Timothy J Scholl

Scopus Publications

Linking tumor viability and immune infiltration with dual-nucleus MRI in preclinical models
Sean W. McRae, Jasmine H. Lau, Francisco M. Martinez, Jingchun Zhao, Corby Fink, et al.
Npj Imaging, 2026
The SRG rat as a novel host for an orthotopic patient-derived xenograft model of breast cancer brain metastasis
Niveen Fulcher, Hien Nguyen, Andrew Deweyert, Mila Uzelac, Maryam Mozaffari, et al.
Scientific Reports, 2025
MAIT cells promote cancer progression and regulatory T cell accumulation in bladder tumor microenvironment
Inbar A Habaz, Xuejin Ou, Nicole I Wang, Angela Schincaglia, Valeryia Shydlouskaya, et al.
Journal for Immunotherapy of Cancer, 2025
Background Mucosa-associated invariant T (MAIT) cells represent a unique population of innate-like T lymphocytes capable of detecting non-peptide antigens in the context of monomorphic antigen-presenting molecules. Due to their abundance in barrier tissues, reactivity to local inflammatory cues, and cytotoxic and regulatory functions, MAIT cells are poised to shape the dynamics of various tumor microenvironments. Growing evidence suggests that MAIT cells can exert protumor and/or antitumor effects in cancers arising from or metastasizing to mucosal tissues. However, MAIT cell roles in bladder cancer (BCa) remains unclear. Methods To begin to identify MAIT cells in BCa, we stained bladder tumor biopsies for T cell receptor (TCR) Vα7.2+ cells. We then refined a human MAIT cell signature, which enabled us to interrogate a bulk RNA sequencing dataset and conduct correlation analyses linking intratumoral MAIT cell abundance and mortality from BCa. To extend our work to an in vivo setting, we employed a clinically relevant mouse model in which Mr1 +/+ B6-MAITCAST (MAIT-sufficient) and Mr1 −/− B6-MAITCAST (MAIT-deficient) mice were exposed to N-butyl-N-(4-hydroxybutyl)nitrosamine, a chemical carcinogen associated with tobacco smoke. In additional experiments, MAIT cells were functionally removed through acetyl-6-formylpterin (Ac-6-FP) administration. Effector and regulatory cell types were phenotyped by flow cytometry, and BCa tumor burden and progression were assessed by MRI and/or H&E and Ki67 staining. Results TCR Vα7.2+ cells were readily detectable in several BCa biopsies, and our bioinformatic analyses correlated heavier MAIT cell presence in BCa tumors with poorer overall survival. Similarly, we found higher tumor burdens in Mr1+/+ B6-MAITCAST mice than in Mr1−/− or Ac-6-FP-treated animals. Bladder MAIT cells from tumor-bearing mice exhibited phenotypic MAIT17 bias based on transcription factors they harbored along with increased interleukin-17A and tumor necrosis factor-α production capacities upon stimulation. Finally, FoxP3+ regulatory T (Treg) cell frequencies were elevated in Mr1+/+ mouse bladder tumors, likely contributing to an immunosuppressive tumor microenvironment, a finding that could be recapitulated in our transcriptomic studies on human BCa. Conclusions MAIT cells are abundant in BCa tumor microenvironments where they potentiate Treg cell accumulation and play protumor roles.
Cluster-based redox-responsive super-atomic MRI contrast agents
Alexandros A. Kitos, Raúl Castañeda, Zachary J. Comeau, Niki Mavragani, Nicholas D. Calvert, et al.
Chem, 2025
Single-Frequency Birdcage Coils for Deep Tissue Perfluorocarbon Magnetic Resonance Imaging in Mice
Sean W. McRae, Francisco M. Martinez, Paula J. Foster, John A. Ronald, Timothy J. Scholl
NMR in Biomedicine, 2025
Fluorine‐19 (19F) MRI has become an established tool for in vivo cell tracking following ex vivo or in vivo labelling of various cell types with 19F perfluorocarbons (PFCs). Here, we developed and evaluated novel mouse‐specific radiofrequency (RF) hardware for improved dual 1H anatomical imaging and deep tissue 19F MR detection of PFCs. Three linearly polarized birdcage RF coils were constructed—a dual‐frequency 1H/19F coil, and a pair of single‐frequency 1H and 19F coils, designed to be used sequentially. RF coil quality factors (Q values), signal homogeneity and sensitivity were benchmarked against a commercially constructed dual‐frequency 1H/19F surface coil. RF homogeneity was assessed using a phantom designed to mimic PFC localization at depth in a mouse. The single‐frequency birdcage coils (1H and 19F) displayed more uniform coverage and enhanced signal‐to‐noise ratios (SNRs) compared to both the birdcage and surface dual‐frequency coils for 19F detection. Bilateral injection of a perfluoropolyether nanoemulsion into the footpads of female athymic nude mice, resulting in drainage to various lymph nodes and subsequent accumulation in lymph node macrophages, provided a platform to assess differences in SNRs and contrast‐to‐noise ratios (CNR) between both coil configurations as a function of depth and location. The single‐frequency 1H coil provided significantly increased CNR in anatomical images (p < 0.001) with increased anatomical coverage compared to the dual‐frequency surface coil. The single‐frequency 19F birdcage coil offered increased PFC detectability with significantly higher SNR in renal, lumbar, sciatic and popliteal lymph nodes (p < 0.01) compared to the dual‐frequency surface coil. Interestingly, the percentage difference between SNR measurements in lymph nodes between the single‐frequency 19F coil and the 1H/19F surface coil had a linear relationship with increasing distance from the surface coil (R2 = 0.6352; p < 0.0001), indicating a potential disagreement for imaging experiments that rely on 19F spin quantification at increasing depth within the mouse using surface RF coils.
Imaging CAR-NK cells targeted to HER2 ovarian cancer with human sodium-iodide symporter-based positron emission tomography
Nourhan Shalaby, Ying Xia, John J Kelly, Rafael Sanchez-Pupo, Francisco Martinez, et al.
European Journal of Nuclear Medicine and Molecular Imaging, 2024
Chimeric antigen receptor (CAR) cell therapies utilize CARs to redirect immune cells towards cancer cells expressing specific antigens like human epidermal growth factor receptor 2 (HER2). Despite their potential, CAR T cell therapies exhibit variable response rates and adverse effects in some patients. Non-invasive molecular imaging can aid in predicting patient outcomes by tracking infused cells post-administration. CAR-T cells are typically autologous, increasing manufacturing complexity and costs. An alternative approach involves developing CAR natural killer (CAR-NK) cells as an off-the-shelf allogeneic product. In this study, we engineered HER2-targeted CAR-NK cells co-expressing the positron emission tomography (PET) reporter gene human sodium-iodide symporter (NIS) and assessed their therapeutic efficacy and PET imaging capability in a HER2 ovarian cancer mouse model.NK-92 cells were genetically modified to express a HER2-targeted CAR, the bioluminescence imaging reporter Antares, and NIS. HER2-expressing ovarian cancer cells were engineered to express the bioluminescence reporter Firefly luciferase (Fluc). Co-culture experiments demonstrated significantly enhanced cytotoxicity of CAR-NK cells compared to naive NK cells. In vivo studies involving mice with Fluc-expressing tumors revealed that those treated with CAR-NK cells exhibited reduced tumor burden and prolonged survival compared to controls. Longitudinal bioluminescence imaging demonstrated stable signals from CAR-NK cells over time. PET imaging using the NIS-targeted tracer 18F-tetrafluoroborate ([18F]TFB) showed significantly higher PET signals in mice treated with NIS-expressing CAR-NK cells.Overall, our study showcases the therapeutic potential of HER2-targeted CAR-NK cells in an aggressive ovarian cancer model and underscores the feasibility of using human-derived PET reporter gene imaging to monitor these cells non-invasively in patients.
Intracellular Acidification in a Rat C6 Glioma Model following Cariporide Injection Investigated by CEST-MRI
Maryam Mozaffari, Nivin N. Nyström, Alex Li, Miranda Bellyou, Timothy J. Scholl, et al.
Metabolites, 2023
Acidification of cancerous tissue induced pharmacologically may slow tumor growth and can be detected using magnetic resonance imaging. Numerous studies have shown that pharmacologically inhibiting specific transporters, such as the Na+/H+ exchanger 1 (NHE1), can alter glycolitic metabolism and affect tumor acidosis. The sodium proton exchanger inhibitor Cariporide can acidify U87MG gliomas in mice. This study aimed to determine whether Cariporide could acidify C6 glioma tumors in rats with an intact immune system. C6 glioma cells were implanted in the right brain hemisphere of ten rats. Chemical exchange saturation transfer (CEST) MRI (9.4T) was acquired on days 7–8 and 14–15 after implantation to measure in vivo tissue intracellular pH (pHi) within the tumors and on the contralateral side. pHi was basic relative to contralateral tissue at both time points assessed using the amine and amide concentration-independent detection (AACID) value. On day 14–15, measurements were made before and up to 160 min after Cariporide injection (N = 6). Twenty minutes after drug injection, the average AACID value in the tumor significantly increased by ∼6.4% compared to pre-injection, corresponding to 0.31 ± 0.20 lower pHi, while in contralateral tissue, AACID value increased significantly by ∼4.3% compared to pre-injection, corresponding to 0.22 ± 0.19 lower pHi. Control rats without tumors showed no changes following injection of Cariporide dissolved in 10% or 1% DMSO and diluted in PBS. This study demonstrates the sensitivity of CEST-based pH-weighted imaging for monitoring the response of tumors to pharmacologically induced acidification.
Development of a Suite of Gadolinium-Free OATP1-Targeted Paramagnetic Probes for Liver MRI
Sean W. McRae, Michael Cleary, Daniel DeRoche, Francisco M. Martinez, Ying Xia, et al.
Journal of Medicinal Chemistry, 2023
Five amphiphilic, anionic Mn(II) complexes were synthesized as contrast agents targeted to organic anion transporting polypeptide transporters (OATP) for liver magnetic resonance imaging (MRI). The Mn(II) complexes are synthesized in three steps, each from the commercially available trans-1,2-diaminocyclohexane-N,N,N',N'-tetraacetic acid (CDTA) chelator, with T1-relaxivity of complexes ranging between 2.3 and 3.0 mM-1 s-1 in phosphate buffered saline at an applied field strength of 3.0 T. Pharmacokinetics were assessed in female BALB/c mice by acquiring T1-weighted images dynamically for 70 min after agent administration and determining contrast enhancement and washout in various organs. Uptake of Mn(II) complexes in human OATPs was investigated through in vitro assays using MDA-MB-231 cells engineered to express either OATP1B1 or OATP1B3 isoforms. Our study introduces a new class of Mn-based OATP-targeted contrast that can be broadly tuned via simple synthetic protocols.
Glucose Infusion Induced Change in Intracellular pH and Its Relationship with Tumor Glycolysis in a C6 Rat Model of Glioblastoma
Qi Qi, Matthew S. Fox, Heeseung Lim, Rebecca Sullivan, Alex Li, et al.
Molecular Imaging and Biology, 2023
Visualizing cell-cell communication using synthetic notch activated MRI
TianDuo Wang, Yuanxin Chen, Nivin N. Nystrom, Shirley Liu, Yanghao Fu, et al.
Proceedings of the National Academy of Sciences of the United States of America, 2023
Cell–cell communication plays a fundamental role in multicellular organisms. Cell-based cancer immunotherapies rely on the ability of innate or engineered receptors on immune cells to engage specific antigens on cancer cells to induce tumor kill. To improve the development and translation of these therapies, imaging tools capable of noninvasively and spatiotemporally visualizing immune-cancer cell interactions would be highly valuable. Using the synthetic Notch (SynNotch) system, we engineered T cells that upon interaction with a chosen antigen (CD19) on neighboring cancer cells induce the expression of optical reporter genes and the human-derived, magnetic resonance imaging (MRI) reporter gene organic anion transporting polypeptide 1B3 (OATP1B3). Administration of engineered T cells induced the antigen-dependent expression of all our reporter genes in mice bearing CD19-positive tumors but not CD19-negative tumors. Notably, due to the high spatial resolution and tomographic nature of MRI, contrast-enhanced foci within CD19-positive tumors representing OATP1B3-expressing T cells were clearly visible and their distribution was readily mapped. We then extended this technology onto human natural killer-92 (NK-92) cells, observing similar CD19-dependent reporter activity in tumor-bearing mice. Furthermore, we show that when delivered intravenously, engineered NK-92 cells can be detected via bioluminescence imaging in a systemic cancer model. With continued work, this highly modular imaging strategy could aid in the monitoring of cell therapies in patients and, beyond this, augment our understanding of how different cell populations interact within the body during normal physiology or disease.
A Genetically Encoded Magnetic Resonance Imaging Reporter Enables Sensitive Detection and Tracking of Spontaneous Metastases in Deep Tissues
Nivin N. Nyström, Sean W. McRae, Francisco M. Martinez, John J. Kelly, Timothy J. Scholl, et al.
Cancer Research, 2023
Effects of pediatric chronic kidney disease and its etiology on tissue sodium concentration: a pilot study
Fabio R. Salerno, Alireza Akbari, Sandrine Lemoine, Timothy J. Scholl, Christopher W. McIntyre, et al.
Pediatric Nephrology, 2023
Complementary early-phase magnetic particle imaging and late-phase positron emission tomography reporter imaging of mesenchymal stem cells in vivo
Nourhan Shalaby, John J. Kelly, Olivia C. Sehl, Julia J. Gevaert, Matthew S. Fox, et al.
Nanoscale, 2023
Gadolinium-free Magnetic Resonance Imaging of the Liver via an Oatp1-Targeted Manganese(III) Porphyrin
Nivin N. Nyström, Hanlin Liu, Francisco M. Martinez, Xiao-an Zhang, Timothy J. Scholl, et al.
Journal of Medicinal Chemistry, 2022
Outcomes and predictors of skin sodium concentration in dialysis patients
Fabio R Salerno, Alireza Akbari, Sandrine Lemoine, Guido Filler, Timothy J Scholl, et al.
Clinical Kidney Journal, 2022
Functional Sodium MRI Helps to Measure Corticomedullary Sodium Content in Normal and Diseased Human Kidneys
Alireza Akbari, Sandrine Lemoine, Fabio Salerno, Taylor L. Marcus, Tristan Duffy, et al.
Radiology, 2022
A Human-derived Dual MRI/PET Reporter Gene System with High Translational Potential for Cell Tracking
Nourhan Shalaby, John Kelly, Francisco Martinez, Mathew Fox, Qi Qi, et al.
Molecular Imaging and Biology, 2022
Multimodality In Vivo Imaging of Perfusion and Glycolysis in a Rat Model of C6 Glioma
Qi Qi, Matthew S. Fox, Heeseung Lim, Robert Bartha, Timothy J. Scholl, et al.
Molecular Imaging and Biology, 2021
Tissue sodium concentrations in chronic kidney disease and dialysis patients by lower leg sodium-23 magnetic resonance imaging
Elena Qirjazi, Fabio R Salerno, Alireza Akbari, Lisa Hur, Jarrin Penny, et al.
Nephrology Dialysis Transplantation, 2021
Monitoring early changes in tumor metabolism in response to therapy using hyperpolarized13C MRSI in a preclinical model of glioma
Heeseung Lim, Francisco Martínez-Santiesteban, Michael D. Jensen, Albert Chen, Eugene Wong, et al.
Tomography, 2020
Development of a human photoacoustic imaging reporter gene using the clinical dye indocyanine green
Nivin N. Nyström, Lawrence C.M. Yip, Jeffrey J.L. Carson, Timothy J. Scholl, John A. Ronald
Radiology Imaging Cancer, 2019
Longitudinal Visualization of Viable Cancer Cell Intratumoral Distribution in Mouse Models Using Oatp1a1 -Enhanced Magnetic Resonance Imaging
Nivin N. Nyström, Amanda M. Hamilton, Wenyao Xia, Shirley Liu, Timothy J. Scholl, et al.
Investigative Radiology, 2019
Characterization of clinical human prostate cancer lesions using 3.0-T sodium MRI registered to Gleason-graded whole-mount histopathology
Nolan C. Broeke, Justin Peterson, Joseph Lee, Peter R. Martin, Adam Farag, et al.
Journal of Magnetic Resonance Imaging, 2019
Gellan gum-based gels with tunable relaxation properties for MRI phantoms
Pawel Brzozowski, Kalin I. Penev, Francisco M. Martinez, Timothy J. Scholl, Kibret Mequanint
Magnetic Resonance Imaging, 2019
Measuring the spin-lattice relaxation magnetic field dependence of hyperpolarized [1-13c]pyruvate
Soojin Kim, Francisco Martinez-Santiesteban, Timothy J. Scholl
Journal of Visualized Experiments, 2019
Aerobic glycolysis is required for spatial memory acquisition but not memory retrieval in mice
Richard A. Harris, Asad Lone, Heeseung Lim, Francisco Martinez, Ariel K. Frame, et al.
Eneuro, 2019
Longitudinal Measurements of Intra- and Extracellular pH Gradient in a Rat Model of Glioma
Heeseung Lim, Mohammed Albatany, Francisco Martínez-Santiesteban, Robert Bartha, Timothy J. Scholl
Tomography Ann Arbor Mich, 2018
Characterization of an Orthotopic Rat Model of Glioblastoma Using Multiparametric Magnetic Resonance Imaging and Bioluminescence Imaging
Trung N.T. Le, Heeseung Lim, Amanda M. Hamilton, Katie M. Parkins, Yuanxin Chen, et al.
Tomography Ann Arbor Mich, 2018
Chapter 2: Gadolinium-based Contrast Agents
Lothar Helm, Janet R. Morrow, Christopher J. Bond, Fabio Carniato, Mauro Botta, et al.
New Developments in NMR, 2018
Nuclear magnetic relaxation dispersion of murine tissue for development of T1 (R1) dispersion contrast imaging
Yonathan T. Araya, Francisco Martínez‐Santiesteban, William B. Handler, Chad T. Harris, Blaine A. Chronik, et al.
NMR in Biomedicine, 2017
T1 nuclear magnetic relaxation dispersion of hyperpolarized sodium and cesium hydrogencarbonate-13C
Francisco M. Martínez‐Santiesteban, Thien Phuoc Dang, Heeseung Lim, Albert P. Chen, Timothy J. Scholl
NMR in Biomedicine, 2017
Synthesis of a poly(Gd(III)-DOTA)-PNA conjugate as a potential MRI contrast agent: Via post-synthetic click chemistry functionalization
Xiaoxiao Wang, Mark Milne, Francisco Martínez, Timothy J. Scholl, Robert H. E. Hudson
Rsc Advances, 2017
An enzyme-activatable and cell-permeable MnIII-porphyrin as a highly efficient: T 1 MRI contrast agent for cell labeling
Inga E. Haedicke, Tan Li, Yong Le K. Zhu, Francisco Martinez, Amanda M. Hamilton, et al.
Chemical Science, 2016
A novel shape-similarity-based elastography technique for prostate cancer assessment
Seyed Reza Mousavi, Haisu Wang, Seyyed Mohammad Hesabgar, Timothy J. Scholl, Abbas Samani
Medical Physics, 2015
Unshielded asymmetric transmit-only and endorectal receive-only radiofrequency coil for 23Na MRI of the prostate at 3 tesla
Adam Farag, Justin Charles Peterson, Trevor Szekeres, Glenn Bauman, Joseph Chin, et al.
Journal of Magnetic Resonance Imaging, 2015
Anatomical, functional and metabolic imaging of radiation-induced lung injury using hyperpolarized MRI
Giles Santyr, Matthew Fox, Kundan Thind, Elaine Hegarty, Alexei Ouriadov, et al.
NMR in Biomedicine, 2014
Construction and evaluation of a switch-tuned 13C - 1H birdcage radiofrequency coil for imaging the metabolism of hyperpolarized 13C-enriched compounds
Heeseung Lim, Kundan Thind, Francisco M. Martinez‐Santiesteban, Timothy James Scholl
Journal of Magnetic Resonance Imaging, 2014
Development and optimization of hardware for delta relaxation enhanced MRI
Chad T. Harris, William B. Handler, Yonathan Araya, Francisco Martínez-Santiesteban, Jamu K. Alford, et al.
Magnetic Resonance in Medicine, 2014
Longitudinal anatomical and metabolic MRI characterization of orthotopic xenograft prostate tumors in nude mice
Christiane L. Mallett, Heeseung Lim, Kundan Thind, Yuhua Chen, Emeline J. Ribot, et al.
Journal of Magnetic Resonance Imaging, 2014
Complementary strategies for developing Gd-free high-field T1 MRI contrast agents based on MnIII porphyrins
Weiran Cheng, Inga E. Haedicke, Joris Nofiele, Francisco Martinez, Kiran Beera, et al.
Journal of Medicinal Chemistry, 2014
New head gradient coil design and construction techniques
William B. Handler, Chad T. Harris, Timothy J. Scholl, Dennis L. Parker, K. Craig Goodrich, et al.
Journal of Magnetic Resonance Imaging, 2014
Binding of a dimeric manganese porphyrin to serum albumin: Towards a gadolinium-free blood-pool T 1 MRI contrast agent Topical Issue on Metal-Based MRI Contrast Agents. Guest editor: Valerie C. Pierre
Weiran Cheng, Tameshwar Ganesh, Francisco Martinez, Jolie Lam, Hyung Yoon, et al.
Journal of Biological Inorganic Chemistry, 2014
Mapping metabolic changes associated with early Radiation Induced Lung Injury post conformal radiotherapy using hyperpolarized 13C-pyruvate Magnetic Resonance Spectroscopic Imaging
Kundan Thind, Michael D. Jensen, Elaine Hegarty, Albert P. Chen, Heeseung Lim, et al.
Radiotherapy and Oncology, 2014
A dual magnetic resonance imaging/fluorescent contrast agent for Cathepsin-D detection
Robert Ta, Mojmir Suchy, Joshua H.K. Tam, Alex X. Li, Francisco S. Martinez‐Santiesteban, et al.
Contrast Media and Molecular Imaging, 2013
Polymer cross-linking: A nanogel approach to enhancing the relaxivity of MRI contrast agents
Abdolrasoul Soleimani, Francisco Martínez, Vasiliki Economopoulos, Paula J. Foster, Timothy J. Scholl, et al.
Journal of Materials Chemistry B, 2013
Field dependence of T 1 for hyperpolarized [1- 13C]pyruvate
N. Chattergoon, F. Martínez‐Santiesteban, W. B. Handler, J. H. Ardenkjær‐Larsen, T. J. Scholl
Contrast Media and Molecular Imaging, 2013
Detection of radiation-induced lung injury using hyperpolarized 13C magnetic resonance spectroscopy and imaging
K. Thind, A. Chen, L. Friesen-Waldner, A. Ouriadov, T. J. Scholl, et al.
Magnetic Resonance in Medicine, 2013
Biodegradable dendritic polymersomes as modular, high-relaxivity MRI contrast agents
Ali Nazemi, Francisco Martínez, Timothy J. Scholl, Elizabeth R. Gillies
Rsc Advances, 2012
Optimisation of dynamic nuclear polarisation of [1-13C] pyruvate by addition of gadolinium-based contrast agents
Lanette Friesen-Waldner, Albert Chen, Will Mander, Timothy J. Scholl, Charles A. McKenzie
Journal of Magnetic Resonance, 2012
Structure-guided directed evolution of highly selective P450-based magnetic resonance imaging sensors for dopamine and serotonin
Eric M. Brustad, Victor S. Lelyveld, Christopher D. Snow, Nathan Crook, Sang Taek Jung, et al.
Journal of Molecular Biology, 2012
Poly(para -phenylene ethynylene)s functionalized with Gd(III) chelates as potential MRI contrast agents
Katelyn M. Atkins, Francisco M. Martínez, Ali Nazemi, Timothy J. Scholl, Elizabeth R. Gillies
Canadian Journal of Chemistry, 2011
First image from a combined positron emission tomography and field-cycled MRI system
Geron A. Bindseil, Kyle M. Gilbert, Timothy J. Scholl, William B. Handler, Blaine A. Chronik
Magnetic Resonance in Medicine, 2011
Results for diffusion-weighted imaging with a fourth-channel gradient insert
Rebecca E. Feldman, Timothy J Scholl, Jamu K. Alford, William B. Handler, Chad T. Harris, et al.
Magnetic Resonance in Medicine, 2011
TU‐A‐BRC‐06: Using Hyperpolarized 13C Magnetic Resonance Spectroscopy to Detect Radiation Induced Lung Injury at an Early Stage
K Thind, A Ouriadov, L Feiesen‐Waldner, A Chen, T Scholl, et al.
Medical Physics, 2011
Measurements of isotope shifts and hyperfine structure in Ti II
Z Nouri, S D Rosner, R Li, T J Scholl, R A Holt
Physica Scripta, 2010
Quantitative comparison of minimum inductance and minimum power algorithms for the design of shim coils for small animal imaging
Parisa Hudson, Stephen D. Hudson, William B. Handler, Timothy J. Scholl, Blaine A. Chronik
Concepts in Magnetic Resonance Part B Magnetic Resonance Engineering, 2010
Sensory and motor stimulation thresholds of the ulnar nerve from electric and magnetic field stimuli: Implications to gradient coil operation
Bryan J. Recoskie, Timothy J. Scholl, Martin Zinke‐Allmang, Blaine A. Chronik
Magnetic Resonance in Medicine, 2010
Proof-of-principle study of a small animal PET/field-cycled MRI combined system using conventional PMT technology
Hao Peng, William B. Handler, Timothy J. Scholl, P.J. Simpson, Blaine A. Chronik
Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment, 2010
The discrepancy between human peripheral nerve chronaxie times as measured using magnetic and electric field stimuli: The relevance to MRI gradient coil safety
Bryan J Recoskie, Timothy J Scholl, Blaine A Chronik
Physics in Medicine and Biology, 2009
Fast-ion-beam laser-fluorescence measurements of oscillator strengths in the lanthanides
R A Holt, R Li, R Chatelain, S J Rehse, S D Rosner, et al.
Physica Scripta T, 2009
Design, fabrication, and testing of an insertable double-imaging-region gradient coil
K. Craig Goodrich, J. Rock Hadley, Sung M. Moon, Blaine A. Chronik, Timothy J. Scholl, et al.
Concepts in Magnetic Resonance Part B Magnetic Resonance Engineering, 2009
Design and construction of a prototype high-power B0 insert coil for field-cycled imaging in superconducting MRI systems
Jamu K. Alford, Timothy J. Scholl, William B. Handler, Blaine A. Chronik
Concepts in Magnetic Resonance Part B Magnetic Resonance Engineering, 2009
Evaluation of a positron emission tomography (PET)-compatible field-cycled MRI (FCMRI) scanner
Kyle M. Gilbert, Timothy J. Scholl, William B. Handler, Jamu K. Alford, Blaine A. Chronik
Magnetic Resonance in Medicine, 2009
Delta relaxation enhanced mr: Improving activation - Speeificity of molecular probes through R1 dispersion imaging
Jamu K. Alford, Brian K. Rutt, Timothy J. Scholl, William B. Handler, Blaine A. Chronik
Magnetic Resonance in Medicine, 2009
RF coil loading measurements between 1 and 50 MHz to guide field-cycled MRI system design
K.M. Gilbert, T.J. Scholl, B.A. Chronik
Concepts in Magnetic Resonance Part B Magnetic Resonance Engineering, 2008
Fast-ion-beam laser-induced-fluorescence measurements of branching fractions and oscillator strengths in Nd II
R Li, S J Rehse, T J Scholl, A Sharikova, R Chatelain, et al.
Canadian Journal of Physics, 2007
Oscillator strength measurements in Pr II with the fast-ion-beam laser-induced-fluorescence technique
R Li, R Chatelain, R A Holt, S J Rehse, S D Rosner, et al.
Physica Scripta, 2007
Fabrication of low-field water-cooled resistive magnets for small animal magnetic resonance imaging
K.M. Gilbert, B. Dalrymple, W.B. Handler, T.J. Scholl, B.A. Chronik
Concepts in Magnetic Resonance Part B Magnetic Resonance Engineering, 2006
Fast-ion-beam laser-induced-fluorescence measurements of spontaneous-emission branching ratios and oscillator strengths in Sm II
S J Rehse, R Li, T J Scholl, A Sharikova, R Chatelain, et al.
Canadian Journal of Physics, 2006
Design of field-cycled magnetic resonance systems for small animal imaging
K M Gilbert, W B Handler, T J Scholl, J W Odegaard, B A Chronik
Physics in Medicine and Biology, 2006
Measurement of hyperfine structure and isotope shifts in Nd II
S D Rosner, D Masterman, T J Scholl, R A Holt
Canadian Journal of Physics, 2005
Absolute wave-number measurements in 130Te2: Reference lines spanning the 420.9-464.6-nm region
T. J. Scholl, S. J. Rehse, R. A. Holt, S. D. Rosner
Journal of the Optical Society of America B Optical Physics, 2005
Broadband precision wavelength meter based on a stepping Fabry-Pérot interferometer
T. J. Scholl, S. J. Rehse, R. A. Holt, S. D. Rosner
Review of Scientific Instruments, 2004
Isotope shifts and hyperfine structure in Sm II
D Masterman, S D Rosner, T J Scholl, A Sharikova, R A Holt
Canadian Journal of Physics, 2003
Measurement of radiative lifetimes in Sm II
T J Scholl, R A Holt, D Masterman, R C Rivest, S D Rosner, et al.
Canadian Journal of Physics, 2002
Measurement of radiative lifetimes in Pr II and Nd II
T J Scholl, R A Holt, D Masterman, R C Rivest, S D Rosner, et al.
Canadian Journal of Physics, 2002
Laser spectroscopic measurements of hyperfine structure in Pr II
R C Rivest, M R Izawa, S D Rosner, T J Scholl, G Wu, et al.
Canadian Journal of Physics, 2002
Measurement of radiative lifetimes in Nd II
C.M. Pinciuc, R.C. Rivest, M.R. Izawa, R.A. Holt, S.D. Rosner, et al.
Canadian Journal of Physics, 2001
Measurement of radiative lifetimes in Nd II
C M Pinciuc, R C Rivest, M R Izawa, R A Holt, S D Rosner, et al.
Canadian Journal of Physics, 2001
Measurements of hyperfine structure in Mn II
R. A. Holt, T. J. Scholl, S. D. Rosner
Monthly Notices of the Royal Astronomical Society, 1999
Fine and Hyperfine Structure in 14N+2: The B2Σ+u-X2Σ +g (0, 0) Band
T.J. Scholl, R.A. Holt, S.D. Rosner
Journal of Molecular Spectroscopy, 1998
B2σ+ state lifetime in CO+
T J Scholl, S D Rosner, R A Holt
Canadian Journal of Physics, 1998
A Study of the X 2Σ+ and a 2Π States of SiO+ Using Fast-Ion-Beam Laser Spectroscopy
S.D. Rosner, R. Cameron, T.J. Scholl, R.A. Holt
Journal of Molecular Spectroscopy, 1998
Laser-rf saturation spectroscopy: A novel fast-ion-beam sub-Doppler method
R A Holt, T J Scholl, S D Rosner
Canadian Journal of Physics, 1997
Lifetime measurements using the cascade-photon-coincidence technique with a sputtered-atom source
S. D. Rosner, R. A. Holt, T. J. Scholl
Physical Review A Atomic Molecular and Optical Physics, 1997
Measurement of the lifetime of the 1s2p[Formula Presented] state in Be III
T. J. Scholl, S. D. Rosner, R. A. Holt
Physical Review A Atomic Molecular and Optical Physics, 1996
Beam-laser measurements of lifetimes in SiO+ and N2+
T. J. Scholl, R. Cameron, S. D. Rosner, R. A. Holt
Physical Review A, 1995
Fast-Ion-Beam Laser Spectroscopy of the B2Σ+-X2Σ+ and B2Σ+-A2Π Systems of SiO+: Experiment
R. Cameron, T.J. Scholl, L. Zhang, R.A. Holt, S.D. Rosner
Journal of Molecular Spectroscopy, 1995
Fast-Ion-Beam laser spectroscopy of the B2Σ+-X2Σ+ and B2Σ+-A2Π Systems of SiO+: Deperturbation Analysis
R. Cameron, T.J. Scholl, L. Zhang, R.A. Holt, S.D. Rosner
Journal of Molecular Spectroscopy, 1995
New observations of the optical spectrum of SiO+ and the prediction of its rotational spectrum
L. Zhang, R. Cameron, R. A. Holt, T. J. Scholl, S. D. Rosner
Astrophysical Journal, 1993
Precision measurement of relativistic and QED effects in heliumlike beryllium
T. J. Scholl, R. Cameron, S. D. Rosner, L. Zhang, R. A. Holt, et al.
Physical Review Letters, 1993
High-resolution study of the B2Σu+-X2Σg+ system of 14N2+ and 15N2+
T.J. Scholl, A.W. Taylor, R.A. Holt, S.D. Rosner
Journal of Molecular Spectroscopy, 1992
Measurement of the atomic lifetime of Kr ii 5p 4D7/2o and Xe ii 6p 4D5/2o using the cascade-photon-coincidence technique
R. E. Mitchell, S. D. Rosner, T. J. Scholl, R. A. Holt
Physical Review A, 1992
Laser-rf double-resonance study of N2+
N. Berrah Mansour, C. Kurtz, T. C. Steimle, G. L. Goodman, L. Young, et al.
Physical Review A, 1991
Precision measurement of the 1s2s 1S0-1s2p 1P1 interval in heliumlike beryllium
T. J. Scholl, R. A. Holt, S. D. Rosner
Physical Review A, 1989
Atomic g -factor measurements by laser-rf double resonance
T. J. Scholl, S. D. Rosner, R. A. Holt
Physical Review A, 1987
Fast-ion-beam laser and laser-rf double-resonance measurements of hyperfine structure in ii83
T. J. Scholl, T. D. Gaily, R. A. Holt, S. D. Rosner
Physical Review A, 1986

Timothy J Scholl

EDUCATION

RESEARCH, TEACHING, or OTHER INTERESTS

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS