Bioprospecting the Endophytic Fungus, Lasiodiplodia theobromae MMPI, for the Integrated Production of Mycoprotein and Exocellular (1→6)-β-Glucan Marcelo Luis Kuhn Marchioro, Gabrielli Aline Pietro Bom Candeia, Luana Malaquias Bertoleti, Aneli M. Barbosa-Dekker, Robert F. H. Dekker, et al. Fermentation, 2025 In response to the growing demand for alternative protein sources and functional biomolecules for industrial applications, this study investigated the production of mycoprotein and extracellular (1→6)-β-D-glucan (lasiodiplodan) by the fungus Lasiodiplodia theobromae MMPI, establishing an integrated biotechnological platform. Soybean molasses were evaluated as a low-cost fermentation substrate and compared to a sucrose-based medium. The experimental design and response surface methodology defined conditions that maximized mycelial biomass and lasiodiplodan production. Mycelial biomass from soybean molasses was rich in essential amino acids, lipids, and polyunsaturated fatty acids like gamma-linolenic and alpha-linolenic acids, while sucrose favored higher lasiodiplodan production. Antioxidant compounds like gallic acid and catechin were also found in the biomass, showing potential for scavenging free radicals. Soybean molasses promoted lipid-rich biomass, suggesting L. theobromae MMPI’s potential for biofuel production. This study highlights the fungus’ utility in producing mycoproteins, lipids, and lasiodiplodan for food, animal feed, and industrial uses.
Filamentous Fungi as Bioremediation Agents of Industrial Effluents: A Systematic Review Fernanda Maria Rosa, Thaís Fernandes Mendonça Mota, Cleverson Busso, Priscila Vaz de Arruda, Patrícia Elena Manuitt Brito, et al. Fermentation, 2024 The industrial sector plays a significant role in global economic growth. However, it also produces polluting effluents that must be treated to prevent environmental damage and ensure the quality of life for future generations is not compromised. Various physical, chemical, and biological methods have been employed to treat industrial effluents. Filamentous fungi, in particular, have garnered attention as effective bioremediation agents due to their ability to produce enzymes capable of degrading recalcitrant compounds, and adsorb different pollutant molecules. The novelty of the work reported herein lies in its comprehensive assessment of the research surrounding the use of white- and brown-rot fungi for removing phenolic compounds from industrial effluents. This study employs a systematic review coupled with scientometric analysis to provide insights into the evolution of this technology over time. It scrutinizes geographical distribution, identifies research gaps and trends, and highlights the most studied fungal species and their applications. A systematic review of 464 publications from 1945 to 2023 assessed the use of these fungi in removing phenolic compounds from industrial effluents. White-rot fungi were predominant (96.3%), notably Phanerochaete chrysosporium, Pleurotus ostreatus, Trametes versicolor, and Lentinula edodes. The cultures employing free cells (64.15%) stand out over those using immobilized cells, just like cultures with isolated fungi regarding systems with microbial consortia. Geographically, Italy, Spain, Greece, India, and Brazil emerged as the most prominent countries in publications related to this area during the evaluated period.
Biological activities of derivatized D-glucans: A review Francini Yumi Kagimura, Mário Antônio A. da Cunha, Aneli M. Barbosa, Robert F.H. Dekker, Carlos Ricardo Maneck Malfatti International Journal of Biological Macromolecules, 2014
