Koushik Das

@beldacollege.ac.in

Assistant Professor and Nutrition
Belda College

https://researchid.co/kdasnut

EDUCATION

Ph.D in Human Physiology

RESEARCH, TEACHING, or OTHER INTERESTS

Food Science, Endocrinology, Diabetes and Metabolism

FUTURE PROJECTS

Scopus Publications

643

Scholar Citations

Scholar h-index

Scholar i10-index

Scopus Publications

Antidiabetic efficacy of sea fish oil in ameliorating hyper-glycaemia by enhancing FFAR1, GLP-1 and inhibiting DPP-4 signalling in the pancreatic tissues of high lipid diet and streptozotocin-induced type 2 diabetic rats
Shrabanti Pyne, Meghamala Mandal, Sanjay Das, Supriya Bhowmick, Koushik Das, J. Sreenavasa Rao, and Jayasree Laha
University of Szeged
Eicosapentaenoic acid and docosahexaenoic acid are n-3 fatty acids that are highly available in sea-fishes. Many studies have revealed that n-3 fatty acids play antidiabetic activity. In this study antidiabetic activity of the three sea fishes oils, ‘volavetki’ (Panna microdon, Bleeker 1849), ‘ruli’ (Coilia dussumieri, Valenciennes 1848), and ‘tapra’ (Opisthopterus tardoore, Cuvier 1829), as well as three fresh-water fishes oils, ‘bata’ (Labeo bata, Hamilton 1822), ‘folui’ (Opisthopterus tardoore, Cuvier 1829), and ‘mourala’ (Amblypharyngodon mola, Hamilton 1822) evaluated high lipid diet (HLD) and STZ-induced type 2 diabetes mellitus (T2DM) rats. The GC-MS analysis revealed high n-3 fatty acid content in volavetki oil. Supplementation of sea-fish oils and antidiabetic effect was monitored by fasting plasma blood glucose and HbA1c. Also, insulin, c-peptide, glucagon-like peptide-1, dipeptidyl peptidase-4, free fatty acid receptor 1, glucokinase, glucose-6 phosphatase, superoxide dismutase, glutathione peroxidase, catalase, malondialdehyde, plasma total cholesterol, low density lipoprotein, triglycerides, high density lipoprotein, c-reactive protein, total protein, alkaline phosphatase, and histopathology of pancreatic tissues were evaluated. Out of six fish oils, oral supplementation with volavetki oil resulted in significant reduction of plasma blood glucose, HbA1c of T2DM rat. All other parameters in T2DM rats were returned to near normally by treatment of volavetki oil. These findings strongly indicate that volavetki oil possess antidiabetic activity.

Anti-cancer potentiality of linoelaidic acid isolated from marine Tapra fish oil (Ophisthopterus tardoore) via ROS generation and caspase activation on MCF-7 cell line
Ananya Dutta, Titli Panchali, Amina Khatun, Sreenivasa Rao Jarapala, Koushik Das, Kuntal Ghosh, Sudipta Chakrabarti, and Shrabani Pradhan
Springer Science and Business Media LLC
AbstractThe implication of inflammation in the pathophysiology of several types of cancers has been under intense investigation. Conjugated fatty acids can modulate inflammation and present anticancer effects, promoting cancer cell death. In this paper, we evaluated the efficacy of new conjugated fatty acids isolated from marine Opisthopterus tardoore (Tapra fish) in human breast cancer cell lines MCF-7. Linoelaidic acid, a marine fish (O. tardoore) derived unsaturated fatty acids, showed effective anticancer activity against MCF-7. Cell viability (MTT) assay revealed a dose-dependent decline in cancer cell viability. It was noteworthy that 5 µM linoelaidic acid decreased the MCF-7 cell viability by 81.82%. Besides that, linoelaidic acid significantly (P< 0.05) increased the level of tumor necrosis factor-α (TNF-α) and interleukin-1 receptor antagonist (IL-1ra) studied by ELISA. Not only that, linoelaidic acid significantly decreased the reduced glutathione level and increased the oxidized glutathione level in MCF-7 cells indicating the oxidative stress inside the cell. Two different cell staining methods with acridine orange-ethidium bromide and DAPI confirmed that the linoelaidic acid rendered their detrimental effect on cancer cells. To decipher the mode of apoptosis Western blotting was performed in which the expression pattern of several proteins (p53, IL-10, and IL-1ra) established the apoptosis in the studied cell lines after linoelaidic acid exposure. Hence it may be conferred that linoelaidic acid has prompt anticancer activity. Therefore this drug can be used further for the treatment of cancer.

Anti-hyperlipidemic effect of oils from Sesamum indicum L. and Vicia faba L. on male Wistar rats
Holima Khatun, Koushik Das, Dilip Kumar Nandi, Jayasree Laha, J. Sreenivasa Rao, and Atiskumar Chattopadhyay
Elsevier BV

Reduction of oxidative stress and apoptosis in hyperlipidemic rats by composite oil (CO) of Sesamum indicum L. And Vicia faba L.
Holima Khatun, Mousumi Mitra, Koushik Das, Atiskumar Chattopadhyay, and Dilip Kumar Nandi
IOS Press
BACKGROUND: Hyperlipidemia associated with cardiovascular diseases (CVDs) is a global health issue that can be alleviated by functional foods. OBJECTIVES: The present study aimed to investigate the effect of composite oil (CO) of sesame seed oil (SSiO) and Vicia faba seed oil (SVfO) on inflammatory factors, ROS generation level, and cell apoptosis level on high lipid diet (HLD) induced hyperlipidemic rat model. METHODS: Hyperlipidemic rat model was developed by feeding HLD to the experimental rats for eight weeks. Male albino rats weighing around 200–210 g were randomly divided into three equal groups: group I: control, received a normal diet; group II: received HLD for eight weeks, and group III: received the HLD with CO orally. After 60 days of treatment, the levels of C-reactive protein (CRP), interleukin (IL)-10; tumor necrosis factor (TNF)-α, IL-18, reactive oxygen species (ROS), and cell apoptosis were serially assessed. RESULTS: After eight weeks of CO treatment, TNF- α, IL-18, CRP, and oxidative ROS generation significantly decreased in CO treated group (group III) compared to group II. On the other hand, IL-10 levels significantly increased in CO treated group compared to group II animals. It was also observed that the percentage of the late apoptotic cell reduced considerably in the CO treated group (group III) compared to HLD-fed animals (group II). CONCLUSION: The results indicate that the CO could prevent CVDs via suppressing oxidative stress, and ameliorating inflammation and apoptosis in hyperlipidemic rats.

Supplementation of seed dust of vicia faba and sesame ameliorates high lipid diet-induced dyslipidemia in rats
HOLIMA KHATUN, KOUSHIK DAS, DILIP KUMAR NANDI, and ATISKUMAR CHATTOPADHYAY
Enviro Research Publishers
Dyslipidaemia is a life style disorder characterized by increased levels of total cholesterol, LDL cholesterol and triglycerides and also decreased HDL cholesterol levels which is turned into cardiovascular disease, a first leading cause of death in Worldwide. Lifestyle changes mainly healthy diet should be introduced to reduce the cardiovascular risk. Recent research on functional foods consumption for lipid-lowering effects has been well established. Seeds of Vicia faba (SVf) and sesame seeds (SSi) is one of the most popular foods due to high content of dietary fiber, proteins, vitamins, minerals, phytosterol, omega 3 fatty acids and other functional compounds. The study aimed to establish SVf and SSi as a powerful functional food for prevention and management of dyslipidemia. We formulated a normal diet (ND) and high lipid diet (HLD) for rats. HLD was formulated by increasing the 10.48%energy, 60.07% lipid, 100% cholesterol and 50% sucrose than ND. Rats were randomly divided into five groups fed ND, HLD, HLD+10%SVf dust,HLD+10%SSi dust and HLD + 5% SVf + 5% SSi of total food for 60 days. After 60 days of treatment, it was observed that there was a significant (p < 0.05) increase in plasma triglyceride, total cholesterol, LDL-C, malondialdehyde (MDA) and IL-18 levels but a significant (p < 0.05) decrease in HDL-C, superoxide dismutase (SOD) & catalase activity in HLD in compared with ND and other treated groups. HLD induced dyslipidemia while SVf and SSi produced antidyslipidemic activity decreasing plasma triglyceride, total cholesterol, LDL-C, MDA, IL-18 level and increasing HDL-C, SOD, and catalase. SVf and SSi combined feeding was potential synergistic effect and results suggest that this functional food consumption can prevent and management of dyslipidemia.

Consortia of bioactives in supercritical carbon dioxide extracts of mustard and small cardamom seeds lower serum cholesterol levels in rats: new leads for hypocholesterolaemic supplements from spices
Soumi Chakraborty, Kaninika Paul, Priyanka Mallick, Shrabani Pradhan, Koushik Das, Saikat Chakrabarti, Dilip Kumar Nandi, and Paramita Bhattacharjee
Cambridge University Press (CUP)
AbstractMelatonin-rich and 1,8-cineole-rich extracts have been successfully obtained from yellow mustard (YM) and small cardamom (SC) seeds, respectively, employing green technology of supercritical CO2(SC-CO2) extraction. Chemical profiling confirmed the presence of melatonin and 1,8-cineole and co-extractants in the respective extracts. Electron paramagnetic resonance spectroscopy attested strong antioxidant activities of the extracts foregoing pan-assay interference compounds involved in spectroscopic analysis. These extracts also exhibited synergistic efficacies greater than unity confirming antioxidant synergy among the co-extracted bioactives therein. To ascertain hypocholesterolaemic efficacies, these extracts were co-administered orally with Triton X (at the pre-optimised dose of 175 mg/kg body weight (BW)) to Wistar albino rats at doses of 550, 175 and 55 mg/kg BW. Serum total cholesterol levels in the rats were monitored on days 3, 7, 15 and 21. On day 21, total cholesterol level reduced appreciably by 49·44 % in rats treated with YM seed extract and by 48·95 % in rats treated with SC seed extract, comparable with atorvastatin-administered rats (51·09 %). Either extract demonstrated inhibitory effects on hepatic 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase activity. A molecular docking exercise identified specific compounds in the extracts which possessed binding affinities comparable with therapeutically used HMG-CoA reductase inhibitors.In silicoandin vivostudies concertedly concluded that the consortium of bioactive components in the extracts cannot be considered as invalid metabolic panaceas and therefore these ‘green’ extracts could be safely subjected to clinical studies as preventive biotherapeutics for hypercholesterolaemia. These extracts could be consumedper seas hypocholesterolaemic supplements or could be ingredients of new spice-based therapeutic foods.

Hypoxia: A cause of acute renal failure and alteration of gastrointestinal microbial ecology
DilipKumar Nandi, Animesh Samanta, Arpita Patra, Shreya Mandal, Suchismita Roy, Koushik Das, and Sanjay Kar
Medknow
Oxygen is very important to the existence of life. Oxygen deficiency, defined as hypoxia, elicits adaptive responses in cells and tissues. Lower oxygen concentration can cause the alteration of renal function, affects the maintenance of a balance of the body fluids, electrolytes, pH, and blood pressure homeostasis. Impaired fluid regulation could, in addition, contribute to the precipitation of pulmonary edema and exacerbate hypoxemia which may accelerate the progression of chronic kidney disease. In this context, the present study attempted to evaluate the association of renal injury and oxidative stress at different atmospheric pressures (1829, 3657, and 5486 m). Limited fecal analysis of experimental animals was also done to evaluate the impact of hypobaric hypoxia on the composition of dominant gastrointestinal microbiota. The study was performed on 24 male Wister strain rats and divided into four groups (C, HA-I, HA-II, and HA-III), and exposure was carried out for seven days period. In hypoxic exposure rats, plasma urea, creatinine, electrolytes and malonaldehyde level elevated and catalase and superoxide dismutase level diminished significantly compared to the controls. Increase in blood uremia profile, toxicity markers, and lipid peroxidation marker enzymes indicated that hypoxia causes renal failure. Histological structures of the kidney of group HA-II and HA-III animals showed severe disorganization of glomerulus and dilation of renal tubules. These results indicate nephrotoxicity or acute renal failure can occur at hypobaric hypoxia and it also affected the gut microbial population. This alteration was observed significantly above 3000 m.

Physiological indications and gut-microbial community in army personnel in high- altitude and base-line environments: A comparative study

Nephroprotective efficacy of Asparagus racemosus root extract on acetaminophen-induced renal injury in rats
Suchismita Roy, Shrabani Pradhan, Shreya Mandal, Koushik Das, and Dilip Kumar Nandi
University of Szeged
Acetaminophen-induced renal necrosis and insufficiency occurs in patients with acetaminophen overdose. Renal failure is rapidly assuming epidemic proportions globally. In absence of reliable and effective nephroprotective drugs, strategies towards exploring alternative therapies for treatment of kidney diseases are essential. Asparagus racemosus is a medicinal plant used for treatment of various ailments. This research was undertaken to investigate the protective effect of ethanol fraction of A. racemosus roots extract in acetaminophen-induced uraemia and renal failure in rats. Rats were co-administered with acetaminophen injection and oral administration of A. racemosus roots extract in an attempt of protection against renal failure. Uremic biomarkers significantly decreased, and elevated levels of antioxidant enzymes were found, in the animals treated with ethanol fraction of A. racemosus when compared with acetaminophen treated uremic animals. Also, histology of kidneys showed control like structure in animals treated with this extract but severe damage in the uremic animals. HPLC analysis of the ethanol fraction of A. racemosus roots extract revealed eight compounds out of which one had a retention time near to the quercetin standard. It may be concluded that this extract of A. racemosus has therapeutically useful nephroprotective potential.

Effect of phytosterol extract from sesame seed on experimentally induced hyperlipidemic rats: Dose dependent study

Therapeutic potential of different commercially available synbiotic on acetaminophen-induced uremic rats
Arpita Mandal, Arpita Patra, Shreya Mandal, Suchismita Roy, Shreya Das Mahapatra, Tapasi Das Mahapatra, Tanmay Paul, Koushik Das, Keshab Chandra Mondal, and Dilip Kumar Nandi
Springer Science and Business Media LLC

Acetaminophen induced kidney failure in rats: A dose response study
Suchismita Roy, Shrabani Pradhan, Koushik Das, Arpita Mandal, Shreya Mandal, Arpita Patra, Animesh Samanta, Banadeb Sinha, and Dilip Kumar Nandi
Science Alert
Acetaminophen is a commonly used analgesic and antipyretic drug, high doses of which cause hepatic and renal injury. In development and progression of kidney disease research, it is necessary to have a suitable common drug to induce uremia and renal failure of rats. It is also required to select the threshold doses for the said drug; a therapeutic dose and toxic dose for kidney failure using standard guidelines. An acute toxicity of acetaminophen was conducted by the limit test at a dose of 2000 mg kgG b.wt., on either sex rats (n = 5) and a main test was conducted by a dose progression factor of 3.2 times as per Organization of Economic Co-Operation and Development guidelines 425. Eighteen male albino rats (n = 18) were divided into three groups, group I served as control, groups II and III rats were administered 175 mg and 550 mg kgG b.wt., acetaminophen intraperitoneally for 14 days, respectively. Different parameters were considered to analyze renal failure. Urea, creatinine, GOT, GPT and MDA levels were increased significantly (p<0.05) in group III, compared to groups I and II. Antioxidant enzymes like SOD, catalase and GSH level were decreased significantly (p<0.05) in group III rats, compared to group I and II rats. Increase in blood uremia profile indicated that the higher dose of acetaminophen causes uremia. Increase in the toxicity markers and lipid peroxidation marker enzymes indicate the nephrotoxicity. Histological structures of kidney of group III animals showed a severe disorganization of glomerulus and dilation of renal tubules. These results indicate that intraperitoneal injection of acetaminophen at high dose causes nephrotoxicity and renal cellular damage to experimental rats.

Alpha-lipoic acid a cholesterol reducer for targeting acetaminophen induced uremic male albino rat models

Phytochemical analysis, Antimicrobial activity and assessment of potential compounds by thin layer chromatography of ethanol fraction of asparagus racemosus roots

Therapeutic potential of Lactobacillus ingluviei ADK10, a newly established probiotic organism against acetaminophen induced uremic rats
Arpita Mandal, Tanmay Paul, Suchismita Roy, Shreya Mandal, Shrabani Pradhan, Koushik Das, Keshab Chandra Mondal, and Dilip Kumar Nandi
Springer Science and Business Media LLC
In the present study, Lactobacillus ingluviei ADK10 (Acc. No. JQ395039) from intestinal origin was tested for its probiotic characteristic as well as uremia ameliorating activity on acetaminophen induced uremic rats. The results revealed that L. ingluviei ADK10 was able to tolerate pH 3.0–9.0 and 0.5% bile salt along with good hydrophobicity (67%) and adherence index with Ht-29 cell line on 258/100 cells. It was susceptible to 20 antibiotics. The organism was able to degrade food ingredients, like starch and milk proteins. The strain showed significant growth inhibition of Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Shigella dysentery, Pseudomonas aeruginosa, and Klebsiella pneumoniae (average diameter of 10 mm). The therapeutic potentiality of this probiotic bacterium was tested against acetaminophen induced uremic rats. It was found that supplementation of L. ingluviei ADK10 for 14 days with food reduced severe increase of uremic profiles, such as blood urea (85%), creatinine (68%) and uric acid (41%) in comparison to the uremic rats. Moreover, during the feeding of rats with probiotic strain at a dose of 1×109 bacteria, reduction of enterobacteria in faeces was observed. Our studies indicated that L. ingluviei ADK10 could be used as a health-promoting probiotic along with antiuremic efficacy.

Analysis of phytochemical profile of Terminalia arjuna bark extract with antioxidative and antimicrobial properties
Shreya Mandal, Arpita Patra, Animesh Samanta, Suchismita Roy, Arpita Mandal, Tapasi Das Mahapatra, Shrabani Pradhan, Koushik Das, and Dilip Kumar Nandi
Medknow

Assessment of efficacy of a potential probiotic strain and its antiuremic andantioxidative activities
Arpita Mandal, Shreya Mandal, Suchismita Roy, Arpita Patra, Shrabani Pradhan, Koushik Das, Tanmay Paul, Keshab Ch. Mondal, and Dilip Kumar Nandi
Elsevier BV

Attenuation of uremia by orally feeding alpha-lipoic acid on acetaminophen induced uremic rats
Shrabani Pradhan, Shreya Mandal, Suchismita Roy, Arpita Mandal, Koushik Das, and Dilip K. Nandi
Elsevier BV

In vivo assessment of bacteriotherapy on acetaminophen-induced uremic rats
Arpita Mandal, Koushik Das, Suchismita Roy, Keshab Ch. Mondal, and Dilip Kumar Nandi
SAGE Publications
OBJECTIVES Acetaminophen is a commonly used antipyretic agent which, at high doses, causes renal tubular damage and uremia. Bacteriotherapy affords a promising approach to mitigating uremic intoxication by ingestion of live microbes able to catabolize uremic solutes in the gut. The present study evaluates the nonpathogenic soil-borne urease-positive bacterium Sporosarcina pasteurii (Sp) as a potential urea-targeted component for such an "enteric dialysis" formulation. METHODS Twenty-four albino male rats were randomly divided into 4 groups: The control group (group NC) received distilled water intraperitoneally for 7 days. The positive control group (group U) received 500 mg/kg acetaminophen intraperitoneally for 7 days. The tested group (group UP) was administered Sp at a dosage of 10(9) cells/day for 5 weeks, after receiving 500 mg/kg per day of acetaminophen intraperitoneally for 7 days. Vehicle control (group VC) received only Sp at a dosage of 10(9) cells/day for 5 weeks without acetaminophen treatment. Blood, kidney, liver and stool samples were collected after scarification, for biochemical (urea, creatinine, malondialdehyde, superoxide dismutase, catalase, glutamate oxaloacetate transaminase [GOT] and glutamate pyruvate transaminase [GPT] of blood, kidney and liver) tests. Limited fecal analysis was performed. RESULTS Blood urea nitrogen (urea, creatinine) and toxicity indicators (GOT, GPT) were increased, and antioxidant enzymes were decreased in group U. Blood urea nitrogen and toxicity indicators were reduced, and antioxidant enzymes were increased significantly in the group UP (p<0.05) compared with group U. The number of Sp was increased in Sp-treated groups compared with groups NC and U. CONCLUSIONS The study demonstrated that the bacteria tested reduced blood urea nitrogen levels significantly.

Protective effect of aqueous extract of terminalia arjuna against dehydrating induced oxidative stress and uremia in male rat

Effect of extract of Withania Somnifera on dehydration-induced oxidative stress-related uremia in male rats.

New experimental design: Dehydration induced uremia and oxidative stress on male albino rats, innovative approach to researchers for further study on kidney disease

RECENT SCHOLAR PUBLICATIONS

Antidiabetic efficacy of sea fish oil in ameliorating hyperglycaemia by enhancing FFAR1, GLP-1 and inhibiting DPP-4 signalling in the pancreatic tissues of high lipid diet and
JL Shrabanti Pyne, Meghamala Mandal, Sanjay Das, Supriya Bhowmick, Koushik ...
Acta Biologica Szegediensis 67 (1) 2023

TO STUDY THE ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF OIL FROM LEAVES OF CAMELLIA SINENSIS L. IN EXPERIMENTAL ANIMAL MODELS
KDJL Meghamala Mandal, Shrabanti Pyne , Supriya Bhowmik , Deblina Giri
International Journal of Pharmaceutical Sciences and Research 14 (1), 1000-1017 2023

Protective Effect of Arjunakwatha and Arjunasheeta in Paracetamol-induced Kidney Injury in Rat Model
KD Supriya Bhowmick , Deblina Giri , Meghamala Mandal , Shrabanti Pyne ...
Int. J. Pharm. Investigation 13 (1), 53-61 2022

Anti-hyperlipidemic effect of oils from Sesamum indicum L. and Vicia faba L. on male Wistar rats
H Khatun, K Das, DK Nandi, J Laha, JS Rao, A Chattopadhyay
Future Foods 4, 100060 2021

Sea fish consumption is associated with lower risk of diabetes mellitus: A cross-sectional study
S Pyne, S Bhowmik, P Pal, J Bhattacharya, S Giri, JK Laha, K Das
Int J Nutr Sci 6 (4), 1060 2021

Reduction of oxidative stress and apoptosis in hyperlipidemic rats by composite oil (CO) of Sesamum indicum L. and Vicia faba L.
H Khatun, M Mitra, K Das, A Chattopadhyay, DK Nandi
Mediterranean Journal of Nutrition and Metabolism 14 (1), 79-89 2021

Supplementation of seed dust of Vicia faba and sesame ameliorates high lipid diet-induced dyslipidemia in rats
H Khatun, K Das, DK Nandi, A Chattopadhyay
Current Research in Nutrition and Food Science Journal 7 (1), 202-217 2019

Analysis Of Fatty Acids From Oil Of Green Tea (Camellia Sinensis L) By Gas Chromatography Coupled With Flame Ionization Detector And Its Anticancer And Antibacterial Activity
M Mandal, K Das, DK Nandi, B Das, RJ Sreenivas
Int J Pharm Pharm Sci 11, 104-111 2019

Establishment of novel urinary kidney disease new biomarkers and therapeutic effect of methanol fraction of Terminalia arjuna on acetaminophen induced kidney disease in rats
D Giri, K Das, DK Nandi
Asian J Pharm Clin Res 12 (3), 117-124 2019

Nephroprotective efficacy of Asparagus racemosus root extract on acetaminophen-induced renal injury in rats
S Roy, S Pradhan, S Mandal, K Das, DK Nandi
Acta Biologica Szegediensis 62 (1), 17-23 2018

Hypoxia: A cause of acute renal failure and alteration of gastrointestinal microbial ecology
A Samanta, A Patra, S Mandal, S Roy, K Das, S Kar, DK Nandi
Saudi Journal of Kidney Diseases and Transplantation 29 (4), 879-888 2018

Physiological indications and gut-microbial community in army personnel in high-altitude and base-line environments: A comparative study
A Samanta, A Patra, A Mandal, S Roy, S Mandal, K Das, B Sinha, S Kar, ...
Jordan Journal of Biological Sciences (JJBS) 11 (2), 2141 2018

Nephro-Protective Activity Of Isolated Methanol Fractions Phyto-Compound From Bark Of Terminalia Arjuna
S Mandal, A Patra, S Pradhan, S Roy, A SAMANTA, K DAS, ...
Int J Pharm Pharm Sci 9, 175-80 2017

To investigate which solvent extract (aqueous, methanol, acetone and hexane) of Apple banana is more potent content of phytocompound
S Maity, K Das, N Mandal
International Journal of Physiology, Nutrition and Physical Education 1 (1 2016

Effect of phytosterol extract from sesame seed on experimentally Induced hyperlipidemic rats: dose dependent study
S Mallick, M Mandal, S Roy, S Pradhan
International Journal of Pharma and Bio Sciences IJPBS 2016

Koushik Das1., Suchismita Roy1., Shreya Mandal1., Shrabani Pradhan1., Sukumar Debnath2., Debidas Ghosh3 and Dilip Kumar Nandi1
RPBYIP FROM, BFONDI UREMIA
2016

Protective effect of alpha-lipoic acid on hepato renal toxicity on acetaminophen induced uremic male albino rat
S Pradhan, S Roy, S Mandal, K Das, S Das, DK Nandi
Eur J Biomed Pharm Sci 3, 668-74 2016

Protective role of selected probiotics on experimentally induced kidney failure in rats
DK Nandi, S Mandal, S Roy, S Pradhan, A Samanta, A Patra, A Mandal, ...
International Research Journal of Basic and Applied Sciences 1 (2), 29-36 2016

Therapeutic potential of different commercially available synbiotic on acetaminophen-induced uremic rats
A Mandal, A Patra, S Mandal, S Roy, S Das Mahapatra, T Das Mahapatra, ...
Clinical and Experimental Nephrology 19, 168-177 2015

MOST CITED SCHOLAR PUBLICATIONS

Analysis of phytochemical profile of Terminalia arjuna bark extract with antioxidative and antimicrobial properties
S Mandal, A Patra, A Samanta, S Roy, A Mandal, TD Mahapatra, ...
Asian Pacific journal of tropical biomedicine 3 (12), 960-966 2013
Citations: 232

Acetaminophen induced kidney failure in rats: a dose response study
S Roy, S Pradhan, K Das, A Mandal
Journal of Biological Sciences 2015
Citations: 47

Protective effect of aqueous extract of Terminalia arjuna against dehydrating induced oxidative stress and uremia in male rat
K Das, PP Chakraborty, D Ghosh, DK Nandi
Iranian Journal of Pharmaceutical Research: IJPR 9 (2), 153 2010
Citations: 47

Attenuation of uremia by orally feeding alpha-lipoic acid on acetaminophen induced uremic rats
S Pradhan, S Mandal, S Roy, A Mandal, K Das, DK Nandi
Saudi Pharmaceutical Journal 21 (2), 187-192 2013
Citations: 38

Effect of extract of Withania Somnifera on dehydration-induced oxidative stress-related uremia in male rats
K Das, TT Samanta, P Samanta, DK Nandi
Saudi Journal of Kidney Diseases and Transplantation 21 (1), 75-80 2010
Citations: 34

In vivo assessment of bacteriotherapy on acetaminophen-induced uremic rats
A Mandal, K Das, S Roy, KC Mondal, DK Nandi
J Nephrol 26 (1), 228-36 2013
Citations: 33

Protective effect of composite extract of Withania somnifera, Ocimum sanctum and Zingiber officinale on swimming-induced reproductive Endocrine dysfunctions in male rat
DS Misra, R Maiti, S Bera, K Das, D Ghosh
IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT) 4 (2), 110-117 2005
Citations: 30

Crude root extract of Asparagus racemosus ameliorates acetaminophen induced uremic rats
S Roy, K Das, S Mandal, S Pradhan, A Patra, DK Nandi
Int J Pharm Sci Res 4, 3004-12 2013
Citations: 11

Asparagus racemosus roots ameliorates acetaminophen induced hepatotoxicity in rats: an experimental, biochemical and histological study
S Roy, S Pradhan, K Das, S Mandal
International Journal of Recent Scientific Research 2014
Citations: 10

Phytochemical analysis, antimicrobial activity and assessment of potential compounds by thin layer chromatography of ethanol fraction of Asparagus racemosus roots
S Roy, S Pradhan, S Mandal, K Das, A Patra, A Samanta, B Sinha, S Kar, ...
Int J Pharm Pharm Sci 6, 367-370 2014
Citations: 10

Impact of Probiotic supplementation on intestinal microflora of rat under environmental hypobaric pressure
A Samanta, A Mandal, A Patra, S Mandal, S Roy, S Pradhan, K Das, ...
International journal of current microbiology and spplied sciences 3 (8 2014
Citations: 7

Therapeutic potential of Lactobacillus ingluviei ADK10, a newly established probiotic organism against acetaminophen induced uremic rats
A Mandal, T Paul, S Roy, S Mandal, S Pradhan, K Das, KC Mondal, ...
Biologia 68, 1072-1078 2013
Citations: 7

Assessment of efficacy of a potential probiotic strain and its antiuremic and antioxidative activities
A Mandal, S Mandal, S Roy, A Patra, S Pradhan, K Das, T Paul, ...
e-SPEN Journal 8 (4), e155-e163 2013
Citations: 6

Koushik Das

EDUCATION

RESEARCH, TEACHING, or OTHER INTERESTS

FUTURE PROJECTS

Establishment of antidiabetic peptide

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS