- B.Sc. Medical Laboratory Sciences – University of Science and Technology, Sudan 2005 .
- Pre-master qualifying year – University of Khartoum, Sudan ,2007.
- M.Sc. Medical laboratory Science (Hematology and Immunohematology) Sudan University of Science and Technology, Sudan 2010.
- Ph.D. in Medical laboratory Science (Hematology and Immunohematology), Sudan University of Science and Technology, Sudan 2015.
- American Board for clinical pathology, International Specialist in Hematology (SH – ASCPi),ID: 25713617. The American Society for Clinical Pathology,
Pharmacogenomics and Opioid Efficacy in Sickle Cell Disease Rabab H. Elshaikh, Asaad M. Babker, Sanaa Elfatih Hussein, Khalid Abdelsamea Mohamed Ahmed, Ashok Kumar Sah, et al. Medicina Lithuania, 2026 The impact of genetic variation in sickle cell patients plays a significant role in opioid therapy individual response and pain management. This review aims to provide a comprehensive overview of the importance of exploring genetic variability and its impact on pain management in patients with sickle cell disease. It also explores opioid therapy variability and opioid Safety. With respect to literature, the polymorphisms in the key metabolic enzymes CYP2D6, UGT2B7, and COMT, as well as variations in the OPRM1, are important modifiers of the pharmacokinetics and pharmacodynamics of opioids. Variations in the COMT gene can influence how the body manages certain brain chemicals and how pain is experienced, while changes in the OPRM1 gene can alter how well opioids bind to their receptors. They help determine how opioids are broken down in the body, how well they attach to pain receptors, and how pain is felt by someone with sickle cell disease. Patients with reduced-function and ultra-rapid CYP2D6 alleles have a modified metabolism of codeine and tramadol, which presents either a reduced analgesic response or a risk for increased toxicity. These observations support the case for the need for tailored opioid prescriptions in a population that is genetically diverse, as well as the risk of not having standardized pain measurement, and the absence of clinical implementation. There remains the risk of unrecognized pharmacogenomics, lack of data, and personalized opioid descriptions persist. Future research should focus on integrating genetic testing into clinical practice to optimize opioid selection, personalize medicine, minimize adverse effects, and ensure each patient receives treatment that is both effective and safe to enhance quality of life for individuals with sickle cell disease.
RETICULOCYTE SUBPOPULATION ANALYSIS AND ITS CORRELATION WITH IRON DEFICIENCY ANEMIA: A RETROSPECTIVE STUDY IN A PREDOMINANTLY FEMALE POPULATION Georgian Medical News, 2026
DIFFERENTIAL ASSOCIATIONS BETWEEN PHYSICAL ACTIVITY AND GLYCEMIC CONTROL ACROSS BODY MASS INDEX IN TYPE 2 DIABETES: A COMPARATIVE ANALYSIS OF HBA1C AND FRUCTOSAMINE Georgian Medical News, 2026
Next-generation lipid nanocarriers for Parkinson's therapy: nose-to-brain innovations and clinical prospects Nadine Wafik Nabih, Mohamed S. Nafie, Asaad Babker, Ayman Ali Mohammed Alameen, Sherif Ashraf Fahmy Nanoscale, 2025 Parkinson's disease (PD) remains one of the most formidable challenges in central nervous system (CNS) drug delivery due to the restrictive blood–brain barrier (BBB) and limited efficacy of current dopaminergic therapies. Created in BioRender. Fahmy, S. (2025) https://BioRender.com/vsusgrv.
Mucoadhesive chitosan-coated boswellic acids nanoparticles as promising gastroprotective nanoagents via modulation of the RAS/ERK signaling pathway Reem T. Attia, Asaad Babker, Mohamed S. Nafie, Fatma Aboelmagd Saleh, Manar Ashraf Abdelwareth, et al. Discover Nano, 2025 Chitosan, a natural biological macromolecule, was employed to coat boswellic acids extract nanoparticles (CT/BA NPs) to enhance their gastroprotective potential. This study evaluated the therapeutic effects of CT/BA NPs compared to free boswellic acids (BA) in a murine model of ethanol-induced gastric ulcers. Histological analysis showed that CT/BA NPs preserved gastric gland integrity and minimized inflammatory infiltration, achieving a ~ 97% reduction in ulcer index compared to the ulcer group, whereas BA alone achieved ~ 80% protection. CT/BA NPs treatment markedly modulated key growth factors, with TGF-α and TGF-β1 increased by more than 100% relative to the ulcer group, while VEGF expression was suppressed by ~ 74%, indicating more controlled angiogenesis. In addition, CT/BA NPs significantly reduced RAS and ERK levels (by ~ 1.6- and 1.2-fold, respectively) and lowered TNF-α compared to BA, highlighting their role in regulating the RAS–ERK signaling pathway. The superior mucoadhesive properties of CT/BA NPs (76.4% vs. 15.8% for BA NPs) improved gastric mucosal retention, contributing to localized therapeutic effects. Collectively, these findings demonstrate that CT/BA NPs provide promising gastroprotection by promoting epithelial healing, modulating growth factors and signaling pathways, and mitigating ulcer severity.
A Review on Type 2 Diabetes Mellitus: Pathophysiology, Risk Factors, and Vascular Complications Ashok Kumar Sah, Darla Srinivasarao, Nuwo David, Shagun Agarwal, Vijaya Simha, et al. Biomedical and Pharmacology Journal, 2025 The significant mortality and morbidity linked to Diabetes mellitus Type 2 are triggered by many of vascular complications, consisting of insulin resistance and persistent hyperglycemia. T2DM is a serious issue for people all around the world. Macrovascular outcomes include peripheral artery disease, cardiovascular disease, cerebrovascular accidents, and abdominal aortic aneurysms, all of which are brought on by increasing atherosclerosis due to endothelial cell dysfunction, oxidative damage, and vascular calcification. Microvascular complications, including retinopathy, nephropathy, peripheral neuropathy, as well as delayed healing of wounds, contribute to additional impairment. The challenges that patients with type 2 diabetes frequently experience from an endovascular standpoint are rather distinct and involve diffuse and calcified tumors, decreased collateral damage, smaller blood vessel caliber, as well as a greater likelihood of restenosis following angioplasty or stenting. In this study, we look at the present level of knowledge on the detrimental effects of type 2 diabetes, discuss how it affects endovascular implications, and highlight the difficulties and potential solutions to lessen the disease's vascular impact.
Frequency of ACE I/D and PAI-1 4G/5G Polymorphisms in Women with Recurrent Pregnancy Loss in Sudan Asaad Babker, Hanan Khalid Fadul Ahmed, Salaheldein Elzaki, Shawgi Elsiddig, Sarah Elsiddig Dafallah, et al. Biomedical and Pharmacology Journal, 2025 This study aimed to investigate the prevalence of ACE I/D and PAI-1 4G/5G polymorphisms in Sudanese women experiencing recurrent pregnancy loss (RPL), and to explore their possible relationship with this condition. A retrospective study was carried out at Omdurman Maternity Hospital in Sudan. The study involved 125 participants: 64 RPL cases (defined as women with a history of at least three unexplained spontaneous abortions) and 61 healthy controls with normal success pregnancies and. A 5 mL EDTA blood sample was taken from each participant, and demographic, personal, and family medical information was collected using a questionnaire. Genomic DNA was extracted from blood leukocytes utilizing the GF-1 Blood DNA Extraction Kit. The polymorphisms of the PAI-1 4G/5G and ACE I/D genes were examined through polymerase chain reaction (PCR). Data analysis was conducted employing SPSS version 24. The ACE I/D polymorphism was found to have a notable association with recurrent pregnancy loss (RPL), with the I/D and D/D genotypes linked to an increased risk (odds ratio 1.29). Although the 4G allele and the 4G/4G genotype showed statistical significance, they were more prevalent in the control group (2.8% and 45.9%, respectively) compared to the cases (6.2%, p < 0.001). Homozygosity for the D allele of ACE, when combined with the PAI-1 4G/4G genotype, significantly raised the likelihood of RPL (p < 0.001). Despite a higher occurrence of the 4G/4G genotype in controls (17% versus 44.7%), these findings suggest complex interactions with other genetic factors. Overall, the homozygous D allele of ACE and the PAI-1 4G/4G genotype are more frequently observed among Sudanese women suffering from recurrent miscarriage, highlighting the commonality of these genetic variations within this population.
IMMUNOMETABOLIC CORRELATIONS OF AUTOANTIBODIES IN LATENT AUTOIMMUNE DIABETES IN ADULTS PATIENTS (LADA): A CROSS-SECTIONAL STUDY Georgian Medical News, 2025
FOLLICLE-STIMULATING HORMONE RECEPTOR MUTATIONS IN SUDANESE WOMEN: A STUDY ON POLYCYSTIC OVARY SYNDROME Georgian Medical News, 2025
BIOCHEMICAL INSIGHTS AND HORMONAL MARKERS OF POLYCYSTIC OVARY SYNDROME IN SUDANESE WOMEN: EXPLORING INFERTILITY AND RISK FACTORS IN RED SEA STATE Georgian Medical News, 2025
Immune-expression of estrogen receptors alpha in oral mucosa among sudanese patients with breast cancer Pakistan Journal of Medical and Health Sciences, 2020
Methylenetetrahydrofolate reductase C677T polymorphism in sudanese women with recurrent spontaneous abortions Kuwait Medical Journal, 2016
Molecular characterization of prothrombin G20210A gene mutations in pregnant sudanese women with spontaneous recurrent abortions Rawal Medical Journal, 2015
RECENT SCHOLAR PUBLICATIONS
RETICULOCYTE SUBPOPULATION ANALYSIS AND ITS CORRELATION WITH IRON DEFICIENCY ANEMIA: A RETROSPECTIVE STUDY IN A PREDOMINANTLY FEMALE POPULATION MKM Madi, MI Hannan Awad, M Butaboyev, J Bobokalonzoda, ... Georgian Medical News 370 (1), 170-176 , 2026 2026
Reprogramming Cancer Therapeutics through Artificial Intelligence-Guided Drug Repurposing: Computational Innovation, Experimental Validation, and Translational Challenges MP Fawzy, MS Nafie, NW Nabih, MK Diab, A Babker, H Mohamed, ... Artificial Intelligence in the Life Sciences, 100168 , 2026 2026
Pharmacogenomics and Opioid Efficacy in Sickle Cell Disease RH Elshaikh, AM Babker, SE Hussein, KAM Ahmed, AK Sah, AH Alfeel Medicina (Lithuania) 62 (1), 172 , 2026 2026 Citations: 1
DIFFERENTIAL ASSOCIATIONS BETWEEN PHYSICAL ACTIVITY AND GLYCEMIC CONTROL ACROSS BODY MASS INDEX IN TYPE 2 DIABETES: A COMPARATIVE ANALYSIS OF HBA1C AND FRUCTOSAMINE M Ismail, M Hassan, M Khalid, M Jaborova, A Gherdaoui, M Alnaimi, ... Georgian medical news, 193-199 , 2026 2026
A Review on Type 2 Diabetes Mellitus: Pathophysiology, Risk Factors, and Vascular Complications AK Sah, D Srinivasarao, N David, S Agarwal, V Simha, P Mishra Biomedical and Pharmacology Journal 18 (4), 2653-2663 , 2025 2025
Next-generation lipid nanocarriers for Parkinson's therapy: nose-to-brain innovations and clinical prospects NW Nabih, MS Nafie, A Babker, AAM Alameen, SA Fahmy Nanoscale , 2025 2025 Citations: 10
Mucoadhesive chitosan-coated boswellic acids nanoparticles as promising gastroprotective nanoagents via modulation of the RAS/ERK signaling pathway RT Attia, A Babker, MS Nafie, FA Saleh, MA Abdelwareth, EM Loutfy, ... Discover Nano 20 (1), 1-19 , 2025 2025 Citations: 8
Innovative design and synthesis of dual-acting hCA IX/CDK-2 inhibitors through hetero ring fused pyrimidine utilization for cutting-edge anticancer therapy: Zein nanoparticles … HM Abosalim, TF El-Moselhy, N Sharafeldin, S Giovannuzzi, P Begines, ... Bioorganic Chemistry, 109057 , 2025 2025 Citations: 12
Frequency of ACE I/D and PAI-1 4G/5G Polymorphisms in Women with Recurrent Pregnancy Loss in Sudan A Babker, HKF Ahmed, S Elzaki, S Elsiddig, SE Dafallah, TYE Yousif, ... Biomedical & Pharmacology Journal 18 (3), 1953-1961 , 2025 2025
Antibody-functionalized lipid nanocarriers for RNA-based cancer gene therapy: advances and challenges in targeted delivery NW Nabih, HAFM Hassan, E Preis, J Schaefer, A Babker, AM Abbas, ... Nanoscale Advances , 2025 2025 Citations: 38
Recent advances in nano vehicles encapsulating cinnamic acid and its derivatives as promising anticancer agents NW Nabih, MS Nafie, A Babker, HAFM Hassan, SA Fahmy RSC advances 15 (26), 20815-20847 , 2025 2025 Citations: 14
Innovative strategies in the diagnosis and treatment of liver cirrhosis and associated syndromes AK Sah, M Afzal, RH Elshaikh, AM Abbas, MG Shalabi, PK Prabhakar, ... Life 15 (5), 779 , 2025 2025 Citations: 18
Role of artificial intelligence and personalized medicine in enhancing HIV management and treatment outcomes AK Sah, RH Elshaikh, MG Shalabi, AM Abbas, PK Prabhakar, ... Life 15 (5), 745 , 2025 2025 Citations: 40
IMMUNOMETABOLIC CORRELATIONS OF AUTOANTIBODIES IN LATENT AUTOIMMUNE DIABETES IN ADULTS PATIENTS (LADA): A CROSS-SECTIONAL STUDY A Elebaid, M Khalid, AA Saeed, H Higazi, EK Abdalhabib, R Babiker, ... Georgian medical news 362 (5), 145-151 , 2025 2025
The future of diagnostics: cutting-edge advances in healthcare technology. AK Sah, DS Rao, AM Abbas, M Chandrasekar, MAM Adam, ... Italian Journal of Medicine 19 (2) , 2025 2025 Citations: 1
Advances in Image Processing and Pattern Recognition in Cancer Detection, Prediction, Diagnosis, and Prognosis S Ak, S Agarwal, AM Abbas, MG Shalabi, PK Prabhakar, RH Elshaikh, ... 2025
Advances in image processing and pattern recognition in cancer detection, prediction, diagnosis, and prognosis A kumar Sah, S Agarwal, AM Abbas, MG Shalabi, PK Prabhakar, ... Preprints , 2025 2025 Citations: 1
Carbon monoxide poisoning: diagnosis, prognostic factors, treatment strategies, and future perspectives M Afzal, S Agarwal, RH Elshaikh, AMA Babker, RK Choudhary, ... Diagnostics 15 (5), 581 , 2025 2025 Citations: 35
Exploring the efficacy of AMACR, ERG, and AR immunostains in prostatic adenocarcinoma and their association with novel grade groups AO Mohamed, H Otifi, H Hassan, AA Yousif, SA Mustafa, SA Elsiddig, ... European Journal of Histochemistry: EJH 69 (1), 4172 , 2025 2025 Citations: 2
BIOCHEMICAL INSIGHTS AND HORMONAL MARKERS OF POLYCYSTIC OVARY SYNDROME IN SUDANESE WOMEN: EXPLORING INFERTILITY AND RISK FACTORS IN RED SEA STATE W Mohamed, R Eltayeb, HA Osman, M Omer, EI Ali, A Abdelmola, ... Georgian medical news 359 (2), 32-39 , 2025 2025
MOST CITED SCHOLAR PUBLICATIONS
The methodology of wavelet analysis as a tool for cytology preparations image processing VV Lyashenko, AMAA Babker, OA Kobylin Cukurova Medical Journal 41 (3), 453-463 , 2016 2016 Citations: 57
Physiological changes in some hematological and coagulation profile among Sudanese healthy pregnant women AO Mohamed, KM Hamza, AM Babker Int J Med Sci Public Health 5 (3), 525-8 , 2016 2016 Citations: 57
Information technologies of the processing of the spaces of the states of a complex biophysical object in the intellectual medical system health AM Babker, AA Abd Elgadir, I Tvoroshenko, V Lyashenko International Journal of Advanced Trends in Computer Science and Engineering , 2019 2019 Citations: 54
Nanotube Breakthroughs: Unveiling the Potential of Carbon Nanotubes as a Dual Therapeutic Arsenal for Alzheimer's disease and Brain Tumors D Elsori, G Rashid, NA Khan, P Sachdeva, R Jindal, F Kayenat, ... Frontiers in Oncology 13, 1265347 , 2023 2023 Citations: 52
Hematological changes during all trimesters in normal pregnancy AM Babker, EO Di Elnaim Journal of Drug Delivery and Therapeutics 10 (2), 1-4 , 2020 2020 Citations: 41
Role of artificial intelligence and personalized medicine in enhancing HIV management and treatment outcomes AK Sah, RH Elshaikh, MG Shalabi, AM Abbas, PK Prabhakar, ... Life 15 (5), 745 , 2025 2025 Citations: 40
Antibody-functionalized lipid nanocarriers for RNA-based cancer gene therapy: advances and challenges in targeted delivery NW Nabih, HAFM Hassan, E Preis, J Schaefer, A Babker, AM Abbas, ... Nanoscale Advances , 2025 2025 Citations: 38
Molecular Characterization of Prothrombin G20210A gene Mutations In pregnant Sudanese women with spontaneous recurrent abortions AMAAA Babker, FEIMH Gameel Rawal Medical Journal 40 (2), 207-209 , 2015 2015 Citations: 36
Carbon monoxide poisoning: diagnosis, prognostic factors, treatment strategies, and future perspectives M Afzal, S Agarwal, RH Elshaikh, AMA Babker, RK Choudhary, ... Diagnostics 15 (5), 581 , 2025 2025 Citations: 35
miRNA expression in PCOS: Unveiling a paradigm shift toward biomarker discovery G Rashid, NA Khan, D Elsori, RA Youness, H Hassan, D Siwan, N Seth, ... Archives of Gynecology and Obstetrics 309 (5), 1707-1723 , 2024 2024 Citations: 29
Non-steroidal anti-inflammatory drugs and biomarkers: A new paradigm in colorectal cancer G Rashid, NA Khan, D Elsori, A Rehman, H Ahmad, H Maryam, A Rais, ... Frontiers in Medicine 10, 1-21 , 2023 2023 Citations: 27
Wavelet Analysis of Cytological Preparations Image in Different Color Systems VAL Lyashenko, Vyacheslav V., Asaad MA Babker Open Access Library Journal 4 (07), 1 , 2017 2017 Citations: 27
Evaluation of platelets count and coagulation parameters among patients with liver disease ME Mustafa, MM Mansoor, A Mohammed, AA Babker World Journal of Pharmaceutical Research 4 (10), 360-368 , 2015 2015 Citations: 26
Influence of Ramadan fasting on hemoglobin A1C, lipid profile, and body mass index among type 2 diabetic patients in Najran City, Saudi Arabia H Mohamed, AM Abbas, MA Huneif, SM Alqahtani, AM Ahmed, ... Open Access Macedonian Journal of Medical Sciences 9 (B), 318-325 , 2021 2021 Citations: 25
Methylenetetrahydrofolate reductase c677t polymorphism in Sudanese women with recurrent spontaneous abortions AM Babker, FE Gameel Kuwait medical journal 48 (2), 100-4 , 2016 2016 Citations: 24
Using the methodology of wavelet analysis for processing images of cytology preparations V Lyashenko, A Babker, O Kobylin MedSci Publications , 2016 2016 Citations: 22
The Role of Inherited Blood Coagulation Disorders in Recurrent Miscarriage Syndrome AM Babker Journal of Critical Reviews 7 (1), 16-20 , 2020 2020 Citations: 20
Features of packaging from polymers in pharmaceutics V Lyashenko, S Sotnik Scholars Middle East Publishers , 2018 2018 Citations: 20
Red cell alloimmunization in blood transfusion dependent Patients with Sickle Cell Disease in El-Obied city, Sudan AAA Eldour, ME Ismail, T Osman, A Babker IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) 14 (12), 137 , 2015 2015 Citations: 20
Comparative Study of Levels of Selective Oxidative Stress Markers (Malondialdehyde, Zinc, and Antioxidant Vitamins A, E, and C) In Ischemic and Non-Ischemic Heart Disease … AMAB ABD ELGADIR A ALTOUM, AHMED L OSMAN Asian J Pharm Clin Res 11 (8), 508-510 , 2018 2018 Citations: 19