Filippo Spreafico

Scopus Publications

Robot-assisted versus conventional minimally invasive surgery in the treatment of paediatric neuroblastoma: a single-centre retrospective study
Stefano Avanzini, Serena Reali, Federico Palo, Massimo Conte, Stefania Sorrentino, Filippo Spreafico, Girolamo Mattioli
Pediatric Surgery International, 2026
Neuroblastoma is the most common extracranial solid tumour in childhood. Although minimally invasive surgery (MIS) is increasingly used in selected patients with neuroblastic tumours, comparative data between robot-assisted and conventional MIS are lacking. A single-centre retrospective study was conducted on 84 patients who underwent minimally invasive resection of neuroblastic tumours between 2008 and 2025. Patients were divided into conventional MIS and robot-assisted surgery groups. Demographic data, tumour characteristics and surgical and oncological outcomes were compared. The robot-assisted group included a higher number of patients with Image-Defined Risk Factor (IDRF) ≥ 1 (57% vs. 8%). Robotic surgery was therefore preferentially employed in more complex cases, resulting in higher conversion rate and longer operative time. Despite the higher prevalence of patients with IDRF ≥ 1 in the robotic group, intraoperative and postoperative complication rates were comparable between groups. Notably, conversions were not performed for emergency reasons but were based on intraoperative decision-making. Robot-assisted surgery may safely expand selection criteria to selected patients with positive IDRFs, while maintaining oncological principles and without increasing intra and postoperative morbidity.
Navigating ethical challenges in the FORTEe randomised controlled trial: a multi-centre staff survey on exercise intervention for children and adolescents undergoing cancer treatment
Francesca Alt, Elias Dreismickenbecker, Francesca Lanfranconi, Adriana Balduzzi, Eila Watson, Hayley Marriott, Joachim Wiskemann, Nikolai Bauer, Rodolf Mongondry, Martin Kaj Fridh, Alejandro Lucia, Carmen Fiuza-Luces, Ronja Beller, Filippo Spreafico, Barbara Konda, Milica Stefanović, Heidi Diel, Mareike Kühn, Lena Wypyrsczyk, Norbert W. Paul, Marie A. Neu, Jörg Faber, , Alba Solera-Sanchez, Tommaso Pietro Moriggi, Linda Peli, Eleonora Corti, Emanuele Villa, Olivia Pérol, Eva Santa Cruz-Ramos, Miriam Götte, William Zardo, Marco Chisari, Domen Ravnik, Meta Rovan, Martin Bjørn Hansen, Hanne Bækgaard Larsen
BMC Medical Ethics, 2026
BACKGROUND: The FORTEe randomised controlled trial (NCT05289739) investigates an exercise intervention for children and adolescents undergoing cancer treatment. Conducting research with this vulnerable population poses unique ethical challenges, including participant burden, child autonomy, and parental decision-making. This study explored the ethical experiences of healthcare professionals (HCPs) involved in the trial. METHODS: A multicentre survey was conducted across ten clinical sites in Europe using a structured, browser-based questionnaire comprising both closed and open-ended questions. Domains included burden and benefits assessment, informed consent, child autonomy, parental influence and moral distress. Quantitative responses were analysed descriptively, while qualitative data underwent content analysis. RESULTS: Seventy-nine HCPs participated, including exercise professionals (n = 30), physicians (n = 19), nurses (n = 8), psychologists (n = 5), social workers (n = 3), one social scientist, one medical ethicist and 12 individuals in other roles. A large majority of respondents (86.1%) agreed or strongly agreed that the overall burden-benefit balance of trial participation was appropriate, while 11.4% were unsure and 2.5% disagreed. Open-text responses described perceived challenges related to questionnaire burden, logistical demands, and emotional discomfort associated with control-group allocation. Informed consent procedures were generally perceived as appropriate. However, some respondents reported situations in which parental influence appeared to outweigh children’s expressed preferences, and difficulties were noted in assessing children’s evolving decision-making capacity. Among HCPs who described prognosis-related events (n = 45), 68.9% described experiences they associated with moral distress, particularly in relation to communication and decisions regarding continuation of participation. CONCLUSION: The trial's ethical climate was largely perceived as positive, though emotional and logistical burdens were noted. Reports of emotional discomfort and moral distress among staff highlight the ethical tensions between research integrity and individual well-being. Furthermore, divergent views on children’s capacity to give consent suggest the need for clearer guidance on paediatric autonomy and shared decision-making. IMPLICATIONS: Ethically sound paediatric research must address real-world burdens and emotional dynamics beyond procedural compliance. Findings from the FORTEe trial staff survey highlight the importance of flexible, child-centred approaches, sustainable access to beneficial interventions, and institutional structures that promote ethical reflection. TRIAL REGISTRATION: Registered on ClinicalTrials.gov (NCT05289739, 21 March 2022) and in the German Clinical Trials Register (DRKS00027978, 28 January 2022).
The mainz resilience assessment in childhood cancer (MRAcc): development of a novel age-specific patient-reported outcome measure to assess resilience in childhood cancer patients
Marie A. Neu, Franziska Ortmüller, Abigale L. Robinson, Elias Dreismickenbecker, Henrike Otto, Lena Wypyrsczyk, Mareike Kühn, Michèle Wessa, Oliver Tüscher, Joerg Faber, , Tobias Christian Baader, Adriana Balduzzi, Nikolai Bauer, Hanne Bækgaard Larsen, Ronja Beller, Wilhelm Bloch, Carmen Fiuza-Luces, Martin Kaj Fridh, Miriam Götte, Martin Bjørn Hansen, Barbara Heißerer, Florian Javelle, Nina Karguth, Lidija Kitanovski, Barbara Konda, Francesca Lanfranconi, Alejandro Lucia, Hayley Marriott, Rodolf Mongondry, Tommaso Pietro Moriggi, Norbert W. Paul, Linda Peli, Olivia Pérol, Katie Rizvi, Domen Ravnik, Eva Santa Cruz Ramos, Meta Rovan, Alba Solera-Sanchez, Filippo Spreafico, Milica Stefanović, Eila Watson, Joachim Wiskemann, Peter Wright, William Zardo
BMC Cancer, 2026
BACKGROUND: During intensive cancer treatment, children, adolescents and young adults are exposed to numerous toxicities and psychosocial stressors that can cause psychosocial distress and impair mental health. The maintenance or rapid recovery of mental health during and after exposure to significant stressors has been defined as resilience. To date, resilience research has focused primarily on cross-sectional assessment of specific, trait-like resilience factors and concepts in long-term survivors of childhood cancer, typically omitting the influence of context-specific biopsychosocial stressors and resilience dynamics throughout treatment. Little is known about outcome-based resilience and mental health resources in childhood cancer patients undergoing cancer treatment. In addition, specific instruments for age-appropriate assessment of resilience in childhood cancer patients are lacking. To address this gap, within the EU Horizon 2020-funded FORTEe project, we developed a novel self-report instrument for longitudinal assessment of resilience in children, adolescents, and young adults with cancer, featuring age-appropriate items tailored to their specific contexts. METHODS: An interdisciplinary team of psychologists, psychiatrists and pediatric oncologists developed an age-appropriate self-report instrument to assess resilience longitudinally in children, adolescents, and young adults undergoing cancer treatment. Following current resilience research frameworks, resilience is defined as the ratio of changes in mental health problems to stressor exposure. Accordingly, the measure comprises two domains: mental health problems (anxiety, depression, distress, fatigue) and stressor exposure (daily hassles, cancer-related stressors), with stressors rated for both frequency and intensity. RESULTS: The Mainz Resilience Assessment in Childhood Cancer (MRAcc) consists of three age-specific versions (children 5–11 years, adolescents 12–17 years, young adults 18–21 years), each including the sections: 'Emotions & Distress', 'Fatigue', and 'Situations & Experienced Stress'. It is available in German and English and uses either five-point-Likert scales or visual analogue scales presented as thermometers. CONCLUSION: The MRAcc is a novel instrument designed to provide age-appropriate measurement of resilience in children, adolescents and young adults with cancer. It reflects the unique stressors and psychological challenges of this population and allows for longitudinal assessment throughout treatment and follow-up. Future validation studies are required to establish its psychometric properties and evaluate its utility in resilience research and clinical practice.
Characteristics and outcome of patients with second and subsequent relapse of Wilms tumour - A report from the SIOP Renal Tumour Study Group
Alissa Groenendijk, Annelies M.C. Mavinkurve-Groothuis, Harm van Tinteren, Ronald R. de Krijger, Reem Al-Saadi, Kathy Pritchard-Jones, Gema L. Ramírez-Villar, Gordan Vujanic, Patrick Melchior, Jan Godzinski, Jens-Peter Schenk, Norbert Graf, Heidi Segers, Hélène Sudour-Bonnange, Arnauld C. Verschuur, Jarno Drost, Daniela Perotti, Christa Koenig, Filippo Spreafico, Jesper Brok, Marry M. van den Heuvel-Eibrink
Ejc Paediatric Oncology, 2026
Background: Second or subsequent relapses of Wilms tumour (WT) are rarely reported. We assessed the characteristics, treatments, and outcome of such patients through a retrospective international cohort study of patients treated according to recent SIOP-RTSG protocols. Methods: Patients with a second or subsequent relapse enrolled in SIOP WT 2001 and the UK-IMPORT study, and registered in the SIOP-RTSG database between 2001 and 2021 were included. Risk groups were defined per the SIOP-RTSG-2016 UMBRELLA protocol (AA-BB (second relapse after initial standard risk (AA) relapse), BB-CC (initial high risk (BB) relapse), and CC-CC (initial very high risk (CC) relapse). Five-year event-free survival (EFS) and overall survival (OS) rates were estimated using Kaplan-Meier and competing risk methods; survival between relapse risk groups was compared with log-rank testing. Findings: Among 572 patients with first relapse, 114 (20%) patients experienced a subsequent relapse. The estimated 5-year EFS and OS after second relapse were 17.7% (95% Confidence Interval (CI): 11.1–28.0%) and 22.4% (95% CI: 15.3–32.9%). In group AA-BB (n = 39) 5-year EFS and OS were 39.0% (95% CI: 25.0–60.7%) and 41.0% (95% CI: 26.8–62.8%). In group BB-CC (n = 32), 5-year EFS was 14.8% (95% CI: 6.05–36.3%) and 5-year OS was 21.9% (95% CI: 10.9–44.0%). All CC-CC patients (n = 35) either died within 3 years of the second relapse or lacked adequate follow-up. Group AA-BB had predominantly been treated with ICE/CyCE regimens, and group BB-CC patients mainly with VIT/TOTEM regimens. Conclusion: A second relapse WT remains curable in a proportion of AA-BB patients. In contrast, survival rates for BB-CC patients are minimal and dismal for CC-CC patients, who should be allocated to a relevant early-phase trial if feasible.
Characteristics and outcome of congenital mesoblastic nephroma: A report of 376 patients registered in the SIOP 93-01, SIOP WT 2001, UK-IMPORT, and AIEOP protocols
Paola Quarello, Rana Dandis, Tanzina Chowdhury, Arnauld Verschuur, Jesper Brok, Gordan Vujanic, Christian Vokuhl, Paola Collini, Aurore Coulomb, Annalisa Serra, Davide Biasoni, Paula Flores, Leo Kager, Heidi Segers, Karolina Malić Tudor, Marta Maria Burman, Nuno Jorge dos Reis Farinha, Patrik Romerius, Jan Godzinski, Martine van Grotel, Gema Lucia Ramirez-Villar, Beatriz De Camargo, Rhoikos Furtwängler, Reem Al-Saadi, Harm Van Tinteren, Norbert Graf, Filippo Spreafico, Marry van den Heuvel-Eibrink
Plos One, 2026
Background Congenital mesoblastic nephroma (CMN) is the most common renal neoplasm diagnosed in the very first months of life. Complete nephrectomy only is the gold standard treatment. Objectives and methods This retrospective study aimed to explore the characteristics and outcome of CMN patients registered in the SIOP 93–01, SIOP WT 2001, UK-IMPORT, and AIEOP studies (1993–2019). Results A total of 376 CMN cases were identified, with a median age at diagnosis of 28 days. Stage information was available for 337 patients: 92/337 (27.4%) were diagnosed with stage I, 177/337 (52.6%) with stage II, and 67/337 (20%) with stage III. Among 272 patients with available histological data, 113/272 (41.5%) had classic, 105/272 (38.6%) cellular, and 54/272 (19.9%) mixed subtype. Treatment details were available for 314 patients; 248 (79%) underwent initial surgery, and 66 (21%) received preoperative chemotherapy. Among the latter group, 60% of patients showed a measurable reduction in tumor volume, indicating a favorable response to chemotherapy. The 5-year event-free survival rate was 93.8%, and the overall survival rate was 96.9%. The cumulative 5-year incidence of relapse was 5.3%, with a median time to recurrence of 4 months. Of the 16 relapse cases, 8 were in the cellular subtype, 5 in the mixed subtype, and 3 in the classical subtype. Conclusions This study confirms that CMN patients have an excellent outcome, with complete surgical resection being curative in the majority of cases. Chemosensitivity is observed in a significant proportion, suggesting that neoadjuvant chemotherapy may be a viable option in selected cases. While age at diagnosis, histological subtype, and survival outcomes are consistent with previous reports, we highlight that recurrences, though infrequent, tend to occur early and are not restricted to the cellular subtype. Further prospective studies and molecular investigations are required to refine clinical management strategies and update treatment recommendations.
Residual Absolute Volume of Blastema as a Predictor of Clinical Outcomes in Patients With Wilms Tumor: A Report From the SIOP WT 2001 Study
Rhoikos Furtwängler, Rana Dandis, Harm van Tinteren, Nils Welter, Christian Vokuhl, Gordan Vujanic, Aurore Coulomb-L’Hermine, Jan Godzinski, Jens-Peter Schenk, Hervé Brisse, Manfred Gessler, Leo Kager, Patrick Melchior, Steven W. Warmann, Arnauld Verschuur, Beatriz de Camargo, Gema Ramirez-Villar, Filippo Spreafico, Jesper Brok, Tanzina Chowdhury, Marry M. van den Heuvel-Eibrink, Norbert Graf
Journal of Clinical Oncology, 2026
PURPOSE The International Society of Paediatric Oncology–Renal Tumour Study Group (SIOP-RTSG) classifies blastemal-type Wilms tumor (WT) after preoperative chemotherapy as high-risk (HRWT). It remains unresolved whether residual absolute volume of blastema (AVB) functions as an independent prognostic factor across WT subtypes. MATERIALS AND METHODS AVB was calculated from preoperative tumor volume, necrosis percentage, and viable blastema using prospectively collected data from 3,459 patients with unilateral WT treated in the SIOP WT 2001 study between 2001 and 2018. Martingale residual plots defined AVB thresholds discriminating survival in localized HRWT, intermediate-/low-risk WT (IRWT/LRWT), and metastatic WT (stage IV). Complete AVB data were available for 1,802 patients (51.2%); 298 (16.5%) had stage IV disease. Of 1,504 patients with localized WT, 265 (17.6%) had HRWT, 1,203 (79.9%) had IRWT, and 36 (2.4%) had LRWT. RESULTS Multivariable Cox regression adjusted for age, sex, and local stage confirmed significantly worse survival for patients exceeding these AVB thresholds: (1) IRWT (≥20 mL): Hazard ratio for event-free survival (EFS) 2.93 (95% CI, 2.08 to 4.12) and overall survival (OS) 2.76 (95% CI, 1.32 to 5.77); (2) HRWT (≥100 mL): EFS 2.89 (95% CI, 1.59 to 5.26) and OS 3.25 (95% CI, 1.45 to 7.27); and (3) stage IV (≥10 mL): EFS 5.78 (95% CI, 3.65 to 9.17) and OS 4.59 (95% CI, 2.57 to 8.17). Patients above these thresholds had significantly lower 2-year EFS ( P < .0001). In stage II to III IRWT patients with AVB ≥20 mL, those treated with doxorubicin had superior EFS versus those without (87.6%, 95% CI, 81.5 to 94.1 v 69.2%, 95% CI, 59.8 to 80.1; P = .0064). CONCLUSION AVB after preoperative chemotherapy is a strong, independent predictor of both EFS and OS in WT across risk groups. An AVB of ≥20 mL identifies a clinically relevant subset of patients with IRWT who may benefit from intensified therapy with doxorubicin. These findings support the use of AVB as a stratification criterion in future SIOP-RTSG protocols.
Tumor Microenvironment and Immune Response Against Wilms Tumor: Evasion Mechanisms and Implications for Immunotherapeutic Approaches
Claudia Cantoni, Valerio Gaetano Vellone, Barbara Cafferata, Gabriele Gaggero, Martina Serra, Filippo Spreafico, Cristina Bottino, Grazia Maria Spaggiari
Cancers, 2026
Wilms tumor (WT) is the most common malignant renal tumor in childhood and represents one of the major success stories of pediatric oncology, with very good survival achieved through risk-adapted multimodal therapy. Nevertheless, a subset of patients—particularly those with diffuse anaplasia, blastemal-type tumors persisting after chemotherapy, or relapsed disease—continues to experience poor outcomes and significant long-term treatment-related morbidity. These challenges highlight the need for novel therapeutic strategies beyond conventional cytotoxic approaches. Growing evidence indicates that WT is characterized by a complex and distinctive tumor microenvironment (TME) shaped by its developmental origin and triphasic histology. Immune cell infiltration, inflammatory mediators, and immune checkpoint pathways interact differently with blastemal, epithelial, and stromal tumor components, generating heterogeneous immune surveillance and escape mechanisms. In particular, tumor-associated macrophages (TAMs), functionally impaired natural killer (NK) cells, and immunosuppressive stromal elements play a central role in shaping an immune milieu that may limit the efficacy of immune-based therapies. Although immunotherapy has changed the management of several adult malignancies and some pediatric cancers, its translation to WT has so far been limited, with modest results in unselected patient populations. Recent immunogenomic and proteogenomic studies, however, suggest the existence of biologically distinct WT subsets with different immune features and potential susceptibility to targeted immunotherapeutic approaches. This narrative review integrates pathological, immunological, and clinical perspectives to summarize current knowledge on the WT immune microenvironment, mechanisms of tumor immune evasion, and emerging immunotherapeutic strategies. By providing a unified framework, it aims at supporting a multidisciplinary approach for the rational development of future immune-based and combination therapies tailored to specific WT subgroups.
Composite Wilms Tumor and Renal Cell Carcinoma
Gordan M. Vujanić, Vera A. Paulson, Laura Galluzzo, Paola Collini, Nilda Gonzalez Roibon, Filippo Spreafico, Anna Mitrofanova, Jeremy Pryce, Michael McDermott, Maureen O’Sullivan, Dicle Orhan, Neil Sebire, Maria Tretiakova
American Journal of Surgical Pathology, 2026
We report the largest series of 18 cases of an uncommon composite renal tumor comprised of Wilms tumor (WT) and renal cell carcinoma (RCC). The tumors were identified by rereviewing WT with “unusual” epithelial components. The age at presentation ranged from 3 months to 11 years (median: 3.7 y), with 13/18 (72%) patients under the age of 5 years, and only 3/18 (17%) older than 10 years of age. There was a striking (2:1) female predominance. All tumors presented as a renal mass that measured from 5 to 18 cm (median 9.3 cm) on gross examination. Histologically, the ratio between WT and RCC components varied from 99%:1% to 5%:95%, respectively. There was a marked prevalence of anaplastic WT (39% vs. ~10% in large cohorts of WTs), and papillary RCC (89% vs. ~20% in large pediatric RCC series). The papillary RCC component included subtypes not previously described in children (biphasic squamoid alveolar RCC and sarcomatoid RCC). Most tumors were stage III (10/18, 56%), which is significantly higher than in large cohorts of WT (~20%). The most common reason for local stage III diagnosis was lymph node metastases with PRCC component (6/11, 55%). Five patients were treated with primary nephrectomy, and 13 with preoperative chemotherapy for WT. Postoperative treatment was tailored according to WT and/or RCC histology and stage. Twelve patients (12/18, 67%) relapsed between 7 months and 12 years after diagnosis (7/12, 58%, within 1 y; there were 2 very late relapses at 5.5 y and 12 y after the diagnosis). In 7/12 (58%) cases, the site of relapses was the lung. Histology of the relapse was available in 10 cases, including 4 cases with both WT and PRCC components, 3 cases with WT component only, 2 cases with RCC component only, and 1 case with WT relapse in the contralateral kidney and PRCC in the lung. Thirteen patients were alive at the last follow-up, including 6 patients who had event-free survival (median follow-up 1.9 y, range 0.4 to 3.1 y) and 7 patients who relapsed but survived (median follow-up 6 y, range 2 to 18 y). All 5 deaths were related to progressing relapsed disease. Immunohistochemical studies allowed RCC subtyping and showed statistically significant differential expression between the WT versus RCC components. In the WT component, we found a higher expression of WT1 ( P =0.007), CD57 ( P =0.002), and SALL4 ( P =0.04), whereas CK7 ( P =0.004) and P504 ( P =0.002) were higher in RCC. Co-expression of WT1 and CD56 was identified in both components in 61% cases, suggesting a close relationship between RCC and WT components. p53 overexpression was present in 5/12 (42%) tested WT and 4 RCC (33%). Molecular studies confirmed the clonal relationship of all paired samples with sufficient neoplastic content for comparison. Recurrent genomic alterations included mutations in TP53 (6/8, 75%) as well as genes involved in the PI3K/mTOR pathway (5/8, 63%) and cell cycle regulation (3/8, 38%). In addition, all tumors with sufficient neoplastic content were negative for microsatellite instability with a low tumor mutation burden. Our study described the characteristics of composite renal tumors combining WT and RCC, highlighting several unusual and specific features. Its behavior appeared to be more aggressive than that of WT or RCC alone, and we propose that it should be recognized as a separate entity, which may require different treatment from WT or RCC alone.
A Finite Element Framework to Study Trauma Risk During Daily Physical Activities on Patients With an Implanted Port-a-Cath
Vittorio Lissoni, Giulia Luraghi, Federica Campagna, Maura Massimino, Carlo Morosi, Filippo Spreafico, Jose Felix Rodriguez Matas
Journal of Medical Devices, 2026
A Port-a-cath is an implantable device placed under the skin to draw blood or deliver treatments such as intravenous fluids, medications, or transfusions. Patients often worry about accidentally hitting the device or nearby tissues, as it slightly protrudes from the skin. This concern can limit participation in daily activities, including sports, affecting quality of life. In this study, we propose a framework to investigate the risk of accidental tissue trauma by simulating a ball impact in the area surrounding an implanted Port-a-cath using finite element analysis. The simulation revealed increased stress in tissues surrounding the device (approximately five times higher in both the skin and the muscle when the device is implanted), suggesting a potential risk for muscle injury upon impact. These findings highlight the need for awareness regarding external forces acting on the Port-a-cath region during physical activity. To our knowledge, this is the first study using biomechanical modeling to explore trauma risk associated with Port-a-cath impacts. This study represents the first attempt to elucidate this risk in the literature. Overall, this study contributes to improving patient safety and quality of life by providing a quantitative understanding of the mechanical risks associated with implanted Port-a-caths.
Second Generation of AHOPCA (Asociación de Hemato-Oncología Pediátrica de Centro América) Treatment Guidelines for Wilms Tumor: A Report of Outcomes
Thelma Velasquez‐Herrera, Patricia Valverde, Soad Fuentes, Armando Peña, Roberta Ortiz, Patricia Calderon, Margarita Montero, Giovanna Gattuso, Jessica Blanco, Magda Arreola, Israel Fernandez‐Pineda, Monika Metzger, Sandra Luna‐Fineman, Judith Wilimas, Filippo Spreafico
Pediatric Blood and Cancer, 2026
Background The AHOPCA (Asociación de Hemato‐Oncología Pediátrica de Centro América) Wilms tumor (WT) treatment guidelines, adapted from NWTS‐4 and ‐5 and recommending upfront nephrectomy (UN), were modified to include 4–6 weeks of preoperative chemotherapy (POC) in frail patients with advanced disease. We aim to describe the outcomes of this implemented approach. Procedure A retrospective analysis of prospectively collected data from newly diagnosed patients with unilateral WT between 2012 and 2018. Results Of 353 eligible patients, 247 (70%) received POC. The POC group had higher initial tumor volume (median 590 mL vs. 308 mL, p < 0.0001) and more Stage IV disease (30% vs. 3%, p < 0.0001) compared to the UN group. During POC, there were 4 deaths, 14 abandonments, and 11 progressive diseases. After response assessment, 62% showed partial tumor response with a median tumor volume reduction to 257 mL. A total of 218 (88.2%) patients underwent nephrectomy. Tumor rupture/spillage occurred in 17.9% of the UN and 18.8% of the POC group; local Stage III was found in 55% of the UN and 68.3% of the POC group. Anaplasia (focal and diffuse) was present in 13.6% (17% UN and 11.9% POC). The 5‐year abandonment‐sensitive event‐free survival (asEFS) and abandonment‐sensitive overall survival (asOS) rates were 69% ± 2.5% and 75% ± 2.4%, respectively. The asEFS rates were 75% ± 4.3% for UN and 66% ± 3.0% for POC ( p = 0.07). Conclusions Many AHOPCA patients presented with unresectable advanced disease, requiring the use of POC. POC effectively reduced tumor volume and facilitated safe surgery in fragile patients. Adopting the standard SIOP WT neoadjuvant approach could enhance staging and risk stratification in AHOPCA.
Long-term adverse effects of modern Wilms tumour therapies: implications for monitoring
Filippo Spreafico, Giovanna Gattuso, Marta G. Podda, Olga Nigro, Valeria Colombo, Sabina Vennarini, Antonio Mastrangelo, Francesca Filippi, Giovanni Montini, Maura Massimino, Monica Terenziani
Nature Reviews Urology, 2026
Stage at Diagnosis and International Survival Variation in Childhood Tumors in the BENCHISTA Study
Laura Botta, Fabio Didonè, Angela Lopez-Cortes, Adela Cañete Nieto, Emmanuel Desandes, Lisa L. Hjalgrim, Zsuzsanna Jakab, Charles A. Stiller, Bernward Zeller, Simon Bailey, Nathalie Gaspar, Filippo Spreafico, Sandra J. Strauss, Gemma Gatta, Kathy Pritchard-Jones, , Joanne Aitken, Leisa O'Neil, Danny Youlden, Monika Hackl, Ruth Ladenstein, Elizabeth Van Eycken, Nancy Van Damme, Beatriz De Camargo, Marceli de Oliveira Santos, Carlos A. Lima, Walmiro Ramos, Lucrecia Aline Cabral Formigosa, Luciana Ferreira dos Santos, Claudina Agnese Casale, Gil Patrus Pena, Juliana Nativio, Cyntia Asturian Laporte, Cristiana Santos de Menezes Miranda, Cristiane Bastos Daniel, Raimunda Nonata de Paulo, Donaldo B. Veneziano, Angela Pontes de Aquino, Paulo Cesar Fernandes de Souza, Rebeca Valentim Leite, Zdravka Valerianova, Dobrin Konstantinov, Sumit Gupta, Jason D. Pole, Jan Stary, Jaroslav Sterba, Lisa L. Hjalgrim, Jeanette Falck Winther, Keiu Paapsi, Brigitte Lacour, Emmanuel Desandes, Jacqueline Clavel, Claire Poulalhon, Meike Ressing, Claudia Truenbach, Claudia Spix, Eleni T. Petridou, Evdoxia Bouka, Zsusanna Jakab, Miklos Garami, Rocco Galasso, Giuseppe Sampietro, Patrizia Piga, Marcella Sessa, Milena M. Maule, Carlotta Sacerdote, Paola Ballotari, Luigino Dal Maso, Antonina Torrisi, Rosalia Ragusa, Luca Boni, Magda Rognomi, Rosalba Amodio, Francesco Cuccaro, Danila Bruno, Antonio G Russo, Federico Gervasi, Maria L. Gambino, Elisabetta Borciani, Maria L. Michiara, Luciana Mangone, Gianbattista Spagnoli, Stefano Ferretti, Fabio Falcini, Eugenia Spata, Sonia Manasse, Paolo Coccia, Fabrizio Stracci, Daniela Piras, Pasquala Pinna, Francesca Bella, Adele Caldarella, Teresa Intrieri, Tiziana Scuderi, William Mantovani, Manuel Zorzi, Stefano Guzzinati, Deidre Murray, Tomohiro Matsuda, Kayo Nakata, Miriam J. Azzopardi, Tom Borge Johannesen, Aina H. Dahlen, Bernward Zeller, Jerzy Kowalczyk, Anna Raciborska, Ana M. Ferreira, Gabriela Caldas, Mihaela Bucurenci, Daniela Coza, Vesna Zadnik, Arantza Lopez de Munain, Fernando Alemda-Vich, Noura Jeghalef-El Karoui, Montse Puigdemonte, Maria Jose Sanchez, Nuria Aragones, David Parra-Blazquez, Maria Dolores Chirlaque, Marcela Guevara, Elena Pardo, Rafael Peris-Bonet, Adela Canete Nieto, Maria Carulla, Päivi Lähteenmäki, Claudia E. Kuehni, Shelagh M. Redmond, Otto Visser, Henrike Karim-Kos, Sarah Stevens, Lucy Irvine, Charles Stiller, Anna Gavin, Deidre Fitzpatrick, Damien Bennett, David S. Morrison, Karen Smith, Dyfed Wyn Huws, Stephanie Smits, Angela Polanco, Giles Greene, Riccardo Capocaccia, Andrea Di Cataldo, Meric Klein
JAMA Network Open, 2026
The use of an augmented reality app to support an exercise intervention for children and young people with cancer: perspectives of users and exercise and healthcare professionals in the FORTEe trial
Hayley Marriott, Alba Solera-Sanchez, Stanley Windsor, Kim Straun, Marie A. Neu, Elias Dreismickenbecker, Francesca Lanfranconi, Emanuele Villa, Joachim Wiskemann, Nikolai Bauer, Miriam Götte, Ronja Beller, Filippo Spreafico, William Zardo, Peter Wright, Joerg Faber, Eila Watson
Frontiers in Pediatrics, 2026
Data-Driven Motion Correction of 11C-Methionine PET Images on a Cohort of Pediatric Patients With Brain Tumor in a PET/MRI Study
Ilaria Neri, Matthew Spangler-Bickell, Federico Fallanca, Giovanna Gattuso, Maurizio Barbera, Samuele Ghezzo, Carolina Bezzi, Paola Mapelli, Sara Pizzamiglio, Paolo Verderio, Andrea Falini, Maura Massimino, Filippo Spreafico, Arturo Chiti, Cristina Baldoli, Maria Picchio, Paola Scifo
IEEE Transactions on Radiation and Plasma Medical Sciences, 2026
Development and Usability of the “FORTEe Get Strong” App to Promote Physical Activity and Health Awareness in Children and Adolescents With Cancer During Intensive Treatment Using an App-Based Approach: Mixed Methods Study
Mareike Kuehn, Lena Wypyrsczyk, Francesca Lanfranconi, Adriana Cristina Balduzzi, Hayley Marriott, Alba Solera-Sanchez, Joachim Wiskemann, Nikolai Bauer, Nina Karguth, Barbara Heißerer, Norbert W Paul, Rodolf Mongondry, Wilhelm Bloch, Katie Rizvi, Martin Kaj Fridh, Eva S C Ramos, Carmen Fiuza-Luces, Miriam Götte, Gabriele Gauß, Filippo Spreafico, Barbara Konda, Milica Stefanović, Elias Dreismickenbecker, Marie A Neu, Joerg Faber, and
Jmir Serious Games, 2026
Pediatric palliative care in patients with brain tumors: Timing, activation, and management of acute events
Olga Nigro, Marta Podda, Elisabetta Schiavello, Veronica Biassoni, Roberto Luksch, Monica Terenziani, Andrea Ferrari, Filippo Spreafico, Michela Casanova, Cristina Meazza, Stefano Chiaravalli, Nadia Puma, Luca Bergamaschi, Giovanna Gattuso, Giovanna Sironi, Valeria Colombo, Igor Catalano, Federico Pellegatta, Francesco Barretta, Sabina Vennarini, Giuseppe Forzini, Maura Massimino
Tumori, 2025
Get strong to fight childhood cancer - an exercise intervention for children and adolescents undergoing anti-cancer treatment (FORTEe): Rationale and design of a randomized controlled exercise trial
Marie Astrid Neu, Elias Dreismickenbecker, Francesca Lanfranconi, Sandra Stössel, Adriana Balduzzi, Peter Wright, Stan Windsor, Joachim Wiskemann, Inaam El-Rajab, Alejandro Lucia, Carmen Fiuza-Luces, Rodolf Mongondry, Martin Kaj Fridh, Filippo Spreafico, Barbara Konda, Lidija Kitanovski, Barbara Heißerer, Marco Polak, Tobias Baader, Wilhelm Bloch, Miriam Götte, , Katie Rizvi, , Christian Ruckes, Norbert W. Paul, Joerg Faber, , Ameli Schwalber, Olivia Pérol, Hanne Bækgaard Larsen, Tommaso Pietro Moriggi, William Zardo, Amandine Bertrand, Lena Wypyrsczyk, Mareike Kühn, Abigale Robinson, Heidi Diel
BMC Cancer, 2025
A Rare Case of Pediatric Translocation Renal Cell Carcinoma Following Medulloblastoma
Francesca Parisi, Valerio Gaetano Vellone, Gabriele Gaggero, Filippo Spreafico, Paola Collini, Virginia Livellara, Gianluca Piccolo, Marta Molteni, Elena Arkhangelskaya, Maria Beatrice Damasio, Stefano Avanzini, Federico Palo, Stefania Sorrentino
Pediatric Blood and Cancer, 2025
Outcome of patients with a first relapse after intermediate- or high-risk Wilms tumor, treated according to SIOP WT 2001/UK-IMPORT study; A report from the SIOP renal tumor study group
Alissa Groenendijk, Harm van Tinteren, Ronald R. de Krijger, Gordan Vujanic, Reem Al-Saadi, Kathy Pritchard-Jones, Gema L. Ramírez-Villar, Patrick Melchior, Jan Godzinski, Jens-Peter Schenk, Norbert Graf, Heidi Segers, Hélène Sudour-Bonnange, Arnauld C. Verschuur, Jarno Drost, Daniela Perotti, Sarah Al-Jilaihawi, Jesper Brok, Marry M. van den Heuvel-Eibrink, Filippo Spreafico, Annelies M.C. Mavinkurve-Groothuis
Urologic Oncology Seminars and Original Investigations, 2025
Remaining Challenges in the Treatment of Relapsed Wilms Tumor: Children's Oncology Group and International Society of Paediatric Oncology Perspectives
Kathryn S. Sutton, Amy L. Walz, Alissa Groenendijk, Andrew J. Murphy, Luke Pater, Geert O. Janssens, Jack Brzezinski, Elizabeth A. Mullen, Filippo Spreafico, Jan Godzinski, Justine van der Beek, Marc HWA Wijnen, Marry M. van den Heuvel‐Eibrink, Max Pachl, Norbert Graf, Peter F. Ehrlich, Rhoikos Furtwangler, Jesper Brok, James Geller
Pediatric Blood and Cancer, 2025
Malignant Peripheral Nerve Sheath Tumor in Children and Adolescents: Local Treatment in a Retrospective Single-Center Experience
Andrea Ferrari, Luca Bergamaschi, Stefano Chiaravalli, Marco Fiore, Chiara Colombo, Emilia Pecori, Arianna Trovò, Carlo Morosi, Roberto Luksch, Monica Terenziani, Filippo Spreafico, Cristina Meazza, Marta Podda, Veronica Biassoni, Elisabetta Schiavello, Nadia Puma, Giovanna Gattuso, Giovanna Sironi, Olga Nigro, Valeria Colombo, Patrizia Gasparini, Sandro Pasquali, Maura Massimino, Michela Casanova, Sabina Vennarini
Pediatric Blood and Cancer, 2025
Pediatric Craniofacial Osteosarcoma: The Milano Experience
Cristina Meazza, Francesca Parisi, Francesco Barretta, Giovanna Sironi, Olga Nigro, Carlo Morosi, Roberto Luksch, Marta Podda, Andrea Ferrari, Monica Terenziani, Filippo Spreafico, Michela Casanova, Veronica Biassoni, Elisabetta Schiavello, Antonina Parafioriti, Paola Collini, Stefano Chiaravalli, Nadia Puma, Luca Bergamaschi, Giovanna Gattuso, Valeria Colombo, Sabina Vennarini, Emilia Pecori, Marco Guzzo, Sarah Colombo, Arianna Trovò, Maura Massimino
Pediatric Blood and Cancer, 2025
Hallmark discoveries in the biology of non-Wilms tumour childhood kidney cancers
Daniela Perotti, Maureen J. O’Sullivan, Amy L. Walz, Jonathan Davick, Reem Al-Saadi, Daniel J. Benedetti, Jack Brzezinski, Sara Ciceri, Nicholas G. Cost, Jeffrey S. Dome, Jarno Drost, Nicholas Evageliou, Rhoikos Furtwängler, Norbert Graf, Mariana Maschietto, Elizabeth A. Mullen, Andrew J. Murphy, Michael V. Ortiz, Justine N. van der Beek, Arnauld Verschuur, Jenny Wegert, Richard Williams, Filippo Spreafico, James I. Geller, Marry M. van den Heuvel-Eibrink, Andrew L. Hong
Nature Reviews Urology, 2025
Assessment of Clinical and Neurological Alterations Before Radiation Therapy in Children With Malignant Brain Tumours
M. Lecchi, A. Erbetta, P. Grampa, C. Cavatorta, S. Meroni, A. Nigri, F. Spreafico, E. Pecori, M.C. Oprandi, V. Biassoni, E. Schiavello, D. Peruzzo, R. Laureanti, L. Mainardi, S. Vennarini, G. Poggi, O. Nigro, P. Verderio, E. Pignoli, M. Massimino
Clinical Oncology, 2025
Challenges and Opportunities of a Multi-Institutional Treatment Guideline for Wilms Tumor in Low-Middle-Income Countries—A Report From the Asociación de Hemato-Oncología Pediátrica de Centro América (AHOPCA)
Patricia Valverde, Thelma Velasquez, Roberta Ortiz, Soad Linneth Fuentes‐Alabi, Armando Peña, José Fernando Gonzalez, Tito Luis Gutierrez, Luis Enrique Melendez, Enrique Tome, Magda Arreola, Maria Grazia Valsecchi, Valeria Colombo, Sandra Luna‐Fineman, Jessica Blanco‐Lopez, Monika L. Metzger, Filippo Spreafico
Pediatric Blood and Cancer, 2025
Long-term outcome of the Milano-hyperfractionated accelerated radiotherapy strategy for high-risk medulloblastoma, including the impact of molecular subtype
Maura Massimino, Francesco Barretta, Chiara Dossena, Simone Minasi, Francesca Romana Buttarelli, Veronica Biassoni, Matilde Oriani, Elisabetta Schiavello, Marica Ficorilli, Olga Nigro, Bianca Pollo, Manila Antonelli, Vittoria Donofrio, Marco Maggioni, Marcel Kool, Emilia Pecori, Sabina Vennarini, Felice Giangaspero, Francesca Gianno, Alessandra Erbetta, Luisa Chiapparini, Roberto Luksch, Elena Barzanò, Cristina Meazza, Marta Podda, Filippo Spreafico, Monica Terenziani, Luca Bergamaschi, Andrea Ferrari, Michela Casanova, Stefano Chiaravalli, Giovanna Gattuso, Piergiorgio Modena, Simon Bailey, Loris De Cecco
Neuro Oncology, 2025
Children and adolescent solid tumours and high-intensity end-of-life care: what can be done to reduce acute care admissions?
Marta Giorgia Podda, Elisabetta Schiavello, Carlo Alfredo Clerici, Roberto Luksch, Monica Terenziani, Andrea Ferrari, Michela Casanova, Filippo Spreafico, Cristina Meazza, Veronica Biassoni, Stefano Chiaravalli, Nadia Puma, Luca Bergamaschi, Giovanna Gattuso, Giovanna Sironi, Olga Nigro, Maura Massimino
BMJ Supportive and Palliative Care, 2024
Outcome after treatment with axitinib in children, young adults, and adults with renal cell carcinoma: a narrative review
Julia Sprokkerieft, Justine N. van der Beek, Filippo Spreafico, Barbara Selle, Tanzina Chowdhury, Norbert Graf, Arnauld C. Verschuur, Rana Dandis, Axel Bex, James I. Geller, Godelieve A.M. Tytgat, Marry M. van den Heuvel-Eibrink
Critical Reviews in Oncology Hematology, 2024
Foreign patients and multicultural challenges in pediatric oncology: The experience of the Istituto Nazionale dei Tumori in Milan
Martina Lombardi, Matteo Silva, Monica Giovanetti, Daniele Cabibbe, Roberto Luksch, Monica Terenziani, Michela Casanova, Filippo Spreafico, Cristina Meazza, Marta Podda, Veronica Biassoni, Elisabetta Schiavello, Stefano Chiaravalli, Nadia Puma, Luca Bergamaschi, Giovanna Gattuso, Olga Nigro, Giovanna Sironi, Valeria Colombo, Andrea Ferrari, Maura Massimino, Carlo Alfredo Clerici
Pediatric Blood and Cancer, 2024
Widening the spectrum of players affected by genetic changes in Wilms tumor relapse
Sara Ciceri, Alessia Bertolotti, Annalisa Serra, Giovanna Gattuso, Luna Boschetti, Maria Capasso, Cecilia Cecchi, Stefania Sorrentino, Paola Quarello, Chiara Maura Ciniselli, Paolo Verderio, Loris De Cecco, Giacomo Manenti, Francesca Diomedi Camassei, Paola Collini, Filippo Spreafico, Daniela Perotti
Iscience, 2024
Caring for children with cancer evacuated from Ukraine: The patients’ perception
Marcello Bolognese, Maura Massimino, Daniele Cabibbe, Marco Zecca, Marta Fornara, Mariangela Armiraglio, Roman Kyzima, Roberto Luksch, Monica Terenziani, Michela Casanova, Filippo Spreafico, Cristina Meazza, Marta Podda, Veronica Biassoni, Elisabetta Schiavello, Stefano Chiaravalli, Nadia Puma, Shushan Hovsepyan, Luca Bergamaschi, Giovanna Gattuso, Olga Nigro, Paolo Grampa, Annarita Adduci, Andrea Ferrari, Carlo Alfredo Clerici
Pediatric Blood and Cancer, 2024
General support of physical exercise programs in pediatric oncology but differences in perception by childhood cancer care professionals at European and North-African/Arab centers
Moatasem El-Ayadi, Kyra Druivenga, Thomas Perwein, Gunther Nussbaumer, Filippo Spreafico, Maura Massimino, Shady Fadel, Nisreen Amayiri, Nisrine Khoubila, Laila Hessissen, Omar Chamdine, Natàlia Rodríguez, Gemma Calaf Valls, Andres Morales la Madrid, Christine Dahl, Darren Hargrave, Elwira Szychot, Simon Bailey, Dannis G. van Vuurden, Martin Benesch, Ina Hunger, Ingrid Kühnle, Simone Mascher, Albane Bertha Rosa Maggio, André O. von Bueren, Christof M. Kramm
Ejc Paediatric Oncology, 2024
Diagnostic magnetic resonance imaging characteristics of congenital mesoblastic nephroma: a retrospective multi-center International Society of Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG) radiology panel study
Justine N. van der Beek, Jens-Peter Schenk, Carlo Morosi, Tom A. Watson, Ana Coma, Norbert Graf, Tanzina Chowdhury, Gema L. Ramírez-Villar, Filippo Spreafico, Nils Welter, Kristina Dzhuma, Harm van Tinteren, Ronald R. de Krijger, Marry M. van den Heuvel-Eibrink, Annemieke S. Littooij
Pediatric Radiology, 2024
Most appropriate surgical approach in children with Wilms tumour, risk of kidney disease, and related considerations
Filippo Spreafico, Davide Biasoni, Giovanni Montini
Pediatric Nephrology, 2024
Local treatment in initially unresected non-rhabdomyosarcoma soft-tissue sarcomas of children and adolescents: A retrospective single-center experience
Andrea Ferrari, Sabina Vennarini, Marco Fiore, Luca Bergamaschi, Stefano Chiaravalli, Carlo Morosi, Chiara Colombo, Emilia Pecori, Nadia Puma, Roberto Luksch, Monica Terenziani, Filippo Spreafico, Cristina Meazza, Marta Podda, Veronica Biassoni, Elisabetta Schiavello, Maura Massimino, Michela Casanova
Pediatric Blood and Cancer, 2024
Childhood cancer survivors: improving our practice today to reduce late, major surgical interventions tomorrow
Olga Nigro, Giovanna Gattuso, Giovanna Sironi, Marta Podda, Elisabetta Schiavello, Filippo Spreafico, Monica Terenziani
Translational Pediatrics, 2024
Bevacizumab-containing treatment for relapsed or refractory Wilms tumor
Sarah Al-Jilaihawi, Filippo Spreafico, Annelies Mavinkurve-Groothuis, Jarno Drost, Daniela Perotti, Christa Koenig, Jesper Brok
Expert Review of Anticancer Therapy, 2024
A Gradual Transition Toward Anaplasia in Wilms Tumor Through Tolerance to Genetic Damage
Kaname Uno, Bahar Rastegar, Caroline Jansson, Geoffroy Durand, Anders Valind, Subhayan Chattopadhyay, Alessia Bertolotti, Sara Ciceri, Filippo Spreafico, Paola Collini, Daniela Perotti, Linda Holmquist Mengelbier, David Gisselsson
Modern Pathology, 2024
Targeted therapies in children with renal cell carcinoma (RCC): An International Society of Pediatric Oncology—Renal Tumor Study Group (SIOP-RTSG)-related retrospective descriptive study
Julia Sprokkerieft, Justine N. van der Beek, Filippo Spreafico, Barbara Selle, Estelle Thebaud, Tanzina Chowdhury, Jesper Brok, Gábor Ottóffy, Xiaofei Sun, Gema L. Ramírez Villar, Garik Sagoyan, Heidi Segers, Dimitrios Doganis, Annalisa Serra, Lauriane Lemelle, Norbert Graf, Arnauld C. Verschuur, Godelieve A. M. Tytgat, Marry M. van den Heuvel‐Eibrink
Cancer Medicine, 2024
Impact of a Regional Pediatric Hematology/Oncology Fellowship Program in Guatemala
Daniel C. Moreira, Claudia Garrido, Roy Rosado, Verónica Girón, Tomás Letona, Gerson Morales, Patricia Valverde, Thelma Velásquez, Jeanine Alfaro, Elizabeth Orellana, Miguel Angel Ortega, Paola Salguero, Leeanna Fox Irwin, Allyson Andujar, Pedro A. de Alarcón, Sandra Luna-Fineman, Marilyn Manco-Johnson, Valentino Conter, Marta Verna, Marta Canesi, Maura Massimino, Filippo Spreafico, Andrea Ferrari, Pascale Y. Gassant, Roberto Vásquez, Paola Friedrich, Ricardo Mack, Raul Ribeiro, Monika L. Metzger, Carlos Rodriguez-Galindo, Federico Antillón-Klussmann
JCO Global Oncology, 2024
Diagnostic MRI characteristics of pediatric clear cell sarcoma of the kidney and rhabdoid tumor of the kidney: A retrospective multi-center SIOP-RTSG Radiology panel study
Justine N. van der Beek, Jens-Peter Schenk, Tom A. Watson, Ana Coma, Carlo Morosi, Norbert Graf, Tanzina Chowdhury, Gema L. Ramírez-Villar, Filippo Spreafico, Kristina Dzhuma, Lidwine B. Mokkink, Ronald R. de Krijger, Marry M. van den Heuvel-Eibrink, Annemieke S. Littooij
Ejc Paediatric Oncology, 2023
End-of-Life transfusion support at hospice and pediatric oncology unit: Bridging the gap between benefits and therapeutic alliance
Olga Nigro, Marta G Podda, Federico Pellegatta, Elisabetta Schiavello, Carlo A Clerici, Igor Catalano, Giovanna Visconti, Marco Albarini, Roberto Luksch, Monica Terenziani, Andrea Ferrari, Michela Casanova, Veronica Biassoni, Cristina Meazza, Filippo Spreafico, Giovanna Gattuso, Giovanna Sironi, Nadia Puma, Luca Bergamaschi, Stefano Chiaravalli, Maura Massimino
Tumori, 2023
Treating secondary malignant neoplasms: A burden of childhood cancer survivors
Marta G Podda, Cristina Meazza, Giovanna Gattuso, Giovanna Sironi, Olga Nigro, Luca Bergamaschi, Veronica Biassoni, Michela Casanova, Stefano Chiaravalli, Andrea Ferrari, Roberto Luksch, Nadia Puma, Elisabetta Schiavello, Filippo Spreafico, Paolo Grampa, Siranoush Manoukian, Sabina Vennarini, Paola Collini, Primo A Daolio, Massimiliano Gennaro, Marco Guzzo, Carlo Morosi, Davide Biasoni, Maura Massimino, Monica Terenziani
Tumori, 2023
Impact of the COVID-19 pandemic on paediatric renal tumour presentation and management, a SIOP renal tumour study group study
Prakriti Roy, Sophie E. van Peer, Rana Dandis, Catriona Duncan, Joaquim Caetano de Aguirre‐Neto, Arnauld Verschuur, Beatriz de Camargo, Henrike E. Karim‐Kos, Luna Boschetti, Filippo Spreafico, Gema L. Ramirez‐Villar, Norbert Graf, Harm van Tinteren, Kathy Pritchard‐Jones, Marry M. van den Heuvel‐Eibrink
Cancer Medicine, 2023
Advances in the clinical management of high-risk Wilms tumors
Michael V. Ortiz, Christa Koenig, Amy E. Armstrong, Jesper Brok, Beatriz de Camargo, Annelies M. C. Mavinkurve‐Groothuis, Thelma B. Velasquez Herrera, Rajkumar Venkatramani, Andrew D. Woods, Jeffrey S. Dome, Filippo Spreafico
Pediatric Blood and Cancer, 2023
Should we reduce routine surveillance imaging in pediatric germ cell tumors?
Monica Terenziani, Francesco Barretta, Giovanna Gattuso, Gianni Bisogno, Massimo Conte, Alessandro Crocoli, Maria Debora De Pasquale, Davide Biasoni, Filippo Spreafico, Paolo D'Angelo
Pediatric Blood and Cancer, 2023
Advances in the clinical management of high-risk Wilms tumors
Michael V. Ortiz, Christa Koenig, Amy E. Armstrong, Jesper Brok, Beatriz de Camargo, Annelies M. C. Mavinkurve‐Groothuis, Thelma B. Velasquez Herrera, Rajkumar Venkatramani, Andrew D. Woods, Jeffrey S. Dome, Filippo Spreafico
Pediatric Blood and Cancer, 2023
Implications of an Underlying Beckwith–Wiedemann Syndrome for Wilms Tumor Treatment Strategies
Paola Quarello, Diana Carli, Davide Biasoni, Simona Gerocarni Nappo, Carlo Morosi, Roberta Cotti, Emanuela Garelli, Giulia Zucchetti, Manuela Spadea, Elisa Tirtei, Filippo Spreafico, Franca Fagioli
Cancers, 2023
Molecular Signature of Biological Aggressiveness in Clear Cell Sarcoma of the Kidney (CCSK)
Michele Fiore, Alberto Taddia, Valentina Indio, Salvatore Nicola Bertuccio, Daria Messelodi, Salvatore Serravalle, Jessica Bandini, Filippo Spreafico, Daniela Perotti, Paola Collini, Andrea Di Cataldo, Gianandrea Pasquinelli, Francesca Chiarini, Maura Fois, Fraia Melchionda, Andrea Pession, Annalisa Astolfi
International Journal of Molecular Sciences, 2023
Relapse after non-metastatic rhabdomyosarcoma: The impact of routine surveillance imaging on early detection and post-relapse survival
Michela Casanova, Luca Bergamaschi, Stefano Chiaravalli, Carlo Morosi, Virginia Livellara, Shushan Hovsepyan, Giovanna Sironi, Nadia Puma, Olga Nigro, Giovanna Gattuso, Roberto Luksch, Monica Terenziani, Filippo Spreafico, Cristina Meazza, Marta Podda, Veronica Biassoni, Elisabetta Schiavello, Patrizia Gasparini, Sabina Vennarini, Maura Massimino, Andrea Ferrari
Pediatric Blood and Cancer, 2023
Recommending exercise and sports for children and adolescents with a solitary kidney after a renal tumor: A view on current evidence-based risks and decisions
Filippo Spreafico, Olga Nigro, Giovanna Gattuso, Virginia Livellara, Giovanna Sironi, Marco Chisari, Francesca Lanfranconi, Michele Murelli, Matteo Silva, Jose F. Rodriguez-Matas, Monica Terenziani, Maura Massimino
Ejc Paediatric Oncology, 2023
Adolescents and young adults with cancer: Surfing the web to know and manage their disease
Annarita Adduci, Paolo Grampa, Francesco Barretta, Giovanna Sironi, Matteo Silva, Roberto Luksch, Monica Terenziani, Michela Casanova, Filippo Spreafico, Cristina Meazza, Marta Podda, Veronica Biassoni, Elisabetta Schiavello, Stefano Chiaravalli, Carlo Alfredo Clerici, Maura Massimino, Andrea Ferrari
Ejc Paediatric Oncology, 2023
Relapse after nonmetastatic rhabdomyosarcoma: Salvage rates and prognostic variables
Luca Bergamaschi, Stefano Chiaravalli, Virginia Livellara, Giovanna Sironi, Nadia Puma, Olga Nigro, Giovanna Gattuso, Roberto Luksch, Monica Terenziani, Filippo Spreafico, Cristina Meazza, Marta Podda, Veronica Biassoni, Elisabetta Schiavello, Shushan Hovsepyan, Carlo Morosi, Sabina Vennarini, Maura Massimino, Michela Casanova, Andrea Ferrari
Pediatric Blood and Cancer, 2023
Secondary osteosarcoma: a challenge indeed
Cristina Meazza, Sironi Giovanna, Olga Nigro, Giovanna Gattuso, Barretta Francesco, Marta Podda, Roberto Luksch, Veronica Biassoni, Elisabetta Schiavello, Andrea Ferrari, Filippo Spreafico, Michela Casanova, Stefano Chiaravalli, Nadia Puma, Luca Bergamaschi, Virginia Livellara, Morosi Carlo, Antonina Parafioriti, Primo Daolio, Stefano Bastoni, Sabina Vennarini, Emilia Pecori, Ombretta Alessandro, Paola Collini, Maura Massimino, Monica Terenziani
International Journal of Clinical Oncology, 2023
Cancer data quality and harmonization in Europe: the experience of the BENCHISTA Project – international benchmarking of childhood cancer survival by stage
Angela Lopez-Cortes, Fabio Didonè, Laura Botta, Lisa L. Hjalgrim, Zsuzsanna Jakab, Adela Cañete Nieto, Charles Stiller, Bernward Zeller, Gemma Gatta, Kathy Pritchard-Jones, The BENCHISTA Project Working Group
Frontiers in Oncology, 2023
Gene expression-based dissection of inter-histotypes, intra-histotype and intra-tumor heterogeneity in pediatric tumors
Sara Ciceri, Andrea Carenzo, Maria Federica Iannó, Alessia Bertolotti, Carlo Morosi, Roberto Luksch, Filippo Spreafico, Paola Collini, Paolo Radice, Maura Massimino, Loris De Cecco, Daniela Perotti
Scientific Reports, 2022
Prolonged COVID-19 infection in a child with lymphoblastic non-Hodgkin lymphoma: which is the best management?
Giovanna Gattuso, Elisabetta Schiavello, Chiara Oltolini, Veronica Biassoni, Monica Terenziani, Stefano Chiaravalli, Marta Giorgia Podda, Cristina Meazza, Roberto Luksch, Andrea Ferrari, Michela Casanova, Giovanna Sironi, Luca Bergamaschi, Nadia Puma, Filippo Spreafico, Maura Massimino
Tumori, 2022
Essential medicines for childhood cancer in Europe: a pan-European, systematic analysis by SIOPE
Maria Otth, Eva Brack, Pamela R Kearns, Olga Kozhaeva, Marko Ocokoljic, Reineke A Schoot, Gilles Vassal, Federica Achini, Adriana Balduzzi, Maja Beck Popovic, Auke Beishuizen, Luca Bergamaschi, Andrea Biondi, Franck Bourdeaut, Elena Braicu, Jesper Brok, Laurence Brugières, Amos Burke, Gabriele Calaminus, Michela Casanova, Marie-Louise Choucair, Morgane Cleirec, Selim Corbaciouglu, Maria Genoveva Correa Llano, Teresa De Rojas, Nerea Domínguez Pinilla, Caroline Elmaraghi, Andrea Ferrari, Alexander Fossa, Nathalie Gaspar, Nikolas Herold, Kyriaki Karapiperi, Maarja Karu, Mimi Kjærsgaar, Fabian Knörr, Christa Koenig, Izabela Kranjcec, Malgorzata Krawczyk, Kai Lehmberg, Thomas Lehrnbecher, Maaike Lunesink, Davide Massano, Nuša Matijasic, Hans Merks, Markus Metzler, Anthony Michalski, Milen Minkov, Bruce Morland, Naghmeh Niktoreh, Elena Oltenau, Daniel Orbach, Cormac Owens, Smaragda Papachristidou, Claudia Pasqualini, Maja Pavlovic, Paula Perez Albert, Fiona Poyer, Ivana Radulovic, Dirk Reinhardt, Joana Rebelo, Eva Roser, Ida Russo, Katrin Scheinemann, Christina Schindera, Martin Schrappe, Astrid Sehested, Jalid Sehouli, Filippo Spreafico, Sandra J Strauss, Janine Stutterheim, Karel Svojgr, Vasiliki Tzotzola, Roelof Van Ewijk, Arnauld Verschuur, Ajay Vora, Willi Woessmann, Olga Zajac-Spychala, Michel Zwaan
Lancet Oncology, 2022
Palliative sedation in paediatric solid tumour patients: choosing the best drugs
Marta Giorgia Podda, Elisabetta Schiavello, Olga Nigro, Carlo Alfredo Clerici, Fabio Simonetti, Roberto Luksch, Monica Terenziani, Andrea Ferrari, Michela Casanova, Filippo Spreafico, Cristina Meazza, Stefano Chiaravalli, Veronica Biassoni, Giovanna Gattuso, Nadia Puma, Luca Bergamaschi, Givanna Sironi, Maura Massimino
BMJ Supportive and Palliative Care, 2022
Relapsing pediatric non-rhabdomyosarcoma soft tissue sarcomas: The impact of routine imaging surveillance on early detection and post-relapse survival
Carlo Morosi, Luca Bergamaschi, Virginia Livellara, Vittoria Hassan, Stefano Chiaravalli, Giuseppina Calareso, Roberto Luksch, Monica Terenziani, Filippo Spreafico, Cristina Meazza, Marta Podda, Veronica Biassoni, Elisabetta Schiavello, Nadia Puma, Giovanna Gattuso, Giovanna Sironi, Olga Nigro, Sabina Vennarini, Maura Massimino, Michela Casanova, Andrea Ferrari
European Journal of Cancer, 2022
Ultra Short Course Chemotherapy for Early-Stage Non-Hodgkin’s Lymphoma in Children
Elisabetta Schiavello, Filippo Spreafico, Francesco Barretta, Giulia Meraviglia, Veronica Biassoni, Monica Terenziani, Luna Boschetti, Giovanna Gattuso, Stefano Chiaravalli, Luca Bergamaschi, Nadia Puma, Giovanna Sironi, Olga Nigro, Marta Podda, Cristina Meazza, Michela Casanova, Andrea Ferrari, Roberto Luksch, Maura Massimino
Children, 2022
How ten-years of reirradiation for paediatric high-grade glioma may shed light on first line treatment
Maura Massimino, Sabina Vennarini, Francesco Barretta, Francesca Colombo, Manila Antonelli, Bianca Pollo, Emanuele Pignoli, Emilia Pecori, Ombretta Alessandro, Elisabetta Schiavello, Luna Boschetti, Marta Podda, Nadia Puma, Giovanna Gattuso, Giovanna Sironi, Elena Barzanò, Olga Nigro, Luca Bergamaschi, Stefano Chiaravalli, Roberto Luksch, Cristina Meazza, Filippo Spreafico, Monica Terenziani, Michela Casanova, Andrea Ferrari, Marco Chisari, Chiara Pellegrini, Carlo Alfredo Clerici, Piergiorgio Modena, Veronica Biassoni
Journal of Neuro Oncology, 2022
Adult-type non-rhabdomyosarcoma soft tissue sarcomas in pediatric age: Salvage rates and prognostic factors after relapse
Stefano Chiaravalli, Luca Bergamaschi, Virginia Livellara, Giovanna Sironi, Nadia Puma, Olga Nigro, Giovanna Gattuso, Roberto Luksch, Monica Terenziani, Filippo Spreafico, Cristina Meazza, Marta Podda, Veronica Biassoni, Elisabetta Schiavello, Carlo Morosi, Maura Massimino, Michela Casanova, Andrea Ferrari
European Journal of Cancer, 2022
Finding the way to Wilms tumor by comparing the primary and relapse tumor samples
Filippo Spreafico, Sara Ciceri, Daniela Perotti
Cell Reports Medicine, 2022
Caring for children with cancer evacuated from Ukraine
Maura Massimino, Giovanna Casiraghi, Mariangela Armiraglio, Daniele Cabibbe, Roberto Luksch, Monica Terenziani, Michela Casanova, Filippo Spreafico, Cristina Meazza, Marta Podda, Veronica Biassoni, Elisabetta Schiavello, Stefano Chiaravalli, Nadia Puma, Luca Bergamaschi, Giovanna Gattuso, Giovanna Sironi, Olga Nigro, Virginia Livellara, Shushan Hovsepyan, Andrea Ferrari, Carlo Alfredo Clerici
Lancet Child and Adolescent Health, 2022
Renal cell carcinoma in children and adolescents: a retrospective study of a French–Italian series of 93 cases
Thomas Denize, Simona Massa, Alexander Valent, Lucia Militti, Alessia Bertolotti, Marta Barisella, Nathalie Rioux‐Leclercq, Gabriel G Malouf, Filippo Spreafico, Arnauld Verschuur, Justine van der Beek, Lieve Tytgat, Marry M van den Heuvel‐Eibrink, Gordan Vujanic, Paola Collini, Aurore Coulomb
Histopathology, 2022
Extraosseous Ewing sarcoma in children and adolescents: A retrospective series from a referral pediatric oncology center
Virginia Livellara, Luca Bergamaschi, Nadia Puma, Stefano Chiaravalli, Marta Podda, Michela Casanova, Patrizia Gasparini, Emilia Pecori, Ombretta Alessandro, Olga Nigro, Giovanna Sironi, Giovanna Gattuso, Monica Terenziani, Filippo Spreafico, Cristina Meazza, Veronica Biassoni, Elisabetta Schiavello, Maura Massimino, Roberto Luksch, Andrea Ferrari
Pediatric Blood and Cancer, 2022
Managing Care during the COVID-19 Pandemic: The Point of View and Fears of Pediatric Cancer Patients’ Families
Olga Nigro, Giovanna Sironi, Andrea Ferrari, Gabriele Tinè, Gabriele Infante, Francesco Barretta, Matteo Silva, Carlo Alfredo Clerici, Stefano Chiaravalli, Elisabetta Schiavello, Veronica Biassoni, Marta Podda, Cristina Meazza, Filippo Spreafico, Michela Casanova, Monica Terenziani, Roberto Luksch, Maura Massimino
Children, 2022
Outcome of SIOP patients with low- or intermediate-risk Wilms tumour relapsing after initial vincristine and actinomycin-D therapy only − the SIOP 93–01 and 2001 protocols
Alissa Groenendijk, Harm van Tinteren, Yilin Jiang, Ronald R. de Krijger, Gordan M. Vujanic, Jan Godzinski, Christian Rübe, Jens-Peter Schenk, Carlo Morosi, Kathy Pritchard-Jones, Reem Al-Saadi, Sucheta J. Vaidya, Arnauld C. Verschuur, Gema L. Ramírez-Villar, Norbert Graf, Beatriz de Camargo, Jarno Drost, Daniela Perotti, Marry M. van den Heuvel-Eibrink, Jesper Brok, Filippo Spreafico, Annelies M.C. Mavinkurve-Groothuis
European Journal of Cancer, 2022
Recommending exercise for children with a single kidney
Filippo Spreafico, Giovanna Gattuso, Olga Nigro, Monica Terenziani, Maura Massimino
Nature Reviews Urology, 2022
Langerhans cell histiocytosis in adults: a retrospective, single-center case series
Stefano Chiaravalli, Andrea Ferrari, Luca Bergamaschi, Nadia Puma, Giovanna Gattuso, Giovanna Sironi, Olga Nigro, Virginia Livellara, Elisabetta Schiavello, Veronica Biassoni, Marta Podda, Cristina Meazza, Filippo Spreafico, Michela Casanova, Monica Terenziani, Roberto Luksch, Maura Massimino
Annals of Hematology, 2022
Rare Tumors of the Urinary Tract
Filippo Spreafico, Norbert Graf
Pediatric Oncology, 2022
Clinical heterogeneity and reduced penetrance in DICER1 syndrome: a report of three families
Jacopo Azzollini, Andrea Ferrari, Alessandra Stracuzzi, Stefano Chiaravalli, Monica Terenziani, Filippo Spreafico, Maurizia Grasso, Paola Collini, Valeria Pensotti, Maura Massimino, Eloisa Arbustini, Siranoush Manoukian
Tumori, 2021
Wilms tumour
Filippo Spreafico, Conrad V. Fernandez, Jesper Brok, Kayo Nakata, Gordan Vujanic, James I. Geller, Manfred Gessler, Mariana Maschietto, Sam Behjati, Angela Polanco, Vivian Paintsil, Sandra Luna-Fineman, Kathy Pritchard-Jones
Nature Reviews Disease Primers, 2021
Fertility counseling in survivors of cancer in childhood and adolescence: time for a reappraisal?
Francesca Filippi, Fedro Peccatori, Siranoush Manoukian, Carlo Alfredo Clerici, Chiara Dallagiovanna, Cristina Meazza, Marta Podda, Edgardo Somigliana, Filippo Spreafico, Maura Massimino, Monica Terenziani
Cancers, 2021
Fifty years of clinical and research studies for childhood renal tumors within the International Society of Pediatric Oncology (SIOP)
N. Graf, C. Bergeron, J. Brok, B. de Camargo, T. Chowdhury, R. Furtwängler, M. Gessler, J. Godzinski, K. Pritchard-Jones, G.L. Ramirez-Villar, C. Rübe, B. Sandstedt, J.-P. Schenk, F. Spreafico, H. Sudour-Bonnange, H. van Tinteren, A. Verschuur, G. Vujanic, M.M. van den Heuvel-Eibrink
Annals of Oncology, 2021
Adolescents with cancer on privacy: Fact-finding survey on the need for confidentiality and space
Matteo Silva, Francesco Barretta, Roberto Luksch, Monica Terenziani, Michela Casanova, Filippo Spreafico, Cristina Meazza, Marta Podda, Veronica Biassoni, Elisabetta Schiavello, Stefano Chiaravalli, Nadia Puma, Luca Bergamaschi, Giovanna Gattuso, Giovanna Sironi, Annarita Adduci, Paolo Grampa, Maura Massimino, Andrea Ferrari
Tumori, 2021
Wilms tumour occurring in a patient with osteopathia striata with cranial sclerosis: A still unsolved biological question
Paola Quarello, Daniela Perotti, Diana Carli, Elisa Giorgio, Fabio Sirchia, Alfredo Brusco, Giovanni Battista Ferrero, Alessandro Mussa, Manuela Spadea, Sara Ciceri, Filippo Spreafico, Franca Fagioli
Pediatric Blood and Cancer, 2021
Analysis of the mutational status of SIX1/2 and microRNA processing genes in paired primary and relapsed Wilms tumors and association with relapse
Sara Ciceri, Rafaela Montalvão-de-Azevedo, Amir Tajbakhsh, Alessia Bertolotti, Rosalin Dolores Spagnuolo, Luna Boschetti, Maria Capasso, Paolo D’Angelo, Annalisa Serra, Francesca Diomedi-Camassei, Mariaclaudia Meli, Marilina Nantron, Paola Quarello, Anna Maria Buccoliero, Angela Tamburini, Chiara Maura Ciniselli, Paolo Verderio, Paola Collini, Paolo Radice, Filippo Spreafico, Daniela Perotti
Cancer Gene Therapy, 2021
Correlation between oncological family history and clinical outcome in a large monocentric cohort of pediatric patients with rhabdomyosarcoma
Valentina Sottili, Stefano Signoroni, Francesco Barretta, Jacopo Azzollini, Siranoush Manoukian, Roberto Luksch, Monica Terenziani, Michela Casanova, Filippo Spreafico, Cristina Meazza, Marta Podda, Veronica Biassoni, Elisabetta Schiavello, Stefano Chiaravalli, Maura Massimino, Patrizia Gasparini, Andrea Ferrari
International Journal of Clinical Oncology, 2021
Prognostic factors for wilms tumor recurrence: A review of the literature
Alissa Groenendijk, Filippo Spreafico, Ronald R. de Krijger, Jarno Drost, Jesper Brok, Daniela Perotti, Harm van Tinteren, Rajkumar Venkatramani, Jan Godziński, Christian Rübe, James I. Geller, Norbert Graf, Marry M. van den Heuvel-Eibrink, Annelies M. C. Mavinkurve-Groothuis
Cancers, 2021
Positive Impact of Organized Physical Exercise on Quality of Life and Fatigue in Children and Adolescents With Cancer
Filippo Spreafico, Francesco Barretta, Michele Murelli, Marco Chisari, Giovanna Gattuso, Monica Terenziani, Andrea Ferrari, Laura Veneroni, Cristina Meazza, Maura Massimino
Frontiers in Pediatrics, 2021
Experiencing Social Isolation (Even in the Era of COVID-19 Pandemic Lockdown): Teachings through Arts from Adolescents with Cancer
Andrea Ferrari, Elena Pagani Bagliacca, Laura Veneroni, Matteo Silva, Patrizia Gasparini, Stefano Signoroni, Roberto Luksch, Monica Terenziani, Michela Casanova, Filippo Spreafico, Cristina Meazza, Marta Podda, Veronica Biassoni, Elisabetta Schiavello, Stefano Chiaravalli, Carlo Alfredo Clerici, Maura Massimino
Journal of Adolescent and Young Adult Oncology, 2021
Medulloblastoma and familial adenomatous polyposis: Good prognosis and good quality of life in the long-term?
Maura Massimino, Stefano Signoroni, Luna Boschetti, Luisa Chiapparini, Alessandra Erbetta, Veronica Biassoni, Elisabetta Schiavello, Andrea Ferrari, Filippo Spreafico, Monica Terenziani, Stefano Chiaravalli, Nadia Puma, Luca Bergamaschi, Maria Teresa Ricci, Laura Cattaneo, Giovanna Gattuso, Francesca Romana Buttarelli, Francesca Gianno, Evelina Miele, Geraldina Poggi, Marco Vitellaro
Pediatric Blood and Cancer, 2021
Diagnostic yield and accuracy of image-guided percutaneous core needle biopsy of paediatric solid tumours: An experience from Italy
Lisa Serati, Carlo Morosi, Francesco Barretta, Paola Collini, Giuseppina Calareso, Stefano Chiaravalli, Filippo Spreafico, Roberto Luksch, Andrea Ferrari, Maura Massimino, Alfonso Marchianò
Pediatric Hematology Oncology Journal, 2021
Malignant sacrococcygeal germ cell tumors in childhood: The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience
Paolo D'Angelo, Maria Debora De Pasquale, Francesco Barretta, Maria Carmen Affinita, Massimo Conte, Patrizia Dall'Igna, Andrea Di Cataldo, Alessandro Inserra, Massimo Provenzi, Lucia Quaglietta, Giovanna Riccipetitoni, Filippo Spreafico, Angela Trizzino, Monica Terenziani, and
Pediatric Blood and Cancer, 2021
Long-term results of suppressing thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism in medulloblastoma/PNET and Hodgkin lymphoma: a prospective cohort study
Maura Massimino, Marta Podda, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Carlo Morosi, Filippo Spreafico, Andrea Ferrari, Emilia Pecori, Monica Terenziani
Frontiers of Medicine, 2021
Unmet needs for relapsed or refractory Wilms tumour: Mapping the molecular features, exploring organoids and designing early phase trials – A collaborative SIOP-RTSG, COG and ITCC session at the first SIOPE meeting
Jesper Brok, Annelies M.C. Mavinkurve-Groothuis, Jarno Drost, Daniela Perotti, James I. Geller, Amy L. Walz, Birgit Geoerger, Claudia Pasqualini, Arnauld Verschuur, Angela Polanco, K. Pritchard-Jones, Marry van den Heuvel-Eibrink, Norbert Graf, Filippo Spreafico
European Journal of Cancer, 2021
Retrospective study of late radiation-induced damages after focal radiotherapy for childhood brain tumors
Claudia Cavatorta, Silvia Meroni, Eros Montin, Maria C. Oprandi, Emilia Pecori, Mara Lecchi, Barbara Diletto, Ombretta Alessandro, Denis Peruzzo, Veronica Biassoni, Elisabetta Schiavello, Marco Bologna, Maura Massimino, Geraldina Poggi, Luca Mainardi, Filippo Arrigoni, Filippo Spreafico, Paolo Verderio, Emanuele Pignoli, Lorenza Gandola
Plos One, 2021
Adolescents with Terminal Cancer: Making Good Use of Illusions
Carlo Alfredo Clerici, Elena Pagani Bagliacca, Laura Veneroni, Marta Podda, Matteo Silva, Patrizia Gasparini, Roberto Luksch, Monica Terenziani, Michela Casanova, Filippo Spreafico, Cristina Meazza, Veronica Biassoni, Elisabetta Schiavello, Stefano Chiaravalli, Tullio Proserpio, Maura Massimino, Andrea Ferrari
Journal of Adolescent and Young Adult Oncology, 2020
A collateral effect of the COVID-19 pandemic: Delayed diagnosis in pediatric solid tumors
Stefano Chiaravalli, Andrea Ferrari, Giovanna Sironi, Giovanna Gattuso, Luca Bergamaschi, Nadia Puma, Elisabetta Schiavello, Veronica Biassoni, Marta Podda, Cristina Meazza, Filippo Spreafico, Michela Casanova, Monica Terenziani, Roberto Luksch, Maura Massimino
Pediatric Blood and Cancer, 2020
SARS-CoV-2 disease and children under treatment for cancer
Monica Terenziani, Maura Massimino, Veronica Biassoni, Michela Casanova, Stefano Chiaravalli, Andrea Ferrari, Roberto Luksch, Cristina Meazza, Marta Podda, Elisabetta Schiavello, Filippo Spreafico
Pediatric Blood and Cancer, 2020
Cancer treatment in disabled children
Cristina Meazza, Elisabetta Schiavello, Veronica Biassoni, Marta Podda, Chiara Barteselli, Francesco Barretta, Giovanna Gattuso, Monica Terenziani, Andrea Ferrari, Filippo Spreafico, Roberto Luksch, Michela Casanova, Stefano Chiaravalli, Nadia Puma, Luca Bergamaschi, Maura Massimino
European Journal of Pediatrics, 2020
Secreting germ cell tumors of the central nervous system: A long-term follow-up experience
Veronica Biassoni, Elisabetta Schiavello, Lorenza Gandola, Emilia Pecori, Geraldina Poggi, Filippo Spreafico, Monica Terenziani, Cristina Meazza, Marta Podda, Andrea Ferrari, Roberto Luksch, Michela Casanova, Nadia Puma, Stefano Chiaravalli, Luca Bergamaschi, Graziella Cefalo, Fabio Simonetti, Giovanna Gattuso, Ettore Cesare Seregni, Federica Pallotti, Francesca Gianno, Barbara Diletto, Francesco Barretta, Maura Massimino
Cancers, 2020
Children with cancer in the time of COVID-19: An 8-week report from the six pediatric onco-hematology centers in Lombardia, Italy
Andrea Ferrari, Marco Zecca, Carmelo Rizzari, Fulvio Porta, Massimo Provenzi, Maddalena Marinoni, Richard Fabian Schumacher, Roberto Luksch, Monica Terenziani, Michela Casanova, Filippo Spreafico, Stefano Chiaravalli, Francesca Compagno, Federica Bruni, Chiara Piccolo, Laura Bettini, Mariella D'Angiò, Giulia Maria Ferrari, Andrea Biondi, Maura Massimino, Adriana Balduzzi
Pediatric Blood and Cancer, 2020
Characteristics and outcome of children with renal cell carcinoma: A narrative review
Justine N. van der Beek, James I. Geller, Ronald R. de Krijger, Norbert Graf, Kathy Pritchard-Jones, Jarno Drost, Arnauld C. Verschuur, Dermot Murphy, Satyajit Ray, Filippo Spreafico, Kristina Dzhuma, Annemieke S. Littooij, Barbara Selle, Godelieve A. M. Tytgat, Marry M. van den Heuvel-Eibrink
Cancers, 2020
How young patients with cancer perceive the COVID-19 (coronavirus) epidemic in Milan, Italy: Is there room for other fears?
Michela Casanova, Elena Pagani Bagliacca, Matteo Silva, Carlo Patriarca, Laura Veneroni, Carlo Alfredo Clerici, Filippo Spreafico, Roberto Luksch, Monica Terenziani, Cristina Meazza, Marta Podda, Veronica Biassoni, Elisabetta Schiavello, Stefano Chiaravalli, Nadia Puma, Luca Bergamaschi, Giovanna Gattuso, Giovanna Sironi, Maura Massimino, Andrea Ferrari
Pediatric Blood and Cancer, 2020
Reduced-dose craniospinal irradiation is feasible for standard-risk adult medulloblastoma patients
Maura Massimino, Marie Pierre Sunyach, Francesco Barretta, Lorenza Gandola, Anna Garegnani, Emilia Pecori, Filippo Spreafico, Alice Bonneville-Levard, David Meyronet, Carmine Mottolese, Luna Boschetti, Veronica Biassoni, Elisabetta Schiavello, Carlo Giussani, Giorgio Carrabba, Barbara Diletto, Federica Pallotti, Roberto Stefini, Andrea Ferrari, Monica Terenziani, Michela Casanova, Roberto Luksch, Cristina Meazza, Marta Podda, Stefano Chiaravalli, Nadia Puma, Luca Bergamaschi, Carlo Morosi, Giuseppina Calareso, Felice Giangaspero, Manila Antonelli, Francesca Romana Buttarelli, Didier Frappaz
Journal of Neuro Oncology, 2020
Salvage treatment for children with relapsed/refractory germ cell tumors: The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience
Maria Debora De Pasquale, Paolo D'Angelo, Alessandro Crocoli, Renata Boldrini, Massimo Conte, Gianni Bisogno, Filippo Spreafico, Alessandro Inserra, Davide Biasoni, Patrizia Dall'Igna, Fortunato Siracusa, Evelina Miele, Monica Terenziani
Pediatric Blood and Cancer, 2020
High dose chemotherapy and autologous hematopoietic cell transplantation for Wilms tumor: a study of the European Society for Blood and Marrow Transplantation
On behalf of EBMT Paediatric Diseases Working Party, F. Spreafico, A. Dalissier, U. Pötschger, F. Locatelli, J. M. Michon, C. Peters, P. Bader, G. Bisogno, D. Yeomanson, A. Willasch, M. van den Heuvel Eibrink, N. Graf, S. Dallorso
Bone Marrow Transplantation, 2020
Is radiotherapy required in first-line treatment of stage I diffuse anaplastic Wilms tumor? A report of SIOP-RTSG, AIEOP, JWiTS, and UKCCSG
Raquel Dávila Fajardo, Marry M. van den Heuvel‐Eibrink, Harm van Tinteren, Filippo Spreafico, Thomas Acha, Christophe Bergeron, Beatriz de Camargo, Foppe Oldenburger, Christian Rübe, Takaharu Oue, Christian Vokuhl, Ronald R. de Krijger, Gordan Vujanic, Neil Sebire, Aurore Coulomb‐L'Hermine, Paola Collini, Lorenza Gandola, Kathy Pritchard‐Jones, Norbert Graf, Geert O. Janssens, Martine van Grotel
Pediatric Blood and Cancer, 2020
Prostate cancer in young men: An emerging young adult and older adolescent challenge
Archie Bleyer, Filippo Spreafico, Ronald Barr
Cancer, 2020
Action observation therapy in pediatric patients with neuromotor deficits of the upper limbs secondary to central nervous system tumors
Marco Chisari, Raffaella Sensi, Carlo Alfredo Clerici, Fulvia Angela Gariboldi, Filippo Spreafico, Veronica Biassoni, Elisabetta Schiavello, Patrizia Gasparini, Augusto Tommaso Caraceni, Andrea Ferrari, Maura Massimino
Tumori, 2019
Wilms tumor, medulloblastoma, and rhabdomyosarcoma in adult patients: lessons learned from the pediatric experience
Filippo Spreafico, Andrea Ferrari, Maurizio Mascarin, Paola Collini, Carlo Morosi, Davide Biasoni, Veronica Biassoni, Elisabetta Schiavello, Lorenza Gandola, Giovanna Gattuso, Stefano Chiaravalli, Maura Massimino
Cancer and Metastasis Reviews, 2019
Sport activities and exercise as part of routine cancer care in children and adolescents
Filippo Spreafico, Michele Murelli, Brian W. Timmons, Maura Massimino, Ronald Barr
Pediatric Blood and Cancer, 2019
Nationwide central diagnosis review for childhood solid tumors: From concept to realization of an Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) integrated project
Filippo Spreafico, Paola Quarello, Rita Alaggio, Paola Collini, Riccardo Haupt, Angela Mastronuzzi, Arcangelo Prete, Marco Rabusin, Carmelo Rizzari, Fabian Schumacher, Marco Zecca, Andrea Pession, Franca Fagioli
Pediatric Blood and Cancer, 2019
Evaluation of needle biopsy as a potential risk factor for local recurrence of Wilms tumour in the SIOP WT 2001 trial
Sabine Irtan, Harm Van Tinteren, Norbert Graf, Marry M. van den Heuvel-Eibrink, Hugo Heij, Christophe Bergeron, Beatriz de Camargo, Tomas Acha, Filippo Spreafico, Gordan Vujanic, Mark Powis, Bruce Okoye, Jim Wilde, Jan Godzinski, Kathy Pritchard-Jones
European Journal of Cancer, 2019
Malignant testicular germ cell tumors in children and adolescents: The AIEOP (Associazione Italiana Ematologia Oncologia Pediatrica) protocol
Monica Terenziani, Maria D. De Pasquale, Gianni Bisogno, Davide Biasoni, Renata Boldrini, Paola Collini, Massimo Conte, Patrizia Dall'Igna, Alessandro Inserra, Fraia Melchionda, Fortunato Siracusa, Filippo Spreafico, Francesco Barretta, Paolo D'Angelo
Urologic Oncology Seminars and Original Investigations, 2018
Follow-up surveillance of Wilm's tumour – Authors' reply
Jesper Brok, Kathy Pritchard-Jones, Filippo Spreafico
Lancet Oncology, 2018
Genetic and epigenetic analyses guided by high resolution whole-genome SNP array reveals a possible role of CHEK2 in Wilms tumour susceptibility
Oncotarget, 2018
Relapse of Wilms' tumour and detection methods: a retrospective analysis of the 2001 Renal Tumour Study Group–International Society of Paediatric Oncology Wilms' tumour protocol database
Jesper Brok, Marta Lopez-Yurda, Harm V Tinteren, Taryn D Treger, Rhoikos Furtwängler, Norbert Graf, Christophe Bergeron, Marry M van den Heuvel-Eibrink, Kathy Pritchard-Jones, Øystein E Olsen, Beatriz de Camargo, Arnauld Verschuur, Filippo Spreafico
Lancet Oncology, 2018
Correction to: Results of nimotuzumab and vinorelbine, radiation and re-irradiation for diffuse pontine glioma in childhood (Journal of Neuro-Oncology, (2014), 10.1007/s11060-014-1428-z)
Maura Massimino, Veronica Biassoni, Rosalba Miceli, Elisabetta Schiavello, Monika Warmuth-Metz, Piergiorgio Modena, Michela Casanova, Emilia Pecori, Felice Giangaspero, Manila Antonelli, Francesca Romana Buttarelli, Paolo Potepan, Bianca Pollo, Raffaele Nunziata, Filippo Spreafico, Marta Podda, Andrea Anichini, Carlo Alfredo Clerici, Iacopo Sardi, Loris De Cecco, Udo Bode, Ferdinand Bach, Lorenza Gandola
Journal of Neuro Oncology, 2018
Rationale for the treatment of children with CCSK in the UMBRELLA SIOP-RTSG 2016 protocol
on behalf of the International Society of Paediatric Oncology–Renal Tumour Study Group (SIOP–RTSG), Saskia L. Gooskens, Norbert Graf, Rhoikos Furtwängler, Filippo Spreafico, Christophe Bergeron, Gema L. Ramírez-Villar, Jan Godzinski, Christian Rübe, Geert O. Janssens, Gordan M. Vujanic, Ivo Leuschner, Aurore Coulomb-L'Hermine, Anne M. Smets, Beatriz de Camargo, Sara Stoneham, Harm van Tinteren, Kathy Pritchard-Jones, Marry M. van den Heuvel-Eibrink
Nature Reviews Urology, 2018
Irinotecan for relapsed Wilms tumor in pediatric patients: SIOP experience and review of the literature—A report from the SIOP Renal Tumor Study Group
Janna A. Hol, Marry M. van den Heuvel‐Eibrink, Norbert Graf, Kathy Pritchard‐Jones, Jesper Brok, Harm van Tinteren, Lisa Howell, Arnauld Verschuur, Christophe Bergeron, Leo Kager, Serena Catania, Filippo Spreafico, Annelies M. C. Mavinkurve‐Groothuis
Pediatric Blood and Cancer, 2018
Pilot guidelines for the use of bidirectional webcams with children suffering from advanced-stage oncological diseases
Barbara Giacon, Veronica Biassoni, Carlo A. Clerici, Filippo Spreafico, Cristina Meazza, Laura Veneroni, Maura Massimino
Minerva Pediatrica, 2017
Factors possibly affecting prognosis in children with Wilms’ tumor diagnosed before 24 months of age: A report from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) Wilms Tumor Working Group
Paolo D'Angelo, Andrea Di Cataldo, Monica Terenziani, Gianni Bisogno, Paola Collini, Martina Di Martino, Fraia Melchionda, Clara Mosa, Marilina Nantron, Daniela Perotti, Giuseppe Puccio, Annalisa Serra, Serena Catania, Filippo Spreafico, and
Pediatric Blood and Cancer, 2017
Position Paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol
on behalf of the International Society of Paediatric Oncology — Renal Tumour Study Group (SIOP–RTSG), Marry M. van den Heuvel-Eibrink, Janna A. Hol, Kathy Pritchard-Jones, Harm van Tinteren, Rhoikos Furtwängler, Arnauld C. Verschuur, Gordan M. Vujanic, Ivo Leuschner, Jesper Brok, Christian Rübe, Anne M. Smets, Geert O. Janssens, Jan Godzinski, Gema L. Ramírez-Villar, Beatriz de Camargo, Heidi Segers, Paola Collini, Manfred Gessler, Christophe Bergeron, Filippo Spreafico, Norbert Graf
Nature Reviews Urology, 2017
Primary metastatic osteosarcoma: results of a prospective study in children given chemotherapy and interleukin-2
Cristina Meazza, Graziella Cefalo, Maura Massimino, Primo Daolio, Ugo Pastorino, Paolo Scanagatta, Carlo Morosi, Marta Podda, Andrea Ferrari, Monica Terenziani, Filippo Spreafico, Michela Casanova, Antonina Parafioriti, Paola Collini, Lorenza Gandola, Stefano Bastoni, Veronica Biassoni, Elisabetta Schiavello, Stefano Chiaravalli, Nadia Puma, Luca Bergamaschi, Roberto Luksch
Medical Oncology, 2017
Malignant ovarian germ cell tumors in pediatric patients: The AIEOP (Associazione Italiana Ematologia Oncologia Pediatrica) study
M. Terenziani, G. Bisogno, R. Boldrini, G. Cecchetto, M. Conte, L. Boschetti, M.D. De Pasquale, D. Biasoni, A. Inserra, F. Siracusa, M.E. Basso, F. De Leonardis, D. Di Pinto, F. Barretta, F. Spreafico, P. D'Angelo
Pediatric Blood and Cancer, 2017
Quality of life in long-term survivors treated for metastatic medulloblastoma with a hyperfractionated accelerated radiotherapy (HART) strategy
L. Veneroni, L. Boschetti, F. Barretta, C. A. Clerici, F. Simonetti, E. Schiavello, V. Biassoni, F. Spreafico, L. Gandola, E. Pecori, B. Diletto, G. Poggi, F. Gariboldi, R. Sensi, M. Massimino
Child S Nervous System, 2017
Results of the Third AIEOP Cooperative Protocol on Wilms Tumor (TW2003) and Related Considerations
Filippo Spreafico, Davide Biasoni, Salvatore Lo Vullo, Lorenza Gandola, Paolo D’Angelo, Monica Terenziani, Maurizio Bianchi, Massimo Provenzi, Paolo Indolfi, Andrea Pession, Marilina Nantron, Andrea Di Cataldo, Carlo Morosi, Daniela Perotti, Serena Catania, Franca Fossati Bellani, Paola Collini, and
Journal of Urology, 2017
Possible role of pandemic AH1N1 swine flu virus in a childhood leukemia cluster
G Cazzaniga, L Bisanti, G Randi, S Deandrea, S Bungaro, F Pregliasco, D Perotti, F Spreafico, G Masera, M G Valsecchi, A Biondi, M Greaves
Leukemia, 2017
Review of phase I and II trials for Wilms' tumour – Can we optimise the search for novel agents?
Jesper Brok, Kathy Pritchard-Jones, James I. Geller, Filippo Spreafico
European Journal of Cancer, 2017
Searching for happiness
Andrea Ferrari, Paola Gaggiotti, Matteo Silva, Laura Veneroni, Chiara Magni, Stefano Signoroni, Michela Casanova, Roberto Luksch, Monica Terenziani, Filippo Spreafico, Cristina Meazza, Carlo Alfredo Clerici, Maura Massimino
Journal of Clinical Oncology, 2017
Winners' cup: A national football tournament brings together Adolescent patients with cancer from all over Italy
Matteo Silva, Marco Chisari, Stefano Signoroni, Alberto Bassani, Luca Tagliabue, Angelo Ricci, Mirco Daversa, Massimo Achini, Filippo Spreafico, Michele Murelli, Giuseppe Maria Milano, Gianni Bisogno, Luca Coccoli, Massimo Conte, Alberto Garaventa, Paolo Indolfi, Silverio Perrotta, Marco Spinelli, Federico Mercolini, Pietro Soloni, Marta Pierobon, Andrea Di Cataldo, Teresa Perillo, Maurizio Mascarin, Elisa Coassin, Laura Veneroni, Michela Casanova, Maura Massimino, Andrea Ferrari
Tumori, 2017
Cancer of the Kidney, Bladder, and Prostate
Michael Leahy, Filippo Spreafico, Archie Bleyer
Pediatric Oncology, 2017
Paediatric renal tumours: Perspectives from the SIOP-RTSG
The SIOP Renal Tumour Study Group
Nature Reviews Urology, 2017
Proteomic analysis of cerebrospinal fluid from children with central nervous system tumors identifies candidate proteins relating to tumor metastatic spread
Filippo Spreafico, Italia Bongarzone, Sara Pizzamiglio, Ruben Magni, Elena Taverna, Maida De Bortoli, Chiara M. Ciniselli, Elena Barzanò, Veronica Biassoni, Alessandra Luchini, Lance A. Liotta, Weidong Zhou, Michele Signore, Paolo Verderio, Maura Massimino
Oncotarget, 2017
Measuring the efficacy of a project for adolescents and young adults with cancer: A study from the Milan Youth Project
Andrea Ferrari, Matteo Silva, Laura Veneroni, Chiara Magni, Carlo Alfredo Clerici, Cristina Meazza, Monica Terenziani, Filippo Spreafico, Stefano Chiaravalli, Michela Casanova, Roberto Luksch, Serena Catania, Elisabetta Schiavello, Veronica Biassoni, Marta Podda, Luca Bergamaschi, Nadia Puma, Alice Indini, Tullio Proserpio, Maura Massimino
Pediatric Blood and Cancer, 2016
Comment on: The UK Experience of a Treatment Strategy for Pediatric Metastatic Medulloblastoma Comprising Intensive Induction Chemotherapy, Hyperfractionated Accelerated Radiotherapy, and Response Directed High-Dose Myeloablative Chemotherapy or Maintenance Chemotherapy (Milan Strategy)
Maura Massimino, Filippo Spreafico, Emanuele Pignoli, Lorenza Gandola
Pediatric Blood Cancer, 2016
The Sooner the Better? How Symptom Interval Correlates With Outcome in Children and Adolescents With Solid Tumors: Regression Tree Analysis of the Findings of a Prospective Study
Andrea Ferrari, Salvatore Lo Vullo, Daniele Giardiello, Laura Veneroni, Chiara Magni, Carlo Alfredo Clerici, Stefano Chiaravalli, Michela Casanova, Roberto Luksch, Monica Terenziani, Filippo Spreafico, Cristina Meazza, Serena Catania, Elisabetta Schiavello, Veronica Biassoni, Marta Podda, Luca Bergamaschi, Nadia Puma, Maura Massimino, Luigi Mariani
Pediatric Blood and Cancer, 2016
The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney
Saskia L. Gooskens, Colin Kenny, Antonio Lazaro, Elaine O'Meara, Harm van Tinteren, Filippo Spreafico, Gordan Vujanic, Ivo Leuschner, Aurore Coulomb‐L'Herminé, Daniela Perotti, Beatriz de Camargo, Christophe Bergeron, Tomas Acha García, Mio Tanaka, Rob Pieters, Kathy Pritchard‐Jones, Norbert Graf, Marry M. van den Heuvel‐Eibrink, Maureen J. O'Sullivan
Genes Chromosomes and Cancer, 2016
Chromosomal anomalies at 1q, 3, 16q, and mutations of SIX1 and DROSHA genes underlie Wilms tumor recurrences
Filippo Spreafico, Sara Ciceri, Beatrice Gamba, Federica Torri, Monica Terenziani, Paola Collini, Fabio Macciardi, Paolo Radice, Daniela Perotti
Oncotarget, 2016
Oral etoposide in relapsed or refractory Ewing sarcoma: A monoinstitutional experience in children and adolescents
Marta G. Podda, Roberto Luksch, Nadia Puma, Lorenza Gandola, Carlo Morosi, Monica Terenziani, Andrea Ferrari, Michela Casanova, Filippo Spreafico, Cristina Meazza, Serena Catania, Elisabetta Schiavello, Veronica Biassoni, Stefano Chiaravalli, Maura Massimino
Tumori, 2016
The Role of Alfa Fetoprotein in the Risk Management of Pediatric Germ Cell Tumors
Carla Moscheo, Filippo Spreafico, Stefano Chiaravalli, Serena Catania, Monica Terenziani, Andrea Di Cataldo
Journal of Pediatric Biochemistry, 2015
Clouds of oxygen: Adolescents With cancer tell their story in music
Andrea Ferrari, Laura Veneroni, Carlo Alfredo Clerici, Michela Casanova, Stefano Chiaravalli, Chiara Magni, Roberto Luksch, Monica Terenziani, Filippo Spreafico, Daniela Polastri, Cristina Meazza, Serena Catania, Elisabetta Schiavello, Veronica Biassoni, Marta Podda, Luca Bergamaschi, Nadia Puma, Carla Moscheo, Giacomo Gotti, Maura Massimino
Journal of Clinical Oncology, 2015
Advances in wilms tumor treatment and biology: Progress through international collaboration
Jeffrey S. Dome, Norbert Graf, James I. Geller, Conrad V. Fernandez, Elizabeth A. Mullen, Filippo Spreafico, Marry Van den Heuvel-Eibrink, Kathy Pritchard-Jones
Journal of Clinical Oncology, 2015
A case of relapsing spinal atypical teratoid/rhabdoid tumor (AT/RT) responding to vinorelbine, cyclophosphamide, and celecoxib
Giacomo Gotti, Veronica Biassoni, Elisabetta Schiavello, Filippo Spreafico, Manila Antonelli, Giuseppina Calareso, Emilia Pecori, Lorenza Gandola, Maura Massimino
Child S Nervous System, 2015
Paediatrics: Towards evidence-based management of paediatric RCC
Filippo Spreafico
Nature Reviews Urology, 2015
Mature and immature teratoma: A report from the second Italian pediatric study
Monica Terenziani, Paolo D'Angelo, Alessandro Inserra, Renata Boldrini, Gianni Bisogno, Gian Luca Babbo, Massimo Conte, Patrizia Dall' Igna, Maria Debora De Pasquale, Paolo Indolfi, Luigi Piva, Giovanna Riccipetitoni, Fortunato Siracusa, Filippo Spreafico, Paolo Tamaro, Giovanni Cecchetto
Pediatric Blood and Cancer, 2015
Treatment of relapsed Wilms tumour (WT) patients: Experience with topotecan. A report from the SIOP Renal Tumour Study Group (RTSG)
A. M. C. Mavinkurve-Groothuis, M. M. van den Heuvel-Eibrink, G. A. Tytgat, H. van Tinteren, G. Vujanic, K. L. P. Pritchard-Jones, L. Howell, N. Graf, C. Bergeron, T. Acha, S. Catania, F. Spreafico
Pediatric Blood and Cancer, 2015
Differences in sports participation for children and adolescents with solitary kidney due to renal tumors across Europe. Time for harmonization
Minerva Pediatrica, 2015
Whole transcriptome sequencing identifies BCOR internal tandem duplication as a common feature of clear cell sarcoma of the kidney
Annalisa Astolfi, Fraia Melchionda, Daniela Perotti, Maura Fois, Valentina Indio, Milena Urbini, Chiara Giusy Genovese, Paola Collini, Nunzio Salfi, Marilina Nantron, Paolo D’Angelo, Filippo Spreafico, Andrea Pession
Oncotarget, 2015
Should we encourage exercise and sports in children and adolescents with cancer?
Filippo Spreafico, Michele Murelli, Andrea Ferrari, Monica Terenziani, Barbara Giacon, Laura Veneroni, Maura Massimino
Pediatric Blood and Cancer, 2014
Treatment and outcome of patients with relapsed clear cell sarcoma of the kidney: A combined SIOP and AIEOP study
S L Gooskens, R Furtwängler, F Spreafico, H van Tinteren, J de Kraker, G M Vujanic, I Leuschner, A Coulomb-L'Herminé, J Godzinski, G Schleiermacher, S Stoneham, C Bergeron, K Pritchard-Jones, N Graf, M M van den Heuvel-Eibrink
British Journal of Cancer, 2014
Outcome and long-term complications
Medulloblastoma Book, 2014
Axial skeletal osteosarcoma: A 25-year monoinstitutional experience in children and adolescents
Cristina Meazza, Roberto Luksch, Primo Daolio, Marta Podda, Alessandro Luzzati, Alessandro Gronchi, Antonina Parafioriti, Lorenza Gandola, Paola Collini, Andrea Ferrari, Michela Casanova, Monica Terenziani, Filippo Spreafico, Daniela Polastri, Veronica Biassoni, Elisabetta Schiavello, Emilia Pecori, Maura Massimino
Medical Oncology, 2014
Bilateral testicular germ cell tumors
Monica Terenziani, Davide Biasoni, Paola Collini, Filippo Spreafico, Giacomo Gotti, Luigi Piva
Journal of Pediatric Surgery, 2014
Long-term renal outcome in adolescent and young adult patients nephrectomized for unilateral Wilms tumor
Filippo Spreafico, Monica Terenziani, Sara Testa, Daniela Perotti, Paola Collini, Luigi Piva, Gianluigi Ardissino
Pediatric Blood and Cancer, 2014
Response Re: Long-term renal outcome in adolescent and young adult patients nephrectomized for unilateral Wilms tumor
Filippo Spreafico, Monica Terenziani, Sara Testa, Daniela Perotti, Paola Collini, Luigi Piva, Gianluigi Ardissino
Pediatric Blood and Cancer, 2014
Why should survivors of childhood renal tumor and others with only one kidney be denied the chance to play contact sports?
Filippo Spreafico, Monica Terenziani, Marry M van den Heuvel-Eibrink, Kathy Pritchard-Jones, Gill Levitt, Norbert Graf, Christophe Bergeron, Maura Massimino
Expert Review of Anticancer Therapy, 2014
Temozolomide is an active agent in children with recurrent medulloblastoma/primitive neuroectodermal tumor: An Italian multi-institutional phase II trial
G. Cefalo, M. Massimino, A. Ruggiero, G. Barone, V. Ridola, F. Spreafico, P. Potepan, M. E. Abate, M. Mascarin, M. L. Garre, G. Perilongo, E. Madon, C. Colosimo, R. Riccardi
Neuro Oncology, 2014
Thyroid carcinoma after treatment for malignancies in childhood and adolescence: From diagnosis through follow-up
Marta Giorgia Podda, Monica Terenziani, Lorenza Gandola, Paola Collini, Natalia Pizzi, Alfonso Marchianò, Carlo Morosi, Roberto Luksch, Andrea Ferrari, Michela Casanova, Filippo Spreafico, Daniela Polastri, Cristina Meazza, Serena Catania, Elisabetta Schiavello, Veronica Biassoni, Maura Massimino
Medical Oncology, 2014
Results of nimotuzumab and vinorelbine, radiation and re-irradiation for diffuse pontine glioma in childhood
Maura Massimino, Veronica Biassoni, Rosalba Miceli, Elisabetta Schiavello, Monika Warmuth-Metz, Piergiorgio Modena, Michela Casanova, Emilia Pecori, Felice Giangaspero, Manila Antonelli, Francesca Romana Buttarelli, Paolo Potepan, Bianca Pollo, Raffaele Nunziata, Filippo Spreafico, Marta Podda, Andrea Anichini, Carlo Alfredo Clerici, Iacopo Sardi, Loris De Cecco, Udo Bode, Ferdinand Bach, Lorenza Gandola
Journal of Neuro Oncology, 2014
Evolving of therapeutic strategies for CNS-PNET
Maura Massimino, Lorenza Gandola, Veronica Biassoni, Filippo Spreafico, Elisabetta Schiavello, Geraldina Poggi, Emilia Pecori, Marco Vajna De Pava, Piergiorgio Modena, Manila Antonelli, Felice Giangaspero
Pediatric Blood and Cancer, 2013
Incidence and outcomes of patients with late recurrence of Wilms' tumor
M. Malogolowkin, F. Spreafico, J.S. Dome, H. van Tinteren, K. Pritchard‐Jones, M.M. van den Heuvel‐Eibrink, C. Bergeron, J. de Kraker, N. Graf, On behalf of the COG Renal Tumors Committee, the SIOP Renal Tumor Study Group
Pediatric Blood and Cancer, 2013
Is there a role for FDG-PET for the assessment of treatment efficacy in Wilms' Tumor? A case report and literature review
M. Provenzi, F. Saettini, V. Conter, D. Chinaglia, P. Vai, A. Bruno, L. Cavalleri, C. Foglia, E. Giraldi, P. Collini, F. Spreafico
Pediatric Hematology and Oncology, 2013
A novel WT1 mutation in familial wilms tumor
Fraia Melchionda, Filippo Spreafico, Sara Ciceri, Mario Lima, Paola Collini, Andrea Pession, Maura Massimino, Paolo Radice, Daniela Perotti
Pediatric Blood and Cancer, 2013
Tumore di Wilms. I risultati dei protocolli condotti dall'AIEOP
Pediatric Reports, 2013
Synchronous bilateral Wilms tumor: A report from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP)
Paolo Indolfi, Alessandro Jenkner, Monica Terenziani, Alessandro Crocoli, Annalisa Serra, Paola Collini, Davide Biasoni, Lorenza Gandola, Gianni Bisogno, Giovanni Cecchetto, Martina Di Martino, Paolo D'Angelo, Maurizio Bianchi, Massimo Conte, Alessandro Inserra, Andrea Pession, Filippo Spreafico, on behalf of the AIEOP Wilms Tumor Working Group
Cancer, 2013
Histological variants of medulloblastoma are the most powerful clinical prognostic indicators
Maura Massimino, Manila Antonelli, Lorenza Gandola, Rosalba Miceli, Bianca Pollo, Veronica Biassoni, Elisabetta Schiavello, Francesca Romana Buttarelli, Filippo Spreafico, Paola Collini, Felice Giangaspero
Pediatric Blood and Cancer, 2013
An international strategy to determine the role of high dose therapy in recurrent Wilms' tumour
Tam C. Ha, Filippo Spreafico, Norbert Graf, Sandro Dallorso, Jeffrey S. Dome, Marcio Malogolowkin, Rhoikos Furtwängler, Juliet P. Hale, Veronica Moroz, David Machin, Kathy Pritchard-Jones
European Journal of Cancer, 2013
Adolescents suffering from cancer: "Youth Project" of the National Cancer Institute of Milan
Recenti Progressi in Medicina, 2013
Loss of heterozygosity analysis at different chromosome regions in wilms tumor confirms 1p allelic loss as a marker of worse prognosis: A study from the Italian association of pediatric hematology and oncology
Filippo Spreafico, Beatrice Gamba, Luigi Mariani, Paola Collini, Paolo D'Angelo, Andrea Pession, Andrea Di Cataldo, Paolo Indolfi, Marilina Nantron, Monica Terenziani, Carlo Morosi, Paolo Radice, Daniela Perotti, AIEOP Wilms Tumor Working Group
Journal of Urology, 2013
Occurrence of breast cancer after chest wall irradiation for pediatric cancer, as detected by a multimodal screening program
Monica Terenziani, Patrizia Casalini, Gianfranco Scaperrotta, Lorenza Gandola, Giovanna Trecate, Serena Catania, Graziella Cefalo, Alberto Conti, Maura Massimino, Cristina Meazza, Marta Podda, Filippo Spreafico, Laura Suman, Massimiliano Gennaro
International Journal of Radiation Oncology Biology Physics, 2013
Quantitative DNA methylation analysis improves epigenotype-phenotype correlations in Beckwith-Wiedemann syndrome
Mariarosaria Calvello, Silvia Tabano, Patrizia Colapietro, Silvia Maitz, Alessandra Pansa, Claudia Augello, Faustina Lalatta, Barbara Gentilin, Filippo Spreafico, Luciano Calzari, Daniela Perotti, Lidia Larizza, Silvia Russo, Angelo Selicorni, Silvia M Sirchia, Monica Miozzo
Epigenetics, 2013
Metastatic renal cell carcinoma in children and adolescents: A 30-year unsuccessful story
Paolo Indolfi, Filippo Spreafico, Paola Collini, Giovanni Cecchetto, Fiorina Casale, Monica Terenziani, Amalia Schiavetti, Paolo Pierani, Luigi Piva, Daniela Cuzzubbo, Maria D. De Pasquale, Elvira Pota, Alessandro Inserra, Gianni Bisogno
Journal of Pediatric Hematology Oncology, 2012
Primary renal soft tissue sarcoma in children
Arianna Tagarelli, Filippo Spreafico, Andrea Ferrari, Rita Alaggio, Giovanni Cecchetto, Paola Collini, Paolo Indolfi, Roberta Burnelli, Laura Morali, Gianni Bisogno
Urology, 2012
Genomic profiling by whole-genome single nucleotide polymorphism arrays in Wilms tumor and association with relapse
Daniela Perotti, Filippo Spreafico, Federica Torri, Beatrice Gamba, Pio D'Adamo, Sara Pizzamiglio, Monica Terenziani, Serena Catania, Paola Collini, Marilina Nantron, Andrea Pession, Maurizio Bianchi, Paolo Indolfi, Paolo D'Angelo, Franca Fossati‐Bellani, Paolo Verderio, Fabio Macciardi, Paolo Radice, on behalf of the Associazione Italiana Ematologia Oncologia Pediatrica Wilms Tumor Working Group
Genes Chromosomes and Cancer, 2012
Long-term results of combined preradiation chemotherapy and age-tailored radiotherapy doses for childhood medulloblastoma
Maura Massimino, Graziella Cefalo, Daria Riva, Veronica Biassoni, Filippo Spreafico, Emilia Pecori, Geraldina Poggi, Paola Collini, Bianca Pollo, Laura Valentini, Paolo Potepan, Ettore Seregni, Michela Casanova, Andrea Ferrari, Roberto Luksch, Daniela Polastri, Monica Terenziani, Federica Pallotti, Carlo Alfredo Clerici, Elisabetta Schiavello, Fabio Simonetti, Cristina Meazza, Serena Catania, Marta Podda, Lorenza Gandola
Journal of Neuro Oncology, 2012
Mirror therapy for phantom limb pain in an adolescent cancer survivor
Carlo Alfredo Clerici, Filippo Spreafico, Gaia Cavallotti, Annalisa Consoli, Laura Veneroni, Alessio Sala, Maura Massimino
Tumori, 2012
Mixed epithelial and stromal tumor of kidney: an exceptional renal neoplasm in an 8-year-old prepubertal girl with isolated clitoral hypertrophy.
Gianluca Vergine, Fabrizio Drudi, Filippo Spreafico, Francesca Barbisan, Sara Brachi, Paola Collini, Silvana Federici, Roberta Pericoli, Alberto Marsciani, Vico Vecchi
Pediatric Hematology and Oncology, 2012
Heterogeneity of disease classified as stage III in Wilms tumor: A report from the associazione Italiana Ematologia Oncologia Pediatrica (AIEOP)
Filippo Spreafico, Lorenza Gandola, Paolo D’Angelo, Monica Terenziani, Paola Collini, Maurizio Bianchi, Massimo Provenzi, Paolo Indolfi, Andrea Pession, Marilina Nantron, Andrea Di Cataldo, Alfonso Marchianò, Serena Catania, Franca Fossati Bellani, Luigi Piva
International Journal of Radiation Oncology Biology Physics, 2012
The youth project at the Istituto Nazionale Tumori in Milan
Andrea Ferrari, Carlo Alfredo Clerici, Michela Casanova, Roberto Luksch, Monica Terenziani, Filippo Spreafico, Daniela Polastri, Cristina Meazza, Laura Veneroni, Serena Catania, Elisabetta Schiavello, Veronica Biassoni, Marta Podda, Maura Massimino
Tumori, 2012
Telomere maintenance in wilms tumors: First evidence for the presence of alternative lengthening of telomeres mechanism
Lorenza Venturini, Maria Grazia Daidone, Rosita Motta, Paola Collini, Filippo Spreafico, Monica Terenziani, Luigi Piva, Paolo Radice, Daniela Perotti, Nadia Zaffaroni
Genes Chromosomes and Cancer, 2011
Clinical and molecular description of a Wilms tumor in a patient with tuberous sclerosis complex
Filippo Spreafico, Lucia Dora Notarangelo, Richard Fabian Schumacher, Gianfranco Savoldi, Beatrice Gamba, Monica Terenziani, Paola Collini, Silvia Fasoli, Lucio Giordano, Bercich Luisa, Fulvio Porta, Maura Massimino, Paolo Radice, Daniela Perotti
American Journal of Medical Genetics Part A, 2011
Malignant rhabdoid tumours of the kidney (MRTKs), registered on recent SIOP protocols from 1993 to 2005: A report of the SIOP renal tumour study group
Marry M. van den Heuvel‐Eibrink, Harm van Tinteren, Harriet Rehorst, Aurore Coulombe, Catharine Patte, Beatriz de Camargo, Jan de Kraker, Ivo Leuschner, Rieneke Lugtenberg, Kathy Pritchard‐Jones, Bengt Sandstedt, Filippo Spreafico, Norbert Graf, Gordan M. Vujanic
Pediatric Blood and Cancer, 2011
Prognostic determinants in epithelioid sarcoma
Patrizia Gasparini, Federica Facchinetti, Mattia Boeri, Erica Lorenzetto, Anna Livio, Alessandro Gronchi, Andrea Ferrari, Maura Massimino, Filippo Spreafico, Felice Giangaspero, Marco Forni, Roberta Maestro, Rita Alaggio, Silvana Pilotti, Paola Collini, Piergiorgio Modena, Gabriella Sozzi
European Journal of Cancer, 2011
Renal cell carcinoma in children and adolescents
Filippo Spreafico, Paola Collini, Monica Terenziani, Alfonso Marchianò, Luigi Piva
Expert Review of Anticancer Therapy, 2010
A lower-dose, lower-toxicity cisplatin-etoposide regimen for childhood progressive low-grade glioma
Maura Massimino, Filippo Spreafico, Daria Riva, Veronica Biassoni, Geraldina Poggi, Carlo Solero, Lorenza Gandola, Lorenzo Genitori, Piergiorgio Modena, Fabio Simonetti, Paolo Potepan, Michela Casanova, Cristina Meazza, Carlo A. Clerici, Serena Catania, Iacopo Sardi, Felice Giangaspero
Journal of Neuro Oncology, 2010
Severe polyuria and polydipsia in hyponatremic-hypertensive syndrome associated with Wilms tumor
Paolo D'Angelo, Serena Catania, Giusy Zirilli, Paola Collini, Serena Tropia, Daniela Perotti, Monica Terenziani, Filippo Spreafico
Pediatric Blood and Cancer, 2010
Teratoma with a malignant somatic component in pediatric patients: The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience
Monica Terenziani, Paolo D'Angelo, Gianni Bisogno, Renata Boldrini, Giovanni Cecchetto, Paola Collini, Massimo Conte, Tina De Laurentis, Ilaria Ilari, Paolo Indolfi, Alessandro Inserra, Luigi Piva, Fortunato Siracusa, Filippo Spreafico, Paolo Tamaro, Margherita Lo Curto
Pediatric Blood and Cancer, 2010
Comparison of the prognostic value of assessing tumor diameter versus tumor volume at diagnosis or in response to initial chemotherapy in rhabdomyosarcoma
Andrea Ferrari, Rosalba Miceli, Cristina Meazza, Michela Casanova, Francesca Favini, Carlo Morosi, Giovanna Trecate, Alfonso Marchianò, Roberto Luksch, Graziella Cefalo, Monica Terenziani, Filippo Spreafico, Daniela Polastri, Marta Podda, Serena Catania, Elisabetta Schiavello, Patrizia Giannatempo, Lorenza Gandola, Maura Massimino, Luigi Mariani
Journal of Clinical Oncology, 2010
End of life in children with cancer: Experience at the Pediatric Oncology Department of the Istituto Nazionale Tumori in Milan
Silvia Beretta, Daniela Polastri, Carlo Alfredo Clerici, Michela Casanova, Graziella Cefalo, Andrea Ferrari, Roberto Luksch, Maura Massimino, Cristina Meazza, Marta Giorgia Podda, Filippo Spreafico, Monica Terenziani, Franca Fossati Bellani
Pediatric Blood and Cancer, 2010
Neuroblastoma in patients over 12 years old: A 20-year experience at the Istituto Nazionale Tumori of Milan
Marta Giorgia Podda, Roberto Luksch, Daniela Polastri, Lorenza Gandola, Luigi Piva, Paola Collini, Graziella Cefalo, Monica Terenziani, Andrea Ferrari, Michela Casanova, Filippo Spreafico, Cristina Meazza, Maria Rita Castellani, Serena Catania, Elisabetta Schiavello, Alfonso Marchianò, Maura Massimino
Tumori, 2010
Constitutional ring chromosome 11 Mosaicism in a Wilms tumor patient: Cytogenetic, molecular and clinico-pathological studies
Massimo Carella, Filippo Spreafico, Orazio Palumbo, Clelia Tiziana Storlazzi, Silvia Tabano, Monica Miozzo, Lucia Miglionico, Savino Calvano, Giulia Sindici, Beatrice Gamba, Luciana Impera, Paola Collini, Leopoldo Zelante, Paolo Radice, Daniela Perotti
American Journal of Medical Genetics Part A, 2010
Psychological intervention in young brain tumor survivors: The efficacy of the cognitive behavioural approach
Geraldina Poggi, Mariarosaria Liscio, Valentina Pastore, Annarita Adduci, Susanna Galbiati, Filippo Spreafico, Lorenza Gandola, Maura Massimino
Disability and Rehabilitation, 2009
Treatment of relapsed Wilms tumors: Lessons learned
Filippo Spreafico, Kathy Pritchard Jones, Marcio H Malogolowkin, Christophe Bergeron, Juliet Hale, Jan de Kraker, Sandro Dallorso, Thomás Acha, Beatriz de Camargo, Jeffrey S Dome, Norbert Graf
Expert Review of Anticancer Therapy, 2009
Radiation-induced thyroid changes: A retrospective and a prospective view
Maura Massimino, Lorenza Gandola, Franco Mattavelli, Natalia Pizzi, Ettore Seregni, Federica Pallotti, Filippo Spreafico, Alfonso Marchianò, Monica Terenziani, Graziella Cefalo, Veronica Biassoni, Cristina Meazza, Giovanna Trecate, Paola Collini
European Journal of Cancer, 2009
Value and difficulties of a common European strategy for recurrent Wilms' tumor
Filippo Spreafico, Kathy Pritchard-Jones, Cristophe Bergeron, Jan de Kraker, Sandro Dallorso, Norbert Graf
Expert Review of Anticancer Therapy, 2009
No Salvage Using High-Dose Chemotherapy Plus/Minus Reirradiation for Relapsing Previously Irradiated Medulloblastoma
Maura Massimino, Lorenza Gandola, Filippo Spreafico, Veronica Biassoni, Roberto Luksch, Paola Collini, Carlo N. Solero, Fabio Simonetti, Emanuele Pignoli, Graziella Cefalo, Geraldina Poggi, Piergiorgio Modena, Luigi Mariani, Paolo Potepan, Marta Podda, Michela Casanova, Emilia Pecori, Stefania Acerno, Andrea Ferrari, Monica Terenziani, Cristina Meazza, Daniela Polastri, Fernando Ravagnani, Franca Fossati-Bellani
International Journal of Radiation Oncology Biology Physics, 2009
Hyperfractionated accelerated radiotherapy in the Milan strategy for metastatic medulloblastoma
Lorenza Gandola, Maura Massimino, Graziella Cefalo, Carlo Solero, Filippo Spreafico, Emilia Pecori, Daria Riva, Paola Collini, Emanuele Pignoli, Felice Giangaspero, Roberto Luksch, Serena Berretta, Geraldina Poggi, Veronica Biassoni, Andrea Ferrari, Bianca Pollo, Claudio Favre, Iacopo Sardi, Monica Terenziani, Franca Fossati-Bellani
Journal of Clinical Oncology, 2009
Soft tissue sarcomas of childhood and adolescence: the prognostic role of tumor size in relation to patient body size
Andrea Ferrari, Rosalba Miceli, Cristina Meazza, Elena Zaffignani, Alessandro Gronchi, Luigi Piva, Paola Collini, Marta Podda, Maura Massimino, Roberto Luksch, Graziella Cefalo, Monica Terenziani, Filippo Spreafico, Daniela Polastri, Franca Fossati-Bellani, Michela Casanova, Luigi Mariani
Journal of Clinical Oncology, 2009
A female survivor of childhood medulloblastoma presenting with growth-hormone-induced edema and inflammatory lesions: A case report
Veronica Biassoni, Federica Pallotti, Filippo Spreafico, Ettore Seregni, Lorenza Gandola, Antonella Martinetti, Emilio Bombardieri, Maura Massimino
Journal of Medical Case Reports, 2009
A novel WT1 mutation in a 46,XY boy with congenital bilateral cryptorchidism, nystagmus and Wilms tumor
Monica Terenziani, Michele Sardella, Beatrice Gamba, Maria Adele Testi, Filippo Spreafico, Gianluigi Ardissino, Fausto Fedeli, Franca Fossati-Bellani, Paolo Radice, Daniela Perotti
Pediatric Nephrology, 2009
Local lymph node involvement in pediatric renal cell carcinoma: A report from the Italian TREP project
Paolo Indolfi, Gianni Bisogno, Giovanni Cecchetto, Filippo Spreafico, Gian Luca De Salvo, Paola Collini, Alessandro Jenkner, Alessandro Inserra, Amalia Schiavetti, Martina di Martino, Fiorina Casale
Pediatric Blood and Cancer, 2008
Moleculaar evidence of the independent origin of multiple wilms tumors in a case of WAGR syndrome
Stefania Uccini, Daniela Perotti, Cristina Colarossi, Antonella Stoppacciaro, Michele Sardella, Olga Mannarino, Paola Collini, Paola Casieri, Denis Cozzi, Loredana Amoroso, Filippo Spreafico, Paolo Radice, Carlo Dominici
Pediatric Blood and Cancer, 2008
Functional inactivation of the WTX gene is not a frequent event in Wilms' tumors
D Perotti, B Gamba, M Sardella, F Spreafico, M Terenziani, P Collini, A Pession, M Nantron, F Fossati-Bellani, P Radice, on behalf of the AIEOP Wilms’ Tumor Study Group
Oncogene, 2008
Treatment of high-risk relapsed Wilms tumor with dose-intensive chemotherapy, marrow-ablative chemotherapy, and autologous hematopoietic stem cell support: Experience by the Italian Association of Pediatric Hematology and Oncology
Filippo Spreafico, Gianni Bisogno, Paola Collini, Alessandro Jenkner, Lorenza Gandola, Paolo D'Angelo, Gabriella Casazza, Luigi Piva, Roberto Luksch, Daniela Perotti, Andrea Pession, Franca Fagioli, Sandro Dallorso
Pediatric Blood and Cancer, 2008
SCT for Wilms' tumour
S Dallorso, G Dini, M Faraci, F Spreafico, on behalf of the EBMT Paediatric Working Party
Bone Marrow Transplantation, 2008
Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancer
Adele Murrell, Yoko Ito, Gaetano Verde, Joanna Huddleston, Kathryn Woodfine, Margherita Cirillo Silengo, Filippo Spreafico, Daniela Perotti, Agostina De Crescenzo, Angela Sparago, Flavia Cerrato, Andrea Riccio
Plos One, 2008
Brain Magnetic Resonance Imaging After High-Dose Chemotherapy and Radiotherapy for Childhood Brain Tumors
Filippo Spreafico, Lorenza Gandola, Alfonso Marchianò, Fabio Simonetti, Geraldina Poggi, Anna Adduci, Carlo Alfredo Clerici, Roberto Luksch, Veronica Biassoni, Cristina Meazza, Serena Catania, Monica Terenziani, Renato Musumeci, Franca Fossati-Bellani, Maura Massimino
International Journal of Radiation Oncology Biology Physics, 2008
Rectal burkitt lymphoma in childhood
Francesca Favini, Maura Massimino, Valentina Esposito, Luciano Maestri, Giorgio Fava, Filippo Spreafico
Journal of Pediatric Hematology Oncology, 2008
Psychological assessment of women on an early breast screening program after radiotherapy to the chest wall for childhood cancer
Carlo Alfredo Clerici, Franca Fossati-Bellani, Paolo Lepera, Massimiliano Gennaro, Silvana Bergonzi, Cristina Meazza, Marta Podda, Lorenza Gandola, Laura Veneroni, Michela Casanova, Graziella Cefalo, Andrea Ferrari, Roberto Luksch, Maura Massimino, Daniela Polastri, Filippo Spreafico, Monica Terenziani
Tumori, 2008
Diffuse pontine gliomas in children: changing strategies, changing results? A mono-institutional 20-year experience.
Maura Massimino, Filippo Spreafico, Veronica Biassoni, Fabio Simonetti, Daria Riva, Giovanna Trecate, Sergio Giombini, Geraldina Poggi, Emilia Pecori, Emanuele Pignoli, Michela Casanova, Andrea Ferrari, Cristina Meazza, Roberto Luksch, Monica Terenziani, Graziella Cefalo, Marta Podda, Daniela Polastri, Carlo A. Clerici, Franca Fossati-Bellani, Lorenza Gandola
Journal of Neuro Oncology, 2008
Adult-type soft tissue sarcomas in paediatric age: A nomogram-based prognostic comparison with adult sarcoma
Andrea Ferrari, Rosalba Miceli, Michela Casanova, Alessandro Gronchi, Paola Collini, Cristina Meazza, Elena Zaffignani, Maura Massimino, Filippo Spreafico, Luigi Mariani
European Journal of Cancer, 2007
Thyroid-Stimulating Hormone Suppression for Protection Against Hypothyroidism Due to Craniospinal Irradiation for Childhood Medulloblastoma/Primitive Neuroectodermal Tumor
Maura Massimino, Lorenza Gandola, Paola Collini, Ettore Seregni, Alfonso Marchianò, Annalisa Serra, Emanuele Pignoli, Filippo Spreafico, Federica Pallotti, Monica Terenziani, Veronica Biassoni, Emilio Bombardieri, Franca Fossati-Bellani
International Journal of Radiation Oncology Biology Physics, 2007
Endodermal sinus tumor of the vagina
Monica Terenziani, Filippo Spreafico, Paola Collini, Cristina Meazza, Maura Massimino, Luigi Piva
Pediatric Blood and Cancer, 2007
Non-chromosome 11-p syndromes in Wilms tumor patients: Clinical and cytogenetic report of two down syndrome cases and one turner syndrome case [2]
Filippo Spreafico, Monica Terenziani, Elena Lualdi, Paola Scarfone, Paola Collini, Franca Fossati‐Bellani, Eulalia Galea, Giovanna De Vecchi, Michele Sardella, Gabriella Sozzi, Paolo Radice, Daniela Perotti
American Journal of Medical Genetics Part A, 2007
The murine Pou6f2 gene is temporally and spatially regulated during kidney embryogenesis and its human homolog is overexpressed in a subset of Wilms tumors
Francesca Di Renzo, Luisa Doneda, Elena Menegola, Michele Sardella, Giovanna De Vecchi, Paola Collini, Filippo Spreafico, Franca Fossati-Bellani, Erminio Giavini, Paolo Radice, Daniela Perotti
Journal of Pediatric Hematology Oncology, 2006
A case of relapsing glioblastoma multiforme responding to vinorelbine
V. Biassoni, M. Casanova, F. Spreafico, L. Gandola, M. Massimino
Journal of Neuro Oncology, 2006
Malignant renal tumours incidence and survival in European children (1978-1997): Report from the Automated Childhood Cancer Information System project
Guido Pastore, Ariana Znaor, Filippo Spreafico, Norbert Graf, Kathy Pritchard-Jones, Eva Steliarova-Foucher
European Journal of Cancer, 2006
Salvage treatment for childhood ependymoma after surgery only: Pitfalls of omitting "at once" adjuvant treatment
Maura Massimino, Felice Giangaspero, Maria Luisa Garrè, Lorenzo Genitori, Giorgio Perilongo, Paola Collini, Daria Riva, Laura Valentini, Giovanni Scarzello, Geraldina Poggi, Filippo Spreafico, Paola Peretta, Maurizio Mascarin, Piergiorgio Modena, Gabriella Sozzi, Nice Bedini, Veronica Biassoni, Alessandro Urgesi, Maria Rosa Balestrini, Gaetano Finocchiaro, Alessandro Sandri, Lorenza Gandola
International Journal of Radiation Oncology Biology Physics, 2006
Unusual primary secreting germ cell tumor of the spine: Case report
Maura Massimino, Lorenza Gandola, Filippo Spreafico, Veronica Biassoni, Monica Terenziani, Emilia Pecori, Antonietta Arcella, Felice Giangaspero
Journal of Neurosurgery Spine, 2006
Transitory, spontaneously recovering, peripheral facial nerve palsy after vinorelbine administration
M. Massimino, F. Simonetti, M. R. Balestrini, F. Spreafico, M. La Spina, M. Terenziani, L. Gandola
Neurological Sciences, 2006
Celiac disease and childhood cancer
Stefano Cereda, Graziella Cefalo, Filippo Spreafico, Serena Catania, Cristina Meazza, Marta Podda, Monica Terenziani
Journal of Pediatric Hematology Oncology, 2006
Supratentorial primitive neuroectodermal tumors (S-PNET) in children: A prospective experience with adjuvant intensive chemotherapy and hyperfractionated accelerated radiotherapy
Maura Massimino, Lorenza Gandola, Filippo Spreafico, Roberto Luksch, Paola Collini, Felice Giangaspero, Fabio Simonetti, Michela Casanova, Graziella Cefalo, Emanuele Pignoli, Andrea Ferrari, Monica Terenziani, Marta Podda, Cristina Meazza, Daniela Polastri, Geraldina Poggi, Fernando Ravagnani, Franca Fossati-Bellani
International Journal of Radiation Oncology Biology Physics, 2006
Papillary thyroid carcinoma of childhood and adolescence: A 30-year experience at the istituto nazionale tumori in Milan
Paola Collini, Maura Massimino, Silvia Fagundes Leite, Franco Mattavelli, Ettore Seregni, Nicola Zucchini, Filippo Spreafico, Andrea Ferrari, Maria Rita Castellani, Giulio Cantù, Franca Fossati‐Bellani, Juan Rosai
Pediatric Blood and Cancer, 2006
Conservative surgical approach for thyroid and lymph-node involvement in papillary thyroid carcinoma of childhood and adolescence
Maura Massimino, Paola Collini, Silvia Fagundes Leite, Filippo Spreafico, Nicola Zucchini, Andrea Ferrari, Franco Mattavelli, Ettore Seregni, Maria Rita Castellani, Giulio Cantù, Franca Fossati‐Bellani, Juan Rosai
Pediatric Blood and Cancer, 2006
Wilms' tumor: Past, present and (possibly) future
Filippo Spreafico, Franca Fossati Bellani
Expert Review of Anticancer Therapy, 2006
Rhabdomyosarcoma of the head and neck region: Experience at the Pediatric Unit of the Istituto Nazionale Tumori, Milan
Cristina Meazza, Andrea Ferrari, Michela Casanova, Maura Massimino, Roberto Luksch, Filippo Spreafico, Graziella Cefalo, Monica Terenziani, Daniela Polastri, Marta Podda, Serena Catania, Stefano Cereda, Lorenza Gandola, Franca Fossati-Bellani, Giulio Cantù
Journal of Otolaryngology, 2006
Assistance to parents who have lost their child with cancer
Carlo Alfredo Clerici, Andrea Ferrari, Maura Massimino, Roberto Luksch, Graziella Cefalo, Monica Terenziani, Michela Casanova, Filippo Spreafico, Daniela Polastri, Cristina Meazza, Marta Podda, Franca Fossati-Bellani
Tumori, 2006
Adult-type soft tissue sarcomas in pediatric-age patients: Experience at the Istituto Nazionale Tumori in Milan
Andrea Ferrari, Michela Casanova, Paola Collini, Cristina Meazza, Roberto Luksch, Maura Massimino, Graziella Cefalo, Monica Terenziani, Filippo Spreafico, Serena Catania, Lorenza Gandola, Alessandro Gronchi, Luigi Mariani, Franca Fossati-Bellani
Journal of Clinical Oncology, 2005
Wilms tumor in monozygous twins: Clinical, pathological, cytogenetic and molecular case report
Daniela Perotti, Giovanna De Vecchi, Elena Lualdi, M Adele Testi, Gabriella Sozzi, Paola Collini, Filippo Spreafico, Monica Terenziani, Franca Fossati-Bellani, Paolo Radice
Journal of Pediatric Hematology Oncology, 2005
Stage 4 neuroblastoma: Sequential hemi-body irradiation or high-dose chemotherapy plus autologous haemopoietic stem cell transplantation to consolidate primary treatment
R Luksch, M Podda, L Gandola, D Polastri, L Piva, R Castellani, P Collini, M Massimino, G Cefalo, M Terenziani, A Ferrari, M Casanova, F Spreafico, C Meazza, F Bozzi, A Marchianò, F Ravagnani, F Fossati-Bellani
British Journal of Cancer, 2005
Survival of adults treated for medulloblastoma using paediatric protocols
Filippo Spreafico, Maura Massimino, Lorenza Gandola, Graziella Cefalo, Elena Mazza, Giuseppe Landonio, Emanuele Pignoli, Geraldina Poggi, Monica Terenziani, Paolo Pedrazzoli, Salvatore Siena, Franca Fossati-Bellani
European Journal of Cancer, 2005
Brain tumors in children and adolescents: Cognitive and psychological disorders at different ages
Geraldina Poggi, Mariarosaria Liscio, Susanna Galbiati, Annarita Adduci, Maura Massimino, Lorenza Gandola, Filippo Spreafico, Carlo Alfredo Clerici, Franca Fossati-Bellani, Michela Sommovigo, Enrico Castelli
Psycho Oncology, 2005
Bilateral preaxial polydactyly in a WAGR syndrome patient
Siranoush Manoukian, John A. Crolla, Palma M.A. Mammoliti, Maria Adele Testi, Rinaldo Zanini, Maria Luisa Carpanelli, Elena Piozzi, Gabriella Sozzi, Giovanna De Vecchi, Monica Terenziani, Filippo Spreafico, Paola Collini, Paolo Radice, Daniela Perotti
American Journal of Medical Genetics, 2005
WT1 gene analysis in sporadic early-onset and bilateral Wilms tumor patients without associated abnormalities
Daniela Perotti, Patrizia Mondini, Monica Terenziani, Filippo Spreafico, Paola Collini, Franca Fossati-Bellani, Paolo Radice
Journal of Pediatric Hematology Oncology, 2005
Etoposide, cisplatin, epirubicin chemotherapy in the treatment of pediatric liver tumors
Michela Casanova, Maura Massimino, Andrea Ferrari, Filippo Spreafico, Luigi Piva, Jorgelina Coppa, Roberto Luksch, Graziella Cefalo, Monica Terenziani, Daniela Polastri, Franca Fossati Bellani, Vincenzo Mazzaferro
Pediatric Hematology and Oncology, 2005
Evolving treatment strategies for parameningeal rhabdomyosarcoma: The experience of the Istituto Nazionale Tumori of Milan
Cristina Meazza, Andrea Ferrari, Michela Casanova, Lorenza Gandola, Paola Collini, Maura Massimino, Roberto Luksch, Filippo Spreafico, Graziella Cefalo, Daniela Polastri, Monica Terenziani, Marta Podda, Giulio Cantù, Davide Scaramuzza, Franca Fossati-Bellani
Head and Neck, 2005
Sequential chemotherapy, high-dose thiotepa, circulating progenitor cell rescue, and radiotherapy for childhood high-grade glioma
Maura Massimino, Lorenza Gandola, Roberto Luksch, Filippo Spreafico, Daria Riva, Carlo Solero, Felice Giangaspero, Franco Locatelli, Marta Podda, Fabio Bozzi, Emanuele Pignoli, Paola Collini, Graziella Cefalo, Marco Zecca, Michela Casanova, Andrea Ferrari, Monica Terenziani, Cristina Meazza, Daniela Polastri, Davide Scaramuzza, Fernando Ravagnani, Franca Fossati-Bellani
Neuro Oncology, 2005
Germline mutations of the POU6F2 gene in wilms tumors with loss of heterozygosity on chromosome 7p14
Daniela Perotti, Giovanna De Vecchi, Maria A. Testi, Elena Lualdi, Piergiorgio Modena, Patrizia Mondini, Fernando Ravagnani, Paola Collini, Francesca Di Renzo, Filippo Spreafico, Monica Terenziani, Gabriella Sozzi, Franca Fossati-Bellani, Paolo Radice
Human Mutation, 2004
Five questions for assessing psychological problems in pediatric patients cured of neoplastic disease
Carlo Alfredo Clerici, Andrea Ferrari, Maura Massimino, Monica Terenziani, Michela Casanova, Roberto Luksch, Filippo Spreafico, Graziella Cefalo, Daniela Polastri, Franca Fossati-Bellani, Cesare Albasi, Paolo Gelli
Pediatric Hematology and Oncology, 2004
Adult Wilms' tumor: A monoinstitutional experience and a review of the literature
Monica Terenziani, Filippo Spreafico, Paola Collini, Luigi Piva, Daniela Perotti, Marta Podda, Lorenza Gandola, Maura Massimino, Stefano Cereda, Graziella Cefalo, Roberto Luksch, Michela Casanova, Andrea Ferrari, Daniela Polastri, Pinuccia Valagussa, Franca Fossati‐Bellani
Cancer, 2004
Case report: Pseudomonas aeruginosa-related intervertebral discitis in a young boy with medulloblastoma
E. Mazza, F. Spreafico, G. Cefalo, D. Scaramuzza, M. Massimino
Journal of Neuro Oncology, 2004
Hyperfractionated radiotherapy and chemotherapy for childhood ependymoma: Final results of the first prospective AIEOP (Associazione Italiana di Ematologia-Oncologia Pediatrica) study
Maura Massimino, Lorenza Gandola, Felice Giangaspero, Alessandro Sandri, Pinuccia Valagussa, Giorgio Perilongo, Maria Luisa Garrè, Umberto Ricardi, Marco Forni, Lorenzo Genitori, Giovanni Scarzello, Filippo Spreafico, Salvina Barra, Maurizio Mascarin, Bianca Pollo, Martina Gardiman, Armando Cama, Pierina Navarria, Maurizio Brisigotti, Paola Collini, Rita Balter, Paola Fidani, Maurizio Stefanelli, Roberta Burnelli, Paolo Potepan, Marta Podda, Guido Sotti, Enrico Madon
International Journal of Radiation Oncology Biology Physics, 2004
Clinical experience with psychological aspects in pediatric patients amputated for malignancies
Carlo Alfredo Clerici, Andrea Ferrari, Roberto Luksch, Michela Casanova, Maura Massimino, Graziella Cefalo, Monica Terenziani, Filippo Spreafico, Daniela Polastri, Sergio Mapelli, Primo Daolio, Franca Fossati Bellani
Tumori, 2004
Amelanotic melanoma in a child with oculocutaneous albinism [3]
Monica Terenziani, Filippo Spreafico, Annalisa Serra, Marta Podda, Stefano Cereda, Filiberto Belli
Medical and Pediatric Oncology, 2003
Revised SIOP working classification of renal tumors of childhood.
Filippo Spreafico, Monica Terenziani, Franca Fossati‐Bellani, Paola Collini, Luigi Piva, Lorenza Gandola
Medical and Pediatric Oncology, 2003
Immunomodulation in a treatment program including pre- and post-operative interleukin-2 and chemotherapy for childhood osteosarcoma
Roberto Luksch, Daniela Perotti, Graziella Cefalo, Carlo Gambacorti Passerini, Maura Massimino, Filippo Spreafico, Michela Casanova, Andrea Ferrari, Monica Terenziani, Daniela Polastri, Felicita Gambirasio, Marta Podda, Fabio Bozzi, Fabrizio Ravagnani, Giorgio Parmiani, Franca Fossati Bellani
Tumori, 2003
High response rate to cisplatin/etoposide regimen in childhood low-grade glioma
Maura Massimino, Filippo Spreafico, Graziella Cefalo, Riccardo Riccardi, John David Tesoro-Tess, Lorenza Gandola, Daria Riva, Antonio Ruggiero, Laura Valentini, Elena Mazza, Lorenzo Genitori, Concezio Di Rocco, Piera Navarria, Michela Casanova, Andrea Ferrari, Roberto Luksch, Monica Terenziani, Maria Rosa Balestrini, Cesare Colosimo, Franca Fossati-Bellani
Journal of Clinical Oncology, 2002
Clinical stage I nonseminomatous germ cell tumors of the testis in childhood and adolescence: An analysis of 31 cases
Monica Terenziani, Luigi Piva, Filippo Spreafico, Roberto Salvioni, Maura Massimino, Roberto Luksch, Graziella Cefalo, Michela Casanova, Andrea Ferrari, Daniela Polastri, Elena Mazza, Franca Fossati Bellani, Nicola Nicolai
Journal of Pediatric Hematology Oncology, 2002
Vinorelbine in previously treated advanced childhood sarcomas: Evidence of activity in rhadbomyosarcoma
Michela Casanova, Andrea Ferrari, Filippo Spreafico, Monica Terenziani, Maura Massimino, Roberto Luksch, Graziella Cefalo, Daniela Polastri, Ilaria Marcon, Franca Fossati Bellani
Cancer, 2002
Intensive, very short-term chemotherapy for advanced Burkitt's lymphoma in children
Filippo Spreafico, Maura Massimino, Roberto Luksch, Michela Casanova, Graziella S. Cefalo, Paola Collini, Andrea Ferrari, Daniela Polastri, Monica Terenziani, Marco Gasparini, Franca Fossati-Bellani
Journal of Clinical Oncology, 2002
Psychological support in children and adolescents with cancer when amputation is required
Andrea Ferrari, Carlo Alfredo Clerici, Filippo Spreafico, Michela Casanova, Maura Massimino, Roberto Luksch, Monica Terenziani, Graziella Cefalo, Daniela Polastri, Franca Fossati Bellani
Medical and Pediatric Oncology, 2002
Serum and cerebrospinal fluid human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP) in intracranial germ cell tumors
E. Seregni, M. Massimino, S. Nerini Molteni, F. Pallotti, B. van der Hiel, G. Cefalo, F. Spreafico, F. Fossati, E. Bombardieri
International Journal of Biological Markers, 2002
Psychological aspects in patients with surgical amputations in pediatric age for malignant tumor
Italian Journal of Pediatrics, 2001
Synovial sarcoma in children. Experience of the Istituto Nazionale Tumori, Milano
Italian Journal of Pediatrics, 2001
Prognostic significance of p80 and visceral involvement in childhood CD30 anaplastic large cell lymphoma (ALCL)
M. Massimino, F. Spreafico, R. Luksch, R. Giardini
Medical and Pediatric Oncology, 2001
Effects of recombinant human granulocyte-macrophage colony-stimulating factor in an intensive treatment program for children with Ewing's sarcoma
Haematologica, 2001
Childhood malignant ovarian germ cell tumors: A monoinstitutional experience
Monica Terenziani, Maura Massimino, Michela Casanova, Graziella Cefalo, Andrea Ferrari, Roberto Luksch, Filippo Spreafico, Danela Polastri, Rosanna Fontanelli, Luigi Piva, Franca Fossati-Bellani
Gynecologic Oncology, 2001
Undifferentiated nasopharyngeal carcinoma in children and adolescents: Comparison between staging systems
M. Casanova, A. Ferrari, L. Gandola, E. Orlandi, F. Spreafico, M. Terenziani, P. Navarria, R. Luksch, M. Massimino, G. Cefalo, F. Lombardi, F. Fossati-Bellani
Annals of Oncology, 2001
Non-ALC peripheral T-cell lymphomas in children: Report on two cases and a review of the literature
Haematologica, 2000
Childhood liposarcoma: A single-institutional twenty-year experience
Andrea Ferrari, Michela Casanova, Filippo Spreafico, Roberto Luksch, Monica Terenziani, Graziella Cefalo, Maura Massimino, Lorenza Gandola, Piera Navarria, Franca Fossati-Bellani
Pediatric Hematology and Oncology, 1999
Malignant peripheral nerve sheath tumors in children: A single- institution twenty-year experience
Michela Casanova, Andrea Ferrari, Filippo Spreafico, Roberto Luksch, Monica Terenziani, Graziella Cefalo, Maura Massimino, Lorenza Gandola, Fabrizio Lombardi, Franca Fossati-Bellani
Journal of Pediatric Hematology Oncology, 1999

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