SONU KIZHAKKEPURA

@umass.edu

Postdoctoral Research Associate, Chemistry
University of Massachusetts Amherst

SONU KIZHAKKEPURA


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https://researchid.co/sonukp08

RESEARCH, TEACHING, or OTHER INTERESTS

Materials Science, Chemistry, Analytical Chemistry, Organic Chemistry
11

Scopus Publications

137

Scholar Citations

7

Scholar h-index

5

Scholar i10-index

Scopus Publications

  • Temporally programmed switching of functional states in polyaniline film
    K. P. Sonu, Shikha Dhiman, Abhishek Garg, D. Selvakumar, Subi J. George, et al.
    APL Materials, 2023
    Polyaniline films are under extensive consideration for applications in sensors, memory devices, displays, biomedicals, etc., owing to their unique optical and electronic functional states that are switchable in response to external stimuli. The application arena of these materials could be enhanced by creating active, adaptive, and autonomous systems with preprogramable spatiotemporal control over the functional states. Here, we present a simple approach to achieve autonomous temporal regulation of polyaniline films’ optical and electrical states by integrating enzyme-catalyzed biochemical reaction. The enzymatic reaction produces a feedback-induced transient pH profile, and correspondingly, the functional states of polyaniline films give rise to a similar switching profile, whose lifetime could be preprogrammed via enzyme concentration. This autonomous, temporally regulated polymer film system represents an advancement to the existing switchable materials that operate at equilibrium.
  • Sustained release of alpha-methylacyl-CoA racemase (AMACR) antibody-conjugated and free doxorubicin from silica nanoparticles for prostate cancer cell growth inhibition
    Toyin Aina, Ali A. Salifu, Sonu Kizhakkepura, Yiporo Danyuo, John D. Obayemi, et al.
    Journal of Biomedical Materials Research Part B Applied Biomaterials, 2023
    This article presents silica nanoparticles for the sustained release of AMACR antibody‐conjugated and free doxorubicin (DOX) for the inhibition of prostate cancer cell growth. Inorganic MCM‐41 silica nanoparticles were synthesized, functionalized with phenylboronic acid groups (MCM‐B), and capped with dextran (MCM‐B‐D). The nanoparticles were then characterized using Fourier‐transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, zeta potential analysis, nitrogen sorption, X‐ray diffraction, and thermogravimetric analysis, before exploring their potential for drug loading and controlled drug release. This was done using a model prostate cancer drug, DOX, and a targeted prostate cancer drug, α‐Methyl Acyl‐CoA racemase (AMACR) antibody‐conjugated DOX, which attaches specifically to AMACR proteins that are overexpressed on the surfaces of prostate cancer cells. The kinetics of sustained drug release over 30 days was then studied using zeroth order, first order, second order, Higuchi, and the Korsmeyer–Peppas models, while the thermodynamics of drug release was elucidated by determining the entropy and enthalpy changes. The flux of the released DOX was also simulated using the COMSOL Multiphysics software package. Generally, the AMACR antibody‐conjugated DOX drug‐loaded nanoparticles were more effective than the free DOX drug‐loaded formulations in inhibiting the growth of prostate cancer cells in vitro over a 96 h period. The implications of the results are then discussed for the development of drug‐eluting structures for the localized and targeted treatment of prostate cancer.
  • Strain-Stiffening Hydrogels with Dynamic, Secondary Cross-Linking
    K. P. Sonu, Le Zhou, Santidan Biswas, John Klier, Anna C. Balazs, et al.
    Langmuir, 2023
    Hydrogels are water-swollen, typically soft networks useful as biomaterials and in other fields of biotechnology. Hydrogel networks capable of sensing and responding to external perturbations, such as light, temperature, pH, or force, are useful across a wide range of applications requiring on-demand cross-linking or dynamic changes. Thus far, although mechanophores have been described as strain-sensitive reactive groups, embedding this type of force-responsiveness into hydrogels is unproven. Here, we synthesized multifunctional polymers that combine a hydrophilic zwitterion with permanently cross-linking alkenes, and dynamically cross-linking disulfides. From these polymers, we created hydrogels that contain irreversible and strong thiol-ene cross-links and reversible disulfide cross-links, and they stiffened in response to strain, increasing hundreds of kPa in modulus under compression. We examined variations in polymer composition and used a constitutive model to determine how to balance the number of thiol-ene vs disulfide cross-links to create maximally force-responsive networks. These strain-stiffening hydrogels represent potential biomaterials that benefit from the mechanoresponsive behavior needed for emerging applications in areas such as tissue engineering.
  • Heterostructures of polyaniline and Ce–ZnO nanomaterial coated flexible PET thin films for LPG gas sensing at standard environment
    D. Selvakumar, K.P. Sonu, G. Ramadoss, R. Sivaramakrishnan, R. Jayavel, et al.
    Chemosphere, 2023
  • Facile coconut inflorescence sap mediated synthesis of silver nanoparticles and its diverse antimicrobial and cytotoxic properties
    Rajesh M.K., Muralikrishna K.S., Swapna S. Nair, Kumar B. Krishna, Subrahmanya T.M., et al.
    Materials Science and Engineering C, 2020
  • The design, synthesis and in vivo biological evaluations of [V(IV)O(2,6-pyridine diacetatato) (H2O)2] (PDOV): Featuring its prolonged glucose lowering effect and non-toxic nature
    Varma H. Rambaran, S.M. Saumya, Soumyabrata Roy, K.P. Sonu, Muthusamy Eswaramoorthy, et al.
    Inorganica Chimica Acta, 2020
  • Controlled delivery of essential oils for the management of rhinocerosbeetle(OryctesrhinocerosL.)incoconut
    Journal of Plantation Crops, 2019
  • Porous Materials: Recent Developments
    K. P. Sonu, Subhajit Laha, Muthusamy Eswaramoorthy, Tapas Kumar Maji
    Advances in the Chemistry and Physics of Materials Overview of Selected Topics, 2019
  • Bio-inspired temporal regulation of ion-transport in nanochannels
    K. P. Sonu, Sushmitha Vinikumar, Shikha Dhiman, Subi J. George, Muthusamy Eswaramoorthy
    Nanoscale Advances, 2019
    Mesoporous silica showing pH responsive gating was coupled with an enzymatic reaction to achieve the temporal regulation of ion transport.
  • Supramolecular Switching of Ion-Transport in Nanochannels
    B. V. V. S. Pavan Kumar, K. P. Sonu, K. Venkata Rao, S. Sampath, Subi J. George, et al.
    ACS Applied Materials and Interfaces, 2018
    Noncovalent approaches to achieve smart ion-transport regulation in artificial nanochannels have garnered significant interest in the recent years because of their advantages over conventional covalent routes. Herein, we demonstrate a simple and generic approach to control the surface charge in mesoporous silica nanochannels by employing π-electron-rich charged motifs (pyranine-based donors) to interact with the surface of mesoporous silica modified with π-electron-deficient motifs (viologen-based acceptors) through a range of noncovalent forces, namely, charge-transfer, electrostatic, and hydrophobic interactions. The extent of each of these interactions was independently controlled by molecular design and pH, while employing them in a synergistic or antagonistic fashion to modulate the binding affinity of the charged motifs. This enabled the precise control of the surface charge of the nanochannels to achieve multiple ion-transport states.
  • Simple and Facile Approach To Create Charge Reversible Pores via Hydrophobic Anchoring of Ionic Amphiphiles
    K. P. Sonu, B. V. V. S. Pavan Kumar, Subi J. George, Muthusamy Eswaramoorthy
    ACS Applied Materials and Interfaces, 2017

RECENT SCHOLAR PUBLICATIONS

  • Force-Responsive Networks
    KP Sonu, SR Peyton
    American Chemical Society , 2024
    2024
  • Strain-Stiffening Modular Gels with Dynamic, Secondary Cross-Linking
    S Kizhakkepura, J Klier, S Peyton
    2023 AIChE Annual Meeting , 2023
    2023
  • Temporally programmed switching of functional states in polyaniline film
    KP Sonu, S Dhiman, A Garg, D Selvakumar, SJ George, ...
    APL Materials 11 (3) , 2023
    2023
    Citations: 2
  • Sustained release of alpha‐methylacyl‐CoA racemase (AMACR) antibody‐conjugated and free doxorubicin from silica nanoparticles for prostate cancer cell growth inhibition
    T Aina, AA Salifu, S Kizhakkepura, Y Danyuo, JD Obayemi, JC Oparah, ...
    Journal of Biomedical Materials Research Part B: Applied Biomaterials 111 (3 … , 2023
    2023
    Citations: 6
  • Strain-Stiffening Hydrogels with Dynamic, Secondary Cross-Linking
    KP Sonu, L Zhou, S Biswas, J Klier, AC Balazs, T Emrick, SR Peyton
    Langmuir 39 (7), 2659–2666 , 2023
    2023
    Citations: 16
  • Heterostructures of polyaniline and Ce–ZnO nanomaterial coated flexible PET thin films for LPG gas sensing at standard environment
    D Selvakumar, KP Sonu, G Ramadoss, R Sivaramakrishnan, R Jayavel, ...
    Chemosphere 314, 137492 , 2023
    2023
    Citations: 28
  • Strain-Stiffening Hydrogel with Tunable Water Content
    S Kizhakkepura, Y Tran, NH Tseng, S Peyton
    2020 Virtual AIChE Annual Meeting , 2020
    2020
  • Fabrication of Mechanically Activatable Polymer Adhesive Via Kinetically Controlled Crosslinking
    S Kizhakkepura, Y Tran, Y Liu, HH Winter, J Klier, S Peyton
    2020 Virtual AIChE Annual Meeting , 2020
    2020
  • Facile coconut inflorescence sap mediated synthesis of silver nanoparticles and its diverse antimicrobial and cytotoxic properties
    MK Rajesh, KS Muralikrishna, SN Swapna, BK Kumar, TM Subrahmanya, ...
    Materials Science and Engineering: C 111, 110834 , 2020
    2020
    Citations: 30
  • The design, synthesis and in vivo biological evaluations of [V (IV) O (2, 6-pyridine diacetatato)(H2O) 2](PDOV): Featuring its prolonged glucose lowering effect and non-toxic …
    VH Rambaran, SM Saumya, S Roy, KP Sonu, M Eswaramoorthy, ...
    Inorganica Chimica Acta 504, 119448 , 2020
    2020
    Citations: 7
  • Coconut inflorescence sap mediated synthesis of silver nanoparticles and its diverse antimicrobial properties
    MK Rajesh, KS Muralikrishna, SS Nair, BK Kumar, TM Subrahmanya, ...
    bioRxiv, 775940 , 2019
    2019
    Citations: 1
  • Design strategies for charge reversal and temporally regulated functionalities in porous and non-porous systems
    KP Sonu
    Jawaharlal Nehru Centre for Advanced Scientific Research , 2019
    2019
  • Porous Materials: Recent Developments
    KP Sonu, S Laha, M Eswaramoorthy, TK Maji
    Advances in the Chemistry and Physics of Materials, 148-172 , 2019
    2019
    Citations: 1
  • Controlled delivery of essential oils for the management of rhinoceros beetle (Oryctes rhinoceros L.) in coconut
    KP Sonu
    J. Planta. Crops 47, 31-40 , 2019
    2019
    Citations: 4
  • Bio-inspired temporal regulation of ion-transport in nanochannels
    KP Sonu, S Vinikumar, S Dhiman, SJ George, M Eswaramoorthy
    Nanoscale Advances 1 (5), 1847-1852 , 2019
    2019
    Citations: 18
  • Supramolecular Switching of Ion-Transport in Nanochannels.
    K BVVSP, KP Sonu, KV Rao, S Sampath, SJ George, M Eswaramoorthy
    ACS Applied Materials & Interfaces 10 (28), 23458-23465 , 2018
    2018
    Citations: 1
  • Supramolecular switching of ion-transport in nanochannels
    BP Kumar, KP Sonu, KV Rao, S Sampath, SJ George, M Eswaramoorthy
    ACS Applied Materials & Interfaces 10 (28), 23458-23465 , 2018
    2018
    Citations: 14
  • Simple and facile approach to create charge reversible pores via hydrophobic anchoring of ionic amphiphiles
    KP Sonu, B Pavan Kumar, SJ George, M Eswaramoorthy
    ACS Applied Materials & Interfaces 9 (10), 9136-9142 , 2017
    2017
    Citations: 9
  • Synthesis and modification of gold nanorods for biomedical applications
    KP Sonu
    Jawaharlal Nehru Centre for Advanced Scientific Research , 2014
    2014

MOST CITED SCHOLAR PUBLICATIONS

  • Facile coconut inflorescence sap mediated synthesis of silver nanoparticles and its diverse antimicrobial and cytotoxic properties
    MK Rajesh, KS Muralikrishna, SN Swapna, BK Kumar, TM Subrahmanya, ...
    Materials Science and Engineering: C 111, 110834 , 2020
    2020
    Citations: 30
  • Heterostructures of polyaniline and Ce–ZnO nanomaterial coated flexible PET thin films for LPG gas sensing at standard environment
    D Selvakumar, KP Sonu, G Ramadoss, R Sivaramakrishnan, R Jayavel, ...
    Chemosphere 314, 137492 , 2023
    2023
    Citations: 28
  • Bio-inspired temporal regulation of ion-transport in nanochannels
    KP Sonu, S Vinikumar, S Dhiman, SJ George, M Eswaramoorthy
    Nanoscale Advances 1 (5), 1847-1852 , 2019
    2019
    Citations: 18
  • Strain-Stiffening Hydrogels with Dynamic, Secondary Cross-Linking
    KP Sonu, L Zhou, S Biswas, J Klier, AC Balazs, T Emrick, SR Peyton
    Langmuir 39 (7), 2659–2666 , 2023
    2023
    Citations: 16
  • Supramolecular switching of ion-transport in nanochannels
    BP Kumar, KP Sonu, KV Rao, S Sampath, SJ George, M Eswaramoorthy
    ACS Applied Materials & Interfaces 10 (28), 23458-23465 , 2018
    2018
    Citations: 14
  • Simple and facile approach to create charge reversible pores via hydrophobic anchoring of ionic amphiphiles
    KP Sonu, B Pavan Kumar, SJ George, M Eswaramoorthy
    ACS Applied Materials & Interfaces 9 (10), 9136-9142 , 2017
    2017
    Citations: 9
  • The design, synthesis and in vivo biological evaluations of [V (IV) O (2, 6-pyridine diacetatato)(H2O) 2](PDOV): Featuring its prolonged glucose lowering effect and non-toxic …
    VH Rambaran, SM Saumya, S Roy, KP Sonu, M Eswaramoorthy, ...
    Inorganica Chimica Acta 504, 119448 , 2020
    2020
    Citations: 7
  • Sustained release of alpha‐methylacyl‐CoA racemase (AMACR) antibody‐conjugated and free doxorubicin from silica nanoparticles for prostate cancer cell growth inhibition
    T Aina, AA Salifu, S Kizhakkepura, Y Danyuo, JD Obayemi, JC Oparah, ...
    Journal of Biomedical Materials Research Part B: Applied Biomaterials 111 (3 … , 2023
    2023
    Citations: 6
  • Controlled delivery of essential oils for the management of rhinoceros beetle (Oryctes rhinoceros L.) in coconut
    KP Sonu
    J. Planta. Crops 47, 31-40 , 2019
    2019
    Citations: 4
  • Temporally programmed switching of functional states in polyaniline film
    KP Sonu, S Dhiman, A Garg, D Selvakumar, SJ George, ...
    APL Materials 11 (3) , 2023
    2023
    Citations: 2
  • Coconut inflorescence sap mediated synthesis of silver nanoparticles and its diverse antimicrobial properties
    MK Rajesh, KS Muralikrishna, SS Nair, BK Kumar, TM Subrahmanya, ...
    bioRxiv, 775940 , 2019
    2019
    Citations: 1
  • Porous Materials: Recent Developments
    KP Sonu, S Laha, M Eswaramoorthy, TK Maji
    Advances in the Chemistry and Physics of Materials, 148-172 , 2019
    2019
    Citations: 1
  • Supramolecular Switching of Ion-Transport in Nanochannels.
    K BVVSP, KP Sonu, KV Rao, S Sampath, SJ George, M Eswaramoorthy
    ACS Applied Materials & Interfaces 10 (28), 23458-23465 , 2018
    2018
    Citations: 1
  • Force-Responsive Networks
    KP Sonu, SR Peyton
    American Chemical Society , 2024
    2024
  • Strain-Stiffening Modular Gels with Dynamic, Secondary Cross-Linking
    S Kizhakkepura, J Klier, S Peyton
    2023 AIChE Annual Meeting , 2023
    2023
  • Strain-Stiffening Hydrogel with Tunable Water Content
    S Kizhakkepura, Y Tran, NH Tseng, S Peyton
    2020 Virtual AIChE Annual Meeting , 2020
    2020
  • Fabrication of Mechanically Activatable Polymer Adhesive Via Kinetically Controlled Crosslinking
    S Kizhakkepura, Y Tran, Y Liu, HH Winter, J Klier, S Peyton
    2020 Virtual AIChE Annual Meeting , 2020
    2020
  • Design strategies for charge reversal and temporally regulated functionalities in porous and non-porous systems
    KP Sonu
    Jawaharlal Nehru Centre for Advanced Scientific Research , 2019
    2019
  • Synthesis and modification of gold nanorods for biomedical applications
    KP Sonu
    Jawaharlal Nehru Centre for Advanced Scientific Research , 2014
    2014