SANDIP BABARAO SAPKAL
@lcpbuldana.ac.in
PROFESSOR IN PHARMACEUTICS
LADDHAD COLLEGE OF PHARMACY, YELGAON, BULDANA
Sandip Sapkal currently working as Professor at Laddhad College of Pharmacy, Buldana. Total 15 years teaching & research experience. Sandip does research in Pharmacy. Their current project is 'Solubility & Bio-availability enhancement of some BCS class II drugs by Solid dispersion technique using Natural polymer'.
EDUCATION
M. Pharm in Pharmaceutics in 2010, PhD in Pharmacy in 2018.
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmaceutical Science, Pharmacy, Pharmacology, Toxicology and Pharmaceutics, Drug Discovery
Scopus Publications
Scopus Publications
Sandip Babarao SAPKAL, Vaibhav Suresh ADHAO, Raju Rambhau THENGE, Rahul Ashok DARAKHE, Sushilkumar Ananda SHINDE, and Vinayak Natthuji SHRIKHANDE
Galenos Yayinevi
Objectives: The main objective of the present investigation to develop and evaluate solid dispersions of BCS Class II drugs etoricoxib employing various natural polymers, compatible with conventional manufacturing method to enhance solubility of poorly soluble drugs. Materials and Methods: In this study, etoricoxib solid dispersion were prepared using xanthan gum, gaur gum and acacia and their combinations by solvent evaporation method. Solid dispersions and pure etoricoxib in the form of powder were characterized in comparison with pure drug and corresponding physical mixtures in the same ratios by Fourier transform infrared spectroscopy, differential scanning calorimetry (DSC), powder X-ray diffractogram, and in vitro drug release. Results: Solid dispersion (ET11) prepared with 1: 2: 2: 2 drug carrier ratios were showed highest solubility in different solvents. Hence the solid dispersion (ET11) of 1: 2: 2: 2 ratios were selected for characterization. The DSC study indicated that the crystalline nature of etoricoxib was reduced to amorphous. The diffraction pattern of the solid dispersions in each figure indicates that diffraction peaks at 2ɵ values has less intensity than that of pure drugs. This indicated that the crystalline nature of drug sample was converted to amorphous with ET11. Scanning electron microscope photographs of solid dispersion seem to be more porous in nature. From the in vitro drug release profile, it can be seen that formulation ETM11 shows higher dissolution rate i.e. 98.2±1.3% compared with other formulations. It is predicted that, increasing concentration of carrier, increases the drug dissolution rate. Conclusion: This study has shown that the solid dispersion of etoricoxib using natural carrier can be promising formulation for solubility and dissolution enhancement. Natural polymers used have shown promising results in the modification of drug release from the formulations.
P.S Gangane, S. B. Sapkal, A.S. Welankiwar, P.S. Magar, and D.V. Bhusari
A and V Publications
The aim of this study was to develop a new intra-gastric floating tablet for controlled delivery of Levofloxacin for the treatment of peptic ulcer disease caused by Helicobacter pylori (H. pylori). The method of preparation is direct compression method. HPMC, K-grade and effervescent material sodium bicarbonate formed the floating layer. The release layer contained Levofloxacin and various polymers such as HPMC-K15M, HPMC-K100M, PVP-K30 and MCC in combination with the drug. The in vitro drug release was studied in pH 1.2 HCl using USP dissolution Apparatus II at 50 rpm. Zero-order, first-order, Higuchi and Korsmeyer et al. models were used to estimate the kinetics of drug release. Optimized formulation released approximately 98% drug in 12 h in vitro, while the floating lag time was 49 sec and the tablet remained floatable throughout all studies. Optimized formulation (D3) followed the Korsmeyer and Peppas model and showed no significant change in physical appearance, drug content, floatability and invitro dissolution pattern after storage at 45°C/75% RH for three month.
Sandip Sapkal
Marmara Pharmaceutical Journal
ABSTRACT Natural polymers and its modified forms can be used as best alternative for improving bioavailability of poorly water soluble drugs in solid dispersion. Most of the natural polymers are hydrophilic and having high swelling capacity. Recent trend towards the use of natural polymer demands the replacement of synthetic additives with natural ones. Many plant derived natural polymers are studied for use in solid dispersion systems, out of which natural gums, cyclodextrin and carbohydrate are most extensively studied and used. This review discusses about the majority of these natural polymers, its uses and some recent investigations about modification of natural polymer in solid dispersion systems. KEYWORDS: Modified natural gum, carbohydrate, dissolution enhancement, solid dispersion