuto, Ciro Mastantuoni, Maria Rosaria Scala, Francesco Ricciardi, Salvatore Di Colandrea, Settimio Leonetti, Pasqualino De Marinis, Sergio Paolini, Vincenzo Esposito, Alfonso Fiorelli, Gualtiero Innocenzi, Oreste de Divitiis, Raffaele de Falco, Antonio Bocchetti Neurosurgery, 2025
Assessing Surgical Approaches and Postoperative Complications for Thoracic Schwannomas: A Multicenter Retrospective Observational Analysis of 106 Cases Giuseppe Corazzelli, Antonio Bocchetti, Marco Filippelli, Maria Marvulli, Sergio Corvino, Valentina Cioffi, Vincenzo Meglio, Settimio Leonetti, Ciro Mastantuoni, Maria Rosaria Scala, Alberto de Bellis, Alessandra Alfieri, Roberto Tafuto, Francesco Ricciardi, Salvatore Di Colandrea, Alessandro D’Elia, Luigi Sigona, Mauro Mormile, Pasqualino De Marinis, Sergio Paolini, Vincenzo Esposito, Alfonso Fiorelli, Gualtiero Innocenzi, Raffaele de Falco Cancers, 2025
From data to practice: brain meningioma treatment in elderly patients – a survey of the Italian Society of Neurosurgery (SINch®) and systematic review and meta-analysis Tamara Ius, Giovanni Raffa, Denis Aiudi, Pier Paolo Panciani, Giuseppe Maria Della Pepa, Federico Pessina, Domenico Solari, Teresa Somma, Filippo Flavio Angileri, Michele Nichelatti, Paolo Cappabianca, Vincenzo Esposito, Maurizio Fornari, Domenico Gerardo Iacopino, Alessandro Olivi, Francesco Sala, Luigi Maria Cavallo, Alessandro La Camera, Giuseppe Barbagallo, Andrea Barbanera, Giacomo Beggio, Silvio Domenico Bellocchi, Claudio Bernucci, Manuela Anna Caroli, Marco Cenzato, Alessandro Della Puppa, Andrea Di Cristofori, Riccardo Draghi, Antonio Fioravanti, Marco Maria Fontanella, Alessandro Frati, Filippo Gagliardi, Diego Garbossa, Antonino Germanò, Maurizio Iacoangeli, Luigi Antonio Lattanzi, Federico Legnani, Davide Locatelli, Vincenza Maiola, Nicola Montemurro, Giovanni Muscas, Antonio Nicolato, Sergio Paolini, Giacomo Pavesi, Maurizio Piparo, Domenico Policicchio, Angelo Pompucci, Antonino Raco, Marta Rossetto, Giovanni Sabatino, Antonio Santoro, Silvio Sarubbo, Alba Scerrati, Francesco Signorelli, Fabio Spanu, Giannantonio Spena, Roberto Stefini, Stefano Telera, Luigino Tosatto, Roberto Trignani, Silvana Tumbiolo, Francesco Volpin, Giampaolo Zambon, Donato Carlo Zotta, and Neurosurgical Review, 2024
Outcome of Epilepsy Surgery in MRI-Negative Patients Without Histopathologic Abnormalities in the Resected Tissue Maurits W. Sanders, Iskander Van der Wolf, Floor E. Jansen, Eleonora Aronica, Christoph Helmstaedter, Attila Racz, Rainer Surges, Alexander Grote, Albert J. Becker, Sylvain Rheims, Hélène Catenoix, John S. Duncan, Jane De Tisi, Thomas S. Jacques, J. Helen Cross, Reetta Kalviainen, Tuomas Rauramaa, Francine Chassoux, Bertrand C. Devaux, Giancarlo Di Gennaro, Vincenzo Esposito, Istvan Bodi, Mrinalini Honavar, Christian G. Bien, Thomas Cloppenborg, Roland Coras, Hajo M. Hamer, Petr Marusic, Adam Kalina, Tom Pieper, Manfred Kudernatsch, Till S. Hartlieb, Tim J. Von Oertzen, Martin Aichholzer, Georg Dorfmuller, Mathilde Chipaux, Soheyl Noachtar, Elisabeth Kaufmann, Andreas Schulze-Bonhage, Christian F. Scheiwe, Cigdem Özkara, Thomas Grunwald, Kristina Koenig, Renzo Guerrini, Carmen Barba, Anna Maria Buccoliero, Flavio Giordano, Felix Rosenow, Katja Menzler, Rita Garbelli, Francesco Deleo, Pavel Krsek, Barbora Straka, Alexis A. Arzimanoglou, Joseph Toulouse, Wim Van Paesschen, Tom Theys, José Pimentel, Isabel M. Loução De Amorim, Nicola Specchio, Luca De Palma, Martha Feucht, Theresa Scholl, Karl Roessler, Rafael Toledano Delgado, Antonio Gil-Nagel, Savo Raicevic, Aleksandar J. Ristic, Olaf Schijns, Jan Beckervordersandforth, Victoria San Antonio-Arce, Jordi Rumia, Ingmar Blumcke, Kees P. Braun, and Neurology, 2024
The “state of the art” of intraoperative neurophysiological monitoring: An Italian neurosurgical survey Riccardo Antonio Ricciuti, Fabrizio Mancini, Giusy Guzzi, Daniele Marruzzo, Alessandro Dario, Alessandro della Puppa, Alessandro Ricci, Andrea Barbanera, Andrea Talacchi, Andreas Schwarz, Antonino Germanò, Antonino Raco, Antonio Colamaria, Antonio Santoro, Riccardo Boccaletti, Carlo Conti, Carlo Conti, Nunzia Cenci, Christian Cossandi, Claudio Bernucci, Corrado Lucantoni, Giovanni Battista Costella, Diego Garbossa, Donato Carlo Zotta, Federico De Gonda, Felice Esposito, Flavio Giordano, Giancarlo D'Andrea, Gianluca Piatelli, Gianluigi Zona, Giannantonio Spena, Giovanni Tringali, Giuseppe Barbagallo, Carlo Giussani, Maurizio Gladi, Andrea Landi, Angelo Lavano, Letterio Morabito, Luciano Mastronardi, Marco Locatelli, Michele D'Agruma, Michele Maria Lanotte, Nicola Montano, Orazio Santo Santonocito, Angelo Pompucci, Raffaele de Falco, Franco Randi, Sara Bruscella, Ivana Sartori, Francesco Signorelli, Luigino Tosatto, Roberto Trignani, Vincenzo Esposito, Gualtiero Innocenzi, Sergio Paolini, Vincenzo Vitiello, Michele Alessandro Cavallo, Francesco Sala Brain and Spine, 2024
The impact of COVID-19 pandemic on surgical neuro-oncology: A survey from the Italian society of neurosurgery (SINch) Luca Zanin, Tamara Ius, Pier Paolo Panciani, Felice Esposito, Andrea Gori, Marco Maria Fontanella, Maria Pia Tropeano, Antonino Raco, Filippo Flavio Angileri, Giovanni Sabatino, Alessandro Olivi, Vincenzo Esposito, Federico Pessina, Edoardo Agosti, Salvatore Aiello, Denis Aiudi, Danilo Aleo, Roberto Altieri, Rosina Amoroso, Anna Maria Auricchio, Giuseppe Barbagallo, Andrea Barbanera, Giacomo Beggio, Andrea Bianco, Riccardo Boccaletti, Stefano Borsa, Giuseppe Canova, Paolo Cappabianca, Manuela Caroli, Michele Alessandro Cavallo, Francesco Certo, Marcella Chimenti, Franco Chioffi, Valentina Cioffi, Fabio Cofano, Christian Cossandi, Giancarlo D’Andrea, Raffaele De Falco, Alessandro D'Elia, Giuseppe Maria Della Pepa, Alessandro Della Puppa, Attilio Della Torre, Paolo Ferroli, Diego Garbossa, Antonino Germanò, Alessandra Giaquinta, Franco Guida, Maurizio Iacoangeli, Domenico Gerardo Iacopino, Angelo Lavano, Giuseppe Maimone, Vincenza Maiola, Rosario Mauferi, Alessandro Melatini, Mario Moro, Domenico Murrone, Giovanni Muscas, Piero Andrea Oppido, Fabrizio Pignotti, Domenico Policicchio, Piermassimo Proto, Paolo Quaglietta, Antonino Raco, Giulia Renisi, Luca Ricciardi, Francesco Romeo, Marta Rossetto, Alba Scerrati, Andreas Schwarz, Miran Skrap, Carlo Somma, Teresa Somma, Giannantonio Spena, Stefano Telera, Luigino Tosatto, Maria Pia Tropeano, Francesco Volpin, Lorenzo Volpin, Cesare Zoia World Neurosurgery X, 2023
Surgical management of Glioma Grade 4: technical update from the neuro-oncology section of the Italian Society of Neurosurgery (SINch®): a systematic review Tamara Ius, Giovanni Sabatino, Pier Paolo Panciani, Marco Maria Fontanella, Roberta Rudà, Antonella Castellano, Giuseppe Maria Vincenzo Barbagallo, Francesco Belotti, Riccardo Boccaletti, Giuseppe Catapano, Gabriele Costantino, Alessandro Della Puppa, Francesco Di Meco, Filippo Gagliardi, Diego Garbossa, Antonino Francesco Germanò, Maurizio Iacoangeli, Pietro Mortini, Alessandro Olivi, Federico Pessina, Fabrizio Pignotti, Giampietro Pinna, Antonino Raco, Francesco Sala, Francesco Signorelli, Silvio Sarubbo, Miran Skrap, Giannantonio Spena, Teresa Somma, Carmelo Sturiale, Filippo Flavio Angileri, Vincenzo Esposito Journal of Neuro Oncology, 2023
Histone-deacetylase 8 drives the immune response and the growth of glioma Alessandro Mormino, Germana Cocozza, Giulia Fontemaggi, Sergio Valente, Vincenzo Esposito, Antonio Santoro, Giovanni Bernardini, Angela Santoni, Francesco Fazi, Antonello Mai, Cristina Limatola, Stefano Garofalo GLIA, 2021
Efficient automated localization of ECoG electrodes in CT images via shape analysis Jessica Centracchio, Antonio Sarno, Daniele Esposito, Emilio Andreozzi, Luigi Pavone, Giancarlo Di Gennaro, Marcello Bartolo, Vincenzo Esposito, Roberta Morace, Sara Casciato, Paolo Bifulco International Journal of Computer Assisted Radiology and Surgery, 2021
Ion Channels in Glioma Malignancy Luigi Catacuzzeno, Luigi Sforna, Vincenzo Esposito, Cristina Limatola, Fabio Franciolini Reviews of Physiology Biochemistry and Pharmacology, 2021
Temporal lobe epilepsy surgery in children and adults: A multicenter study Carmen Barba, Massimo Cossu, Renzo Guerrini, Giancarlo Di Gennaro, Flavio Villani, Luca De Palma, Laura Grisotto, Alessandro Consales, Domenica Battaglia, Nelia Zamponi, Piergiorgio d’Orio, Martina Revay, Michele Rizzi, Sara Casciato, Vincenzo Esposito, Pier Paolo Quarato, Roberta Di Giacomo, Giuseppe Didato, Chiara Pastori, Giusy Carfi Pavia, Simona Pellacani, Giulia Matta, Mattia Pacetti, Gianpiero Tamburrini, Elisabetta Cesaroni, Gabriella Colicchio, Giampaolo Vatti, Sofia Asioli, Massimo Caulo, TLE Study Group, Carlo Efisio Marras, Laura Tassi Epilepsia, 2021
Is age an additional factor in the treatment of elderly patients with glioblastoma? A new stratification model: an Italian Multicenter Study Tamara Ius, Teresa Somma, Roberto Altieri, Filippo Flavio Angileri, Giuseppe Maria Barbagallo, Paolo Cappabianca, Francesco Certo, Fabio Cofano, Alessandro D’Elia, Giuseppe Maria Della Pepa, Vincenzo Esposito, Marco Maria Fontanella, Antonino Germanò, Diego Garbossa, Miriam Isola, Giuseppe La Rocca, Francesco Maiuri, Alessandro Olivi, Pier Paolo Panciani, Fabrizio Pignotti, Miran Skrap, Giannantonio Spena, Giovanni Sabatino Neurosurgical Focus, 2020
Modulation of GABAergic dysfunction due to SCN1A mutation linked to Hippocampal Sclerosis Gabriele Ruffolo, Katiuscia Martinello, Angelo Labate, Pierangelo Cifelli, Sergio Fucile, Giancarlo Di Gennaro, Andrea Quattrone, Vincenzo Esposito, Cristina Limatola, Felice Giangaspero, Eleonora Aronica, Eleonora Palma, Antonio Gambardella Annals of Clinical and Translational Neurology, 2020
Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study Herm J Lamberink, Willem M Otte, Ingmar Blümcke, Kees P J Braun, Martin Aichholzer, Isabel Amorim, Javier Aparicio, Eleonora Aronica, Alexis Arzimanoglou, Carmen Barba, Jürgen Beck, Albert Becker, Jan C Beckervordersandforth, Christian G Bien, Ingmar Blümcke, Istvan Bodi, Kees PJ Braun, Helene Catenoix, Francine Chassoux, Mathilde Chipaux, Thomas Cloppenborg, Roland Coras, J Helen Cross, Luca De Palma, Jane De Tisi, Francesco Deleo, Bertrand Devaux, Giancarlo Di Gennaro, Georg Dorfmüller, John S Duncan, Christian Elger, Katharina Ernst, Vincenzo Esposito, Martha Feucht, Zeljka Petelin Gadze, Rita Garbelli, Karin Geleijns, Antonio Gil-Nagel, Alexander Grote, Thomas Grunwald, Renzo Guerrini, Hajo Hamer, Mrinalini Honavar, Thomas S Jacques, Antonia Jakovcevic, Leena Jutila, Adam Kalina, Reetta Kälviäinen, Karl Martin Klein, Kristina Koenig, Pavel Krsek, Manfred Kudernatsch, Martin Kudr, Herm J Lamberink, Kristina Malmgren, Petr Marusic, Armen Melikyan, Katja Menzler, Soheyl Noachtar, Willem M Otte, Çiğdem Özkara, Tom Pieper, Jose Pimentel, Savo Raicevic, Sylvain Rheims, Joana Ribeiro, Felix Rosenow, Karl Rössler, Bertil Rydenhag, Francisco Sales, Victoria San Antonio-Arce, Karl Lothar Schaller, Olaf Schijns, Theresa Scholl, Johannes Schramm, Andreas Schulze-Bonhage, Raf Sciot, Margitta Seeck, Lyudmila Shishkina, Dragoslav Sokic, Nicola Specchio, Tom Theys, Maria Thom, Rafael Toledano Delgado, Joseph Toulouse, Mustafa Uzan, Johannes van Loon, Wim Van Paesschen, Tim J von Oertzen, Floor Jansen, Frans Leijten, Peter van Rijen, Wim GM Spliet, Angelika Mühlebner, Burkhard S Kasper, Susanne Fauser, Tilman Polster, Thilo Kalbhenn, Daniel Delev, Andrew McEvoy, Anna Miserocchi, Elisabeth Landré, Bares Turak, Pascale Varlet, Sarah Ferrand-Sorbets, Martine Fohlen, Christine Bulteau, Anna Edelvik, Mukesch J Shah, Christian Scheiwe, Eva Gutierrez Delicado, Martin Tisdall, Christin Eltze, Serdar Akkol, Kaancan Deniz, Buge Oz, Hans Holthausen, Till Hartlieb, Martin Staudt, Sara Casciato, Pier P Quarato, Felice Giangaspero, Nathalie Streichenberger, Marc Guenot, Jean Isnard, Antonio Valentijn, Amanda Chang, Nandini Mullatti, Josef Zamecnik, Jana Zarubova, Martin Tomasek, Arto Immonen, Anni Saarela, Tuomas Rauramaa, Johannes A Lobrinus, Kristof Egervari, Shahan Momjian, Elisabeth Harti, Hannah Lohr, Judith Kroell, Lynn Vermeulen, Evy Cleeren, Pavel Vlasov, Antonia Kozlova, Alexey Vorobyev, Gudrun Goeppel, Sharon Samueli, Thomas Czech, Johannes Hainfellner, Gertraud Puttinger, Gabriele Schwarz, Harald Stefanits, Serge Weis, Roberto Spreafico, Flavio Villani, Laura Rossini, Anke Hermsen, Susanne Knake, Christopher Nimsky, Barbara Carl, Anezka Belohlavkova, Barbora Benova, Jeroen Bisschop, Albert Colon, Vivianne van Kranen-Mastenbroek, Rob PW Rouhl, Govert Hoogland, Jordi Rumiá, Alia Ramírez-Camacho, Santiago Candela-Cantó, Karine Ostrowsky-Coste, Eleni Panagiotakaki, Alexandra Montavont, Pascale Keo Kosal, Zeynep Gokce-Samar, Clara Milleret, Anna M Buccoliero, Flavio Giordano, Vlatko Sulentic, Goran Mrak, Andrej Desnica, Giusy CarfíPavia, Alessandro De Benedictis, Carlo E Marras, Vladimir Bascarevic, Nikola Vojvodic, Aleksandar Ristic, Olinda Rebelo, Angel Aledo-Serrano, Irene Garcia-Morales, Carla Anciones Lancet Neurology, 2020
italian consensus and recommendations on diagnosis and treatment of low-grade gliomas an intersociety (siNch/aiNo/siN) document Roberta Rudà, on behalf of the SINch Neuro-Oncology Section, AINO, SIN Neuro-Oncology Section, Filippo F. Angileri, Tamara Ius, Antonio Silvani, Silvio Sarubbo, Alessandra Solari, Antonella Castellano, Andrea Falini, Bianca Pollo, Marialaura Del Basso De Caro, Costanza Papagno, Giuseppe Minniti, Ugo De Paula, Pierina Navarria, Antonio Nicolato, Andrea Salmaggi, Andrea Pace, Alessandra Fabi, Maria Caffo, Giuseppe Lombardi, Carmine M. Carapella, Giannantonio Spena, Maurizio Iacoangeli, Marco Fontanella, Antonino F. Germanò, Alessandro Olivi, Lorenzo Bello, Vincenzo Esposito, Miran Skrap, Riccardo Soffietti Journal of Neurosurgical Sciences, 2020
Erythropoietin Increases GABAA Currents in Human Cortex from TLE Patients Cristina Roseti, Pierangelo Cifelli, Gabriele Ruffolo, Elena Barbieri, Michele Guescini, Vincenzo Esposito, Giancarlo Di Gennaro, Cristina Limatola, Aldo Giovannelli, Eleonora Aronica, Eleonora Palma Neuroscience, 2020
Trends in pediatric epilepsy surgery in Europe between 2008 and 2015: Country-, center-, and age-specific variation Carmen Barba, Judith Helen Cross, Kees Braun, Massimo Cossu, Kerstin Alexandra Klotz, Salvatore De Masi, Maria Angeles Perez Jiménez, Eija Gaily, Nicola Specchio, Pedro Cabral, Joseph Toulouse, Petia Dimova, Domenica Battaglia, Elena Freri, Alessandro Consales, Elisabetta Cesaroni, Oana Tarta‐Arsene, Antonio Gil‐Nagel, Ioana Mindruta, Giancarlo Di Gennaro, Marco Giulioni, Martin M. Tisdall, Christin Eltze, Muhammad Zubair Tahir, Floor Jansen, Peter van Rijen, Maurits Sanders, Laura Tassi, Stefano Francione, Giorgio Lo Russo, Julia Jacobs, Thomas Bast, Giulia Matta, Marcelo Budke, Concepción Fournier del Castillo, Eeva‐Liisa Metsahonkala, Atte Karppinen, José Carlos Ferreira, Krasimir Minkin, Carlo Efisio Marras, European Survey Group, Alexis Arzimanoglou, Renzo Guerrini Epilepsia, 2020
APPROACHES FOR BRAIN AND SPINAL CORD DURAL ARTERIOVENOUS FISTULAS Neurovascular Surgical Diseases A Case Based Approach, 2020
Glioblastoma Multiforme: Tumor Recurrence Francesco Fabbiano, Jacopo Scaggiante, Andrea Wlderk, Alessandro D’Elia, Vincenzo Esposito, Claudio Colonnese, Marcello Bartolo Imaging Gliomas After Treatment A Case Based Atlas Second Edition, 2019
Long-term seizure outcome in frontal lobe epilepsy surgery Roberta Morace, Sara Casciato, Pier Paolo Quarato, Addolorata Mascia, Alfredo D’Aniello, Liliana G. Grammaldo, Marco De Risi, Giancarlo Di Gennaro, Vincenzo Esposito Epilepsy and Behavior, 2019
Environmental stimuli shape microglial plasticity in glioma Stefano Garofalo, Alessandra Porzia, Fabrizio Mainiero, Silvia Di Angelantonio, Barbara Cortese, Bernadette Basilico, Francesca Pagani, Giorgio Cignitti, Giuseppina Chece, Roberta Maggio, Marie-Eve Tremblay, Julie Savage, Kanchan Bisht, Vincenzo Esposito, Giovanni Bernardini, Thomas Seyfried, Jakub Mieczkowski, Karolina Stepniak, Bozena Kaminska, Angela Santoni, Cristina Limatola Elife, 2017
Epilepsy surgery of “low grade epilepsy associated neuroepithelial tumors”: A retrospective nationwide Italian study Marco Giulioni, Gianluca Marucci, Veronica Pelliccia, Francesca Gozzo, Carmen Barba, Giuseppe Didato, Flavio Villani, Giancarlo Di Gennaro, Pier Paolo Quarato, Vincenzo Esposito, Alessandro Consales, Matteo Martinoni, Gianfranco Vornetti, Corrado Zenesini, Carlo Efisio Marras, Nicola Specchio, Luca De Palma, Raffaele Rocchi, Flavio Giordano, Giovanni Tringali, Paolo Nozza, Gabriella Colicchio, Guido Rubboli, Giorgio Lo Russo, Renzo Guerrini, Paolo Tinuper, Francesco Cardinale, Massimo Cossu, the Commission for Epilepsy Surgery of the Italian League Against Epilepsy Epilepsia, 2017
Increasing volume and complexity of pediatric epilepsy surgery with stable seizure outcome between 2008 and 2014: A nationwide multicenter study Carmen Barba, Nicola Specchio, Renzo Guerrini, Laura Tassi, Salvatore De Masi, Francesco Cardinale, Simona Pellacani, Luca De Palma, Domenica Battaglia, Gianpiero Tamburrini, Giuseppe Didato, Elena Freri, Alessandro Consales, Paolo Nozza, Nelia Zamponi, Elisabetta Cesaroni, Giancarlo Di Gennaro, Vincenzo Esposito, Marco Giulioni, Paolo Tinuper, Gabriella Colicchio, Raffaele Rocchi, Guido Rubboli, Flavio Giordano, Giorgio Lo Russo, Carlo Efisio Marras, Massimo Cossu Epilepsy and Behavior, 2017
Effects of hispolon on glioblastoma cell growth Antonietta Arcella, Maria Antonietta Oliva, Massimo Sanchez, Sabrina Staffieri, Vincenzo Esposito, Felice Giangaspero, Giampaolo Cantore Environmental Toxicology, 2017
Somatostatin analogues increase AIP expression in somatotropinomas, irrespective of Gsp mutations Marie-Lise Jaffrain-Rea, Sandra Rotondi, Annarita Turchi, Gianluca Occhi, Anne Barlier, Erika Peverelli, Lilya Rostomyan, Céline Defilles, Mariolina Angelini, Maria-Antonietta Oliva, Filippo Ceccato, Orlando Maiorani, Adrian F Daly, Vincenzo Esposito, Francesca Buttarelli, Dominique Figarella-Branger, Felice Giangaspero, Anna Spada, Carla Scaroni, Edoardo Alesse, Albert Beckers Endocrine Related Cancer, 2013
Overview of presurgical assessment and surgical treatment of epilepsy from the Italian League Against Epilepsy Renzo Guerrini, Massimo Scerrati, Guido Rubboli, Vincenzo Esposito, Gabriella Colicchio, Massimo Cossu, Carlo Efisio Marras, Laura Tassi, Paolo Tinuper, Maria Paola Canevini, Pierpaolo Quarato, Flavio Giordano, Tiziana Granata, Flavio Villani, Marco Giulioni, Pina Scarpa, Valentina Barbieri, Gabriella Bottini, Angelo Del Sole, Giampaolo Vatti, Roberto Spreafico, Giorgio Lo Russo, the Commission for Epilepsy Surgery of the Italian League Against Epilepsy Epilepsia, 2013
Prognostic significance of serial postoperative EEG in extratemporal lobe epilepsy surgery Bollettino Lega Italiana Contro L Epilessia, 2013
Surgery after intracranial investigation with subdural electrodes in patients with drug-resistant focal epilepsy: Outcome and complications Bollettino Lega Italiana Contro L Epilessia, 2013
Rapamycin inhibits the growth of glioblastoma Antonietta Arcella, Francesca Biagioni, Maria Antonietta Oliva, Domenico Bucci, Alessandro Frati, Vincenzo Esposito, Giampaolo Cantore, Felice Giangaspero, Francesco Fornai Brain Research, 2013
A Phase I Dose-Escalation Study (ISIDE-BT-1) of Accelerated IMRT With Temozolomide in Patients With Glioblastoma Alessio G. Morganti, Mario Balducci, Maurizio Salvati, Vincenzo Esposito, Pantaleo Romanelli, Marica Ferro, Franco Calista, Cinzia Digesù, Gabriella Macchia, Massimo Ianiri, Francesco Deodato, Savino Cilla, Angelo Piermattei, Vincenzo Valentini, Numa Cellini, Gian Paolo Cantore International Journal of Radiation Oncology Biology Physics, 2010
Blockage of A2A and A3 adenosine receptors decreases the desensitization of human GABAA receptors microtransplanted to Xenopus oocytes Cristina Roseti, Eleonora Palma, Katiuscia Martinello, Sergio Fucile, Roberta Morace, Vincenzo Esposito, Gianpaolo Cantore, Antonietta Arcella, Felice Giangaspero, Eleonora Aronica, Addolorata Mascia, Giancarlo Di Gennaro, Pier Paolo Quarato, Mario Manfredi, Gloria Cristalli, Catia Lambertucci, Gabriella Marucci, Rosaria Volpini, Cristina Limatola, Fabrizio Eusebi Proceedings of the National Academy of Sciences of the United States of America, 2009
Expression of aryl hydrocarbon receptor (AHR) and AHR-interacting protein in pituitary adenomas: Pathological and clinical implications Marie-Lise Jaffrain-Rea, Mariolina Angelini, Donatella Gargano, Maria A Tichomirowa, Adrian F Daly, Jean-François Vanbellinghen, Emanuela D'Innocenzo, Anne Barlier, Felice Giangaspero, Vincenzo Esposito, Luca Ventura, Antonietta Arcella, Marily Theodoropoulou, Luciana A Naves, Carmen Fajardo, Sabina Zacharieva, Vincent Rohmer, Thierry Brue, Alberto Gulino, Giampaolo Cantore, Edoardo Alesse, Albert Beckers Endocrine Related Cancer, 2009
Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors Cristina Roseti, Katiuscia Martinello, Sergio Fucile, Vanessa Piccari, Addolorata Mascia, Giancarlo Di Gennaro, Pier Paolo Quarato, Mario Manfredi, Vincenzo Esposito, Gianpaolo Cantore, Antonella Arcella, Michele Simonato, Bertil B. Fredholm, Cristina Limatola, Ricardo Miledi, Fabrizio Eusebi Proceedings of the National Academy of Sciences of the United States of America, 2008
Memory outcome two years after anterior temporal lobectomy in patients with drug-resistant epilepsy Bollettino Lega Italiana Contro L Epilessia, 2008
Changes in depression, anxiety, anger, and personality after resective surgery for drug-resistant temporal lobe epilepsy: A 2-year follow-up study Bollettino Lega Italiana Contro L Epilessia, 2008
A semiautomatic procedure for sequential neuroimage-fusion to localize subdural electrodes in presurgical evaluation of patients with drug-resistant focal epilepsy Bollettino Lega Italiana Contro L Epilessia, 2008
Lateralizing value of memory tests in drug-resistant temporal lobe epilepsy Bollettino Lega Italiana Contro L Epilessia, 2005
Drug-resistant seizures originating in the posterior cortex: Intracranial investigations by subdurally implanted electrodes Bollettino Lega Italiana Contro L Epilessia, 2005
Temporal lobe epilepsy surgery: Different surgical strategies after a non-invasive diagnostic protocol Bollettino Lega Italiana Contro L Epilessia, 2005
Genital and sexual manifestations in drug-resistant partial epilepsy Addolorata Mascia, Giancarlo Di Gennaro, Vincenzo Esposito, Liliana G. Grammaldo, Giulio N. Meldolesi, Teresa Giampà, Fabio Sebastiano, Carolina Falco, Paolo Onorati, Mario Manfredi, Giampaolo Cantore, Pier Paolo Quarato Seizure, 2005
Localizing value of TIRDA (Temporal Intermittent Rhythmical Delta Activity): Video-EEG study in patients with drug-resistant partial epilepsy Bollettino Lega Italiana Contro L Epilessia, 2002
"Negative" ictal phenomena in temporal lobe epilepsy: Prominent involvement of neo-cortical structures? Bollettino Lega Italiana Contro L Epilessia, 2002
Memory functioning study in patients affected by drug resistant temporal lobe epilepsy classified in "mesial", "mesio-lateral" and "lateral" subtypes Bollettino Lega Italiana Contro L Epilessia, 2002
Assessing personality and psychopathology in patients affected by drug-resistant temporal epilepsy evaluated for epilepsy surgery: Preliminary results Bollettino Lega Italiana Contro L Epilessia, 2002
Non invasive pre-surgical evaluation and surgery in drug-resistant temporal lobe epilepsy Bollettino Lega Italiana Contro L Epilessia, 2002
Giant prolactinomas presenting as skull base tumors Giuseppe Minniti, Marie-Lise Jaffrain-Rea, Antonio Santoro, Vincenzo Esposito, Luigi Ferrante, Roberto Delfini, Giampaolo Cantore Surgical Neurology, 2002
Localizing value of Localized Subclinical Ictal Discharges (LOSID): A Video-EEG study in drug-resistant temporal lobe epilepsy Bollettino Lega Italiana Contro L Epilessia, 2001
Memory functioning study in patients affected by drug resistant temporal lobe epilepsy classified in "mesial" and "lateral" subtypes Bollettino Lega Italiana Contro L Epilessia, 2001
Assessing personality and psychopathology in patients affected by drug-resistant partial epilepsy evaluated for epilepsy surgery Bollettino Lega Italiana Contro L Epilessia, 2001
"Quality of life" evaluation in patients affected by drug-resistant partial epilepsy before and after epilepsy surgery Bollettino Lega Italiana Contro L Epilessia, 2001
Epilepsy surgery unit of neuromed institute (Pozzilli): Preliminary results after two years of experience Bollettino Lega Italiana Contro L Epilessia, 2001
Multicentric cerebral gliomas: Case report Nuova Rivista Di Neurologia, 1998
P-043. IGF-I measurement in post-operative evaluation of patients with tumours of the sellar region Endocrinology and Metabolism Supplement, 1997
An experimental contribution on the temporal lobe and epilepsy: The role of diffuse aspecific systems Bollettino Lega Italiana Contro L Epilessia, 1996
Prognostic value of scalp EEG ictal patterns in epilepsy surgery of hippocampal sclerosis G Di Gennaro, A Romigi, PP Quarato, A Mascia, A D’Aniello, C Panzini, ... Neurological Sciences 45 (10), 5003-5009 , 2024 2024 Citations: 4
Hidden intra-meatal CSF fistula related to VP shunt as a cause for fatal tension pneumocephalus after vestibular schwannoma resection P di Russo, R Morace, T Vangelista, N Gorgoglione, M De Angelis, ... British Journal of Neurosurgery 38 (4), 1010-1015 , 2024 2024 Citations: 1
The anterior sylvian point as a reliable landmark for the anterior temporal lobectomy in mesial temporal lobe epilepsy: technical note, case series, and cadaveric dissection A Fava, SV Lisi, L Mauro, R Morace, M Ciavarro, N Gorgoglione, ... Frontiers in Medicine 11, 1352321 , 2024 2024 Citations: 3
Posterolateral approaches to the thoracic spine for calcific disc herniation: is wider exposure always better? G Corazzelli, G Di Noto, A Ciardo, M Colangelo, S Corvino, S Leonetti, ... Acta Neurochirurgica 166 (1), 267 , 2024 2024 Citations: 4
Parasagittal meningiomas: The impact of sinus opening and grade of resection on clinical outcome and recurrence in a consecutive series of patients G Petrella, A Piazza, A Fava, N Gorgoglione, M De Angelis, T Vangelista, ... World Neurosurgery 186, e683-e693 , 2024 2024 Citations: 3
A study of alternative TrkA splicing identifies TrkAIII as a novel potentially targetable participant in PitNET progression M Sbaffone, ML Jaffrain-Rea, L Cappabianca, F Carbonara, F Gianno, ... Biology 13 (3), 171 , 2024 2024 Citations: 4
Clinical and molecular characteristics of gonadotroph pituitary tumors according to the WHO Classification F Carbonara, T Feola, F Gianno, MA Polidoro, RM Di Crescenzo, ... Endocrine Pathology 35 (1), 1-13 , 2024 2024 Citations: 6
Outcome of epilepsy surgery in MRI-negative patients without histopathologic abnormalities in the resected tissue MW Sanders, I Van der Wolf, FE Jansen, E Aronica, C Helmstaedter, ... Neurology 102 (4), e208007 , 2024 2024 Citations: 37
The “state of the art” of intraoperative neurophysiological monitoring: An Italian neurosurgical survey RA Ricciuti, F Mancini, G Guzzi, D Marruzzo, A Dario, A Della Puppa, ... Brain and Spine 4, 102796 , 2024 2024 Citations: 3
Anatomical landmarks during high-magnification microsurgery for a safe and effective resection of high-grade gliomas: how i do it A Fava, P di Russo, R Morace, V Esposito Acta neurochirurgica 165 (12), 4235-4240 , 2023 2023 Citations: 4
Identifying brain tumor patients’ subtypes based on pre-diagnostic history and clinical characteristics: a pilot hierarchical clustering and association analysis S Esposito, E Ruggiero, A Di Castelnuovo, S Costanzo, M Bonaccio, ... Frontiers in Oncology 13, 1276253 , 2023 2023
The impact of COVID-19 pandemic on surgical neuro-oncology: A survey from the Italian society of neurosurgery (SINch) L Zanin, T Ius, PP Panciani, F Esposito, A Gori, MM Fontanella, ... World Neurosurgery: X 20, 100233 , 2023 2023 Citations: 1
Long-term treatment outcomes of temozolomide-based chemoradiation in patients with adult-type diffuse IDH-mutant grade 2 astrocytoma G Minniti, S Paolini, M Antonelli, F Gianno, P Tini, G Lanzetta, A Arcella, ... Journal of Neuro-Oncology 164 (2), 331-339 , 2023 2023 Citations: 10
Surgical management of Glioma Grade 4: technical update from the neuro-oncology section of the Italian Society of Neurosurgery (SINch®): a systematic review T Ius, G Sabatino, PP Panciani, MM Fontanella, R Rudà, A Castellano, ... Journal of Neuro-oncology 162 (2), 267-293 , 2023 2023 Citations: 42
Feasibility of clinical target volume reduction for glioblastoma treated with standard chemoradiation based on patterns of failure analysis G Minniti, P Tini, M Giraffa, L Capone, G Raza, I Russo, E Cinelli, ... Radiotherapy and Oncology 181, 109435 , 2023 2023 Citations: 43
Key role of microsurgical dissections on cadaveric specimens in neurosurgical training: setting up a new research anatomical laboratory and defining neuroanatomical milestones A Fava, N Gorgoglione, M De Angelis, V Esposito, P Di Russo Frontiers in Surgery 10, 1145881 , 2023 2023 Citations: 15
Food processing and risk of central nervous system tumours: A preliminary case–control analysis from the MEditerranean DIet in relation to CancEr of brAin (MEDICEA) study S Esposito, M Bonaccio, E Ruggiero, S Costanzo, A Di Castelnuovo, ... Clinical Nutrition 42 (2), 93-101 , 2023 2023 Citations: 21
The Dietary Intake of Polyphenols Is Associated with a Lower Risk of Severe Lumbar Spinal Stenosis: A Case-Control Analysis from the PREFACE Study E Ruggiero, S Esposito, S Costanzo, A Di Castelnuovo, M Storto, ... Nutrients 14 (24), 5229 , 2022 2022
Sleep macrostructure and cyclic alternating pattern in patients who underwent surgery for hippocampal sclerosis: A prospective controlled polysomnographic study A Romigi, A D'Aniello, M Caccamo, F Testa, G Vitrani, L Grammaldo, ... Sleep Medicine 100, 419-426 , 2022 2022 Citations: 7
Immunotherapy for aggressive and metastatic pituitary neuroendocrine tumors (PitNETs): state-of-the art T Feola, F Carbonara, M Verrico, RM Di Crescenzo, F Gianno, ... Cancers 14 (17), 4093 , 2022 2022 Citations: 34
MOST CITED SCHOLAR PUBLICATIONS
Single-fraction versus multifraction (3× 9 Gy) stereotactic radiosurgery for large (> 2 cm) brain metastases: a comparative analysis of local control and risk of radiation … G Minniti, C Scaringi, S Paolini, G Lanzetta, A Romano, F Cicone, M Osti, ... International Journal of Radiation Oncology* Biology* Physics 95 (4), 1142-1148 , 2016 2016 Citations: 551
Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study HJ Lamberink, WM Otte, I Blümcke, KPJ Braun, M Aichholzer, I Amorim, ... The Lancet Neurology 19 (9), 748-757 , 2020 2020 Citations: 387
Anomalous levels of Cl − transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory E Palma, M Amici, F Sobrero, G Spinelli, S Di Angelantonio, D Ragozzino, ... Proceedings of the National Academy of Sciences 103 (22), 8465-8468 , 2006 2006 Citations: 372
Long-term follow-up of intramedullary spinal cord tumors: a series of 202 cases A Raco, V Esposito, J Lenzi, M Piccirilli, R Delfini, G Cantore Neurosurgery 56 (5), 972-981 , 2005 2005 Citations: 365
Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cells M Catalano, G D'Alessandro, F Lepore, M Corazzari, S Caldarola, ... Molecular oncology 9 (8), 1612-1625 , 2015 2015 Citations: 328
Multidose stereotactic radiosurgery (9 Gy× 3) of the postoperative resection cavity for treatment of large brain metastases G Minniti, V Esposito, E Clarke, C Scaringi, G Lanzetta, M Salvati, A Raco, ... International Journal of Radiation Oncology* Biology* Physics 86 (4), 623-629 , 2013 2013 Citations: 258
Treatment of trigeminal neuralgia by thermocoagulation, glycerolization, and percutaneous compression of the gasserian ganglion and/or retrogasserian rootlets: long-term … B Fraioli, V Esposito, B Guidetti, G Cruccu, M Manfredi Neurosurgery 24 (2), 239-245 , 1989 1989 Citations: 233
Somatotopy in the basal ganglia: experimental and clinical evidence for segregated sensorimotor channels P Romanelli, V Esposito, DW Schaal, G Heit Brain research reviews 48 (1), 112-128 , 2005 2005 Citations: 218
Alpha, beta and gamma electrocorticographic rhythms in somatosensory, motor, premotor and prefrontal cortical areas differ in movement execution and observation in humans C Babiloni, C Del Percio, F Vecchio, F Sebastiano, G Di Gennaro, ... Clinical Neurophysiology 127 (1), 641-654 , 2016 2016 Citations: 196
The long‐term efficacy of conventional radiotherapy in patients with GH‐secreting pituitary adenomas G Minniti, ML Jaffrain‐Rea, M Osti, V Esposito, A Santoro, F Solda, ... Clinical endocrinology 62 (2), 210-216 , 2005 2005 Citations: 177
Expression of aryl hydrocarbon receptor (AHR) and AHR-interacting protein in pituitary adenomas: pathological and clinical implications ML Jaffrain-Rea, M Angelini, D Gargano, MA Tichomirowa, AF Daly, ... Endocrine-related cancer 16 (3), 1029-1043 , 2009 2009 Citations: 173
A critical reappraisal of MIB-1 labelling index significance in a large series of pituitary tumours: secreting versus non-secreting adenomas. ML Jaffrain-Rea, D Di Stefano, G Minniti, V Esposito, A Bultrini, E Ferretti, ... Endocrine-related cancer 9 (2), 103-113 , 2002 2002 Citations: 160
Transmaxillosphenoidal approach to tumors invading the medial compartment of the cavernous sinus B Fraioli, V Esposito, A Santoro, G Iannetti, R Giuffrè, G Cantore Journal of neurosurgery 82 (1), 63-69 , 1995 1995 Citations: 160
Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice S Garofalo, G D’Alessandro, G Chece, F Brau, L Maggi, A Rosa, A Porzia, ... Nature Communications 6 (1), 6623 , 2015 2015 Citations: 156
Ictal heart rate increase precedes EEG discharge in drug-resistant mesial temporal lobe seizures G Di Gennaro, PP Quarato, F Sebastiano, V Esposito, P Onorati, ... Clinical neurophysiology 115 (5), 1169-1177 , 2004 2004 Citations: 151
The role of fractionated radiotherapy and radiosurgery in the management of patients with craniopharyngioma G Minniti, V Esposito, M Amichetti, R Maurizi Enrici Neurosurgical review 32 (2), 125-132 , 2009 2009 Citations: 144
Long-term follow-up results of postoperative radiation therapy for Cushing’s disease G Minniti, M Osti, ML Jaffrain-Rea, V Esposito, G Cantore, R Maurizi Enrici Journal of neuro-oncology 84 (1), 79-84 , 2007 2007 Citations: 143
Correlation between O 6 -methylguanine-DNA methyltransferase and survival in elderly patients with glioblastoma treated with radiotherapy plus concomitant and … G Minniti, M Salvati, A Arcella, F Buttarelli, A D’Elia, G Lanzetta, ... Journal of neuro-oncology 102 (2), 311-316 , 2011 2011 Citations: 135
Stereotactic radiosurgery combined with nivolumab or Ipilimumab for patients with melanoma brain metastases: evaluation of brain control and toxicity G Minniti, D Anzellini, C Reverberi, GCA Cappellini, L Marchetti, ... Journal for immunotherapy of cancer 7 (1), 102 , 2019 2019 Citations: 134
Diagnosis and management of pituitary tumours in the elderly: a review based on personal experience and evidence of literature G Minniti, V Esposito, M Piccirilli, A Fratticci, A Santoro, ML Jaffrain-Rea European journal of endocrinology 153 (6), 723-735 , 2005 2005 Citations: 132