Silvia Persichilli

Scopus Publications

Impact of an autonomous delivery robot on sample turnaround time in a clinical laboratory: an early evaluation of first implementation
Jacopo Gervasoni, Davide Pedrazzini, Michela Cicchinelli, Silvia Persichilli, Silvia Baroni, Sandro Rocchetti, Giovanni Arcuri, Andrea Urbani
Clinical Chemistry and Laboratory Medicine, 2026
Objectives The aim of this study was to evaluate the impact of introducing an autonomous courier in a clinical laboratory, focusing on specimen turnaround time (TAT). We assessed whether high-frequency robotic transport from the central accessioning area to analytical sections could reduce delays and variability compared with manual delivery. Methods We retrospectively analyzed routine lithium–heparin glucose specimens processed during the initial days of robot deployment (13–23 May 2025, weekdays, 08:00–16:00) and compared them with the same period in 2024 under manual transport. TAT was defined as the interval from check-in at accessioning to technical validation in the Laboratory Information System (LIS). Data were assessed globally and stratified by time of day, examining changes in central tendency, dispersion, and extreme delays. Results In total, 6,299 samples in 2024 and 5,759 in 2025 were analyzed, showing a leftward shift of the distribution with fewer delay. In 2025, the mean TAT decreased from 122.64 to 106.72 min, the median from 112 to 101 min, and dispersion tightened. Stratification by time of day also demonstrated consistent improvements. Conclusions Even in its earliest days of operation, the delivery robot reduced TAT and variability, converting specimen transport from batch runs into near-continuous flow. These findings highlight ease of adoption and the potential of robotic transport to improve speed, predictability, and safety in intralaboratory logistics. Further validation across longer periods and additional laboratory sections is warranted.
Development of a novel Ultra Performance Liquid Chromatography Tandem-Mass Spectrometry (UPLC-MS/MS) method to measure L-arginine metabolites in plasma
Lavinia Santucci, Sara Lomuscio, Aniello Primiano, Riccardo Calvani, Silvia Persichilli, Federica Iavarone, Anna Picca, Francesca Canu, Andrea Urbani, Jacopo Gervasoni
Clinica Chimica Acta, 2023
INTRODUCTION: Arginine metabolism is involved in the regulation of several biological processes. Many liquid chromatography tandem-mass spectrometry methods for the determination of arginine and its metabolites have been developed but they are time consuming and imply long pre-analytical procedures. The purpose of this study was to develop a rapid method for the simultaneous determination of arginine, citrulline, ornithine, symmetric and asymmetric dimethylarginine and monomethylarginine in human plasma. MATERIALS AND METHODS: The pre-analytical procedure consisted in a simple deproteinization. The chromatographic separation was performed using hydrophilic interaction liquid chromatography. Analytes detection was performed with a triple quadrupole equipped with electrospray ion source operating in positive ion mode. Mass spectrometry experiments were conducted in multiple reaction monitoring mode. RESULTS AND CONCLUSIONS: Recovery ranged from 92.2 to 108.0%. The within-run imprecision and between-run imprecision ranged from 1.5 to 6.8 % and 3.8 to 11.9%, respectively. Carry over and matrix effect did not affect quantitative analysis. Extraction recovery was between 95 and 105 %. Stability after pre-analytical procedure was tested and all the metabolites were stable after 48 h at 4 °C. In conclusion, our novel method allow a rapid and easy determination of arginine and its metabolites both for research and clinical routine use.
Intestinal Permeability and Dysbiosis in Female Patients with Recurrent Cystitis: A Pilot Study
Cristina Graziani, Lucrezia Laterza, Claudia Talocco, Marco Pizzoferrato, Nicoletta Di Simone, Silvia D’Ippolito, Caterina Ricci, Jacopo Gervasoni, Silvia Persichilli, Federica Del Chierico, Valeria Marzano, Stefano Levi Mortera, Aniello Primiano, Andrea Poscia, Francesca Romana Ponziani, Lorenza Putignani, Andrea Urbani, Valentina Petito, Federica Di Vincenzo, Letizia Masi, Loris Riccardo Lopetuso, Giovanni Cammarota, Daniela Romualdi, Antonio Lanzone, Antonio Gasbarrini, Franco Scaldaferri
Journal of Personalized Medicine, 2022
Recurrent cystitis (RC) is a common disease, especially in females. Anatomical, behavioral and genetic predisposing factors are associated with the ascending retrograde route, which often causes bladder infections. RC seems to be mainly caused by agents derived from the intestinal microbiota, and most frequently by Escherichia coli. Intestinal contiguity contributes to the etiopathogenesis of RC and an alteration in intestinal permeability could have a major role in RC. The aim of this pilot study is to assess gut microbiome dysbiosis and intestinal permeability in female patients with RC. Patients with RC (n = 16) were enrolled and compared with healthy female subjects (n = 15) and patients with chronic gastrointestinal (GI) disorders (n = 238). We calculated the Acute Cystitis Symptom Score/Urinary Tract Infection Symptom Assessment (ACSS/UTISA) and Gastrointestinal Symptom Rating Scale (GSRS) scores and evaluated intestinal permeability and the fecal microbiome in the first two cohorts. Patients with RC showed an increased prevalence of gastrointestinal symptoms compared with healthy controls. Of the patients with RC, 88% showed an increased intestinal permeability with reduced biodiversity of gut microbiota compared to healthy controls, and 68% of the RC patients had a final diagnosis of gastrointestinal disease. Similarly, GI patients reported a higher incidence of urinary symptoms with a diagnosis of RC in 20%. Gut barrier impairment seems to play a major role in the pathogenesis of RC. Further studies are necessary to elucidate the role of microbiota and intestinal permeability in urinary tract infections.
Metabolic profiling of Costello syndrome: Insights from a single-center cohort
Chiara Leoni, Miriam Massese, Jacopo Gervasoni, Aniello Primiano, Valentina Giorgio, Roberta Onesimo, Eliza Kuczynska, Donato Rigante, Silvia Persichilli, Giovanna Carpentieri, Elisabetta Flex, Roberta Pastorino, Marco Tartaglia, Giuseppe Zampino
European Journal of Medical Genetics, 2022
Folic acid and autism: A systematic review of the current state of knowledge
Bianka Hoxha, Malvina Hoxha, Elisa Domi, Jacopo Gervasoni, Silvia Persichilli, Visar Malaj, Bruno Zappacosta
Cells, 2021
Folic acid has been identified to be integral in rapid tissue growth and cell division during fetal development. Different studies indicate folic acid’s importance in improving childhood behavioral outcomes and underline its role as a modifiable risk factor for autism spectrum disorders. The aim of this systematic review is to both elucidate the potential role of folic acid in autism spectrum disorders and to investigate the mechanisms involved. Studies have pointed out a potential beneficial effect of prenatal folic acid maternal supplementation (600 µg) on the risk of autism spectrum disorder onset, but opposite results have been reported as well. Folic acid and/or folinic acid supplementation in autism spectrum disorder diagnosed children has led to improvements, both in some neurologic and behavioral symptoms and in the concentration of one-carbon metabolites. Several authors report an increased frequency of serum auto-antibodies against folate receptor alpha (FRAA) in autism spectrum disorder children. Furthermore, methylene tetrahydrofolate reductase (MTHFR) polymorphisms showed a significant influence on ASD risk. More clinical trials, with a clear study design, with larger sample sizes and longer observation periods are necessary to be carried out to better evaluate the potential protective role of folic acid in autism spectrum disorder risk.
Attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) detection as a rapid and convenient screening test for cystinuria
Aniello Primiano, Silvia Persichilli, Flavio Di Giacinto, Gabriele Ciasca, Silvia Baroni, Pietro Manuel Ferraro, Marco De Spirito, Andrea Urbani, Jacopo Gervasoni
Clinica Chimica Acta, 2021
Identification of biomarkers for physical frailty and sarcopenia through a new multi-marker approach: results from the BIOSPHERE study
Riccardo Calvani, Anna Picca, Federico Marini, Alessandra Biancolillo, Jacopo Gervasoni, Silvia Persichilli, Aniello Primiano, Hélio J. Coelho-Junior, Matteo Cesari, Maurizio Bossola, Andrea Urbani, Graziano Onder, Francesco Landi, Roberto Bernabei, Emanuele Marzetti
Geroscience, 2021
Investigating different forms of hydrogen sulfide in cerebrospinal fluid of various neurological disorders
Viviana Greco, Cristina Neri, Damiana Pieragostino, Alida Spalloni, Silvia Persichilli, Matteo Gastaldi, Nicola B. Mercuri, Patrizia Longone, Andrea Urbani
Metabolites, 2021
Over the past 30 years a considerable amount of data has accumulated on the multifaceted role of hydrogen sulfide (H2S) in the central nervous system. Depending on its concentrations, H2S has opposite actions, ranging from neuromodulator to neurotoxic. Nowadays, accurate determination of H2S is still an important challenge to understand its biochemistry and functions. In this perspective, this study aims to explore H2S levels in cerebrospinal fluid (CSF), key biofluid for neurological studies, and to assess alleged correlations with neuroinflammatory and neurodegenerative mechanisms. A validated analytical determination combining selective electrochemical detection with ion chromatography was developed to measure free and bound sulfur forms of H2S. A first cohort of CSF samples (n = 134) was analyzed from patients with inflammatory and demyelinating disorders (acute disseminated encephalomyelitis; multiple sclerosis), chronic neurodegenerative diseases (Alzheimer disease; Parkinson disease), and motor neuron disease (Amyotrophic lateral sclerosis). Given its analytical features, the chromatographic method resulted sensitive, reproducible and robust. We also explored low molecular weight-proteome linked to sulphydration by proteomics analysis on matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS). This study is a first clinical report on CSF H2S concentrations from neurological diseases and opens up new perspectives on the potential clinical relevance of H2S and its potential therapeutic application.
Erratum: Prognostic role of serum amino acids in head and neck cancer (Disease Markers (2020) 2020 (8) DOI: 10.1155/2020/2291759)
Gabriella Cadoni, Luca Giraldi, Carlo Chiarla, Jacopo Gervasoni, Silvia Persichilli, Aniello Primiano, Stefano Settimi, Jacopo Galli, Gaetano Paludetti, Dario Arzani, Stefania Boccia, Ivo Giovannini, Giovanni Almadori
Disease Markers, 2021
[This corrects the article DOI: 10.1155/2020/2291759.].
Ceramic-on-metal bearing in short stem total hip arthroplasty: ions, functional and radiographic evaluation at mid-term follow-up
Michela Saracco, Giulio Maccauro, Andrea Urbani, Domenico Ciavardelli, Silvia Persichilli, Giulio Ancillai, Patrizio Pasqualetti, Vittorio Calvisi, Giandomenico Logroscino
HIP International, 2020
Introduction: The aim of this study is to evaluate clinical, radiographic and laboratory results of ceramic-on-metal (CoM) (hybrid hard bearing) in total hip arthroplasty (THA), associated with a short stem implant. Methods: From a cohort of 37 patients suffering from primary or secondary hip osteoarthritis who underwent THA using CoM bearing, 19 were suitable for this study. All procedures were performed by the same surgeon using a posterior-lateral approach. All patients were compared clinically using the Harris Hip Score (HHS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), visual analogue scale (VAS), 12-item Short Form Health Survey (SF12F/M), and radiographically (offset, CD angle, limb length discrepancy, cup inclination and anteversion, subsidence, osseointegration, heterotopic ossification). Blood samples were collected in order to evaluate chromium (Cr) and cobalt (Co) ions level. Radiographic evaluations were carried out by 3 different blinded surgeons. A statistical analysis was performed. Results: At a mean follow-up of 97 (73–125) months all implanted stems were well-positioned and osseointegrated. Clear improvements were observed for clinical scores comparing preoperative and postoperative values. Radiographic evaluation showed a good ability to restore proper articular geometry. Cr ion analysis revealed values below the safety threshold except for 1 case. Serum levels of Co were below the threshold in all patients. There was a statistically significant correlation only between Cr metal ions and length of follow-up. Conclusions: CoM bearing has proven to be reliable and safe at a mean 8-year follow-up for patients in whom the components were correctly implanted. The rise of blood metal ions was minimal and involved neither systemic or local toxicity nor influenced clinical results.
Fourier-transform infrared spectroscopy of skeletal muscle tissue: Expanding biomarkers in primary mitochondrial myopathies
Jacopo Gervasoni, Aniello Primiano, Federico Marini, Andrea Sabino, Alessandra Biancolillo, Riccardo Calvani, Anna Picca, Emanuele Marzetti, Silvia Persichilli, Andrea Urbani, Serenella Servidei, Guido Primiano
Genes, 2020
A novel multi-marker discovery approach identifies new serum biomarkers for Parkinson’s disease in older people: an EXosomes in PArkiNson Disease (EXPAND) ancillary study
Riccardo Calvani, Anna Picca, Giovanni Landi, Federico Marini, Alessandra Biancolillo, Hélio José Coelho-Junior, Jacopo Gervasoni, Silvia Persichilli, Aniello Primiano, Annalaura Arcidiacono, Andrea Urbani, Maurizio Bossola, Anna Rita Bentivoglio, Matteo Cesari, Roberto Bernabei, Maria Rita Lo Monaco, Emanuele Marzetti
Geroscience, 2020
Exploring the HeLa Dark Mitochondrial Proteome
Federica Marini, Victor Corasolla Carregari, Viviana Greco, Maurizio Ronci, Federica Iavarone, Silvia Persichilli, Massimo Castagnola, Andrea Urbani, Luisa Pieroni
Frontiers in Cell and Developmental Biology, 2020
A Specific Urinary Amino Acid Profile Characterizes People with Kidney Stones
Aniello Primiano, Silvia Persichilli, Pietro Manuel Ferraro, Riccardo Calvani, Alessandra Biancolillo, Federico Marini, Anna Picca, Emanuele Marzetti, Andrea Urbani, Jacopo Gervasoni
Disease Markers, 2020
Prognostic Role of Serum Amino Acids in Head and Neck Cancer
Gabriella Cadoni, Luca Giraldi, Carlo Chiarla, Jacopo Gervasoni, Silvia Persichilli, Aniello Primiano, Stefano Settimi, Jacopo Galli, Gaetano Paludetti, Dario Arzani, Stefania Boccia, Ivo Giovannini, Giovanni Almadori
Disease Markers, 2020
Circulating amino acid signature in older people with Parkinson's disease: A metabolic complement to the EXosomes in PArkiNson Disease (EXPAND) study
Anna Picca, Riccardo Calvani, Giovanni Landi, Federico Marini, Alessandra Biancolillo, Jacopo Gervasoni, Silvia Persichilli, Aniello Primiano, Andrea Urbani, Maurizio Bossola, Anna Rita Bentivoglio, Matteo Cesari, Francesco Landi, Roberto Bernabei, Emanuele Marzetti, Maria Rita Lo Monaco
Experimental Gerontology, 2019
A combination of infrared spectroscopy and morphological analysis allows successfully identifying rare crystals and atypical urinary stones
A. Primiano, S. Persichilli, P. M. Ferraro, A. Minucci, G. Gambaro, A. Urbani, J. Gervasoni
Annali Dell Istituto Superiore Di Sanita, 2019
Intestinal permeability in physiological and pathological conditions: Major determinants and assessment modalities
C. Graziani, C. Talocco, R. D. Sire, V. Petito, L. Lopetuso, J. Gervasoni, S. Persichilli, Francesco Franceschi, V. Ojetti, A. Gasbarrini, F. Scaldaferri
European Review for Medical and Pharmacological Sciences, 2019
A distinct pattern of circulating amino acids characterizes older persons with physical frailty and sarcopenia: Results from the BIOSPHERE study
Riccardo Calvani, Anna Picca, Federico Marini, Alessandra Biancolillo, Jacopo Gervasoni, Silvia Persichilli, Aniello Primiano, Hélio José Coelho-Junior, Maurizio Bossola, Andrea Urbani, Francesco Landi, Roberto Bernabei, Emanuele Marzetti
Nutrients, 2018
Validation of UPLC-MS/MS Method for determination of urinary lactulose/mannitol
Jacopo Gervasoni, Aniello Primiano, Cristina Graziani, Franco Scaldaferri, Antonio Gasbarrini, Andrea Urbani, Silvia Persichilli
Molecules, 2018
Proteomics and toxicity analysis of spinal-cord primary cultures upon hydrogen sulfide treatment
Viviana Greco, Alida Spalloni, Victor Corasolla Carregari, Luisa Pieroni, Silvia Persichilli, Nicola B. Mercuri, Andrea Urbani, Patrizia Longone
Antioxidants, 2018
Improvement of Urinary Stones Analysis Combining Morphological Analysis and Infrared Spectroscopy
Jacopo Gervasoni, Aniello Primiano, Pietro Manuel Ferraro, Andrea Urbani, Giovanni Gambaro, Silvia Persichilli
Journal of Chemistry, 2018
Bioanalytical method validation of quantitative mass spectrometry based assay: Experimental protocols and regulations
A. D’Avolio, M. Cantú, J. Gervasoni, C. Artusi, M. Marinova, A. Nonnato, G. Cangemi, S. Persichilli
Biochimica Clinica, 2018
Erratum to: A novel CYP24A1 genotype associated to a clinical picture of hypercalcemia, nephrolithiasis and low bone mass (Urolithiasis, (2017), 45, 3, (291-294), 10.1007/s00240-016-0923-4)
Pietro Manuel Ferraro, Angelo Minucci, Aniello Primiano, Elisa De Paolis, Jacopo Gervasoni, Silvia Persichilli, Alessandro Naticchia, Ettore Capoluongo, Giovanni Gambaro
Urolithiasis, 2017
A novel CYP24A1 genotype associated to a clinical picture of hypercalcemia, nephrolithiasis and low bone mass
Pietro Manuel Ferraro, Angelo Minucci, Aniello Primiano, Elisa De Paolis, Jacopo Gervasoni, Silvia Persichilli, Alessandro Naticchia, Ettore Capoluongo, Giovanni Gambaro
Urolithiasis, 2017
Development of a liquid chromatography-Tandem mass spectometry (LC-MS/MS) method to evaluate intestinal permeability in clinical practice
Biochimica Clinica, 2017
Usefulness of infrared spectroscopy for stone analysis: A case study
Biochimica Clinica, 2017
Simultaneous quantification of 17-hydroxyprogesterone, androstenedione, testosterone and cortisol in human serum by LC-MS/MS using TurboFlow online sample extraction
Jacopo Gervasoni, Arcangelo Schiattarella, Aniello Primiano, Ilaria D'Addurno, Andrea Cocci, Cecilia Zuppi, Silvia Persichilli
Clinical Biochemistry, 2016
Role of Fourier transform infrared (FT-IR) spectroscopy in the evaluation of urinary stone disease
Biochimica Clinica, 2016
Validation of an LC-MS/MS Method for Urinary Lactulose and Mannitol Quantification: Results in Patients with Irritable Bowel Syndrome
Jacopo Gervasoni, Arcangelo Schiattarella, Valentina Giorgio, Aniello Primiano, Consuelo Russo, Valentina Tesori, Franco Scaldaferri, Andrea Urbani, Cecilia Zuppi, Silvia Persichilli
Disease Markers, 2016
Plasma thiols levels in Alzheimer's disease mice under diet-induced hyperhomocysteinemia: effect of S-adenosylmethionine and superoxide-dismutase supplementation
Silvia Persichilli, Jacopo Gervasoni, Alessandra Di Napoli, Andrea Fuso, Vincenzina Nicolia, Bruno Giardina, Sigfrido Scarpa, Claudia Desiderio, Rosaria A. Cavallaro
Journal of Alzheimer S Disease JAD, 2015
5,10-Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms: Genotype frequency and association with homocysteine and folate levels in middle-southern Italian adults
Bruno Zappacosta, Mirella Graziano, Silvia Persichilli, Augusto Di Castelnuovo, Pierpaolo Mastroiacovo, Licia Iacoviello
Cell Biochemistry and Function, 2014
FT-IR analysis of urinary stones: a helpful tool for clinician comparison with the chemical spot test
Aniello Primiano, Silvia Persichilli, Giovanni Gambaro, Pietro Manuel Ferraro, Alessandro D’Addessi, Andrea Cocci, Arcangelo Schiattarella, Cecilia Zuppi, Jacopo Gervasoni
Disease Markers, 2014
Decreased bone mineral density in Costello syndrome
Chiara Leoni, David A. Stevenson, Lucilla Martini, Roberto De Sanctis, Giovanna Mascolo, Francesca Pantaleoni, Sara De Santis, Ilaria La Torraca, Silvia Persichilli, Paolo Caradonna, Marco Tartaglia, Giuseppe Zampino
Molecular Genetics and Metabolism, 2014
Effects of lutein supplementation on biological antioxidant status in preterm infants: A randomized clinical trial
Simonetta Costa, Carmen Giannantonio, Costantino Romagnoli, Giovanni Vento, Jacopo Gervasoni, Silvia Persichilli, Cecilia Zuppi, Francesco Cota
Journal of Maternal Fetal and Neonatal Medicine, 2013
Homocysteine lowering by folate-rich diet or pharmacological supplementations in subjects with moderate hyperhomocysteinemia
Bruno Zappacosta, Pierpaolo Mastroiacovo, Silvia Persichilli, George Pounis, Stefania Ruggeri, Angelo Minucci, Emilia Carnovale, Generoso Andria, Roberta Ricci, Iris Scala, Orazio Genovese, Aida Turrini, Lorenza Mistura, Bruno Giardina, Licia Iacoviello
Nutrients, 2013
Folate, vitamin B12 and homocysteine status in an Italian blood donor population
B. Zappacosta, S. Persichilli, L. Iacoviello, A. Di Castelnuovo, M. Graziano, J. Gervasoni, E. Leoncini, G. Cimino, P. Mastroiacovo
Nutrition Metabolism and Cardiovascular Diseases, 2013
Total 25-hydroxyvitamin D determination by an entry level triple quadrupole instrument: Comparison between two commercial kits
Jacopo Gervasoni, Andrea Cocci, Cecilia Zuppi, Silvia Persichilli
Biomed Research International, 2013
Role of SH levels and markers of immune response in the stroke
Maria Musumeci, Stefano Sotgiu, Silvia Persichilli, Giannina Arru, Silvia Angeletti, Maria Laura Fois, Angelo Minucci, Salvatore Musumeci
Disease Markers, 2013
Measurement of 25-hydroxyvitamin vitamin D by liquid chromatography tandem-mass spectrometry with comparison to automated immunoassays
Cinzia Carrozza, Silvia Persichilli, Giulia Canu, Jacopo Gervasoni, Eleonora Torti, Luigi Tazza, Cecilia Zuppi
Clinical Chemistry and Laboratory Medicine, 2012
Assessment of salivary free cortisol levels by liquid chromatography with tandemass spectrometry (LC-MS/MS) in patients treated with mitotane
Cinzia Carrozza, Rosa Lapolla, Jacopo Gervasoni, Carlo Antonio Rota, Pietro Locantore, Alfredo Pontecorvi, Cecilia Zuppi, Silvia Persichilli
Hormones, 2012
Determination of asymmetric dimethyl arginine in human serum by liquid chromatography-tandem mass spectrometry: Clinical application in hypertensive subjects
Jacopo Gervasoni, Fabio Bonelli, Cecilia Zuppi, Bruno Zappacosta, Alvaro Mordente, Riccardo Calvani, Silvia Persichilli
Clinical Chemistry and Laboratory Medicine, 2011
A reversed-phase HPLC fluorimetric method for simultaneous determination of homocysteine-related thiols in different body fluids
Silvia Persichilli, Jacopo Gervasoni, Massimo Castagnola, Cecilia Zuppi, Bruno Zappacosta
Laboratory Medicine, 2011
Morpho-functional modifications of human neutrophils induced by aqueous cigarette smoke extract: Comparison with chemiluminescence activity
B. Zappacosta, G.E. Martorana, S. Papini, J. Gervasoni, F. Iavarone, S. Fasanella, B. Giardina, P. De Sole, S. Persichilli
Luminescence, 2011
A simple liquid chromatography-tandem mass spectrometry method for urinary free cortisol analysis: Suitable for routine purpose
Silvia Persichilli, Jacopo Gervasoni, Federica Iavarone, Cecilia Zuppi
Clinical Chemistry and Laboratory Medicine, 2010
A simplified method for the determination of total homocysteine in plasma by electrospray tandem mass spectrometry
Silvia Persichilli, Jacopo Gervasoni, Federica Iavarone, Cecilia Zuppi, Bruno Zappacosta
Journal of Separation Science, 2010
Lutein absorption in premature infants
C Romagnoli, C Tirone, S Persichilli, J Gervasoni, C Zuppi, G Barone, E Zecca
European Journal of Clinical Nutrition, 2010
Genotype prevalence and allele frequencies of 5,10- methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in Italian newborns
Bruno Zappacosta, Lucio Romano, Silvia Persichilli, Luigi A. Cutrone, Mirella Graziano, Antonia Vitrani, Augusto Di Castelnuovo, Bruno Giardina, Salvatore Musumeci, Pierpaolo Mastroiacovo
Laboratory Medicine, 2009
Reliability and correlation study of a new homocysteine assay
Silvia Persichilli, Jacopo Gervasoni, Daniel De Martino, Antonia Vitrani, Domenico Ettore Capoluongo, Bruno Giardina, Bruno Zappacosta
Clinical Chemistry and Laboratory Medicine, 2008
Salivary glutathione and uric acid levels in patients with head and neck squamous cell carcinoma
Giovanni Almadori, Francesco Bussu, Jacopo Galli, Attilio Limongelli, Silvia Persichilli, Bruno Zappacosta, Angelo Minucci, Gaetano Paludetti, Bruno Giardina
Head and Neck, 2007
Salivary thiols and enzyme markers of cell damage in periodontal disease
Bruno Zappacosta, Armando Manni, Silvia Persichilli, Antonia Boari, Donata Scribano, Angelo Minucci, Luca Raffaelli, B. Giardina, P. De Sole
Clinical Biochemistry, 2007
Analytical evaluation of a new immunonephelometric method for homocysteine measurement
Bruno Zappacosta, Silvia Persichilli, Angelo Minucci, Donata Scribano, Mirca Antenucci, Silvia Fasanella, Paola Neri, Bruno Giardina, Pasquale De Sole
Clinica Chimica Acta, 2007
Evaluation of a new enzymatic method for homocysteine measurement
Bruno Zappacosta, Silvia Persichilli, Angelo Minucci, Donata Scribano, Silvia Baroni, Silvia Fasanella, Paola Neri, Pio Dante Daloiso, Bruno Giardina, Pasquale De Sole
Clinical Biochemistry, 2006
Elevated levels of plasma homocysteine in postmenopausal women in Burkina Faso
Rosa Chillemi, Jacques Simpore, Silvia Persichilli, Angelo Minucci, Alfonsina D'Agata, Salvatore Musumeci
Clinical Chemistry and Laboratory Medicine, 2005
Serum levels of folate, homocysteine, and vitamin B12 in head and neck squamos cell carcinoma and in laryngeal leukoplakia
Giovanni Almadori, Francesco Bussu, Jacopo Galli, Gabriella Cadoni, Bruno Zappacosta, Silvia Persichilli, Angelo Minucci, Bruno Giardina, Maurizio Maurizi
Cancer, 2005
Effect of cigarette smoke extract on the polymorphonuclear leukocytes chemiluminescence: Influence of a filter containing glutathione
B. Zappacosta, S. Persichilli, A. Minucci, S. Fasanella, D. Scribano, B. Giardina, De Sole P
Luminescence, 2005
Hyperhomocysteinemia in acute Plasmodium falciparum malaria: An effect of host-parasite interaction
R. Chillemi, B. Zappacosta, J. Simporè, S. Persichilli, M. Musumeci, S. Musumeci
Clinica Chimica Acta, 2004
HPLC analysis of some sulphur compounds in saliva: Comparison between healthy subjects and periodontopathic patients
Bruno Zappacosta, Armando Manni, Silvia Persichilli, Donata Scribano, Angelo Minucci, Daniele Lazzaro, Pasquale De Sole, Bruno Giardina
Clinica Chimica Acta, 2003
Comparing different methods for homocysteine determination
Bruno Zappacosta, Silvia Persichilli, Donata Scribano, Angelo Minucci, Daniele Lazzaro, Pasquale De Sole, Bruno Giardina
Clinical Chemistry and Laboratory Medicine, 2002
Inhibition of salivary enzymes by cigarette smoke and the protective role of glutathione
B Zappacosta, S Persichilli, A Mordente, A Minucci, D Lazzaro, E Meucci, B Giardina
Human and Experimental Toxicology, 2002
Serum folate and homocysteine levels in head and neck squamous cell carcinoma
Giovanni Almadori, Francesco Bussu, Jacopo Galli, Gabriella Cadoni, Bruno Zappacosta, Silvia Persichilli, Angelo Minucci, Bruno Giardina
Cancer, 2002
Hyperhomocysteinemia and prevalence of polymorphisms of homocysteine metabolism-related enzymes in patients with inflammatory bowel disease
A Papa
American Journal of Gastroenterology, 2001
A fast chemiluminescent method for H2O2 measurement in exhaled breath condensate
Bruno Zappacosta, Silvia Persichilli, Flaminio Mormile, Angelo Minucci, Andrea Russo, Bruno Giardina, Pasquale De Sole
Clinica Chimica Acta, 2001
Is homocysteine a pro-oxidant?
Bruno Zappacosta, Alvaro Mordente, Silvia Persichilli, Angelo Minucci, Paola Carlino, Giuseppe Ettore Martorana, Bruno Giardina, Pasquale de Sole
Free Radical Research, 2001
Effect of aqueous cigarette smoke extract on the chemiluminescence kinetics of polymorphonuclear leukocytes and on their glycolytic and phagocytic activity
Bruno Zappacosta, Silvia Persichilli, Angelo Minucci, Enrico Di Stasio, Paola Carlino, Gabriella Pagliari, Bruno Giardina, Pasquale De Sole
Luminescence, 2001
Effect of aqueous extract of cigarette smoke on peripheral blood polymorphonuclear leukocytes chemiluminescence
Bruno Zappacosta, Silvia Persichilli, Bruno Giardina, Pasquale De Sole
Luminescence, 2000
Effect of homocysteine on polymorphonuclear leukocyte activity and luminol-dependent chemiluminescence
B. Zappacosta, A. Mordente, S. Persichilli, B. Giardina, P. De Sole
Luminescence, 2000
High total antioxidant activity and uric acid in tracheobronchial aspirate fluid of preterm infants during oxidative stress: An adaptive response to hyperoxia?
G Vento, MC Mele, A Mordente, C Romagnoli, PG Matassa, E Zecca, B Zappacosta, S Persichilli
Acta Paediatrica International Journal of Paediatrics, 2000
Purine metabolites and malondialdehyde in platelets of diabetic patients
Bruno Zappacosta, Pasquale De Sole, Silvia Persichilli, Dario Pitocco, Gianpiero Marra, Giovanni Ghirlanda, Bruno Giardina
Diabetes Research and Clinical Practice, 1999
Prevalence of mild hyperhomocysteinaemia and association with thrombophilic genotypes (factor V Leiden and prothrombin G20210A) in Italian patients with venous thromboembolic disease
Valerio De Stefano, Bruno Zappacosta, Silvia Persichilli, Elena Rossi, Ida Casorelli, Katia Paciaroni, Patrizia Chiusolo, Antonio Maria Leone, Bruno Giardina, Giuseppe Leone
British Journal of Haematology, 1999
Effect of smoking one cigarette on antioxidant metabolites in the saliva of healthy smokers
Bruno Zappacosta, Silvia Persichilli, Pasquale De Sole, Alvaro Mordente, Bruno Giardina
Archives of Oral Biology, 1999

Silvia Persichilli

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Scopus Publications