Silvia Alboni

Scopus Publications

Cell line-specific modulation of inflammation by oestradiol in an in vitro model of antenatal depression
Madeline Kirkpatrick, Silvia Alboni, Federico Imbeni, Nicole Mariani, Nuriza Tukiran, Erin Mason-White, Carmine M. Pariante, Alessandra Borsini
Brain Behavior and Immunity, 2026
Antenatal depression is linked to adverse neurodevelopmental outcomes in offspring, likely mediated by a multitude of biological mechanisms, including elevated maternal cytokines. However, factors modulating fetal vulnerability or resilience to inflammatory exposure remain unclear. This study examines whether the steroid hormone, oestradiol, can modulate inflammatory responses in an in vitro model of hippocampal neurogenesis, using two fetal hippocampal progenitor cell lines: female-derived HPC0A07/03C and male-derived HIP-009. Cells were pre-treated with oestradiol for 24- and 48-hours during proliferation, followed by interleukin-1beta (IL-1β) exposure prior to the initiation of differentiation. Markers of proliferation and neurogenesis, as well as inflammatory cytokines and kynurenine pathway metabolites, were assessed. In female HPC0A07/03C cells, oestradiol pre-treatment prevented IL-1β-induced proliferation and apoptosis, and reduced cytokine production. Conversely, in male HIP-009 cells, oestradiol pre-treatment did not prevent IL-1β-induced reduction of proliferation and apoptosis and indeed enhanced inflammatory responses after 48 h. In terms of differentiation, IL-1β produced opposite effects on neurogenesis across cell lines, increasing neuronal maturation in female HPC0A07/03C cells, but decreasing neurite complexity in male HIP-009 cells. Notably, oestradiol pre-treatment in both lines reduced neuronal differentiation and increased kynurenine levels, suggesting potentially detrimental long-term effects. These results highlight complex, potentially cell-line-dependent, sex-specific hormone-immune interactions shaping fetal neurodevelopment and underscore the need to investigate these interactions when assessing risks and developing therapeutic interventions for inflammation-related neurodevelopmental disorders.
Microbiota-gut-brain axis dysregulation in Alzheimer’s disease and its modulation through probiotic supplementation
Moira Marizzoni, Elisa Mombelli, Silvia Alboni, Melissa Rosa, Davide Vito Moretti, Peppino Mirabelli, Luigi Coppola, Delia Luongo, Dominic Salamone, Samantha Saleri, Fabrizio Piazza, Veronica Begni, Marco Salvatore, Giovanni B. Frisoni, Annamaria Cattaneo
Brain Behavior and Immunity, 2026
BACKGROUND: The microbiota-gut-brain axis (MGBA) has been implicated in the pathophysiology of Alzheimer's Disease (AD).Probiotics reduced the progression of ADin different mouse models, possibly through MGBA modulation, but human data are still limited. OBJECTIVE: Here, we evaluated whether differences in the gut microbiome (GM), pro-inflammatory markers and other MGBA mediators were associated with probable AD (pAD). We also assessed the impact of a 12-week probiotic treatment on MGBA. METHODS: Forty-five pAD patients and 47 healthy subjects (HC) were recruited at IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli of Brescia (Italy). An uncontrolled clinical investigation was performed to test the effects of 12-week probiotic supplementation in the pAD group. Fecal microbiota composition, intestinal and blood inflammatory markers, and microbiota-related metabolites were assessed before supplementation in all participants and after only in pAD. RESULTS: pAD patients showed intestinal inflammation, an altered GM profile, blood changes in the tryptophan metabolism, and reduced glutamate levels compared with HC (p-value < 0.049). Probiotic supplementation partially modulated these alterations, determining a reduction in several pro-inflammatory mediators, and an increase of GM-related protective factors, such as butyrate (p-value < 0.040) in pAD. CONCLUSIONS: These findings confirmed the presence of MGBA alterations in AD and suggested a potential beneficial effect of probiotic supplementation through modulation of GM functionality rather than composition. Further research is required to confirm these results and their clinical relevance.
Searching for New Possible Peripheral Biomarkers of Cognitive Decline in Down Syndrome: The Role of IL-18 Pathway and its Interaction with TGF-β1 and TNF-α
Margherita Grasso, Annamaria Fidilio, Francesca L’Episcopo, Marilena Recupero, Concetta Barone, Marta Lovino, Silvia Alboni, Maria Giulia Bacalini, Giuseppe Caruso, Donatella Greco, Serafino Buono, Rafael De La Torre, Fabio Tascedda, Johanna MC Blom, Cristina Benatti, Filippo Caraci
Neuromolecular Medicine, 2026
The dietary ligands, omega-3 fatty acid endocannabinoids and short-chain fatty acids prevent cytokine-induced reduction of human hippocampal neurogenesis and alter the expression of genes involved in neuroinflammation and neuroplasticity
Gargi Mandal, Silvia Alboni, Nadia Cattane, Moira Marizzoni, Samantha Saleri, Nikita Arslanovski, Nicole Mariani, Madeline Kirkpatrick, Annamaria Cattaneo, Carmine M. Pariante, Alessandra Borsini
Molecular Psychiatry, 2025
The dietary ligands, omega-3 fatty acid endocannabinoids (eCBs) eicosapentaenoyl ethanolamide (EPEA) and docosahexaenoyl ethanolamide (DHEA), and short-chain fatty acids (SCFAs) acetate, propionate and butyrate, have anti-inflammatory and antidepressant properties. However, the molecular mechanisms underlying their action in the human brain remain elusive. Here, we treated human hippocampal neurons (HPC0A07/03 C) with eCBs (EPEA (300 pM) or DHEA (700 pM)), or SCFAs (acetate (200 uM), propionate (30 uM), butyrate (20 uM)), followed by interleukin (IL)1β (10,000 pg/ml) or IL6 (50 pg/ml). We found that treatment with either eCBs or SCFAs prevented IL1β- and IL6-induced reduction in neurogenesis and increase in apoptosis. These effects were mediated by IL1β-induced production of IL6, interferon-gamma (IFNγ) and tumour necrosis factor-alpha (TNFα), and by IL6-induced IL1β, IL8 and IL13, all of which were prevented by treatment with eCBs. In contrast, IL1β-induced production of IL6, IL12 and fractalkine (CX3CL1), and IL6-induced production of CX3CL1, were prevented by SCFAs. Treatment with IL1β and IL6 also increased the production of candidate kynurenine pathway metabolites, such as kynurenine (KYN) and nicotinic acid (NICA), which again were prevented by eCBs and SCFAs. We then conducted mRNA sequencing analysis to investigate cellular genes and signalling pathways relevant for the neuro-inflammatory changes previously observed, and putatively prevented by eCB and SCFA treatment. We found that IL1β decreased the expression of the neuroplasticity gene, FRY microtubule binding gene (FRY), and increased the expression of the neuroinflammation gene, U3 small nucleolar ribonucleoprotein homolog C subunit processome component (UTP14C), and both these effects were prevented by either acetate or propionate. Similarly, the expression of the proinflammatory gene, ADAM metallopeptidase with thrombospondin type 1 motif 1 (ADAMTS1), was increased by IL6, an effect that was prevented by either EPEA or acetate. Altogether, we identify novel anti-inflammatory and neurogenic mechanisms mediating the effect of eCBs and SCFAs on human hippocampal neurogenesis, which can be significant as potential future treatment candidates in the context of neuropsychiatric disorders.
Para-Cresol and the Brain: Emerging Role in Neurodevelopmental and Neurodegenerative Disorders and Therapeutic Perspectives
Laura Bertarini, Federico Imbeni, Virginia Brighenti, Isabella Martusciello, Federica Pellati, Silvia Alboni
ACS Pharmacology and Translational Science, 2025
C may represent a promising strategy to improve pathological phenotypes in the context of neurodevelopmental and neurodegenerative disorders.
Interleukin 18 and the brain: neuronal functions, neuronal survival and psycho-neuro-immunology during stress
Silvia Alboni, Fabio Tascedda, Akihito Uezato, Shuei Sugama, Zuxin Chen, Maria Cecilia Garibaldi Marcondes, Bruno Conti
Molecular Psychiatry, 2025
Unraveling lipopolysaccharide-induced behavioral and molecular effects in Lymnaea stagnalis, an emerging model organism for translational neuroscience
Veronica Rivi, Giovanna Rigillo, Silvia Alboni, Joris M. Koene, Luca Pani, Ken Lukowiak, Fabio Tascedda, Johanna M.C. Blom, Cristina Benatti
International Immunopharmacology, 2025
In this study, we employed a reductionist (yet not simplistic) approach utilizing the established invertebrate model system of the pond snail, Lymnaea stagnalis , to investigate the behavioral and molecular effects of systemic administration of lipopolysaccharide (LPS)—a bacterial endotoxin—on the snails' central ring ganglia. Snails received injections of either a low dose (2.5 μg) or a high dose (25 μg) of LPS, and their behavioral and molecular responses were assessed at 2, 6, and 24 h post-injection. With the high dose, snails exhibited a significant increase in homeostatic aerial respiration lasting for at least 24 h, consistent with a sickness-like state induced by the immune challenge. Additionally, we found that when administered 2, 6, or 24 h before operant conditioning training, the high dose of LPS, impaired memory formation. To further explore the underlying molecular mechanisms, we examined the transcriptional effects of the two doses of LPS in the snails' central ring ganglia. Our analysis showed a dose- and time-dependent upregulation of immune and stress-related genes, including key enzymes involved in the kynurenine pathway (KP), toll-like receptor 4 (TLR4), and heat shock protein 70 (HSP70). Metabolomic analysis suggested that the high LPS dose shifted KP metabolism toward the production of neurotoxic metabolites within the ganglia, indicating a LPS-induced neuroinflammatory state. Together, our findings provide valuable insight into the conserved mechanisms of neuroinflammation in this invertebrate model, offering a simplified yet effective tool to further explore the molecular interactions between the immune and central nervous systems. • Lymnaea stagnalis was used to study behavioral and molecular effects of LPS. • High-dose LPS increased aerial respiration, indicating a sickness-like state. • LPS impaired learning and memory, mirroring effects seen in mammals. • LPS upregulated immune and stress genes in snail's central ring ganglia. • High-dose LPS shifted kynurenine metabolism toward neurotoxic metabolites in ganglia.
Targeted Metabolomics for the Analysis of p-Cresol in Mouse Brain: Impact of Biological Sex and Strain
Laura Bertarini, Federico Imbeni, A. Vilella, Silvia Alboni, Federica Pellati
ACS Chemical Neuroscience, 2025
p-Cresol, an environmental contaminant and endogenous metabolite derived primarily from the conversion of l-tyrosine by intestinal microflora, is gaining increasing attention, due to its potential impact on human health. Recent studies have highlighted elevated levels of p-cresol and its metabolites, including p-cresyl sulfate and p-cresyl glucuronide, in various populations, suggesting a correlation with neurodevelopmental and neurodegenerative conditions. While the role of this compound as a uremic toxin is well established, its presence and concentration within the central nervous system (CNS) remain largely unexplored. To address this gap, an high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS) method was optimized and validated for the first time in this work for the targeted metabolomics of p-cresol in brain tissues. This method enabled the quantification of this compound in different brain areas of adult male and female C57BL/6J mice and in the cortex of various mouse strains, including CD-1 and the idiopathic autism model BTBR T+Itpr3tf/J. Additionally, preliminary analyses of human cortex samples confirmed the presence of p-cresol, suggesting its relevance in human brain health. Moreover, metabolomic analyses have further explored the correlations between p-cresol and neurotransmitters, with a particular focus on dopaminergic and noradrenergic pathways. These findings pave the way for understanding the potential impact of p-cresol on neurochemical networks and its implications for neurodevelopmental and neurodegenerative disorders.
Female mice exhibit similar long-term plasticity and microglial properties between the dorsal and ventral hippocampal poles
Eleonora De Felice, Bianca Caroline Bobotis, Giovanna Rigillo, Mohammadparsa Khakpour, Elisa Gonçalves de Andrade, Cristina Benatti, Antonietta Vilella, Fabio Tascedda, Cristina Limatola, Marie-Ève Tremblay, Silvia Alboni, Laura Maggi
Brain Behavior and Immunity, 2025
The hippocampus is a heterogenous structure that exhibits functional segregation along its longitudinal axis. We recently showed that in male mice, microglia, the brain's resident immune cells, differ between the dorsal (DH) and ventral (VH) hippocampus, impacting long-term potentiation (LTP) mainly through the CX3CL1-CX3CR1 signaling. Here, we assessed the specific features of the hippocampal poles in female mice, demonstrating a similar LTP amplitude in VH and DH in both control and Cx3cr1 knock-out mice. In addition, the expression levels of Cx3cr1 and Cx3cl1 mRNA do not differ between the two poles in control mice. These data support the critical role of the CX3CL1-CX3CR1 signaling in setting the physiological amount of plasticity, equally between poles in females. Although BDNF is higher in DH compared to VH, the expression levels of inflammatory markers involved in plasticity and of phagocytosis markers in microglia are comparable between the two poles. In accordance, microglia soma and arborization area/perimeter, and microglial ultrastructure are similar across regions, with the exception of microglial density, cells arborization solidity and circularity that are higher in DH. Understanding the molecular processes underlying microglial sex differences and their potential implications for plasticity in specific brain regions is of major importance in physiological and pathological conditions.
Neuroimmune modulatory effects of the NLRP3 inflammasome: the role of sex and living environment in brain affecting conditions
Miriam Ciani, Giovanna Rigillo, Beatrice Bertarini, Cristina Benatti, Silvia Alboni, Fabio Tascedda
Frontiers in Immunology, 2025
The NLRP3 inflammasome is a master regulator of neuroinflammation, linking systemic perturbations to brain dysfunction and thereby influencing overall brain health. Its sensitivity to biological sex and environmental factors suggests that NLRP3 may act both as a contributor to sex-dependent disease mechanisms and a modifiable therapeutic target for pharmacological and non-pharmacological interventions. In this mini-review, we summarize emerging evidence on sex-specific differences in NLRP3 signaling that may contribute to disparities between males and females in disease incidence, symptomatology, and treatment response. Neuroinflammation-driven disorders, including atherosclerosis, neuropathic pain, substance use, and stress-related syndromes, show how sex influences NLRP3 inflammasome expression and activity with downstream effects on cognition and behavior. We also examine the modulatory influence of environmental factors, with emphasis on social behavior and environmental enrichment, as determinants of NLRP3 dynamics relevant to neurocognitive function and brain health. Overall, the findings suggest that NLRP3 acts as a central hub integrating sex and environmental influences, with broad implications for personalized interventions in brain-related disorders.
Exploring the Frontiers of Neuroinflammation: New Horizons in Research and Treatment
Giovanna Rigillo, Silvia Alboni
Current Issues in Molecular Biology, 2024
Ketamine Prevents Inflammation-Induced Reduction of Human Hippocampal Neurogenesis via Inhibiting the Production of Neurotoxic Metabolites of the Kynurenine Pathway
Gargi Mandal, Madeline Kirkpatrick, Silvia Alboni, Nicole Mariani, Carmine M Pariante, Alessandra Borsini
International Journal of Neuropsychopharmacology, 2024
Behavioral and transcriptional effects of carnosine in the central ring ganglia of the pond snail Lymnaea stagnalis
Veronica Rivi, Giuseppe Caruso, Filippo Caraci, Silvia Alboni, Luca Pani, Fabio Tascedda, Ken Lukowiak, Johanna M. C. Blom, Cristina Benatti
Journal of Neuroscience Research, 2024
Time- and Region-specific Effect of Vortioxetine on Central LPS-induced Transcriptional Regulation of NLRP3 Inflammasome
Miriam Ciani, Giovanna Rigillo, Cristina Benatti, Luca Pani, Johanna M.C. Blom, Nicoletta Brunello, Fabio Tascedda, Silvia Alboni
Current Neuropharmacology, 2024
Hydroxypropyl-β-Cyclodextrin Depletes Membrane Cholesterol and Inhibits SARS-CoV-2 Entry into HEK293T-ACEhi Cells
Silvia Alboni, Valentina Secco, Bianca Papotti, Antonietta Vilella, Maria Pia Adorni, Francesca Zimetti, Laurent Schaeffer, Fabio Tascedda, Michele Zoli, Pascal Leblanc, Erica Villa
Pathogens, 2023
TEMPORARY REMOVAL: Sex affects the transcriptional effects of a neuroinflammatory hit experienced in development in the mouse hippocampus
Y. Toscano, C. Benatti, S. Alboni, M. Ciani, G. Rigillo, F. Tascedda, J.M.C. Blom, N. Brunello
Neuroscience Applied, 2023
Gut microbiota alterations promote traumatic stress susceptibility associated with p-cresol-induced dopaminergic dysfunctions
Samuele Laudani, Sebastiano A. Torrisi, Silvia Alboni, Thomaz F.S. Bastiaanssen, Cristina Benatti, Veronica Rivi, Rachel D. Moloney, Virginia Fuochi, Pio M. Furneri, Filippo Drago, Salvatore Salomone, Fabio Tascedda, John F. Cryan, Gian Marco Leggio
Brain Behavior and Immunity, 2023
Identification and characterization of the kynurenine pathway in the pond snail Lymnaea stagnalis
Benatti Cristina, Rivi Veronica, Alboni Silvia, Grilli Andrea, Castellano Sara, Pani Luca, Brunello Nicoletta, Blom Johanna M.C., Bicciato Silvio, Tascedda Fabio
Scientific Reports, 2022
Microglial diversity along the hippocampal longitudinal axis impacts synaptic plasticity in adult male mice under homeostatic conditions
E. De Felice, E. Gonçalves de Andrade, M. T. Golia, F. González Ibáñez, M. Khakpour, M. A. Di Castro, S. Garofalo, E. Di Pietro, C. Benatti, N. Brunello, F. Tascedda, B. Kaminska, C. Limatola, D. Ragozzino, M. E. Tremblay, S. Alboni, L. Maggi
Journal of Neuroinflammation, 2022
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth
Luca Costantino, Stefania Ferrari, Matteo Santucci, Outi MH Salo-Ahen, Emanuele Carosati, Silvia Franchini, Angela Lauriola, Cecilia Pozzi, Matteo Trande, Gaia Gozzi, Puneet Saxena, Giuseppe Cannazza, Lorena Losi, Daniela Cardinale, Alberto Venturelli, Antonio Quotadamo, Pasquale Linciano, Lorenzo Tagliazucchi, Maria Gaetana Moschella, Remo Guerrini, Salvatore Pacifico, Rosaria Luciani, Filippo Genovese, Stefan Henrich, Silvia Alboni, Nuno Santarem, Anabela da Silva Cordeiro, Elisa Giovannetti, Godefridus J Peters, Paolo Pinton, Alessandro Rimessi, Gabriele Cruciani, Robert M Stroud, Rebecca C Wade, Stefano Mangani, Gaetano Marverti, Domenico D'Arca, Glauco Ponterini, Maria Paola Costi
Elife, 2022
Gender differences in Anxious-depressive symptomatology, Metabolic Syndrome and Colorectal Adenomas among outpatients undergoing colonoscopy: a cross-sectional study according to a PNEI perspective
G. Rioli, G. Mattei, Caterina Bonamici, S. Mancini, S. Alboni, G. Cannazza, P. Sena, L. Roncucci, L. Pingani, S. Ferrari, G. Galeazzi
Acta Biomedica, 2022
Non-psychotropic Cannabis sativa L. phytocomplex modulates microglial inflammatory response through CB2 receptors-, endocannabinoids-, and NF-κB-mediated signaling
Vittoria Borgonetti, Cristina Benatti, Paolo Governa, Giovanni Isoldi, Federica Pellati, Silvia Alboni, Fabio Tascedda, Monica Montopoli, Nicoletta Galeotti, Fabrizio Manetti, Elisabetta Miraldi, Marco Biagi, Giovanna Rigillo
Phytotherapy Research, 2022
Indoleamine 2, 3-Dioxygenase 1 Mediates Survival Signals in Chronic Lymphocytic Leukemia via Kynurenine/Aryl Hydrocarbon Receptor-Mediated MCL1 Modulation
Claudio Giacinto Atene, Stefania Fiorcari, Nicolò Mesini, Silvia Alboni, Silvia Martinelli, Monica Maccaferri, Giovanna Leonardi, Leonardo Potenza, Mario Luppi, Rossana Maffei, Roberto Marasca
Frontiers in Immunology, 2022
Stress, hormones, and metabolism
Giulia Radighieri, Silvia Alboni
Encyclopedia of Behavioral Neuroscience Second Edition, 2021
What can we teach Lymnaea and what can Lymnaea teach us?
Veronica Rivi, Cristina Benatti, Ken Lukowiak, Chiara Colliva, Silvia Alboni, Fabio Tascedda, Johanna M.C. Blom
Biological Reviews, 2021
Serum metabolic signature of binge-like palatable food consumption in female rats by nuclear magnetic resonance spectroscopy
Carlo Cifani, Silvia Alboni, Adele Mucci, Cristina Benatti, Luca Botticelli, Nicoletta Brunello, Maria Vittoria Micioni Di Bonaventura, Valeria Righi
NMR in Biomedicine, 2021
Preliminary results of a multidisciplinary italian study adopting a psycho-neuro-endocrine-immunological (Pnei) approach to the study of colorectal adenomas
S. Mancini, S. Alboni, G. Mattei, G. Rioli, P. Sena, M. Marchi, A. Sacchetti, V. Boarino, L. Roncucci, G. Galeazzi, S. Ferrari
Acta Biomedica, 2021
Vortioxetine Prevents Lipopolysaccharide-Induced Memory Impairment Without Inhibiting the Initial Inflammatory Cascade
S. Alboni, C. Benatti, C. Colliva, G. Radighieri, J. M. C. Blom, N. Brunello, F. Tascedda
Frontiers in Pharmacology, 2021
Stress, Hormones, and Metabolism
Giulia Radighieri, Silvia Alboni
Encyclopedia of Behavioral Neuroscience Volumes 1 3 Second Edition, 2021
Depressive Disorders
Silvia Ferrari, Jordi Blanch, Shadi Lavasani, Steven C. Beall, Steven J. Gibson, Federica Maria Magarini, Silvia Alboni
HIV Psychiatry A Practical Guide for Clinicians, 2021
Interplay between inflammation and neural plasticity: Both immune activation and suppression impair LTP and BDNF expression
Maria Teresa Golia, Silvia Poggini, Silvia Alboni, Stefano Garofalo, Naomi Ciano Albanese, Aurelia Viglione, Maria Antonietta Ajmone-Cat, Abygaël St-Pierre, Nicoletta Brunello, Cristina Limatola, Igor Branchi, Laura Maggi
Brain Behavior and Immunity, 2019
Modulation of neuroplasticity-related targets following stress-induced acute escape deficit
C. Benatti, G. Radighieri, S. Alboni, J.M.C. Blom, N. Brunello, F. Tascedda
Behavioural Brain Research, 2019
The association between symptoms of anxiety, depression, and cardiovascular risk factors results from an Italian cross-sectional study
Giulia Rioli, Silvia Tassi, Giorgio Mattei, Silvia Ferrari, Gian Maria Galeazzi, Stefano Mancini, Silvia Alboni, Luca Roncucci
Journal of Nervous and Mental Disease, 2019
Combined fluoxetine and metformin treatment potentiates antidepressant efficacy increasing IGF2 expression in the dorsal hippocampus
Silvia Poggini, Maria Teresa Golia, Silvia Alboni, Giampaolo Milior, Livio Pepè Sciarria, Aurelia Viglione, Gloria Matte Bon, Nicoletta Brunello, Stefano Puglisi-Allegra, Cristina Limatola, Laura Maggi, Igor Branchi
Neural Plasticity, 2019
Neither all anti-inflammatory drugs nor all doses are effective in accelerating the antidepressant-like effect of fluoxetine in an animal model of depression
Silvia Alboni, Cristina Benatti, Giacomo Capone, Fabio Tascedda, Nicoletta Brunello
Journal of Affective Disorders, 2018
Molecular changes associated with escitalopram response in a stress-based model of depression
Cristina Benatti, Silvia Alboni, Joan M.C. Blom, Julien Mendlewicz, Fabio Tascedda, Nicoletta Brunello
Psychoneuroendocrinology, 2018
Rescue of IL-1β-induced reduction of human neurogenesis by omega-3 fatty acids and antidepressants
Alessandra Borsini, Silvia Alboni, Mark A. Horowitz, Luis M. Tojo, Giuseppe Cannazza, Kuan-Pin Su, Carmine M. Pariante, Patricia A. Zunszain
Brain Behavior and Immunity, 2017
Hippocampus-related effects of fluoxetine treatment under stressful vs enriched conditions
S Alboni, M van Dijk, S Poggini, G Milior, ML Perrotta, T Drenth, N Brunello, D Wolfer, C Limatola, I Amrein, F Cirulli, L Maggi, I Branchi
Molecular Psychiatry, 2017
Fluoxetine effects on molecular, cellular and behavioral endophenotypes of depression are driven by the living environment
S Alboni, R M van Dijk, S Poggini, G Milior, M Perrotta, T Drenth, N Brunello, D P Wolfer, C Limatola, I Amrein, F Cirulli, L Maggi, I Branchi
Molecular Psychiatry, 2017
Hypothalamic expression of inflammatory mediators in an animal model of binge eating
Silvia Alboni, Maria Vittoria Micioni Di Bonaventura, Cristina Benatti, Maria Elena Giusepponi, Nicoletta Brunello, Carlo Cifani
Behavioural Brain Research, 2017
Fluoxetine treatment affects the inflammatory response and microglial function according to the quality of the living environment
Silvia Alboni, Silvia Poggini, Stefano Garofalo, Giampaolo Milior, Hassan El Hajj, Cynthia Lecours, Isabelle Girard, Steven Gagnon, Samuel Boisjoly-Villeneuve, Nicoletta Brunello, David P. Wolfer, Cristina Limatola, Marie-Ève Tremblay, Laura Maggi, Igor Branchi
Brain Behavior and Immunity, 2016
Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress
Giampaolo Milior, Cynthia Lecours, Louis Samson, Kanchan Bisht, Silvia Poggini, Francesca Pagani, Cristina Deflorio, Clotilde Lauro, Silvia Alboni, Cristina Limatola, Igor Branchi, Marie-Eve Tremblay, Laura Maggi
Brain Behavior and Immunity, 2016
The proinflammatory cytokine interleukin 18 regulates feeding by acting on the bed nucleus of the stria terminalis
Walter Francesconi, Manuel Sánchez-Alavez, Fulvia Berton, Silvia Alboni, Cristina Benatti, Simone Mori, William Nguyen, Eric Zorrilla, Gianluca Moroncini, Fabio Tascedda, Bruno Conti
Journal of Neuroscience, 2016
Disease-induced neuroinflammation and depression
Cristina Benatti, Joan M.C. Blom, Giovanna Rigillo, Silvia Alboni, Francesca Zizzi, Riccardo Torta, Nicoletta Brunello, Fabio Tascedda
CNS and Neurological Disorders Drug Targets, 2016
Erratum to: Changes in the NMR Metabolic Profile of Live Human Neuron-Like SH-SY5Y Cells Exposed to Interferon-α2 (J Neuroimmune Pharmacol, 2015, DOI 10.1007/s11481-015-9641-x)
Valeria Righi, Luisa Schenetti, Adele Mucci, Stefania Benatti, Fabio Tascedda, Nicoletta Brunello, Carmine M. Pariante, Silvia Alboni
Journal of Neuroimmune Pharmacology, 2016
Changes in the NMR Metabolic Profile of Live Human Neuron-Like SH-SY5Y Cells Exposed to Interferon-α2
Righi Valeria, Schenetti Luisa, Mucci Adele, Benatti Stefania, Tascedda Fabio, Brunello Nicoletta, Pariante M Carmine, Alboni Silvia
Journal of Neuroimmune Pharmacology, 2016
Editorial: Cytokines as players of neuronal plasticity and sensitivity to environment in healthy and pathological brain
Silvia Alboni, Laura Maggi
Frontiers in Cellular Neuroscience, 2016
The role of microglia in mediating the effect of the environment in brain plasticity and behavior
Igor Branchi, Silvia Alboni, Laura Maggi
Frontiers in Cellular Neuroscience, 2014
Behavioural and transcriptional effects of escitalopram in the chronic escape deficit model of depression
Cristina Benatti, Silvia Alboni, Joan M.C. Blom, Francesco Gandolfi, Julien Mendlewicz, Nicoletta Brunello, Fabio Tascedda
Behavioural Brain Research, 2014
Interleukin 18 activates MAPKs and STAT3 but not NF-κB in hippocampal HT-22 cells
Silvia Alboni, Claudia Montanari, Cristina Benatti, Manuel Sanchez-Alavez, Giovanna Rigillo, Joan M.C. Blom, Nicoletta Brunello, Bruno Conti, M. Carmine Pariante, Fabio Tascedda
Brain Behavior and Immunity, 2014
Successful treatment of HIV-1 infection increases the expression of a novel, short transcript for IL-18 receptor α chain
Milena Nasi, Silvia Alboni, Marcello Pinti, Fabio Tascedda, Cristina Benatti, Stefania Benatti, Lara Gibellini, Sara De Biasi, Vanni Borghi, Nicoletta Brunello, Cristina Mussini, Andrea Cossarizza
Journal of Acquired Immune Deficiency Syndromes, 2014
Chronic antidepressant treatments resulted in altered expression of genes involved in inflammation in the rat hypothalamus
Silvia Alboni, Cristina Benatti, Claudia Montanari, Fabio Tascedda, Nicoletta Brunello
European Journal of Pharmacology, 2013
N-acetyl-cysteine prevents toxic oxidative effects induced by IFN-α in human neurons
Silvia Alboni, Lara Gibellini, Claudia Montanari, Cristina Benatti, Stefania Benatti, Fabio Tascedda, Nicoletta Brunello, Andrea Cossarizza, Carmine M. Pariante
International Journal of Neuropsychopharmacology, 2013
Neuropeptide S stimulates human monocyte chemotaxis via NPS receptor activation
M. Filaferro, C. Novi, V. Ruggieri, S. Genedani, S. Alboni, D. Malagoli, G. Caló, R. Guerrini, G. Vitale
Peptides, 2013
Transcriptional profiles underlying vulnerability and resilience in rats exposed to an acute unavoidable stress
Cristina Benatti, Cristina Valensisi, Joan M.C. Blom, Silvia Alboni, Claudia Montanari, Francesco Ferrari, Enrico Tagliafico, Julien Mendlewicz, Nicoletta Brunello, Fabio Tascedda
Journal of Neuroscience Research, 2012
Central effects of a local inflammation in three commonly used mouse strains with a different anxious phenotype
Cristina Benatti, Silvia Alboni, Claudia Montanari, Federica Caggia, Fabio Tascedda, Nicoletta Brunello, Joan M.C. Blom
Behavioural Brain Research, 2011
Stress induces altered CRE/CREB pathway activity and BDNF expression in the hippocampus of glucocorticoid receptor-impaired mice
Silvia Alboni, Fabio Tascedda, Daniela Corsini, Cristina Benatti, Federica Caggia, Giacomo Capone, Nicholas Barden, Joan M.C. Blom, Nicoletta Brunello
Neuropharmacology, 2011
Sex- and age-specific differences in core body temperature of C57Bl/6 mice
Manuel Sanchez-Alavez, Silvia Alboni, Bruno Conti
Age, 2011
Constitutive and LPS-regulated expression of interleukin-18 receptor beta variants in the mouse brain
Silvia Alboni, Claudia Montanari, Cristina Benatti, Johanna M.C. Blom, Maria Luisa Simone, Nicoletta Brunello, Federica Caggia, Gianluigi Guidotti, Maria Cecilia Garibaldi Marcondes, Manuel Sanchez-Alavez, Bruno Conti, Fabio Tascedda
Brain Behavior and Immunity, 2011
Time-dependent effects of escitalopram on brain derived neurotrophic factor (BDNF) and neuroplasticity related targets in the central nervous system of rats
Silvia Alboni, Cristina Benatti, Giacomo Capone, Daniela Corsini, Federica Caggia, Fabio Tascedda, Julien Mendlewicz, Nicoletta Brunello
European Journal of Pharmacology, 2010
Interleukin 18 in the CNS
Silvia Alboni, Davide Cervia, Shuei Sugama, Bruno Conti
Journal of Neuroinflammation, 2010
Erratum: HTR1B as a risk profile maker in psychiatric disorders: A review through motivation and memory (European Journal of Clinical Pharmacology DOI:10.1007/s00228-009-0724-6)
Antonio Drago, Silvia Alboni, Nicoletta Brunello, Diana De Ronchi, Alessandro Serretti
European Journal of Clinical Pharmacology, 2010
HTR1B as a risk profile maker in psychiatric disorders: A review through motivation and memory
Antonio Drago, Silvia Alboni, Brunello Nicoletta, Diana De Ronchi, Alessandro Serretti
European Journal of Clinical Pharmacology, 2010
Chronic treatment with the selective NOP receptor antagonist [Nphe 1,Arg14,Lys15]N/OFQ-NH2 (UFP-101) reverses the behavioural and biochemical effects of unpredictable chronic mild stress in rats
Giovanni Vitale, Valentina Ruggieri, Monica Filaferro, Claudio Frigeri, Silvia Alboni, Fabio Tascedda, Nicoletta Brunello, Remo Guerrini, Carlo Cifani, Maurizio Massi
Psychopharmacology, 2009
Early neonatal inflammation affects adult pain reactivity and anxiety related traits in mice: genetic background counts
Cristina Benatti, Silvia Alboni, Giacomo Capone, Daniela Corsini, Federica Caggia, Nicoletta Brunello, Fabio Tascedda, Joan M.C. Blom
International Journal of Developmental Neuroscience, 2009
Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain
Silvia Alboni, Davide Cervia, Brendon Ross, Claudia Montanari, Alejandro Sanchez Gonzalez, Manuel Sanchez-Alavez, Maria Cecilia Garibaldi Marcondes, David De Vries, Shuei Sugama, Nicoletta Brunello, Joan Blom, Fabio Tascedda, Bruno Conti
Journal of Neuroimmunology, 2009
The transporters GlyT2 and VIAAT cooperate to determine the vesicular glycinergic phenotype
K. R. Aubrey, F. M. Rossi, R. Ruivo, S. Alboni, G. C. Bellenchi, A. Le Goff, B. Gasnier, S. Supplisson
Journal of Neuroscience, 2007
Early postnatal chronic inflammation produces long-term changes in pain behavior and N-methyl-D-aspartate receptor subtype gene expression in the central nervous system of adult mice
Joan M.C. Blom, C. Benatti, S. Alboni, G. Capone, C. Ferraguti, N. Brunello, F. Tascedda
Journal of Neuroscience Research, 2006
Shortened onset of action of antidepressants in major depression using acetylsalicylic acid augmentation: A pilot open-label study
Julien Mendlewicz, Philippe Kriwin, Pierre Oswald, Daniel Souery, Silvia Alboni, Nicoletta Brunello
International Clinical Psychopharmacology, 2006
Acetylsalicylic acid accelerates the antidepressant effect of fluoxetine in the chronic escape deficit model of depression
Nicoletta Brunello, Silvia Alboni, Giacomo Capone, Cristina Benatti, Joan M.C. Blom, Fabio Tascedda, Philippe Kriwin, Julien Mendlewicz
International Clinical Psychopharmacology, 2006

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