Krishna Chandra Panda is currently an Associate Professor in the faculty of Pharmacy in the State of Odisha, under Odisha university of Health Sciences, India. He has 16 years of teaching and Research experience. He has completed his Ph. D Degree in Pharmacy from Biju Patanaik University of Technology, Rourkela, Odisha, India. He achieved research Scholar award from Biju Patnaik University of Technology in the year 2022. He credited more than 26 International journals, 15 national journals, 6 book chapters and 2 Indian patents, 2 books in his name. He is a peer editorial member in different international journals like LIFE RESEARCH, ASIAN JOURNAL OF GREEN CHEMISTRY and worked as a reviewer in different journals like Bentham Science, JAMPS etc. He is expertise in Green chemistry, Heterocyclic chemistry, Drug Designing, Characterization, Phytochemical screening, Biological evaluation, Neurobiology, Life science.
EDUCATION
M.Pharm, Ph.D
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmaceutical Science, Drug Discovery, Pharmacology, Organic Chemistry
14
Scopus Publications
248
Scholar Citations
6
Scholar h-index
4
Scholar i10-index
Scopus Publications
Evolutionary Study on the Y Chromosome: A Comprehensive Review Ansuman Sahu, Bimalendu Chowdhury, Nitish Sahu, Sanjiv Kumar Panda, Krishna Chandra Panda Current Pharmacogenomics and Personalized Medicine, 2026 Introduction: The Y chromosome, essential for male sex determination and reproduction, has undergone significant evolutionary shrinkage, losing most of its genetic content. This review explores the biological and historical significance of the Y chromosome, its role in male-specific traits, spermatogenesis, and secondary sexual characteristics. It also examines the implications of its shrinking for male infertility, cancer risk, and aging-related diseases, along with potential pharmacological and genetic solutions Method: A comprehensive review of existing literature, cross-species studies, and recent advancements in genetics and medical research was conducted. Based on mechanisms of Y chromosome degeneration, its impact on health, and possible therapeutic interventions, including hormone replacement therapies, assisted reproductive technologies, and geneediting techniques like CRISPR. Results: Despite reducing from 1,400 to 55 active genes, the Y chromosome retains key functions in testosterone production and sperm maturation through genes like SRY, DAZ, and TSPY. Studies suggest alternative mechanisms for male traits in the absence of the Y chromosome, raising questions about its future in humans. Discussion: The shrinkage is linked to infertility, increased cancer risk, and aging-related disorders. Potential pharmacological approaches involve hormone replacement therapies, assisted reproductive technologies, and gene-editing techniques like CRISPR. Conclusion: The shrinking Y chromosome poses challenges to male health, but scientific advancements offer hope for mitigating its effects. Integrating genetic research, evolutionary studies, and medical innovations is crucial for addressing Y-linked disorders and guiding the future of male health and reproduction.
Neuroprotective and Antioxidant Study of Cyanobacteria Arthrospira Krishna Chandra Panda, Rajaram Das, B.V.V. Ravi Kumar, J. Sruti Current Aging Science, 2025 The search for novel neuroprotective and antioxidant agents is crucial in combating neurodegenerative diseases and oxidative stress-related disorders. This study explores the neuroprotective and antioxidant properties of Arthrospira (commonly known as Spirulina), a cyanobacterium renowned for its rich nutritional profile and potential health benefits. Arthrospira has gained attention for its high content of bioactive compounds, including phycocyanin, carotenoids, and essential fatty acids, 60% protein, 8% fats, 15-25% Carbohydrates, minerals, vitamins, and pigments which are thought to contribute to its therapeutic and nutritional effects. In this research, Arthrospira was evaluated for its neuroprotective and antioxidant capabilities through a series of in vitro and in vivo experiments. The study utilized cell-based assays to assess the ability of Arthrospira extracts to protect neuronal cells from oxidative damage induced by various stressors, including hydrogen peroxide and glutamate. Additionally, the study employed animal models to further investigate the effects of Arthrospira on cognitive function and oxidative stress in vivo. The findings revealed that Arthrospira extracts exhibited significant antioxidant activity, as demonstrated by their ability to neutralize free radicals and reduce oxidative stress markers in neuronal cells. In vitro assays showed that Arthrospira enhanced cellular viability and reduced markers of oxidative damage, such as malondialdehyde (MDA) and reactive oxygen species (ROS). These results suggest that Arthrospira possesses potent antioxidant properties that can mitigate oxidative stress and protect neuronal cells. In vivo studies using rodent models further confirmed the neuroprotective effects of Arthrospira. Animals supplemented with Arthrospira showed improved cognitive performance in behavioral tests, including memory and learning tasks. Additionally, histological analysis revealed a reduction in neuroinflammation and neuronal damage in the brains of Arthrospira-treated animals. Biochemical assays supported these findings, indicating a decrease in oxidative stress markers and an increase in endogenous antioxidant enzyme activities.
AI in Clinical Trials and Drug Development: Challenges and Potential Advancements Divyanshi Gupta, Pranay Wal, Ankita Wal, Sribhavani K.R, Mudit kumar, Krishna Chandra Panda, Mukesh Chandra Sharma Current Drug Discovery Technologies, 2025 Artificial intelligence (AI) is one of the fastest-growing fields in various industries, including engineering, architecture, medical and clinical research, aerospace, and others. AI, which is a combination of machine learning (ML), deep learning (DL), and human intelligence (HI), is revolutionizing drug discovery and development by making it more cost-effective and efficient. It is also being used in fields such as medicinal chemistry, molecular and cell biology, pharmacology, pharmacokinetics, formulation development, and toxicology. AI plays a crucial role in clinical testing by enhancing patient stratification, patient sample evaluation, and trial design, assisting in the identification of biomarkers, determining efficacy criteria, dose selection, trial length, and target patient population selection. The primary objective of this study is to emphasize the importance of AI in clinical trials and drug development, while also exploring the existing challenges and potential advancements in AI within the healthcare industry. A comprehensive literature review was conducted, covering the period from 1998 to 2023. The Science Direct, PubMed, and Google Scholar databases were searched for relevant information. A variety of publications, including Research Gate, Nature, MDPI, and Springer Link, provided pertinent data. This study aimed to gain a deeper understanding of the use of AI in clinical research and drug development, as well as its potential and limitations. We also discuss the benefits and main data limitations of the traditional trial and drug development approach. AI approaches are currently being used to overcome research obstacles and eliminate conceptual or methodological limitations. After discussing possible obstacles and coping mechanisms, we provide several recommendations to help individuals understand the challenges and difficulties associated with clinical research and drug development. It is essential for pharmaceutical companies to have a cutting-edge AI strategy if AI is to become a routine tool for clinical research and drug development.
Gene expression and hormonal signaling in osteoporosis: from molecular mechanisms to clinical breakthroughs Gurinderdeep Singh, Ronald Darwin, Krishna Chandra Panda, Shaikh Amir Afzal, Shashwat Katiyar, Ram C. Dhakar, Sangeetha Mani Journal of Biomaterials Science Polymer Edition, 2025 Osteoporosis is well noted to be a universal ailment that realization impaired bone mass and micro architectural deterioration thus enhancing the probability of fracture. Despite its high incidence, its management remains highly demanding because of the multifactorial pathophysiology of the disease. This review highlights recent findings in the management of osteoporosis particularly, gene expression and hormonal control. Some of the newest approaches regarding the subject are described, including single-cell RNA sequencing and long non-coding RNAs. Also, the review reflects new findings on hormonal signaling and estrogen and parathyroid hormone; patient-specific approaches due to genetic and hormonal variation. Potential new biomarkers and AI comprised as factors for improving the ability to anticipate and manage fractures. These hold great potential of new drugs, combination therapies and gene based therapies for osteoporosis in the future. Further studies and cooperation of scientists and clinicians will help to apply such novelties into practical uses in the sphere of medicine in order to enhance the treatment of patients with osteoporosis.
Microwave Induced Green Synthesis: Sustainable Technology for Efficient Development of Bioactive Pyrimidine Scaffolds Biswa Mohan Sahoo, Bimal Krishna Banik, Bera Venkata Varaha Ravi Kumar, Krishna Chandra Panda, Abhishek Tiwari, Varsha Tiwari, Sunil Singh, Manish Kumar Current Medicinal Chemistry, 2023 Microwave radiation is used as a heating source during the synthesis of heterocyclic compounds. The heating mechanisms involved in microwave-induced synthesis include dipolar polarization and ionic conduction. This heating technology follows the green protocol as it involves the use of recyclable organic solvents during synthesis. The microwave heating approach offers a faster rate of reaction, easier work-up procedure, and higher product yield with purity and also reduces environmental pollution. So, microwave heating is applied as a sustainable technology for the efficient production of pyrimidine compounds as one of the heterocyclic moieties. Pyrimidine is a six-membered nitrogenous heterocyclic compound that plays a significant role due to several therapeutic applications. This moiety acts as an essential building block for generating drug candidates with diverse biological activities, including anti-cancer (capecitabine), anti-thyroid (propylthiouracil), antihistaminic (pemirolast), antimalarial (pyrimethamine), antidiabetic (alloxan), antihypertensive (minoxidil), anti-inflammatory (octotiamine), antifungal (cyprodinil), antibacterial (sulfamethazine), etc. This review is focused on the synthesis of pyrimidine analogs under microwave irradiation technique and the study of their therapeutic potentials.
Green Chemistry Approach for the Synthesis of Isoxazole Derivatives and Evaluation of their Anti-epileptic Activity Krishna Chandra Panda, Ravi Kumar Venkata Varaha Bera, Biswa Mohan Sahoo, Parijat Swain Current Drug Discovery Technologies, 2023 Background: Green strategy involves the design, synthesis, processing, and use of chemical substances by eliminating the generation of chemical hazards. This approach focuses on atom economy, use of safer solvents or chemicals, consumption of energy, and decomposition of the chemical substances to non-toxic materials which are eco-friendly. Objective: So, the microwave irradiated heating method is considered a green and sustainable technique for the development of novel heterocyclic scaffold-like isoxazole derivatives via chalcones. Isoxazole derivatives play a vital role due to their diverse pharmacological activities such as antibiotic (Sulfamethoxazole, Cloxacillin, Flucloxacillin, Cycloserine), anti-fungal (Drazoxolon), Antirheumatic (Leflunomide), antidepressant (Isocarboxazid), antineoplastic (Acivicin), anticonvulsant (Zonisamide), antipsychotic (Risperidone) and anti-inflammatory drugs (Valdecoxib), etc. Methods: The isoxazole derivatives were synthesized with the help of microwave irradiation that follows green chemistry protocol. Results: The titled compounds were subjected to antiepileptic evaluation to determine their therapeutic potential. Conclusion: The use of microwave radiation enhances the rate of the reaction which leads to high selectivity with improved product yields in comparison with the traditional heating methods. The tested compounds exhibited promising antiepileptic activity as compared to the standard drug (Phenytoin).
Molecular Docking, Multicomponent One-pot Synthesis of Pyrimidine Derivatives as Anti-mycobacterial Agents Krishna Chandra Panda, B.V.V. Ravi Kumar, Biswa Mohan Sahoo, Balakumar Chandrasekaran, Parijat Swain Anti Infective Agents, 2023 Background: Molecular docking study is used significantly in the drug discovery process for predicting the interaction between drug and receptor. This technique has been used commonly to identify the binding affinity and orientation of drug molecules at the binding site of the target. The main objectives of docking studies include accurate modeling of molecular structure and precise prediction of the biological activity of the drug molecules. Methods: Based on this concept, a series of 2-amino-6-(substituted phenyl)-4-oxo-4,5-dihydropyrimidine-5-carbonitrile derivatives have been designed and synthesized via multi-component reaction. The synthetic protocol involves the one-pot, three-component reaction be-tween equimolar quantities of substituted benzaldehydes, ethyl cyanoacetate, and guanidine in an ethanolic sodium hydroxide solution. Results: The characterization of the titled compounds was carried out by assessing infrared spectroscopy (IR), proton nuclear magnetic resonance (1H-NMR), and mass spectrometry (MS) data. The synthesized compounds were screened for their in vitro anti-mycobacterial activity by using the luciferase reporter phage (LRP) assay method. Conclusion: The determination of anti-mycobacterial activity was carried out in terms of the percent reduction in the relative light unit (RLU). The test compounds displayed significant ac-tivity against Mycobacterium strain H37Rv in comparison to isoniazid as a standard drug.
Microwave Induced Synthesis of 1,2,4-triazole derivatives and Study of their Anthelmintic and Anti-microbial Activities Krishna Chandra Panda, B. V. V. Ravi Kumar, Biswa Mohan Sahoo Research Journal of Pharmacy and Technology, 2022 Microwave-assisted chemical reactions are utilized as an emerging tool in drug synthesis as this technique is simple, economic, and efficient. So, a new series of 1,2,4-triazole derivatives are obtained via multi-component reactions under microwave irradiation. First of all, benzohydrazide was obtained by esterification of benzoyl chloride with methanol in presence of concentrated sulphuric acid followed by reaction with hydrazine hydrate. So, carbon disulfide was added dropwise to benzohydrazide in ethanolic potassium hydroxide solution to yield potassium dithiocarbazinate which was cyclized by reacting with hydrazine hydrate to afford 1,2,4-triazole-3-thiol. Further, various Schiff’s bases were prepared by reacting 1,2,4-triazole-3-thiol with different substituted benzaldehydes under microwave irradiations. The characterization of the newly synthesized triazole derivatives were carried out by spectral studies including FT-IR, 1H-NMR, and LC-MS. The tested compounds exhibited significant in-vitro anthelmintic and antimicrobial activities as compared to the standard drugs.
Unravelling Cardiovascular Diseases: Pathogenesis and Therapies KCPBC Ansuman Sahu1,*, Nitish Sahu1 Current Neurovascular Research, DOI: 10.2174/011567202643663026012006395 , 2026 2026
A Comprehensive review on Modelling techniques in Drug Research and development HKSKSA Krishna Chandra Panda1,* , Bera Venkata Varaha Ravi Kumar2 , Jammula ... Applied Drug Research, Clinical Trials and Regulatory Affairs, DOI: 10.2174 … , 2026 2026
Evolutionary Study on the Y Chromosome: A Comprehensive Review SKPKCP Ansuman Sahu, Bimalendu Chowdhury*, Nitish Sahu Current Pharmacogenomics and Personalized Medicine, e18756921389203 , 2026 2026
Evolutionary Study on the Y Chromosome: A Comprehensive Review A Sahu, B Chowdhury, N Sahu, SK Panda, KC Panda Current Pharmacogenomics and Personalized Medicine 23 (1), E18756921389203 , 2026 2026
Brain–Gut Axis Focusing on High-Throughput Technologies Like Gene Sequencing, Brain Imaging, and Metabolomics PS Vaibhav Dagaji AherAbhishek SharmaSimanchal Panda,Krishna Chandra Panda CRC Press, Taylor & Francies 1, 1-17 , 2025 2025
Brain–Gut Axis Focusing on High-Throughput Technologies Like Gene Sequencing, Brain Imaging, and Metabolomics VD Aher, A Sharma, S Panda, KC Panda, P Sharma Biotics and the Gut–Brain Axis in Neurological Disorders, 201-217 , 2025 2025
Neuroprotective and Antioxidant Study of Cyanobacteria Arthrospira BVVRKJS Krishna Chandra Panda1,*, Rajaram Das1 Current Aging Science, DOI: 10.2174/0118746098365217250828003 , 2025 2025
NUTRITIONAL INTERVENTIONS FOR AUTOIMMUNE DISEASES: A COMPREHENSIVE REVIEW BMS 1Krishna Chandra Panda1, B. V. V Ravi Kumar2, Rajaram Das3, Ch.Niranjan ... JOURNAL OF ODISHA UNIVERSITY OF HEALTH SCIENCES 1 (2), 97-113 , 2025 2025
A Comprehensive Review on Current Microwave Chemistry BMS Krishna Chandra Panda,Ravi Kumar B.V.V.,Sruti Jammula Current Microwave Chemistry, DOI: 10.2174/012213335638206825070609075 , 2025 2025 Citations: 2
Gene expression and hormonal signaling in osteoporosis: from molecular mechanisms to clinical breakthroughs G Singh, R Darwin, KC Panda, SA Afzal, S Katiyar, RC Dhakar, S Mani Journal of Biomaterials Science, Polymer Edition 36 (10), 1466-1501 , 2025 2025 Citations: 5
Management of Steroid-Induced Diabetes: A Review of Herbal Medications and Their Role in Modulating Insulin Signaling Pathways HKPW Jitendra Gupta, Neha Verma, Ankita Wal, Krishna Chandra Panda, Vishnu ... Endocrine, Metabolic & Immune Disorders - Drug Targets/10.2174 … , 2025 2025
Management of Steroid-Induced Diabetes: A Review of Herbal Medications and Their Role in Modulating Insulin Signaling Pathways J Gupta, N Verma, A Wal, KC Panda, VV Yeleti, B Singh, S Mahajan, ... Endocr Metab Immune Disord Drug Targets , 2025 2025 Citations: 2
Unlocking the Potential of Nanotechnology: A Comprehensive Guide for Drug Research J KC Panda ,BVVR Kumar Recent Research in Science, engineering & Technology, 265-280 , 2024 2024
Green Catalysis: A Comprehensive Guide to Medicinal Chemistry KC Panda, BVV Ravi Kumar, S J Recent Research in Science, engineering & Technology, 249-264 , 2024 2024
GREEN SYNTHESIS OF PYRAZOLINES WITH POTENTIAL ANTIOXIDANT PROPERTIES GS Er. Manasvi Jain1, Shalini Bhatnagar2, Jyothi Muddagoni3, Rashi ... African Journal of Biological Sciences 6 (14), 3044-3059 , 2024 2024
Preclinical Evaluation Of Antidiabetic Properties Of Murraya Koenigii And Abelmoschus Esculentus In Diabetic Rats DSKY Dr. Ankita Alice Singh1 , Ramenani Hari Babu2 , Dr. Vema Kiran3 , Yadav ... Revista electrónica de Veterinaria - ISSN 1695-7504 25 (1 (2024)), 2278-2285 , 2024 2024
Microwave Assisted Synthesis, Antihypertensive Activity, Docking and SAR Studies of Some Di-Hydro Pyrimidines JS Krishna Chandra Panda*, B.V.V Ravi Kumar Bioscene 21 (3), 1084-1105 , 2024 2024 Citations: 3
AI in Clinical Trials and Drug Development: Challenges and Potential Advancements KCPMCS Divyanshi Gupta, Pranay Wal, Ankita Wal, Sribhavani K.R, Mudit kumar Current Drug Discovery Technologies , 2024 2024 Citations: 7
Design and characterization pyrido [2, 3-d] pyrimidines substituted chalcone derivatives for antimicrobial activity. DD Kini, S Basak, S Prasanthi, YK Reddy, Mallamma, KS Mamatha, ... 2024
MOST CITED SCHOLAR PUBLICATIONS
Apoptosis and autophagy modulating dietary phytochemicals in cancer therapeutics: Current evidences and future perspectives S Patra, B Pradhan, R Nayak, C Behera, KC Panda, S Das, M Jena, ... Phytotherapy Research 35 (8), 4194-4214 , 2021 2021 Citations: 77
Green synthetic approach: An efficient eco-friendly tool for synthesis of biologically active oxadiazole derivatives BK Banik, BM Sahoo, BVVR Kumar, KC Panda, J Jena, MK Mahapatra, ... Molecules 26 (4), 1163 , 2021 2021 Citations: 68
Microwave induced green synthesis: sustainable Technology for efficient development of bioactive pyrimidine scaffolds BM Sahoo, BK Banik, BVVR Kumar, KC Panda, A Tiwari, V Tiwari, ... Current Medicinal Chemistry 30 (9), 1029-1059 , 2023 2023 Citations: 27
Exploring the synthetic strategies and biological activities of pyrazole derivatives M Kotnala, G Singh, K Singh, R Nath, KC Panda, A Kumar, S Dutta Naturalista Campano 28 (1), 3238-3248 , 2024 2024 Citations: 10
AI in Clinical Trials and Drug Development: Challenges and Potential Advancements KCPMCS Divyanshi Gupta, Pranay Wal, Ankita Wal, Sribhavani K.R, Mudit kumar Current Drug Discovery Technologies , 2024 2024 Citations: 7
Microwave induced green chemistry approach towards the synthesis of heterocyclic compounds via cn bond forming reactions BK Banik, BM Sahoo, BVVR Kumar, KC Panda Current Microwave Chemistry 8 (3), 204-214 , 2021 2021 Citations: 7
Microwave Irradiated Eco-friendly Synthesis of Pyridine Derivatives as Potential Antitubercular Agents KC Panda, B Kumar, BS Sahoo, BK Banik, A Tiwari Asian J. Chem 34 (4), 907-911 , 2022 2022 Citations: 6
Gene expression and hormonal signaling in osteoporosis: from molecular mechanisms to clinical breakthroughs G Singh, R Darwin, KC Panda, SA Afzal, S Katiyar, RC Dhakar, S Mani Journal of Biomaterials Science, Polymer Edition 36 (10), 1466-1501 , 2025 2025 Citations: 5
Microwave-assisted facile synthesis and in vitro anti-microbial activities of some novel isoxazole derivatives via chalcones. KC Panda, BVVR Kumar, BM Sahoo 2021 Citations: 5
Green chemistry approach for the synthesis of isoxazole derivatives and evaluation of their anti-epileptic activity KC Panda, RKV Varaha Bera, BM Sahoo, P Swain Current Drug Discovery Technologies 20 (3), 74-81 , 2023 2023 Citations: 4
Microwave Induced Synthesis of 1, 2, 4-triazole derivatives and Study of their Anthelmintic and Anti-microbial Activities KC Panda, BV Kumar, BM Sahoo Research Journal of Pharmacy and Technology 15 (12), 5746-50 , 2022 2022 Citations: 4
Microwave Assisted Synthesis, Antihypertensive Activity, Docking and SAR Studies of Some Di-Hydro Pyrimidines JS Krishna Chandra Panda*, B.V.V Ravi Kumar Bioscene 21 (3), 1084-1105 , 2024 2024 Citations: 3
Chemical Biology of Natural Products: Expanding the Drug Discovery Toolbox with Bioactive Molecules MG Pavan K. P, Manuj K. A, B.Sanjeeb K. P, Suvarna M. B, Kamran J N,Krishna ... African Journal of Biological Sciences 6 ((9)), 1145-1170 , 2024 2024 Citations: 3
Molecular docking, multicomponent one-pot synthesis of pyrimidine derivatives as anti-mycobacterial agents K Chandra Panda, BVVR Kumar, BM Sahoo, B Chandrasekaran, P Swain Anti-Infective Agents 21 (4), 6-12 , 2023 2023 Citations: 3
Microwave irradiated green synthesis of novel isoxazole derivatives as anti-epileptic agent KC Panda, B Kumar, BM Sahoo Curr Trends Biotechnol Pharm 16, 25-30 , 2022 2022 Citations: 3
Synthesis of Schiff’s bases of 1, 2, 4-triazole derivatives under microwave irradiation technique and evaluation of their anti-diabetic activity KC Panda, BVVR Kumar, BM Sahoo Current Microwave Chemistry 8 (3), 215-224 , 2021 2021 Citations: 3
A Comprehensive Review on Current Microwave Chemistry BMS Krishna Chandra Panda,Ravi Kumar B.V.V.,Sruti Jammula Current Microwave Chemistry, DOI: 10.2174/012213335638206825070609075 , 2025 2025 Citations: 2
Management of Steroid-Induced Diabetes: A Review of Herbal Medications and Their Role in Modulating Insulin Signaling Pathways J Gupta, N Verma, A Wal, KC Panda, VV Yeleti, B Singh, S Mahajan, ... Endocr Metab Immune Disord Drug Targets , 2025 2025 Citations: 2
PYRAZOLE SCAFFOLDS: A PROMISING FRONTIER IN DRUG DISCOVERY T Sunitha, PV Dixit, A Naaz, P Chitrapu, KC Panda, PB Kumar, D Sahu, ... Biochem. Cell. Arch 24 (1), 625-638 , 2024 2024 Citations: 2
Isoxazole Derivatives as Potential Pharmacophore for New Drug Development BM Sahoo, BVVR Kumar, KC Panda, BK Banik, A Tiwari, V Tiwari, ... Frontiers in Medicinal Chemistry: Volume 10, 1-49 , 2023 2023 Citations: 2