KHALID ELTAHIR KHALID KHEIRALLA

@bu.edu.sa

Department of Basic Medical Sciences, Faculty of Applied Medical Sciences
Al-Baha University

KHALID ELTAHIR KHALID KHEIRALLA


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https://researchid.co/kheiralla

RESEARCH, TEACHING, or OTHER INTERESTS

Clinical Biochemistry, Immunology and Microbiology, Genetics, Molecular Biology
9

Scopus Publications

458

Scholar Citations

12

Scholar h-index

13

Scholar i10-index

Scopus Publications

  • Prevalence And Determinants of Anemia Among Pregnant and Lactating Women in Rural Western Sudan
    Hassan A. Mohamed
    Journal of Applied Bioanalysis, 2025
  • The Cytokine Profile in Sudanese Patients Infected with COVID-19 in Kassala State, Eastern Sudan
    Abubaker Awad Ramli, Mohammed Osman Hussien, Abdualmoniem O Musa, Mohammed Adel Shanawaz, Eman O Bakri, Jamal B Salim, Abubakr Omer, Khalid Eltahir Kheiralla, Nadir Musa Abuzeid
    Jundishapur Journal of Microbiology, 2024
    Background: Research is ongoing to better understand the immune response and the role of cytokines in COVID-19's pathogenicity and clinical heterogeneity. Objectives: This study aimed to assess the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-17, IL-6, IL-10, and IL-4 in the blood of patients infected with severe acute respiratory syndrome (SARS)-CoV-2 in Kassala State, Eastern Sudan, compared to healthy individuals residing in the same state. Methods: This case-control study was conducted on 90 adult patients with COVID-19 infection at Kassala Teaching Hospital (KTH), confirmed by RT-PCR, and compared to 90 age- and sex-matched healthy subjects as controls. Serum samples were collected and analyzed for cytokine levels using the enzyme-linked immunosorbent assay (ELISA). Results: The levels of TNF-α, IL-17, and IL-10 in patients were significantly higher (P = 0.021, 0.000, and 0.015, respectively) than those in the control group. Conversely, the IL-4 levels were significantly lower (P = 0.000) in patients than in controls. A comparison between mild, moderate, and severe groups showed that the levels of TNF-α and IL-10 were higher in the severe group than in the mild and moderate groups, whereas the levels of IL-4 decreased with increasing disease severity without reaching significant differences. Tumor necrosis factor-α, IL-17, and IL-4 could predict the disease severity of 2019-nCoV infections according to the area under the curve (AUC) of the receiver operating curve (ROC). Conclusions: Our findings suggest that TNF-α, IL-17, IL-10, and IL-4 can serve as indicators and reliable predictors of severe illness in Sudanese patients with COVID-19.
  • Association of Human Leukocyte Antigen (HLA) class II (DRB1 and DQB1) alleles and haplotypes with Rheumatoid Arthritis in Sudanese patients
    Adil Ahmed Ali, Khalid Eltahir Khalid, Somaya Elhaj Mohammed, Mohammed Salman Akhtar, Osman Khalafalla Saeed
    Frontiers in Immunology, 2023
    The aim of this study was to determine the Human Leukocyte Antigen (HLA) class II (DRB1 and DQB1) alleles and haplotype frequency in Rheumatoid Arthritis (RA) in the Sudanese population. The frequency of HLA-DRB1 and -DQB1 alleles and DRB1-DQB1 haplotypes were determined in 122 RA patients and 100 controls. HLA alleles were genotyped by the polymerase chain reaction-sequence specific primers (PCR-SSP) method. In RA patients, HLA-DRB1*04 and *10 alleles were high in frequency (9.6% vs 14.2%, P = 0.038 and P = 0.042, respectively), and dependently on anti-citrullinated protein antibodies (ACPAs) seropositivity (P = 0.044 and P = 0.027, respectively). In contrast, the frequency of the HLA-DRB1*07 allele was significantly low in patients than in controls (11.7% vs 5.0%, P = 0.010). Moreover, the HLA-DQB1*03 allele was strongly associated with RA risk (42.2%, P = 2.2x10-8), whereas, HLA-DQB1*02 and *06 showed protective effects against RA (23.1% and 42.2%, P = 0.024 and P = 2.2x10-6, respectively). Five different HLA haplotypes, DRB1*03-DQB1*03 (P = 0.00003), DRB1*04-DQB1*03 (P = 0.00014), DRB1*08-DQB1*03 (P = 0.027), DRB1*13-DQB1*02 (P = 0.004), and DRB1*13-DQB1*03 (P = 3.79x10-8) were significantly associated with RA risk, while 3 protective haplotypes, DRB1*03-DQB1*02 (Pc = 0.008), DRB1*07-DQB1*02 (Pc = 0.004), and DRB1*13-DQB1*06 (Pc = 0.02) were identified. This is the first study determining the association between HLA class II alleles and haplotypes and RA risk in our population.
  • Risk-free point-of-care visceral leishmaniasis diagnostics: combining buffy coat microscopy and immunoassay in tertiary rural hospitals in Sudan
    Lana M. El-amin, K.E. Khalid, Ayman A. El-Badry
    Acta Tropica, 2020
  • T1/ST2 deficient mice display protection against Leishmania infantum experimental infection
    Khalid Eltahir Khalid, Manuela Sales Lima Nascimento, Laís Amorim Sacramento, Diego Luís Costa, Djalma Souza Lima-Júnior, Vanessa Carregaro, João Santana da Silva
    Acta Tropica, 2017
  • Effect of tactile kinesthetic stimulation on preterm infants’ weight and length of hospital stay in Khartoum, Sudan
    Ragaa G. Ahmed, Gaafer I. Suliman, Walyeldin A. Elfakey, Karimeldin M. Salih, Ehab I. El-Amin, Waled A. Ahmed, Khalid E. Khalid
    Saudi Medical Journal, 2015
    Objectives: To determine the effect of 7 days tactile kinesthetic stimulation (TKS) on preterm infants’ weight and hospital stays in Khartoum State, Sudan. Methods: This is a quasi-experimental study, it was conducted in 4 hospitals between January and June 2013, Khartoum, Sudan, and it involved 160 preterm infants randomly assigned into the case and control groups (80 neonates in each). Preterm infants in the control group received routine nursing care, while preterm infants in the case group received TKS for 3 periods, 15 minute per day for 7 constitutive days, in addition to routine care. Data was collected using a structured self-designed and validated questionnaire, checklist, and weighting scale. Weight gain and hospital stay were compared between the 2 groups. Results: Over the constitutive 7 days, the case group gained significantly more weight (1071gm versus 1104gm) compared with the control group (1077gm versus 1084gm) (1084.55±90.74) who gained only 6.9gm within the same 7 days without TKS treatment. The mean difference in weight gain was significant (p=0.00). The hospital stay for preterm infants in the case group was significantly shorter (18.05±9.36 versus 25.47±10.25; p=0.00). Conclusion: Tactile kinesthetic stimulation for preterm infants has a beneficial effect on weight gain and earlier discharge from hospital, which are sequentially efficient and cost effective.
  • Outcomes of arteriovenous fistula for hemodialysis in Sudanese patients: single-center experience.
    Saudi Journal of Kidney Diseases and Transplantation an Official Publication of the Saudi Center for Organ Transplantation Saudi Arabia, 2012
  • Prostate-specific antigen level and risk of bone metastasis in Sudanese patients with prostate cancer.
    Saudi Journal of Kidney Diseases and Transplantation an Official Publication of the Saudi Center for Organ Transplantation Saudi Arabia, 2011
  • The effects of gum arabic oral treatment on the metabolic profile of chronic renal failure patients under regular haemodialysis in Central Sudan
    Adil Ahmed Ali, Khalid Eltom Ali, Abd Eigani Fadlalla, Khalid Eltahir Khalid
    Natural Product Research, 2008
    This study aimed at assessing the effect of gum arabic (Acacia senegal) oral treatment on the metabolic profile of chronic renal failure (CRF) patients. A total of 36 CRF patients (under regular haemodialysis) and 10 normal subjects participated in this study. The patients were randomly allocated into three groups–group A: 12 CRF patients under low-protein diet (LPD) (<40 g day−1) and gum arabic (50 g day−1) treatment; group B: 14 CRF patients under LPD and gum arabic, iron (ferrous sulphate, 200 mg day−1) and folic acid (5 mg day−1) treatment; group C (control group): 10 CRF patients under LPD and iron and folic acid treatment and group D: 10 normal volunteers (on normal diet) under daily dose of 50 g gum arabic. Each of the above treatments was continued for three consecutive months. Blood samples were collected from each subject before treatment and twice per month “pre-dialysis” for 3 months. Biochemical parameters measured were: serum urea, serum creatinine, serum uric acid, serum calcium and serum phosphorus. By the end of the 3 months of treatment, serum urea levels significantly decreased by 31.2 and 44.18% for group A and B, respectively, compared with the baseline (0.01 < p < 0.001) and control group (p < 0.05). Serum creatinine levels significantly decreased in the groups of gum users (A, B and D) by 9.94, 12.65 and 11.7%, respectively, compared with the control group (p < 0.001). There was a significant decrease (p < 0.05) in serum uric acid levels by 14 and 19.9% for group A and B, respectively, compared with the baseline. Serum calcium levels increased by 12.64, 15.75 and 8.75% for group A, B and D, respectively, and these increases were significantly different (0.05 < p < 0.001) from baseline and control group for groups A and B. Serum phosphorus levels significantly decreased by 22.54% for group A, 17.69% for group B and 7.71% for group D, compared with the baseline (0.05 < p < 0.001). From this study, we conclude that oral administration of gum arabic could conceivably alleviate adverse effects of CRF.

RECENT SCHOLAR PUBLICATIONS

  • Prevalence and Determinants of Anemia Among Pregnant and Lactating Women in Rural Western Sudan
    Journal of Applied Bioanalysis 11 (4), 167-175 , 2025
    2025
  • Association between Vitamin D levels and Glycemic Control in Sudanese Patients with Type 2 Diabetes
    SM Azhari A.M. Nour, Braa A. Ali, Israa H. Musa, Mohamed A. M. Ibrahim ...
    Afr. J. Biomed. Res. 28 (2s), 949-960 , 2025
    2025
  • Clinico-epidemiological Characteristics of COVID-19 in Patients from Eastern Sudan.
    NMA 3- Abubaker Awad Ramli, Abdualmoniem O Musa, Mohamoud A. Salam, Abdalla ...
    Afr. J. Biomed. Res. 28 (2s), 1285-1289 , 2025
    2025
  • Pleural Fluid Adenosine Deaminase as a Biochemical Indicator in Diagnosing Tuberculous Pleural Effusion in Patients from Sudan
    KEKK Alkamali Alfaki, Abdelsalam M.A. Nail, Mohamed Kharief, GadAllah Modawe ...
    Egypt. Acad. J. Biolog. Sci. 17 (2), 255-263 , 2025
    2025
  • The Impact of Aqueous Piliostigma thonningii Fruit Extract on Certain Biochemical Parameters on Male Wister Albino Rats
    et al Somia A. Agab, Hatil H. EL-Kamali, Mohamed AE.M. Ibrahim, Azhari A ...
    Egypt. Acad. J. Biolog. Sci. 16 (2), 229-336 , 2024
    2024
    Citations: 3
  • Estimation of Plasma Triglyceride Level among Patients with Diabetes Mellitus, Wad Medani, Gezira State, Sudan, in 2022
    GA Modawe, A Alblal, A Ibrahim, EM Aldein, SA Ahmed, AEA Abdorabo, ...
    جامعة سرت-Sirte University , 2024 ‎
    2024
  • Indicators of Biochemistry and Hematology in Patients with Rheumatoid Arthritis Carrying the HLA-DRB1*04 or HLA-DRB1*10 Gene Variants
    KEK Kheiralla
    Egyptian Academic Journal of Biological Sciences C. Physiology & Molecular … , 2024
    2024
  • Association of Hematological and Biochemical Parameters and HLA-DRB1 Alleles With Anticyclic Citrullinated Peptide Autoantibodies in Sudanese Rheumatic Patients
    KE Khalid
    Cureus 16 (4) , 2024
    2024
    Citations: 1
  • The Cytokine Profile in Sudanese Patients Infected with COVID-19 in Kassala State, Eastern Sudan
    NMA Abubaker Awad Ramli, Mohammed Osman Hussien, Abdualmoniem O Musa ...
    Jundishapur J Microbiol 17 (12), e157285 , 2024
    2024
  • Dissemination of Class A Cephalosporinases and Class D Carbapenemases in Escherichia coli Isolates From a Tertiary Hospital in Sudan
    KE Khalid
    Cureus 15 (8), e44365 , 2023
    2023
    Citations: 1
  • The Association of Human Leukocyte Antigen Genotyping Among Sudanese Patients With Rheumatoid Arthritis: Reference to Ethnicity
    AA Ali, KE Khalid, HM Hussien, SE Mohammed, OK Saeed, A Ali, ...
    Cureus 15 (8) , 2023
    2023
  • Association of Human Leukocyte Antigen (HLA) class II ( DRB1 and DQB1 ) alleles and haplotypes with Rheumatoid Arthritis in Sudanese patients
    AA Ali, KE Khalid, SE Mohammed, MS Akhtar, OK Saeed
    Frontiers in Immunology 14, 1178546 , 2023
    2023
    Citations: 16
  • Clinical pathological characteristics and treatment outcomes of renal cell carcinoma (RCC): a retrospective study from Sudan
    MM Bafadni, YM Osman, MEIM Ahmed, MM Taha, DA Idris, KEK Kheiralla, ...
    ecancermedicalscience 17, 1524 , 2023
    2023
    Citations: 9
  • Cytological and molecular screening of Chlamydia trachomatis in infertile women attending a maternity teaching hospital in Gezira State, Sudan: a …
    HMH Omer, KE Khalid, EI Miskeen, MY Taha, EY Saleh, EA Ahmed, ...
    F1000Research 9, 589 , 2023
    2023
    Citations: 5
  • The Association of Intensive Blood Pressure Treatment and Non-Fatal Cardiovascular or Serious Adverse Events in Older Adults With Mortality: Mediation Analysis in SPRINT
    AA Ali, KE Khalid, HM Hussien, SE Mohammed, OK Saeed
    2023
  • Oral Candidiasis in HIV Patients Subjected to Anti-retro Viral Therapy (ART) in Wad Medani HIV Center, Gezira State, Sudan (2021)
    NNE Mohammed, FHA Ellatif, KE Khalid, HMH Omer, EA Ahmed, ...
    International Journal of TROPICAL DISEASE & Health 43 (24), 37-43 , 2022
    2022
  • Sero-pattern and Occupational Risk Factors Associated with Hepatitis B Virus Infection Among Health Care Workers at Wad Medani Teaching Hospital, Sudan
    HMH Omer, KE Khalid, MAH Edrees
    Sudan Medical Laboratory Journal 10 (2), 36-44 , 2022
    2022
  • Implementasi Dashboard Akademik Bebasis Website Berdasarkan Instrumen Akreditasi Program Studi 4.0
    RA Putra, K Khalid, D Rolliawati
    Systemic: Information System and Informatics Journal 7 (1), 1-9 , 2021
    2021
    Citations: 1
  • CTLA-4 (+ 49A/G) polymorphism in type 1 diabetes children of Sudanese population
    KEK Kheiralla
    Global medical genetics 8 (01), 011-018 , 2021
    2021
    Citations: 20
  • Risk-free point-of-care visceral leishmaniasis diagnostics: combining buffy coat microscopy and immunoassay in tertiary rural hospitals in Sudan
    LM El-Amin, KE Khalid, AA El-Badry
    Acta tropica 211, 105599 , 2020
    2020
    Citations: 3

MOST CITED SCHOLAR PUBLICATIONS

  • The effects of gum arabic oral treatment on the metabolic profile of chronic renal failure patients under regular haemodialysis in Central Sudan
    AA Ali, KE Ali, AE Fadlalla, KE Khalid
    Natural product research 22 (1), 12-21 , 2008
    2008
    Citations: 131
  • Effect of tactile kinesthetic stimulation on preterm infants’ weight and length of hospital stay in Khartoum, Sudan
    RG Ahmed, GI Suliman, WA Elfakey, KM Salih, EI El-Amin, WA Ahmed, ...
    Saudi medical journal 36 (2), 196-199 , 2015
    2015
    Citations: 49
  • Outcomes of Arteriovenous Fistula for Hemodialysis in Sudanese Patients: Single-Center Experience
    GM Ahmed, MO Mansour, M Elfatih, KE Khalid, MEIM Ahmed
    Saudi Journal of Kidney Diseases and Transplantation 23 (1), 152-157 , 2012
    2012
    Citations: 25
  • Vitamin D receptor gene polymorphisms in Sudanese children with type 1 diabetes
    KE Khalid
    AIMS Genetics 3 (03), 167-176 , 2016
    2016
    Citations: 21
  • CTLA-4 (+ 49A/G) polymorphism in type 1 diabetes children of Sudanese population
    KEK Kheiralla
    Global medical genetics 8 (01), 011-018 , 2021
    2021
    Citations: 20
  • Prostate Specific Antigen and Risk of Bone Metastasis in Sudanese Patients with Prostate Cancer
    KE Khalid, A IB, ME Ahmed, EA Khalid
    Saudi J Kidney Dis Transpl 22 (5), 1041-1043 , 2011
    2011
    Citations: 20
  • Semen analysis of infertile Sudanese males in Gezira state central Sudan
    E Miskeen
    2009
    Citations: 18
  • Association of Human Leukocyte Antigen (HLA) class II ( DRB1 and DQB1 ) alleles and haplotypes with Rheumatoid Arthritis in Sudanese patients
    AA Ali, KE Khalid, SE Mohammed, MS Akhtar, OK Saeed
    Frontiers in Immunology 14, 1178546 , 2023
    2023
    Citations: 16
  • Prostate Specific Antigen versus Digital Rectal Examination as screening for ca prostate in Sudanese patients
    MA Mohammed El Imam, NZ Higazi, DO Abuidris, AA Idris, KE Khalid, ...
    Sudan J Public Health 4 (2), 278-81 , 2009
    2009
    Citations: 15
  • Nutritional Status of Mothers and Its Determinants in Alemtidad Area, Khartoum
    WAM Ahmed, EA Ahmed, KAO Arafa, EIS El-Amin, ZM Alostaz, KE Khalid
    Food and Nutrition Sciences 5 (22), 2203-2208 , 2014
    2014
    Citations: 14
  • Lengths and positions of the Vermiform Appendix among Sudanese Cadavers
    EI El-Amin, GY Ahmed, WA Ahmed, KE Khalid, AMEA Sakran
    AIMS Medical Science 2 (3), 222-227 , 2015
    2015
    Citations: 13
  • Lipids Profile in Post Renal Transplant Patients Treated with Cyclosporine in Sudan
    ME Ahmed BSE, Mohammed EMA, EL Sabigh M, KE Khalid , Idris ET
    Saudi J Kidney Dis and Transpl 20 (2), 312-317 , 2009
    2009
    Citations: 12
  • T1/ST2 deficient mice display protection against Leishmania infantum experimental infection
    KE Khalid, MSL Nascimento, LA Sacramento, DL Costa, DS Lima-Júnior, ...
    Acta tropica 172, 1-6 , 2017
    2017
    Citations: 11
  • Clinical pathological characteristics and treatment outcomes of renal cell carcinoma (RCC): a retrospective study from Sudan
    MM Bafadni, YM Osman, MEIM Ahmed, MM Taha, DA Idris, KEK Kheiralla, ...
    ecancermedicalscience 17, 1524 , 2023
    2023
    Citations: 9
  • Seroprevalence of cytomegalovirus antibodies among hemodialysis patients in Gezira state, central Sudan
    AAEA Alla, AA Altayeb, MA Alshareef, MS Elboni, SE Ali, KO Abosalif, ...
    World Journal of Pharmaceutical Research 4 (7), 19-25 , 2015
    2015
    Citations: 9
  • Antimycobacterial Activity and Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of Henna (Lawsonia Inermis) Leaves extract.
    EA Anwar Mohammed Abdelrahman, Khalid Eltahir Kheiralla, Nuha Ibrahim, Asrar ...
    Arabian Journal of Medicinal and Aromatic Plants (AJMAP) 6 (3), 1-9 , 2020
    2020
    Citations: 7
  • Health Education Module for Stroke Caregivers
    WAM Ahmed, EIS El-Amin, RG Ahmed, ZM Alostaz, KE Khalid
    J Neurol Disord 3 (2), 2-5 , 2015
    2015
    Citations: 6
  • Phenotype and genotype of extendedspectrum-beta-lactamases in Sudanese patients with UTI
    YMA Ahmed, M Mohammed El Imam, KE Khalid, BA Mohamed, KM Elhag
    Basic Res. J. Microbiol 3, 1-5 , 2014
    2014
    Citations: 6
  • Toxicity Effects of Hair Dye Application on Liver Function in Experimental Animals
    EIS El-Amin, MAALR GahElnabi, WAM Ahmed, RG Ahmed, KE Khalid
    Group 4 (4), 2-5 , 2014
    2014
    Citations: 6
  • Cytological and molecular screening of Chlamydia trachomatis in infertile women attending a maternity teaching hospital in Gezira State, Sudan: a …
    HMH Omer, KE Khalid, EI Miskeen, MY Taha, EY Saleh, EA Ahmed, ...
    F1000Research 9, 589 , 2023
    2023
    Citations: 5