Sahebrao Boraste
@msgpharma.org
Associate Professor, Department of Pharmaceutics, Sir Dr MS Gosavi College of Pharmaceutical Education and Research.
Associate Professor
EDUCATION
M.Pharm (Pharmaceutics)
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmaceutical Science, Pharmacology, Toxicology and Pharmaceutics, Pharmacy, Polymers and Plastics
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Dattatraya Shinkar, Prashant Pingale, Sahebrao Boraste, Raosaheb Ghegade, and Sunil Amrutkar
De Gruyter
Sachin Kothawade, Vishal Pande, Dattatraya Shinkar, Prashant Pingale, and Sahebrao Boraste
De Gruyter
Y. S. Chavan, D. M. Shinkar, S. S. Jadhav, S. S. Boraste, P. L. Pingale, and S. V. Amrutkar
Springer Science and Business Media LLC
and Prashant L Pingale
Medic Scientific
The basic concept of FDT is the incorporation of superdisintegrants, which promotes breakdown of tablet quickly when kept or positioned on the tongue, allowing the drug to be released into the saliva. The rate of absorption is regulated by the solubility of the medication. The faster the dosage form of the medication dissolves in solution, the faster the therapeutic action is absorbed and initiated. In FDT, a medicine or dose form should dissolve or disintegrate in the saliva within 60 seconds. The objective of this research work is to formulate a Pravastatin tablet that disintegrated quickly using natural disintegrants. As a diluent, we employed microcrystalline cellulose. Synthetic superdisintegrant such as crospovidone and croscarmellose sodium were used, they were replaced with natural superdisintegrant. In this study, natural superdisintegrant dehydrated banana powder were used synthetic superdisintegrants viz. croscarmellose sodium, crospovidone. A Natural superdisintegrant was used in this formulation at concentrations of 2, 4, 6 and 8% of total weight of tablet i.e. 4, 8, 12 and 15 mg respectively in 200 mg tablet. According to the data, the tablet formulation containing 6% banana powder (i.e., 12 mg per tablet, formulation code FB4) showed a faster and higher drug release of 97.75% during the in-vitro dissolution investigation.