Dr. Anubhav Dubey
@maharana pratap college of pharmacy kanpur
Assistant Profeesor
Maharana Pratap College of Pharmacy Kanpur
RESEARCH, TEACHING, or OTHER INTERESTS
, Neurology (clinical), Medicine, Behavioral Neuroscience
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Jeetendra Kumar Gupta, Kuldeep Singh, Alok Bhatt, Prateek Porwal, Rekha Rani, Anubhav Dubey, Divya Jain, and Sachchida Nand Rai
Springer Science and Business Media LLC
Alok Batt, Kuldeep Singh, Jeetendra Kumar Gupta, Dilip Kumar Chanchal, Kamlesh Kumar, Anubhav Dubey, Shivendra Kumar, and Divya Jain
Elsevier BV
Anubhav Dubey, Mamta Kumari, Alok Kumar Shukla, Kumara Swamy Samanthula, and Manu Dwivedi
World Researchers Associations
Climate change poses a significant threat to humanity in the 21st century. Global warming and air pollution are two well-recognized consequences of climate change. The progressive rise in surrounding temperature, along with heightened levels of pollution, has a catastrophic impact on our well-being, perhaps leading to an escalated frequency and intensity of various neurological ailments. The primary objective of this review study is to provide insight into the correlation between the occurrences of global warming and air pollution and two prevalent and incapacitating neurological conditions: stroke and neurodegenerative illnesses. Severe ambient temperatures cause damage to the nervous system and lead to a higher occurrence of strokes and death. Global warming does not directly contribute to the development of neurodegenerative illnesses but it worsens the symptoms of dementia, Alzheimer's disease (AD) and Parkinson's disease (PD). There is a strong correlation between high levels of air pollutants, namely particulate matter and the occurrence of ischemic strokes rather than haemorrhagic strokes. Individuals who are exposed to air pollution are more likely to acquire dementia and Alzheimer's disease (AD), but not Parkinson's disease (PD). Oxidative stress, alterations in cardiovascular and cerebrovascular blood flow, excitotoxicity, activation of microglia and cellular apoptosis all contribute significantly to the intersection of climate change's impact on neurological illnesses. The complicated interplay between global warming and air pollution and their complex impact on the neurological system suggests that future measures designed to alleviate climate change must tackle both of these concerns simultaneously.
Diksha Sharma, Bhumi Ruhil, Anubhav Dubey, Divya Jain, Deepika Bhatia, and Georgios Koubouris
MDPI AG
Climatic changes and global warming affect the growth, development, and productivity of crops. In this review, we highlight the possible benefits of using innovative breeding techniques like clustered regularly interspaced short palindromic repeats (CRISPRs), exogenous phytohormone-like strigolactones (SLs), nanomaterials (NMs), and beneficial microbial endophytes to address the challenges in sustainable cultivation of horticultural crops. These applications are evaluated by examining how they affect different metabolic, morphological, and biochemical parameters in diverse crops. Endophytes are symbiotic microorganisms and can be used as nematicides for improving crop yield. With an emphasis on quality control, we examined the impacts of applying NMs, a novel family of phytohormones called SLs, and microbial endophytes on horticultural commodities. Furthermore, we reviewed the benefits of CRISPR for the editing of plant genomes, as well as how it affects gene expression and transcription factors to increase crop tolerance and yield. These innovations hold the potential to improve crop yield, quality, and resilience by acting as safe, natural components in biofertilizers and plant protection solutions. Gradually adopting these methods could decrease reliance on agrochemicals, thereby reducing their negative effects on biodiversity, soil fertility, and human health.
Pankaj Kumar, Kuldip Kumar Savita, Anubhav Dubey, and Sandeep Singh Gaur
Dr. Yashwant Research Labs Pvt. Ltd.
Dithranol is a therapeutic agent mainly used for psoriasis; however, its clinical use is limited by poor stability, skin irritation, and low patient compliance with conventional formulations. This paper reviews the various advanced drug delivery systems that have been formulated to bypass the above limitations and improve the pharmacokinetics of dithranol. In this context, we describe the problems of the current formulations, which are the instability of the drug and adverse reactions to the skin. Further, we present the advantages of advanced delivery systems, including nanoparticles, nanosuspensions, liposomes, niosomes, solid lipid nanoparticles and nanostructured lipid carriers, for drug stabilization and delivery to target tissues. We elaborate on the working of polymeric systems, including hydrogels, microparticles, micelles, and prodrugs, with which drug solubility is improved and drug release is sustained. Finally, through in-vitro and in-vivo studies and clinical procedures, details are given regarding the drug release kinetics, pharmacokinetics, and biodistribution of such formulations. The text elaborates on future directions and new technological approaches toward the delivery of dithranol. These advanced delivery systems will help to overcome the limitations of the existing formulations and achieve a higher therapeutic impact of the drug on psoriasis and other skin diseases.
Anuj Kumar, Jitendra Singh Chaudhary, Anubhav Dubey, and Shubham Sanjay Pachorkar
Dr. Yashwant Research Labs Pvt. Ltd.
Ankylosing spondylitis is a chronic inflammatory disorder primarily affecting the spine and the sacroiliac joints, although it is now considered for new drug target possibilities. It is an area in which nanotechnology has shown significant potential. This report offers an extensive review of the formulation design, clinical utility, and current development in the use of nanotechnology for treating AS. The rational design principles of nanotherapeutics, created to modify the myriad processes implicated in AS pathophysiology, were examined. It comprises drug delivery systems, targeting approaches, and release processes. Clinical and preclinical evidence of nanomedicines’ tolerability and effectiveness in AS therapy is reported. In conclusion, this document reflects the recent state of these nanotechnology-based treatments for AS and discusses the author’s future goals in developing novel, powerful treatment strategies that generate strong patient outcomes.
Anubhav Dubey, Niladry S. Ghosh, and Ranjit Singh
World Researchers Associations
A neuropsychological assessment is a test that assesses how well a person's brain functions. Literacy, language use, attention, learning, processing speed, reasoning, memory, problem-solving, personality and other talents are all assessed. The purpose of this study is to assess the effects of aqueous and ethanolic seed extracts of Asparagus racemosus Linn on the neurobehavioral pattern of acrylamide-induced experimental Zebra fish. In the novel tank test, the number of top entries, top remain time, top entry latency and total distance traveled were all greater in the Asparagus racemosus Linn seed extract group than in the acrylamide group, while the number of bottom entries and bottom duration of stay were lower. In the light-dark test, group II Zebrafish treated with 0.75 mM acrylamide showed anxiety by spending less time in the light zone. In our study, Zebrafish pre-treated with aqueous and ethanolic seed extracts of different concentrations of Asparagus racemosus Linn significantly reversed. In the open field test, the Asparagus racemosus Linn seed extract at different doses significantly improved outer zone (s) and inner zone (S) times compared to the acrylamide control group. In the Y-maze test, the Asparagus racemosus Linn seed extract at different dosages exhibited a dose-influenced significant improvement in the number of entry points to new arms and the total distance walked in the maze in comparison to the acrylamide control group. When compared to the acrylamide control, the Asparagus racemosus Linn seeds extract at various doses demonstrated a significant rise in the amount of time spent in the new arm.
Anubhav Dubey et al.
Egypts Presidential Specialized Council for Education and Scientific Research
The primary objective of this work was to examine the potential neuroprotective properties of a seed extract derived from Asparagus racemosus for neurotoxicity in an acrylamide-induced zebrafish model. After ACR treatment, fish went through neurotoxic effects where glutathione reductase levels decreased by 3 times; lipid peroxidation activity increased by 3.4 times; nitrite levels
Anubhav Dubey, Niladry Ghosh, and Ranjit Singh
World Researchers Associations
The study aimed to explore the phytochemicals present in the aqueous and ethanolextracts of Asparagus racemosus Linn seeds by GC-MS and LC-MS analysis and to determine the neuro protective and antioxidant potential of both the extracts. The GC-MS and LC-MS analysis of the aqueous and ethanol seed extract indicated the presence of various chemical constituents such as ascorbic acid, hydroxycinnamic acid, fatty acids, pyroglutamic acid, pentanoic acid, decanoic acid, hexadecanoic acid, naphthalene, hydroxycinnamic acid, thiamine hydrochloride, coumaroyl putrescin, agrimol, epanorin, brevicarine, rubiadin, pyroglutamic acid, tyrosine derivative, linoleyl acetate etc. Neuroprotective effect of aqueous and ethanol extracts of Asparagus racemosus Linn seeds on SHSY5Y cell line was evaluated by MTT assay and the results showedthat ethanol extract of the plant got more neuroprotective activity on cell lines. The antioxidant results showed that both of the extracts had almost similar DPPH and ABTS radical scavenging. However, the ethanol extract had more potent antioxidant power than the aqueous extract. Study data suggest that whole plant of Asparagus racemosus Linn seeds possessed neuroprotective and anti-oxidative activities and the best neuroprotective and anti-oxidant activity being exhibited by the ethanolic extract of the plant.
Mamta Kumari, Anubhav Dubey, Suruchi Agarwal, Saurabh Kushwaha, and Anupam Kr. Sachan
BSP Books Private Limited
You may agree with us when we say that the pharmaceutical business is not an easy one. It can prove to be quite a task to adapt to the changing healthcare standards, changing production requirements, changing government regulations, and incorporating the latest innovative technologies in the production process of drugs and medicines. Also, the competition is huge in the pharmaceutical business, and you can’t sustain long in the business if you cannot offer the best quality medicines to the customers at truly competitive prices. The whole pharmaceutical area needed various innovative and scientific solutions to solve the current problems related to cGMP practices, production, documentation, regulatory body requirements (US FDA, WHO, EU-GMP, PICS), quality of product, etc. Installing such software will help the Pharma industry to improve its cGMP practices and fulfill regulatory body’s requirements. It also covers the importance and their need in the Pharma industry. It also covers the meaning of software used in the pharmaceutical industry.
Anubhav Dubey, Mrinmoy Basak, Biplab Dey, and Niladry Ghosh
World Researchers Associations
Shatavari (Asparagus racemosus), a member of the Asparagaceae family, is vital in Ayurveda since it may prevent and treat hundreds of ailments. It is known as "herb's queen."Its bioactive constituents include steroidal glycosides, saponins (primarily Shatavarins I, II, III and IV), polyphenols, flavonoids, alkaloids (racemosol) and vitamins. Shatavari is a popular shrub in folk and Ayurvedic medicine due to its sapogenin content, which is the precursor to many pharmacologically active steroids. Most of its components are medicinal, but roots, stems and leaves are the most essential. Shatavari "Rasayanas" boost immunity and infection resistance. Due to its phytochemicals, it is used to cure several illnesses. Due to its phytochemicals, it is used to cure several illnesses. Shatavari has many medicinal properties such as anti-spasmodic, anti-oxidant, anti-diabetic, anti-allergic, anti-malarial, protective, anti-neoplastic activities, immune response enhancement, anti-arthritic, anti-inflammatory, anti-periodic, anti-ulcerogenic action, immune modulatory antistress, anti-diarrheal, antidepressant infections, tuberculosis and so on. Commercial Shatavari extract medications are anti-leprotic, anti-abortifacient, antibacterial, antipyretic and analgesic. Shatavari root, leaf, flower and stem extracts treat dyspepsia, mental disorders, cough, bronchitis, throat and female reproductive system issues.
Anubhav Dubey
Medic Scientific
In South Asia, cattle are afflicted by the expanding virulent condition known as Lumpy Skin Disease (LSD), and sheep pox and goat pox are caused by the Capri virus. These illnesses endanger worldwide trade. Due to inadequate immunisations and poverty in rural areas, Capricorn poxviruses are spreading. This is due to the economic repercussions of the COVID-19 epidemic, debilitating sanctions in endemic countries, a growth in the legal and criminal trade of live animals and animal products, and global climate change. Skin spores are the main route of infection; however, the virus is also excreted through bodily fluids and semen. As a result, the virus is transmitted to susceptible hosts by biting flies, mosquitoes, and other insects. Insects can be transstadial and transovarial. Lumpy skin disease lesions can swell and rupture after 7 to 14 days in experimental settings, but it usually takes 2 to 5 weeks in a normal infection. Lumpy skin disease is characterised by hard, constrictive, few (mild forms) to numerous (severe forms) skin nodules that may encompass respiratory, urogenital, and other organ mucous membranes. Consequently, milk output decreases, and in countries that raise cattle, there are more abortions, cases of temporary or permanent infertility, hide damage, and mortality, all of which result in a financial loss. The best method for limiting the spread and monetary impacts of lumpy skin disease is mass immunisation and other management measures. This review provides the latest information on lumpy skin disease's viral biology, transmission, clinical, and pathological aspects.
Anubha Dubey, N. Ghosh and Dr. Ranjit Singh
Siree Journals
ABSTRACT