Short-course prednisone and methotrexate in a cohort of patients with polymyalgia rheumatica: a potential therapeutic approach Edoardo Conticini, Raffaele Truscelli, Silvia Grazzini, Paolo Falsetti, Caterina Baldi, Alessandra Cartocci, Luca Cantarini, Bruno Frediani BMC Rheumatology, 2026 OBJECTIVES: The optimal treatment of polymyalgia rheumatica (PMR) is far from being fully elucidated. Only a few trials explored the role of conventional DMARDs: none of them adequately ruled out subclinical giant cell arteritis (GCA). The aim of this study was to assess whether the precocious administration of methotrexate (MTX) and a short course of glucocorticoids (GCs) could be safe and effective in recently diagnosed PMR. METHODS: Patients with a recent diagnosis of PMR were prospectively enrolled, upon exclusion of GCA, and treated with MTX and gradually tapered prednisone (PDN). As a control group, a historical cohort treated with GC-monotherapy was included. The primary endpoint was PDN-free remission at 24 weeks. Secondary endpoints were sustained remission at 52 weeks, number of relapses, PDN dosage, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) at 26 and 52 weeks, compared to historical cohort. RESULTS: The prospective and historical cohorts included 41 and 63 patients, respectively. In the MTX-group, at 26 weeks, 66% of patients were in steroid-free remission and a significant reduction of CRP and ESR was observed, while mean daily PDN dosage dropped to 3.42 mg. Twenty-four subjects reached 52-week phase of the study and 83% maintained GC-free remission. A higher number of relapses were reported in the retrospective cohort (12, 27% vs. 34, 43%), in which up to 49 patients were still taking PDN. CONCLUSION: In conclusion, upon a subclinical GCA is excluded, MTX at adequate dosages, is a suitable option for the treatment of PMR, allowing a precocious discontinuation of oral GCs.
Achievement and Maintenance of Remission with Upadacitinib in Patients with Moderate-to-Severe Rheumatoid Arthritis in Italy: 1-Year Data from UPHOLD, a Prospective Real-World Observational Study Caterina Baldi, Eleonora Celletti, Serena Bugatti, Marcello Govoni, Massimiliano Cazzato, Andrea Picchianti Diamanti, Marco Fornaro, Giuliana Guggino, Luca Navarini, Maria Antonietta D’Agostino, Luca Quartuccio, Francesco Ciccia, Lorenzo Dagna, Paolo Stobbione, Massimo Triggiani, Ombretta Viapiana, Annarita Giardina, Gianluca Moroncini, Roberto Caporali, Chiara Bazzani, Enrico Tirri, Claudia Lomater, Sara Di Fino, Francesca Morello, Carlo Selmi Rheumatology and Therapy, 2026 Upadacitinib (UPA) is approved for moderate-to-severe rheumatoid arthritis (RA) based on SELECT trials, but data on real-world effectiveness are limited. UPHOLD is a multicountry study of patients with RA receiving UPA 15 mg. The present interim analysis was based on the Italian cohort performed across 28 centers. Co-primary endpoints were (i) the proportion of patients receiving UPA who achieved DAS28(CRP) remission (< 2.6) at 6 months and (ii) the proportion of patients achieving DAS28(CRP) remission at 6 months who continued to receive UPA and maintained remission (or had no more than a 0.6-point increase in DAS28[CRP]) at 12 months, analyzed by modified non-responder imputation (mNRI) and as observed (AO). Modified full analysis sets (mFAS1 and mFAS2) included patients completing 6 and 12 months, respectively. Safety analysis included reporting of adverse events and treatment-emergent adverse events (TEAEs), as exposure-adjusted event rates (EAERs; events per 100 patient-years [E/100PY]). Among 270 patients, 74 (27.4%) discontinued by 12 months because of lack of efficacy (13.7%) or adverse events (8.1%). In mFAS1 (N = 168), 50.6% (mNRI) and 62% (AO) achieved DAS28(CRP) remission at 6 months. In mFAS2 (N = 55), 80% (mNRI) and 91.7% (AO) maintained DAS28(CRP) remission at 12 months. CDAI and SDAI remission rates at 12 months were 31.3%. Patients on UPA monotherapy at 12 months showed remission rates of 49.5% (DAS28[CRP]), 27.2% (CDAI), and 27.4% (SDAI). Significant improvements in patient-reported pain and physical function were also observed. A total of 278 TEAEs were reported (80.8 E/100PY), including herpes zoster, liver disorders, and serious infections with EAERs of 2.0, 1.5, and 1.2 E/100PY, respectively. UPA 15 mg was observed to effectively treat moderate-to-severe RA in the real-world setting, with ≥ 80% maintaining DAS28(CRP) remission at 12 months, showing a favorable benefit–risk profile. ClinicalTrials.gov identifier, NCT04497597. Rheumatoid arthritis is a chronic autoimmune disease that causes joint pain, swelling, and disability. Although several effective treatments exist, many people with rheumatoid arthritis still struggle to achieve remission and fully control their symptoms. Upadacitinib is a once-daily oral treatment that has shown strong results in clinical trials, but less is known about how well it works in everyday medical practice. This study followed 270 people with moderate-to-severe rheumatoid arthritis who began treatment with upadacitinib across 28 centers in Italy. Rheumatologists monitored their disease activity, pain, physical function, and any side effects over 12 months. After 6 months of treatment, about half of the patients had achieved remission according to a commonly used disease activity measure (DAS28-CRP). After 1 year, more than 80% of those who reached remission were able to maintain it. Other measures of disease control (CDAI and SDAI) also improved, and many patients reported less pain and better ability to perform daily activities. Upadacitinib was seen to be effective both when used alone and when combined with other standard rheumatoid arthritis medications. Side effects were generally consistent with what has been seen in clinical trials, with low rates of serious infections, liver issues, or blood clots, and no major cardiovascular events recorded. Overall, this real-world study shows that upadacitinib is an effective and well-tolerated option for helping people with rheumatoid arthritis achieve and sustain meaningful improvements in symptoms and quality of life.
Ultrasound Beyond Joints: A Review of Extra-Articular Applications in Rheumatology Emilio D’Ignazio, Davide Corradini, Tomas Cazenave, Riccardo Bixio, Caterina Baldi, Harjit Kaur Ubhi, Kate Smith, Richard J. Wakefield, Paul Emery, Andrea Di Matteo Current Rheumatology Reports, 2025 Purpose of Review This review highlights key ultrasound applications for evaluating extra-articular involvement in rheumatic diseases, including the lungs, vessels, salivary glands, muscles, nerves, skin, and nails. It explores recent advances, emerging areas of assessment, and future research directions. Additionally, the review examines current limitations in the routine use of ultrasound for these purposes and considers the potential of new technologies, such as shear-wave elastography, contrast-enhanced ultrasound, and artificial intelligence, to enhance the early detection and monitoring of extra-articular manifestations in rheumatic diseases. Recent Findings Extra-articular manifestations in patients with rheumatic diseases are crucial for diagnosis, management (including treatment strategies), and prognosis, making accurate assessment essential. Growing evidence supports the role of ultrasound in assessing these manifestations for diagnosis, monitoring, and gaining insights into disease pathogenesis. Recent studies emphasize the significant utility of ultrasound in evaluating extra-articular involvement across various organ systems, including the lungs, vessels, salivary glands, muscles, nerves, skin, and nails. Technological advances, such as shear-wave elastography, contrast-enhanced ultrasound, and artificial intelligence, are expanding the scope and precision of ultrasound applications. Despite its potential, challenges such as operator dependency, lack of standardized protocols, and the need for specialized training hinder its widespread adoption. Summary Ultrasound is a non-invasive, cost-effective, and radiation-free imaging modality with high diagnostic accuracy, making it a valuable tool for assessing extra-articular manifestations in rheumatic diseases. Emerging technologies may further enhance its clinical utility. However, efforts to standardize techniques and improve accessibility are necessary to optimize its integration into routine practice.
Effectiveness and Safety of Recombinant Zoster Vaccine in Rheumatic Diseases: Real-World Evidence from a Single-Centre Italian Cohort Silvia Valentini, Jurgen Sota, Irene Fineschi, Edoardo Conticini, Estrella Garcia-Gonzalez, Emilio D’Ignazio, Marco Bardelli, Stefano Gentileschi, Marta Fabbroni, Francesca Bellisai, Paolo Falsetti, Enrico Selvi, Luca Cantarini, Bruno Frediani, Caterina Baldi Vaccines, 2025 Background: Patients with rheumatic diseases (RMDs) are at increased risk of herpes zoster (HZ), particularly when receiving immunosuppressive treatment. While recombinant zoster vaccine (RZV) has shown high effectiveness in the general population, evidence in rheumatologic patients remain limited due to their exclusion from pivotal trials. Objectives: To evaluate the effectiveness of RZV and to collect additional safety data in a heterogeneous cohort of rheumatologic patients, compared with a control cohort from the general population. Methods: We conducted a retrospective study including 179 adults who received two intramuscular doses of RZV between January 2021 and June 2025. The cohort included 114 patients with RMDs and 65 individuals from the general population. Effectiveness was defined as the ability to prevent HZ reactivation while safety concerns were recorded as any adverse event temporally associated with the vaccination. Results: We observed a statistically significant reduction in terms of VZV relapses following vaccination (p < 0.001). Among patients diagnosed with RMDs, only one case of HZ recurrence was observed 14 weeks after vaccination, with no significant difference compared to general care patients. One patient experienced a disease flare requiring glucocorticosteroids. RZV demonstrated a favourable safety profile, with minor adverse events (fever, injection-site reactions, headache and myalgia) reported in 17.5% of patients after the first dose and 21.5% after the second. No significant association was observed between adverse events and advanced immunosuppressive therapy. Conclusions: RZV displayed an effective and reassuring safety profile in a heterogeneous cohort of patients affected by RMDs, irrespective of the diagnosis and the ongoing therapy. This supports the broader use of RZV as a safe and valuable preventive strategy in patients with RMDs.
Real-world effectiveness and retention rate of upadacitinib in patients with rheumatoid arthritis: results from a multicentre study Caterina Baldi, Stefano Gentileschi, Francesca Li Gobbi, Massimiliano Cazzato, Andrea Delle Sedie, Carla Gaggiano, Emilio D’Ignazio, Gemma Lepri, Chiara De Lorenzo, Carlotta Nannini, Laura Niccoli, Anna Panaccione, Luca Di Cato, Andrea Di Matteo, Andrea Picchianti-Diamanti, Serena Guiducci, Bruno Frediani, Maurizio Benucci Clinical and Experimental Medicine, 2025 This study evaluates upadacitinib (UPA) effectiveness and drug retention rate (DRR) in patients with rheumatoid arthritis (RA). Multicentre prospective observational study. Consecutive patients with RA receiving UPA were evaluated at 0, 3, 6, 12, 18, and 24 months of treatment. Key outcomes included UPA DRR and changes in clinical and serological measures over time. The study included 215 patients (72.6% female sex, mean age 60.1 ± 11.7 years). The DRR of UPA was 91.6% (95% CI 88.0–95.4%) at 6 months, 84.6% (95% CI 79.8–89.7%) at 12 months, 80.3% (95% CI 75.0–86.0%) at 18 months and 80% (95% CI 75.0–86.0%) at 24 months. UPA DRR was similar between monotherapy and methotrexate combination (p = 0.47), and across different treatment lines (p = 0.58). A statistically significant improvement from baseline was observed over 24 months considering erythrocyte sedimentation rate, C-reactive protein (CRP), Health Assessment Questionnaire (HAQ), Disease Activity Score (DAS)28-CRP, Physician’s (Ph) and Patient’s (Pt) Global Assessment (GA), Visual Analogue Scale (VAS) Pain, Simplified and Clinical Disease Activity Index (SDAI and CDAI) (p < 0.00 for all of them). Patients discontinuing UPA were more likely to be male (p = 0.02), with a longer disease duration (p = 0.03), higher baseline values of VAS Pain (p < 0.00), PtGA (p < 0.00), PhGA (p < 0.00), CDAI (p < 0.00), SDAI (p < 0.00) and corticosteroid dosage (p = 0.04). This study confirms UPA effectiveness in managing RA in the real-world practice, demonstrating sustained drug retention and improvements in clinical and laboratory measures over time. Also, UPA could be a valuable option for patients with multi-refractory RA and when monotherapy is preferred.
Clinical and ultrasound remission at 48 weeks of upadacitinib in rheumatoid arthritis: real-world results from the Italian multicenter UPARAREMUS study Andrea Picchianti Diamanti, Valentino Paci, Michele Maria Luchetti Gentiloni, Simonetta Salemi, Giorgio Sesti, Ilaria Anna Bellofatto, Caterina Baldi, Paolo Falsetti, Maria Sole Chimenti, Arianna D’Antonio, Gloria Crepaldi, Alen Zabotti, Ivan Giovannini, Marco Canzoni, Donatella Fiore, Gian Domenico Sebastiani, Chiara Scirocco, Carlo Perricone, Bruno Laganà, Annamaria Iagnocco Arthritis Research and Therapy, 2025 BACKGROUND: Achieving clinical remission is a key therapeutic goal in rheumatoid arthritis (RA). While pivotal trials and early real-world studies have demonstrated the efficacy of upadacitinib (UPA), data on its impact as assessed by imaging remain limited. Here, we report the 48 weeks outcomes from the full cohort of the UPARAREMUS study. METHODS: UPARAREMUS is a 12-month follow-up, observational study involving RA patients from 9 Italian rheumatology centers initiating UPA. The primary objective was to evaluate the proportion of patients achieving combined clinical and ultrasound (US) remission. Secondary endpoints included the proportion of patients achieving clinical or US remission alone at multiple time points. RESULTS: A total of 115 patients were enrolled. Combined clinical and US remission was achieved in 35% of patients at week 12, increasing to 55% at week 24 and 72% at week 48. Younger age, lower baseline CDAI, and higher ESR were associated with higher remission rates, while baseline corticosteroid use was linked to a 65% lower likelihood of achieving remission. More than 60% of patients showed absence of power Doppler (PD) signal at week 24, rising to over 80% by week 48. The majority of patients in clinical remission also achieved US remission. CONCLUSIONS: After 12 months of UPA treatment, a substantial proportion of RA patients achieved combined clinical and US remission, independent of prior bDMARDs use or monotherapy. These findings highlight UPA's ability to induce and maintain deep disease control in real-world practice.
Analysis of Short-Term Outcomes in Pancreatic Surgery with Vascular Resection from a Prospective Multicenter Global Study Pascale Tinguely, Camila Hidalgo Salinas, Sebastian M. Staubli, Dimitri A. Raptis, Giuseppe K. Fusai, , Cristina Ferrone, , Mohamed Abu Hilal, Claudio Bassi, Marc Besselink, Kevin Conlon, Brian Davidson, Marco Del Chiaro, Christos Dervenis, Massimo Falconi, Thilo Hackert, Ewen Harrison, Shailesh V. Shrikhande, Ajith Siriwardena, Martin Smith, Christopher Wolfgang, , Aditya Borakati, Deniz Balci, Nikolaos Machairas, Giovanni Marchegiani, Atsushi Oba, Christian Oberkofler, Ioannis Passas, Reena Ravikumar, Patricia Sánchez Velázquez, Martin de Santibañes, Andreas Anton Schnitzbauer, Fiammetta Soggiu, Domenico Tamburrino, Alice Wei, Marinos Zachiotis, , Kamel Bentabak, Salah Eddine Kacimi, Mehrdad Nikfarjam, Aliaksei Shcherba, Gregory Sergeant, Gustavo Coelho, Orlando Torres, Nikolay Belev, Burundi Fabrice, Ephraim Tang, Janet Martin, Christian Diaz, Nicolas Devaud, Kongyuan Wei, Maher Hendi, Danko Mikulic, Nikolaos Gouvas, Andrej Nikov, Dalia Fathallah, Mahmoud Saad, Olav Tammik, Heikki Huhta, Laurent Sulpice, Renato Lupinacci, Gregor Stavrou, Evangelos Felekouras, Vasileios Papaziogas, Sanjeev Misra, Erik Prabowo, Hashim Talib Hashim, Maytham Al-Juaifari Al-Sader, Sohei Satoi, Khaled Obeidat, Maram Mohsen, Ho-Seong Han, Mohamad Khalife, Muhammed Elhadi, Audrius Dulskas, Jin Bong, Shahi Ghani, Alejandro Eduardo Padilla, Javier Melchor-Ruan, Sarnai Erdene, Amine Benkabbou, Pueya Nashidengo, Jonathan Koea, Ademola Adeyeye, Olusegun Alatise, Sami Ullah, Mustafa Abu Jayyab, Sarah Amro, Walaa Mohammed Alnammourah, Catherine The, Michał Pędziwiatr, Wojciech Polkowski, Sorin Barbu, Aleksandar Karamarkovic, Daniel Galun, Brian Goh, Blaž Trotovšek, Jones Omoshoro-Jones, Benedetto Ielpo, Abdelfatah Abdelmageed, Per Sandström, Alessandra Cristaudi, Beat Gloor, Christoph Kuemmerli, Alaa Hamdan Tishreen, Mohammad Karam Chaaban, Chien Hui Wu, Po-Chih Yang Fu Jen, Ammar Houssem, Oussama Baraket, Ahmet Çoker, Mark Taylor, Nigel Jamieson, Satheesh Iype, Emmanouil Giorgakis, Motaz Qadan, Sabha Ganai, Hamza Al-Naggar, Onesai Chihaka, , Amor El Behi, Anisse Tidjane, Ilhem Ouahab, Souad Bouaoud, Mounira Rais, Meriem Abdoun, Amel Ouyahia, Lucas Mc Cormack, Martin de Santibanes, Pablo Barros Schelotto, Shantanu Joglekar, Sivakumar Gananadha, Kat Hall, Russell Hodgson, Alistair Rowcroft, Lynn Chong, Kalpesh Shah, Stanley Chen, David Burnett, Zi Qin Ng, Christos Apostolou, Peter Kornprat, Radoslava Stoyanova, Aliaksei Shcherba, Bert Van den Bossche, Vera Hartman, Filip Gryspeerdt, Frederik Berrevoet, Sébastien Strypstein, Rinaldo Pinto, Gustavo Coelho, Matheus Militz, Pablo Rodrigues, Orlando Torres, Narimã Marques, Adriano Sampaio, Panche Krastev, Mihail Slavchev, Ivelin Takorov, Nikola Vladov, Vassil Mihaylov, Evgeni Nikolaev, Daniel Kostov, Pablo Serrano, Cristian Diaz, Alejandro Brañes, Lei Cai, Yiming Chen, Ivan Štironja, Tomislav Bubalo, Martin Loveček, Pavel Zaruba, Andrej Nikov, Almoatazbellah Attalla, Mosaab Tayiawi, Muneera Alboridy, Mohamed Mourad, Mostafa Elkeleny, Yousef Tanas, Hajer Ealreibi, Mohamed Abd El Moneam, Mohammed Hamouda, Ahmed Nafea, Mohamed Abdelalemm, Ahmed Mansour, Marina Farag, Mohamed Salah, Mohamed Abdelkarem, Hatem Sayed, Sherein Diab, Mira Gobran, Abdelrahman Fahim, Ahmed K. Awad, Sherif Abdelmawgoud, Emad Alazab, Mostafa Nagy, Islam Metwally, Ahmed Shehta, Ahmed Monier, Selmy Awad, Mohammed Omar, Feras Alsabbagh, Joonas Kauppila, Minna Nortunen, Heikki Huhta, Raffaele Brustia, Stéphanie Truant, Guillaume Piessen, Aurélien Dupré, Francois-Regis Souche, Natalia Savala, Renato Lupinacci, Sébastien Gaujoux, Nicolas Goasguen, Morgan Anyla, Lilian Schwarz, Fabio Giannone, Zaza Demetrashvili, Isabel Bartella, Ioannis Pozios, Orlin Belyaev, Dirk Bulian, Christian Praetorius, Sandra Korn, Maximilian Brunner, Elena Mazzella, Martin Reichert, Jochen Gaedcke, Ulrich Ronellenfitsch, Tim Reese, Kim Wagner, Pasquale Scognamiglio, Faik Uzunoglu, Jakob Izbicki, Benjamin Struecker, Dimitrios Kardassis, Silvio Nadalin, Georgios Makridis, Nikolaos Tsoukalas, Aristotelis Kechagias, Argyrios Ioannidis, Nikolaos Arkadopoulos, Dimitrios Papakonstantinou, Nikolaos Michalopoulos, Panagiotis Kokoropoulos, Pantelis Vassiliu, Dimitrios Stergiou, Maria Sotiropoulou, Nefeli Tomara, Panagiotis Dorovinis, George Tzimas, Dimitrios Schizas, Alexandros Papalampros, Andreas Polydorou, Georgios Fragulidis, Konstantinos Toutouzas, Antonios Vezakis, Konstantinos Bramis, Dimitrios Korkolis, Evangelos Fradelos, Georgios Glantzounis, Dimitrios Magouliotis, Grigorios Christodoulidis, Francesk Mulita, Elissaios Kontis, Vasileios Papaziogas, Dimitris Giakoustidis, Anastasios Katsourakis, Achilleas Νtinas, Panagiotis Petras, Attila Bursics, Andras Vereczkei, Sreenivasan Karuparthi, Govind Purushothaman, Rahul Gupta, Kaushal Yadav, Sundeep Jain, Jeewan Ram Vishnoi, Sanjeev Misra, Vaibhav Varshney, Kshaunish Das, Somnath Chattopadhyay, Jayapala Reddy Velagala, Varun Bansal, Induchoodan S, Tarun Kumar, Erik Prabowo, Hashim Talib Hashim, Maytham Al-Juaifari, Eran Sadot, Marco Vivarelli, Valeria Andriola, Michele Ciola, Mario Virgilio Papa, Adelmo Antonucci, Diego Sasia, Valentina Testa, Lapo Bencini, Tommaso Nelli, Fabrizio D’Acapito, Carlo Alberto Pacilio, Giacomo Carganico, Raffaele De Rosa, Stefano D’Ugo, Edoardo Saladino, Alfonso Recordare, Michele Mazzola, Vincenzo Mazzaferro, Alessandro Zerbi, Domenico Tamburrino, Caterina Baldi, Marco Stella, Fabrizio Di Benedetto, Fabio Uggeri, Alessandro Iacomino, Gianluca Rompianesi, Andrea Belli, Lucia Moletta, Francesca Tolin, Mario Giuffrida, Lorenzo Cobianchi, Paolo Regi, Luca Morelli, Emanuele Federico Kauffmann, Enrico Pinotti, Felice Giuliante, Alessandro Coppola, Tommaso Maria Manzia, Alberto Porcu, Claudio Feo, Teresa Perra, Francesco Ciarleglio, Simone Novello, Alessandro Ferrero, Sergio Intini, Giorgio Querini, Andrea Ruzzenente, Tommaso Campagnaro, Simone Conci, Sara Napetti, Alice Frontali, Daisuke Hashimoto, Ippei Matsumoto, Hiromitsu Maehira, Minoru Tanabe, Subhi Alissawi, Aiman Obed, Hebah Rababa, Khayry Al-Shami, Mohamed Alsabah, Saeed Shumrakh, Abdulaziz Al-Samawi, Almu’Atasim Khamees, Ildar Fakhradiyev, Ho-Seong Han, Kristaps Atstupens, Walid Faraj, Mohamad Khalife, Fatoom Alowjali, Abdulhadi Alshatshat, Aihab Benamwor, Eman Younes, Dania Burgan, Marwa Morgom, Muhannud Binnawara, Entisar Alshareea, Sultan Ahmeed Ahmeed, Eman Othman, Ahmed Gerwash, Osama Salem, Wegdan Khalil, Eman Abdulwahed, Mohamed Alharari, Tomas Vanagas, Vitalijus Eismontas, Jonas Jurgaitis, Algirdas Slepavicius, Vytenis Mikutaitis, Mindaugas Kvietkauskas, Edoardo Rosso, Andee Dzulkarnaen Zakaria, Ian Chik, Jin Bong, Carlos Florez Zorrilla, Sarnai Erdene, Moniba Korch, Iltimass Gouazar, Badr Serji, Aziz Zentar, Amine Benkabbou, Reda Elhassouni, Sabrillah Echiguer, Mohammed Anass Majbar, Abdulrashid Pueya Nashidengo, Paleswan Joshi Lakhey, John Windsor, Michael Jen Jie Chu, Peter Johnston, Vanshay Bindra, Andrea Cross, Ashok Gunawardene, Fraser Welsh, Olusegun Alatise, Jibran Abbasy, Tayyab Siddiqui, Mohammad Asghar, Mustafa Abu Jayyab, Qusai Zreqat, Rawand Titi, Fatima Manasrah, Ahlam Hammoudeh, Guillermo Coayla, Catherine Teh, Cenon Alfonso, Marta Flisińska, Justyna Rymarowicz, Marek Sierzega, Wojciech Ciesielski, Oliwia Grząsiak, Patrycja Szewczyk, Krzysztof Szwedziak, Wojciech Korcz, Oskar Kornasiewicz, Emanuel Vigia, Raluca Bievel Radulescu, Traian Dumitrascu, Mara Mardare, Octav Ginghina, Iulian Brezean, Sorin Petrea, Adrian Bartos, Raluca Bodea, Sergiu Matei, Ana-Maria Musina, Natalia Velenciuc, Alexander Belyaev, Denis Mizgirev, Andrey Litvin, Ivan Semenenko, Arkady Bedzhanyan, Nikolay Bagmet, Ayrat Kaldarov, Denis Kuchin, Evgeniy Drozdov, Mahir Gachabayov, Mohammed Alharthi, Aleksandar Bogdanovic, Daniel Galun, Stefan Kmezic, Dragana Arbutina, Mihailo Bezmarevic, Jovan Juloski, Mladjan Protic, Brian Goh, Blaž Trotovšek, Emil Loots, Jones Omoshoro-Jones, Manuel Marcello, Jose Ramia, Maria Del Mar Rico-Morales, Fabio Ausania, Ana Belen Martin Arnau, Benedetto Ielpo, Esther Pilar Santos, Patricia Ruiz, Laia Falgueras, Farah Al Shwely, Juli Busquets, Iago Justo, Jana Dziakova, Marcello Di Martino, Miguel Ángel Suárez-Muñoz, Lorena Solar García, Juan Jose Segura-Sampedro, Fernando Rotellar, Luis Muñoz-Bellvis, Valle Vera, María García Domingo, Carlos Domingo-Del Pozo, Cristina Ballester Ibáñez, Dimitri Dorcaratto, Mario Rodriguez-Lopez, Alejandro Serrablo, Hytham Hamid, Abdelfatah Abdelmageed, Per Sandström, Linda Lundgren, Bobby Tingstedt, Caroline Williamsson, Bodil Andersson, Ernesto Sparrelid, Christoph Kuemmerli, Beat Moeckli, Alessandra Cristaudi, Fariba Abbassi, Jan Schmidt, Stefan Gutknecht, Jan Philipp Jonas, Mais Alhashemi, Zain Douba, Ahmad Kayali, Oula Azizeh, Omar Al-Abed, Aya Abdulmonem, Ahmad Alhouri, Hasan Al Houri, Alnour Suliman, Bashar Haj Hassan, Alaa Hamdan, Ming-Chin Yu, Hanen Bouaziz, Ali Kchaou, Ammar Houssem, Mesut Tez, Mustafa Kerem, Hüseyin Bayhan, Ulaş Aday, Alpen Gumusoglu, Husnu Aydin, Fatema Hanefa, Ali Emre Atici, Hanife Ulgur, Ismail Sert, Semra Demirli Atici, Elif Colak, Denys Skoryi, Kostiantyn Kopchak, Oleksandr Kvasivka, Valeriia Sumarokova, James Skipworth, William Lim, Ahmed Mohamed, Pascale Tinguely, Hemant Kocher, Amjad Khalil, Nicola de’ Liguori Carino, Fahed Gareb, Pandanaboyana Sanjay, Krishnakumure Patel, Carlo Ceresa, Thomas Russell, Matt Mortimer, Megan Sulciner, Thomas Clancy, Martina Nebbia, Rachel Thompson, Dimitrios Moris, Jennifer Gnerlich, Richard Spencer-Cole, Derek Krinock, Tamara Osborn, Hailey Hardgrave, Joe Nigh, Beth Schrope, Ryan Lamm, Harish Lavu, Wilbur Bowne, Jonathan Sham, Paulo Martins, Aisha Albar, Fatima Al-Eryani, Hamza Al-Naggar, Rafat Al-Saban Annals of Surgical Oncology, 2025 Background Pancreatic resection with concomitant vascular resection is increasingly practiced with outcomes mainly reported from specialist centers but lacking results from prospective global data. This study aimed to investigate factors associated with short-term outcomes after vascular resections in pancreatic surgery worldwide. Patients and Methods Data were extracted from a prospective, multicenter, international cross-sectional snapshot study in 2021 (pancreasgroup.org) assessing short-term outcomes after pancreatic surgery worldwide (NCT04652271). In the patient cohort of pancreatic surgery with simultaneous vascular resection for various diseases, short-term outcomes were reported and compared with established benchmark values. Factors affecting major complications, mortality, and histopathological resection status were assessed in multivariable logistic regression analyses with interaction testing. Results From a total of 3926 patients undergoing pancreatic surgery, 565 had associated vascular resections, of which 444 had venous resections alone and 121 had arterial resections alone or with concomitant venous resection. Of the 153 (47%) benchmark cases with pancreatoduodenectomy and venous resection, median postoperative morbidity fell within established benchmark criteria. Median 90-day major complication and mortality rates were similar in pancreatic resection with venous, arterial or no vascular resections (45 and 10%, 47 and 6.6%, 42 and 9.6% respectively). Patients undergoing arterial resections that developed a clinically relevant pancreatic fistula faced substantially elevated odds of 90-day mortality (OR 8.8 CI 1.6–48). In pancreatic ductal adenocarcinoma, the R1 rate was 26%, neoadjuvant chemotherapy being protective for both overall and venous-specific margins. Conclusions Vascular pancreatic surgery is performed across diverse healthcare settings worldwide. While perioperative complications were comparable to nonvascular pancreatic resections, the observed 90-day mortality was considerable overall. International collaborative efforts should focus on understanding practice variations and improve accessibility of optimal perioperative care to promote rescue capabilities.
Are There Definite Disease Subsets in Polymyalgia Rheumatica? Suggestions from a Narrative Review Paolo Falsetti, Ciro Manzo, Marco Isetta, Francesco Placido, Alberto Castagna, Maria Natale, Caterina Baldi, Edoardo Conticini, Bruno Frediani Healthcare Switzerland, 2025 Background: Polymyalgia rheumatica (PMR) has a multifaceted onset and course, and making a distinction between true PMR and so-called “polymyalgic syndrome” (that is, similar manifestations caused by different conditions) is far from easy in clinical practice. The existence of subsets within true PMR may further complicate the diagnostic question. Distinguishing PMR subsets from PMR-mimicking conditions does not just carry nomenclature value and speculative significance. Indeed, the correct diagnosis influences treatment, prognosis, epidemiological assessments, and health policies. Objectives: We aimed to (1) ascertain the presence of a definite and peculiar subset/subgroup/cluster of PMR in the scientific literature; (2) describe any possible subset/cluster/subgroup of PMR identified in at least two different studies. Methods: We performed a non-systematic (PRISMA protocol not followed) literature search on Embase and Medline (OVID interface). The following search terms were used: polymyalgia rheumatica, subset, cluster, subgroup, subclinical giant cell arteritis, mimicking conditions, polymyalgia rheumatica-like conditions, immunotherapy, checkpoint inhibitor, acute-phase reactants or acute-phase proteins, vaccination, infection, and calcium pyrophosphate deposition disease or chondrocalcinosis. Each paper’s reference list was scanned for additional publications meeting this study’s aim. Abstracts submitted at conferences or from non-peer-reviewed sources were not included. Results: The initial search yielded 2492 papers, of which 2389 articles were excluded based on title and abstract screening. A total of 103 articles underwent a full-length review, and 84 of them were finally assessed for eligibility. A total of seven large subsets of PMR could be identified: (1) PMR with normal acute-phase reactants; (2) PMR with an infection trigger; (3) PMR with a vaccination trigger; (4) PMR with subclinical giant cell arteritis (GCA); (5) PMR and calcium pyrophosphate deposition disease (CPPD); (6) PMR following immune checkpoint inhibitor (ICI) therapy; (7) PMR with peculiar clinical clusters (based on clinical or statistic clustering methods). Conclusions: PMR with normal baseline acute-phase reactants and PMR with an infection or a vaccination trigger could be categorized as subsets of disease. PMR with subclinical GCA and most cases of PMR/CPPD should be categorized as mimickers. Finally, further studies are required to better categorize some peculiar clinical subsets emerging from cluster analyses, and ICI-induced PMR.
Impact of age and cardiovascular risk factors on the incidence of adverse events in patients with rheumatoid arthritis treated with Janus Kinase inhibitors: data from a real-life multicentric cohort Stefano Gentileschi, Carla Gaggiano, Arianna Damiani, Carmela Coccia, Pamela Bernardini, Massimiliano Cazzato, Francesco D’Alessandro, Giulia Vallifuoco, Riccardo Terribili, Marco Bardelli, Caterina Baldi, Luca Cantarini, Marta Mosca, Bruno Frediani, Serena Guiducci Clinical and Experimental Medicine, 2024 Inhibiting Janus Kinases (JAK) is a crucial therapeutic strategy in rheumatoid arthritis (RA). However, the use of JAK inhibitors has recently raised serious safety concerns. The study aims to evaluate the safety profile of JAKi in patients with RA and identify potential risk factors (RFs) for adverse events (AEs). Data of RA patients treated with JAKi in three Italian centers from January 2017 to December 2022 were retrospectively analyzed. 182 subjects (F:117, 64.3%) underwent 193 treatment courses. 78.6% had at least one RF, including age ≥ 65 years, obesity, smoking habit, hypertension, dyslipidemia, hyperuricemia, diabetes, previous VTE or cancer, and severe mobility impairment. We identified 70 AEs (28/100 patients/year), among which 15 were serious (6/100 patients/year). A high disease activity was associated with AEs occurrence (p = 0.03 for CDAI at T0 and T6; p = 0.04 for SDAI at T0 and T6; p = 0.01 and p = 0.04 for DAS28ESR at T6 and T12, respectively). No significant differences in AEs occurrence were observed after stratification by JAKi molecules (p = 0.44), age groups (p = 0.08) nor presence of RFs (p > 0.05 for all of them). Neither the presence of any RFs, nor the cumulative number of RFs shown by the patient, nor age ≥ 65 did predict AEs occurrence. Although limited by the small sample size and the limited number of cardiovascular events, our data do not support the correlation between cardiovascular RFs—including age—and a higher incidence of AEs during JAKi therapy. The role of uncontrolled disease activity in AEs occurrence should by emphasized.
Acute diverticulitis management: evolving trends among Italian surgeons. A survey of the Italian Society of Colorectal Surgery (SICCR). Renato Costi, Antonio Amato, Alfredo Annicchiarico, Filippo Montali, Adolfo Petrina, Agostino Fernicola, Alba Oliva, Alberto Gerundo, Alberto Porcu, Alberto Stocco, Alberto Vannelli, Aldo Rocca, Alessandro Bergna, Alessandro Coppola, Alessandro Izzo, Alessandro Soave, Alessandro Vitali, Alessia Fassari, Alessio Giordano, Alessio Impagnatiello, Alessio Rollo, Alex Bruno Bellocchia, Alfonso Amendola, Alfredo Savelli, Amedeo Altamura, Amedeo Antonelli, Andrea Balla, Andrea Barberis, Andrea Bottari, Andrea Favara, Andrea Gianmario Di Santo Albini, Andrea Grego, Andrea Guida, Andrea Lauretta, Andrea Lovece, Andrea Marco Tamburini, Andrea Morini, Andrea Pierre Luzzi, Andrea Romboli, Andrea Tufo, Angelo Alessandro Marra, Anna D’Amore, Anna Guariniello, Annadomenica Cichella, Annalisa Comandatore, Annalisa Pascariello, Antonella Usai, Antonia Lavinia Zuliani, Antonino Spinelli, Antonio Bocchino, Antonio Castaldi, Antonio De Leonardis, Antonio Langone, Arcangelo Picciariello, Arianna Petrungaro, Beatrice Torre, Brunella M. Pirozzi, Bruno Nardo, Bruno Scotto, Bruno Sensi, Carini Stefano, Carlo Alberto Manzo, Carlo Galdino Riva, Carlo Gazia, Carlo Giove, Carlo Salvemini, Carmen Sorrentino, Carolina Bartolini, Carolina Castro Ruiz, Gianmaria Casoni Pataccini, Caterina Baldi, Caterina Lastraioli, Caterina Puccioni, Cecilia Bertarelli, Chiara Caricato, Chiara Piceni, Cinzia Tanda, Claudia Armellin, Claudio Guerci, Corrado Bottini, Cosimo Alex Leo, Cristina Bombardini, Cristina De Padua, Cristina Larotonda, Cristina Soddu, Cristine Brooke Pathirannehalage Don, Dajana Glavas, Damiano Caputo, Daniele Fusario, Daniele Massaro, Daniele Morezzi, Daniele Passannanti, Daniele Sambucci, Daniele Zigiotto, Danilo Vinci, Dario Borreca, Dario D’Antonio, Dario Rosini, Dario Somenzi, Daunia Verdi, David Alessio Merlini, Davide Ferrari, Davide Mascali, Diletta Corallino, Domenico Magagnano, Domenico Rosario Iusco, Domenico Vita, Dorena Caruso, Edoardo Forcignanò, Edoardo Virgilio, Elena Bonati, Eleonora Guaitoli, Elio Francesco Favale, Elisa Bolzoni, Elisa Galasso, Elvira Adinolfi, Emanuela Stratta, Emanuele Caruso, Emanuele Damiano Luca Urso, Emanuele Doria, Emanuele Pontecorvi, Emilio Paolo Emma, Enrico Luzietti, Enrico Pinotti, Erica Monati, Erika Boriani, Ernesto Tartaglia, Ester Marra, Eugenia Rosso, Ezio Lombardo, Fabio Ambrosini, Fabio Carbone, Fabio Crescenti, Fabio Medas, Fabrizio D’Acapito, Federica Chimenti, Federica De Robertis, Federico Cappellacci, Federico Cozzani, Federico Festa, Federico Lovisetto, Federico Maggi, Federico Mazzotti, Filippo D’Agostino, Francesca Ascari, Francesca Di Candido, Francesca Foglio, Francesca Laura Nava, Francesca Mazzarulli, Francesca Meoli, Francesca Paola Tropeano, Francesca Pecchini, Francesca Pegoraro, Francesco Bagolini, Francesco Belia, Francesco Bianco, Francesco Caldaralo, Francesco Casti, Francesco Cobellis, Francesco Colli, Francesco Colombo, Francesco Madeddu, Francesco Maria Romano, Francesco Matarazzo, Francesco Menegon Tasselli, Francesco Pata, Francesco Salvetti, Francesco Serra, Gabriele Bislenghi, Gabriele Luciano Petracca, Gabriella Lionetto, Gaia Colletti, Gennaro Mazzarella, Gennaro Perrone, Giacomo Anedda, Giacomo Carganico, Giacomo Fuschillo, Gian Luca Baiocchi, Gian Luigi Canu, Gianluca Baronio, Gianluca Cassese, Gianluca Fucci, Gianluca Mascianà, Gianluca Pellino, Gianluca Rizzo, Gianluigi Moretto, Gianmario Edoardo Poto, Gianpiero Cione, Giorgio Dalmonte, Giorgio Lisi, Giorgio Rossi, Giovanna Berardi, Giovanna Di Scanno, Giovanna Pavone, Giovanni Battista Damiani, Giovanni Braccini, Giovanni Cestaro, Giovanni Guglielmo Laracca, Giovanni Spiezio, Giovanni Tomasicchio, Giulia Bonfanti, Giulia Cerino, Giulia Maria Francesca Marini, Giulia Turri, Giuliano Barugola, Giuliano Lantone, Giulio Iacob, Giuseppe Candilio, Giuseppe Curro, Giuseppe Frazzetta, Giuseppe Navarra, Giuseppe Palomba, Giuseppe Sica, Giuseppe Trigiante, Gregorio Di Franco, Gregorio Romeo, Guglielmo Clarizia, Guglielmo Giannotti, Guido Mantovani, Guido Sciaudone, Harmony Impellizzeri, Helen Yu, Iacopo Monaci, Ilaria Clementi, Imerio Angriman, Immacolata Iannone, Irnerio Angelo Muttillo, Isabella Ameli, Isabella Pezzoli, Jacopo Guerrini, Jacopo Mercuri, Jacopo Nicolò Marin, Jozel Hila, Laura Fortuna, Laura Olivieri, Leandro Siragusa, Leonardo Solaini, Letizia Santandrea, Lidia Oddis, Ljevin Boglione, Loredana Grezio, Lorenzo Casali, Lorenzo Epis, Lorenzo Gallitiello, Lorenzo Pagliai, Lorenzo Petagna, Lorenzo Ramaci, Lorenzo Tosi, Lorenzo Vona, Luca Amadio, Luca Cestino, Luca Domenico Bonomo, Luca Fabris, Luca Ferrario, Luca Morelli, Luca Perin, Luca Resca, Luca Scaravilli, Lucio Selvaggi, Ludovica Vacca, Ludovico Carbone, Luigi Boccia, Luigi Cayre, Luigi Conti, Luigi Eduardo Conte, Luigi Marano, Maddalena Maria Bignone, Manuela Mastronardi, Marci Pellicciaro, Marco Anania, Marco Angrisani, Marco Beggiato, Marco Calussi, Marco Clementi, Marco D’Ambrosio, Marco Giacometti, Marco Livrini, Marco Materazzo, Marco Montorsi, Marco Pericoli Ridolfini, Marco Realis Luc, Margherita Carbonaro, Maria Carmela Giuffrida, Maria Di Salvo, Maria Francesca Chiappetta, Maria Grazia Sibilla, Marianna Capuano, Mariarita Tarallo, Marina Valente, Mario Giuffrida, Mario Pacilli, Mario Sorrentino, Mario Trompetto, Marta Breda, Marta Mozzin, Marta Spalluto, Marzia Franceschilli, Marzia Tripepi, Massimiliano Caccetta, Massimiliano Mistrangelo, Matelda Bencini, Matteo Capuzzo, Matteo Rossini, Mattia Marinelli, Maurizio Rho, Maurizio Romano, Maurizio Roveroni, Mauro Marzano, Mauro Montuori, Mauro Podda, Mauro Pozzo, Mauro Santarelli, Micaela Piccoli, Michela Campanelli, Michele Cricrì, Michele Manara, Michele Manigrasso, Michelle Vilardo, Miriam Biancu, Nicholas Rizzi, Nick Salimian, Nicola Busi, Nicola Cillara, Nicola Di Bartolomeo, Nicola Tartaglia, Nicoletta Sveva Pipitone Federico, Nicolò De Santis, Noemi Laquatra, Noemi Zorzetti, Nunzio Velotti, Olivia Boccia, Oreste Claudio Buonomo, Pamela Milito, Paola Batistotti, Paolina Saullo, Paolo Massucco, Paolo Pizzini, Pasquale Losurdo, Patrizia Rubini, Peter Marinello, Pierantonio Cardinale, Pierluigi Lobascio, Pierpaolo Sileri, Pietro Anoldo, Pietro Fransvea, Pietro Giorgio Calò, Raffaele De Filippi, Raffaele Lombardi, Renato Meccariello, Renato Pietroletti, Riccardo Magarini, Riccardo Marsengo, Riccardo Nascimbeni, Roberta Longhin, Roberta Tutino, Roberto Cammara, Rocco Aversa, Sabino Capuzzolo, Salvatore Bonarrigo, Salvatore Bracchitta, Salvatore Carrabetta, Sara Cecconi, Sara Gobbi, Sara Ingallinella, Sara Marzorati, Sayali Valiyeva, Sebastiano Grassia, Serafino Marino, Sergio Sforza, Silvia Curcio, Silvia Neri, Silvia Puddu, Silvio Caringi, Simona Badalucco, Simona Grande, Simona Pisicchio, Simone Berardi, Simone Bosi, Simone Gargarella, Sofia Esposito, Stefania Angela Piccioni, Stefania Bettoni, Stefano Barbieri, Stefano Rossi, Stefaon Scabini, Teresa Perra, Tommaso Farolfi, Tommaso Guagni, Tommaso Loderer, Tommaso Stecca, Tommaso Violante, Ugo Elmore, Ugo Grossi, Umberto Cocozza, Valentina Rampulla, Valentina Sbacco, Valentina Zucchini, Vania Silvestri, Vincenza Paola Dinuzzi, Vincenzo Adamo, Vincenzo La Vaccara, Vincenzo Papagni, Vincenzo Schiavone, Vittoria Bellato, Zullo Alessia, Gian Andrea Binda, and Updates in Surgery, 2024
Global disparities in surgeons’ workloads, academic engagement and rest periods: the on-calL shIft fOr geNEral SurgeonS (LIONESS) study Mauro Podda, Marcello Di Martino, Francesco Pata, Giuseppe Nigri, Adolfo Pisanu, Salomone Di Saverio, Gianluca Pellino, Benedetto Ielpo, , Ashenafi Negash Tolla, Mohamed Abdelkhalek, Sameh Emile, Tesfaye Aga Dinagde, Chafik Bouzid, Ahmed Mohammed Farid Mahmoud Mansour, Ibrahim Umar Garzali, Alazar Berhe Aregawi, Tarek M. Zaghloul, Ali Kchaou, Selmy S. Awad, Amine Souadka, Tedla Gebretsadik Ted, Mohammad Saad Saumtally, Selmy S. Awad, Bensaad Ahmed, Nebiyou Simegnew Bayileyegn, Marco Nunziante, Mostafa Shalaby, Dawit Gebregiorgis Debena, Alemayehu Shanko Zena, Olayinka Lukman Adewunmi, Tolera A. Negasa, Mohamed Aboulkacem Bourguiba, Nura Feituri, Kirubel Abebe Kebede, Hossam Elfeki, Abdelhmed Anas, Ahmed K. Awad, Nebiyou Ermias, Dagnachew H. Hailemariam, Gosa Hundie Bejiga, Ruhama Yoseph Imana, Abebe Taffese, Tsega Terefe Feleke, Hosam Mohamed Elghadban, Bizuneh Sime Debela, Desta Shiferaw, Robel Tadesse, Isaac Sunday Chukwu, Abdullahi Ibrahim Mohammed, Khalid Arebo Hassen, Ndubuisi K. Obiagwu, Tadesse H. Tense, Mulugeta Taeme, Ewnte Biniam, Goytom Knfe Tesfay, Ayenachew Getachew Tegegn, Tewodros Abule Bilata Teddy, Bekana L. Bekana, Melkamu Kibret Nidaw, Mahmoud Ibrahim Ali, Kebebe Bekele Gonfa, Samuel Kiros, Tatek Belay, Gebeyaw Mengist Yallew, Chekol Wassie, Alem Mekete Ayalew, Fitsum Terefe Asfaw, Aimal Khan Aimal, Maria Agustina Casas, Fausto A. Madrid, Jose Antonio Diaz-Elizondo, Ignacio Guillermo Merlo, Tercio De Campos, Francisco Schlottmann, Carlos Augusto Gomes, Edgard Efrén Lozada Hernández, Augusto Moncada-Ortega, Antonio Ramos-De la Medina, Patricio Vanerio, Jose Antonio Diaz-Elizondo, Emilio J. Morales, Sarah Beth Stringfield, Cristian Gallardo, Vinicius Cordeiro Fonseca, Maria Emilia Muriel, Frederico Cantarino, Emilio J. Morales, Alessandro Fichera, Agustin E. Rodriguez, Roberto Paúl Andrade Salinas, Gonzalo Gabriel Crosbie, Carlos Augusto Metidieri Menegozzo, Nicolas Avellaneda, Cristhian Gonzalo Aspiazu Briones, Cristopher Varela, Warren E. Lichliter, Cristopher L. Varela, Darren Koppel, Jorge Godoy Lenz, Franco Pascual, Dauber A. Sibaja-Matamoros, Benjamin E. Johnson, Octavio Avila Mercado, Agustín Tita, Indraneil Mukherjee, Irving Lorenzo, Erick Rueda, Douglas Rico, Natasha Loria Terwes, Victor Visag-Castillo, Karol S. Escalante, Alan Francisco Alfaro Salvador, Luca Pio, Edgar B. Rodas, Juan Carlos Cardozo Aguilar, Ignacio Neri, Ernesto J. Barzola, Leonardo A. Barba, Andrés Mendoza Zuchini, Ana Karen Radilla Acevedo, Mahir Gachabayov, Ricardo Alessandro Teixeira Gonsaga, Fernando Bonilla, Chase Barrett Knickerbocker, Ioannis Tsouknidas, Juan C. Salamea, Lawrence Albert Salter Travers, Gustavo Adrian Nari, Diana Alejandra Pantoja Pachajoa, Michel Hernandez Valadez, Lyman Lansing Hale, Guillermo Perez, Asad Choudhry, Michaael L. Foreman, Ismael Brito, Mauricio Pedraza Ciro, Carla Joyce Newton, Hamilton Petry Souza, Daniel G. Davis, Rodrigo Vaz Ferreira, Deborah S. Keller, Gustavo Machain Miguel, Gurpreet Singh-Ranger, Neiling Massiel Oviedo Linares, Eduardo Smith Singares, Xavier HGarcía Valdivieso, Alfonso Ivan Sanchez Teran, Luis Felipe Cabrera Vargas, Agustín Valinoti, David M. Milne, Andrew Martin Fleming, Alejandro Quiroga-Garza, Eduardo Morales Espino, Nicole Mary Bedros, Geoffrey A. Funk, Fernanda V. S. Neves, Tommy Supit, Arshad Ahmed Baba, Mushtaq A. Chalkoo, Gultekin Ozan Kucuk, Ray Inocencio Sarmiento, Shamil I. Galeev, Mohammed J. Korkoman, Wah Yang, Noushif Medappil, Rahmatullah Athar, Ravichandran Subramaniam, Chi Fung Chia, Ahmad Alhazmi, Subhadip Halder, Siti Mayuha Rusli, Arshad Rashid, Barış Gülcü, Prasanth Nagarajan, Khaled Rida, Al-Radjid Jamiri, Oğuzkağan Batıkan, Huma Ahmed Khan, Ashrarur Rahman Mitul, Sergey Efetov, Marcelo A. F. Ribeiro Junior, Baris Gulcu, Marryam Riaz Farooqui, Venu Bhargava Mulpuri, Dinesh Bagaria, Ahmad Ramzi Yusoff, Rauf Wani, Muhammad Umar Younis, Krunal H. Khobragade, Muhammad Ibrahim Marwat, Lovenish Bains, Yoshiro Kobe, Peng Soon Koh, Umasankar Tantravahi, Ikhwan Sani Mohamad Mohamad, Hamdoon Abu-Arish, Ali Cihat Yildirim, Aini Fahriza Ibrahim, Jih Huei Tan, Dumaria Ketty Siagian, Neela Bhattacharya, Jennifer H. F. Chiu, Ganendra Paramasvaran, Kelvin Voon, Berk Göktepe, Lee Yeong Sing Lee, Amit Gupta, Faaiz Rasheed, Mohammed Al-Shehari, Syed Muhammad Ali Syed, Pawan Singh Bhat, Emre Erdoğan, Rajesh Roat, Aeris Jane D. Nacion, Swapnil Mukesh Saraiya, Akinwale Ibrahim Afolabi, Feng Yih Chai, Wagih Ghannam, Kaushik Bhattacharya, Harish NL, Ali Aloun, Hamza Waqar Bhatti, Akshadhar J. Koneti, Mohamad Klib, Ahmad Uzair Qureshi, Nicholas L. Syn, Ajaz Wani, Sara Saeidi, Muhammad Zeb, Kalyan Vijay Kumar Bandaru, Salomone Di Saverio, Maria Paola Menna, Salvador Morales-Conde, Emanuela Gessa, Santiago Sánchez-Cabús, Eleftherios Spartalis, Carmine Antropoli, Michele Manigrasso, Giuseppe S. Sica, Giorgio Ercolani, Andrei Chitul, Giulia Bacchiocchi, José Azevedo, Aleksandar Karamarkovic, Luigi Bonavina, Guglielmo N. Piozzi, Isabel Pascual Migueláñez, David Merlini, Piotr Major, Luciano Grimaldi, Valentin Calu, Aleksandar Karamarkovic, Giuseppe Curro, Christian Cotsoglou, Edoardo Baldini, Spiros Delis, Bojan Kovacevic, Michele Masetti, Francesco Selvaggi, Stefano Scabini, Andrian Reiti, Alessia Zullo, Antonio Giuliani, Pier Francesco Alesina, Lisa H. Massey, Alistair A. P. Slesser, Peter M. Neary, Kapil Sahnan, Jessica J. Tan, Gianluca Colucci, Richard R. W. Brady, Andrei Mihailescu, Michel Adamina, Ioannis Gerogiannis, Gabrielle van Ramshorst, Giulia Paradiso, Gianmario Edoardo Poto, Daniele Massaro, Fozia Nazir, Benjamin M. Stubbs, Francesco Menegon Tasselli, Virginia Durán Muñoz-Cruzado, Domenico Sabia, Alberto Vannelli, Valentina Enrica Marsella, Elisa Paoluzzi Tomada, Mauro Giambusso, Justin Davies, Aleksandar Karamarkovic, Alessandro Uzzau, Andrea Balla, Stefano Scaringi, Fozia Nazir, Francesco Lancellotti, Eleftheria Douka, Giulio Argenio, Stefano Scaringi, Gianluca Cassese, Michele Ammendola, Luca Morelli, Elisa Francone, Miklosh Bala, Prem Thambi, Maurizio Iacobone, Andrea Campisi, Patricia Tejedor, Gabriele Spoletini, Matteo Mascherini, Francesco Belia, Kapil Sahnan, Alessandro Uzzau, Ufuk Oguz Idiz, Elisa Francone, Elif Colak, Paul Adewunmi Peters, Gianluca Pellino, Emilio Peña Ros, Erman Aytac, Ramon Vilallonga, Alejandro Serrablo, Edoardo Maria Muttillo, Gregorio Di Franco, Gianluca Vanni, Arda Isik, Valentina Sbacco, Francesca Paola Tropeano, Iride Porcellini, Rebecca Jayne Butler, Carmen Cagigas Fernandez, Aristeidis Papadopoulos, Silvia Salvans, Jan Sher Khan, Pedro Palazón Bellver, Sebastian Jeri Mc Farlane, Konstantinos Apostolou, Jaume Tur-Martinez, Javier Rivera Castellano, Matteo Santoliquido, Luis Tallon-Aguilar, Valerio Celentano, Vusal Aliyev, Andrei Mihailescu, Issam al-Najami, Florin A. Grama, Jaume Tur-Martinez, Łukasz Masior, Wojciech J. Ciesielski, Antonio Luberto, Marco Sparavigna, Tomasz Jerzy Klimczak, Ionut Negoi, Mario Serradilla-Martín, Athanasios Marinis, Roberto Cammarat, Juan Bellido-luque, Carlo Alberto Manzo, Flavio Milana, Gaetano Luglio, Narcis Octavian Zarnescu, Isidro Martínez, Stefano Olmi, Radu V. Costea, Carlos Cerdán-Santacruz, Nicolae Gica, Gianluca Rompianesi, Gaetano Gallo, Cristina Ridolfi, Saidah Sahid, Tommaso CC, Guillermo López-Soler, Carlos JGómez Díaz, Niamh Mccawley, Andrea Pierre Luzzi, David Abelló, Alba Correa Bonito, Vasileia Ntomi, Stavros Gourgiotis, Natalia Suárez Pazos, Marta Jiménez Toscano, David Ambrona Zafra, Marc Beisani, Alba Oliva, Mert Guler, Marta Jiménez Gómez, Lidia Oddis, Blanca Montcusí, Ander Timoteo Delgado, Mateusz PJęckowski Aingeru Sarriuga Lasarte, Nicola Antonacci, Alberto Sartori, John Vincent Taylor, Francisco Juan de Santos Iglesias, Manuela Mastronardi, Emre Gunay, Andrew Yiu, Oscar Cano-Valderrama, Giulia Costantini, Holly Jane Digne-Malcolm, Thalia Petropoulou, Marta Jiménez Gómez, Nir Horesh, Michael E. Kelly, Nauman Ahmed, Justyna Wyroslak-Najs, Prashant Naik, Vincenzo Vigorita, Michael Michael, Ernest Castro, Anna Paspala, Marco D’Ambrosio, Anang Pangeni, Jana Dziakova, Flavio Milana, Lara Blanco Terés, Leyre Lorente-Poch, Isidoro Di Carlo, Michael Spartalis, David Moro-Valdezate, Matthew G. Davey, Victor Turrado-Rodriguez, Yegor Tryliskyy, Marco Calussi, Silvia Pérez Farré, Miriam Cazador Labat, Chiara Marafante, Marijn Takkenberg, Charlotte Elisabeth Brookes, Antonio S. Soares, Eleftherios Gialamas, Damiano Caputo, Laia Codina Corrons, Nicola Antonacci, Sante Capitano, Alexandros Charalabopoulos, Cristine Brooke Pathirannehalage Don, Enrico Marrano, Maria Carmela Giuffrida, Giovanni Tomasicchio, Vittoria Bellato, Jasper Stijns, Ben Creavin, Dimitrios Schizas, Francisco Blanco-Antona, Stylianos Kykalos, Nicola Tartaglia, Amalia Pelegrina, Alberto G. Barranquero, Carlo Alberto Schena, Simone Cremona, Efstratia Baili, Pasquale Cianci, Annamaria Di Bella, Edoardo Forcignanò, Tiziana Fabbrizio, Francesco Salvetti, Marco Inama, Tommaso Campagnaro, Eva B. Deerenberg, Isabella Reccia, Aldo Rocca, Federico Fazio, Athanasios Tampakis, Kostas Tepelenis, Giovanna Di Meo, Georgios Konstantoudakis, Dimitrios K. Manatakis, Alexandros Charalabopoulos, Michela Mineccia, Antonella Delvecchio, Carmelo Lo Faro, Edoardo Rosso, Samik K. Bandyopadhyay, Michael Queffurus, Jacopo Nicolò Marin, Arianna Corvasce, Gauri Chillarge, Mohammed Mustafa Mohammed, Rebecca Reid, Dario Gherardi, Awais Naeem, Sanjay Pandanaboyana, Salim Tayeh, Mickael Chevallay, Gregory Sergeant, Salvatore Cuccomarino, Nick Salimian, Panagiotis Kapsampelis, Carlotta Ferretti, James Glasbey, Rafique Umer Harvitkar, Muhammad Rafaih Iqbal, Gabriel Paiva de Oliveira, Sonia Pérez-Bertólez, Alessandro Bergna, Giuseppe Brisinda, Matteo Rottoli, Francesco Roscio, Corrado Pedrazzani, Jeremy Meyer, Marco V. Marino, Camille Brasset, Clerc Daniel, Stefanie Devriendt, Gabriele Soldini, Damiano Pennisi, Chris B. 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