CYTOTOXICITY ASSESSMENT OF ADHESIVE SYSTEM COMPONENTS CONTAINING METHACRYLOYLOXYDECYL DIHYDROGEN PHOSPHATE (MDP-10) Georgian Medical News, 2025
ANALYSIS OF STROMAL CELL CULTURE PROLIFERATION BIOMARKER USING MEDICAL ADHESIVES Georgian Medical News, 2025
ANALYSIS OF PERIODONTAL POCKET MICROBIOTA IN PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS Georgian Medical News, 2025
SYSTEMATIC REVIEW OF WOUND DRESSINGS FOR PALATAL DONOR SITE MANAGEMENT IN ORAL SOFT TISSUE SURGERY Georgian Medical News, 2025
Clinical assessment of polyhexanide as an endodontic irrigant in the management of chronic apical periodontitis Yu. A. Generalova, A. Yu. Umarov, A. Wehbe, M. Yu. Dashtieva, I. V. Bagdasarova Endodontics Today, 2025 INTRODUCTION. Chronic forms of apical periodontitis remain a relevant challenge in endodontic practice. The effectiveness of treatment largely depends on the quality of root canal irrigation. Polyhexamethylene guanidine (polyhexanide) is considered a promising alternative to sodium hypochlorite, offering antimicrobial activity with low cytotoxicity. MATERIALS AND METHODS. The study included 49 patients with chronic apical periodontitis, divided into two groups. In the first group, a 0.2% polyhexanide solution was used as the primary irrigant, while the second group received a standard protocol with 3% sodium hypochlorite (NaOCl) and 17% EDTA. Treatment efficacy was evaluated based on clinical symptoms and radiographic changes at 6 and 12 months. The Mann–Whitney U test and Pearson’s chi-squared (χ²) test were used for statistical analysis. RESULTS. The treatment success rate was 98% in the polyhexanide group and 93.6% in the control group. After 12 months, patients in the experimental group showed a lower incidence of persistent periapical lesions. Although the differences did not reach statistical significance (p > 0.05), there was a trend toward a more favorable healing process with polyhexanide use. CONCLUSIONS. The use of a 0.2% polyhexanide solution as an irrigant demonstrated clinical efficacy comparable to the traditional protocol, with a potential reduction in the risk of adverse effects on hard tissues and surrounding structures. Further studies with larger sample sizes and longer follow-up periods are needed to definitively assess the advantages of this approach.
The Effect of Dental Implant Nanotopography on its Osseointegration Journal of International Dental and Medical Research, 2025
Cytotoxicity of Methacrylate – Based Resin Materials in Dentistry Journal of International Dental and Medical Research, 2025
Key Aspects of Working with 8th Generation Adhesive Systems in Direct Restorations: A Case Study of Clearfil Universal Bond Quick Journal of International Dental and Medical Research, 2025
The effect of the irrigation solutions on dentin organic components: Pilot study Z. S. Khabadze, Yu. A. Generalova, Yu. A. Taptun, L. A. Kozhevnikova, F. Ya. Gadzhiev, M. Yu. Dashtieva Endodontics Today, 2024 INTRODUCTION. Tooth decay and its complications are prevalent dental issues among adults. Endodontic treatment is the standard of care for complicated caries, specifically pulpitis and periodontitis. Endodontic irrigants, which are placed in the root canal lumen for a specific duration, can affect the intracanal dentin structure (organic and inorganic substances) in various ways. The use of polyhexanide-based antiseptic products in endodontics is a promising idea to overcome microbial resistance and minimize microbial-related endodontic treatment failures.AIM. The aim of this study is to investigate the qualitative impact of standard irrigation solutions and a polyhexanide-based composition on the collagen matrix of dentin.MATERIALS AND METHODS. The study investigated the effect of nine solutions on the dentin of the tooth root. Twelve intact maxillary third molars extracted for orthodontic reasons were taken for the study. The teeth were fixed in a 10% neutral formalin solution for at least one day and were decalcinated. 5–10 μm thick sample sections were made and stained with picrosirius (Picrosirius Red, Biovitrum, Russia) before being examined under polarized light. The histological slice was analyzed using a Carl Zeiss (Germany) software and hardware complex based on ZEN v3.0 and light microscope Axioimager M.1. All microphotos were loaded into the Fiji distribution program of ImageJ for microscopy pixel classification.RESULTS. Upon analysis of the diagrams, it appears that there is a lower amount and density of stained dentin collagen array after exposure to sodium hypochlorite solutions of 3% and 1.5%, as well as polyhexanide.CONCLUSIONS. The data obtained from the histogram analyzer of samples stained with picrosirius suggests that polyhexanide may have a qualitative effect on the organic structure of hard tissues, particularly collagen.
Investigation of Surface Tension of Classical Endodontic Irrigants and Polyhexanide Based Composition Journal of International Dental and Medical Research, 2024
MDP-10 as the Most Important Functional Monomer of the Last Generation Self - Etching Adhesive Systems Journal of International Dental and Medical Research, 2024
Root Surface Biomodification: Methods and Agents Journal of International Dental and Medical Research, 2024
Investigation of Cytotoxicity of Dental Light-Curing Composite Materials Journal of International Dental and Medical Research, 2023
Occurrence Frequency of Exfoliative Cheilitis in Dental Practice Journal of International Dental and Medical Research, 2023
The "Platform Switching" Effect in Implant-Supported Prosthetics as a Prevention of Alveolar Ridge Bone Loss Journal of International Dental and Medical Research, 2023
Benefits of Different Techniques for the Treatment of Miller Class Iii-Iv Recession: A Systematic Review Journal of International Dental and Medical Research, 2023
The Prevalence of Inflammatory Periodontal Diseases (Gingivitis, Periodontitis) among the Population Journal of International Dental and Medical Research, 2023
Implementation of Ultra-Short Implants into Dental Practice: A Systematic Review Journal of International Dental and Medical Research, 2023
Artificial Intelligence Application in Assessment of Upper Airway on Cone-Beam Computed Tomography Scans Journal of International Dental and Medical Research, 2023
Analysis of the Anaerobic Conversion Efficiency of Various Group Composite Material Journal of International Dental and Medical Research, 2023
The Study of Dentine Matrix Metalloproteinases (Mmps) Activity in Devitalized Teeth Journal of International Dental and Medical Research, 2023
The Use of the Antiseptic Solution “Octenisept” in Endodontic Practice: The Systematic Review Journal of International Dental and Medical Research, 2022
THE INFLUENCE OF FINISHING PROCESSING FEATURES ON THE POLYMERIZED COMPOSITE SURFACE STRUCTURE Georgian Medical News, 2021
