Pabyton Goncalves Cadena

Scopus Publications

Nanoemulsion containing 17α-methyltestosterone as a feed additive showed high sex reversal efficiency in Nile tilapia (Oreochromis niloticus)
Matheus Victor Viana de Melo, Amanda Rodrigues dos Santos-Magnabosco, Jadson Freitas da Silva, Aline Rafaely Damaso Alves, Hansheys Ménard, et al.
Aquaculture International, 2025
Multiscale turbulence hierarchy in active matter: Polarization analysis of a zebrafish shoal
Antonio. R. de C. Romaguera, João V. A. Vasconcelos, Viviane M. de Oliveira, Adauto J. F. de Souza, Anderson L. R. Barbosa, et al.
Physical Review E, 2025
Analysis of the ecotoxicity of waste generated in a laundry in the textile center of the Agreste region of Pernambuco using zebrafish (Danio rerio) as a bioindicator
Paula Raíza Alves Cavalcante, Jadson Freitas da Silva, Renatta Priscila Ferreira Silva, Matheus Victor Viana de Melo, Maria Letícia Santos Carnaúba da Silva, et al.
Environmental Science and Pollution Research, 2025
Single essential oils and their binary mixtures protect against ethanol-induced defects in a zebrafish fetal alcohol spectrum disorder model at the same level as folic acid
Andressa Raphaely de Lima Silva, Maria Letícia Santos Carnaúba da Silva, Jadson Freitas da Silva, Katarine Evelyn Falcão e Falcão, James A. Marrs, et al.
Alcohol, 2025
Nanoemulsions of Sicilian lemon and wild orange essential oils, using soy lecithin as a surfactant, preserve the acrosome of ram sperm post-thawing
Aline Saraiva de Oliveira, Lúcia Cristina Pereira Arruda, Gustavo de Oliveira Alves Pinto, Amanda Rodrigues dos Santos Magnabosco, André Lucas Correa de Andrade, et al.
Animal Reproduction, 2025
The objective of this study was to evaluate the effect of adding Sicilian lemon and wild orange essential oil nanoemulsion, using soy lecithin as a surfactant, to ram semen freezing extender. The nanoemulsions were prepared by high-energy emulsification method using soy lecithin (5%) as a surfactant. The organoleptic and physicochemical characteristics were evaluated. Semen samples (n = 7) obtained from adult rams (n = 6) were frozen in a Tris-egg yolk extender supplemented with Sicilian lemon or wild orange nanoemulsion at different concentrations (0.0%, 1.5%, 2.5%, and 3.5%). After thawing (37oC, 30 s), the samples were evaluated for kinematics, plasma and acrosomal membrane integrity, and mitochondrial membrane potential. Visually, the nanoemulsions of Sicilian lemon or wild orange essential oil appeared homogeneous, fluid, opaque, without lumps, odorless, and colored, immediately after preparation (0 h) and after thermal stress (24 h). The physicochemical characterization of the nanoemulsions showed vesicles with average sizes < 220.00 nm, polydispersity index < 0.30, and zeta potential of -59.00 mV. Semen samples from the groups treated with Sicilian lemon (1.5%, 2.5%, and 3.5%) or wild orange (1.5%, 2.5%, and 3.5%) nanoemulsions did not differ (P ≤ 0.05) in terms of kinematics, plasma membrane integrity, and mitochondrial membrane potential when compared to the control group. However, the groups treated with Sicilian lemon (2.5% and 3.5%) and wild orange (1.5%, 2.5%, and 3.5%) nanoemulsions had a higher percentage (P ≤ 0.05) of cells with intact acrosomes when compared to the control group. It can be concluded that nanoemulsions of essential oils of Sicilian lemon (2.5% and 3.5%) and wild orange (1.5%, 2.5%, and 3.5%), using soy lecithin (5%) as a surfactant, can be used as additives to the Tris-egg yolk extender for ram semen freezing due to their ability to preserve the acrosome post-thawing.
Nanoemulsions with cannabidiol reduced autistic-like behaviors and reversed decreased hippocampus viable cells and cerebral cortex neuronal death in a prenatal valproic acid rat model
MARIANA DE F.O. DA SILVA, AMANDA R. SANTOS-MAGNABOSCO, CLÁUDIA KATHARINY DA S. FARIAS, SANDRA MARIA DE TORRES, ANTÔNIO JOSÉ ALVES, et al.
Anais Da Academia Brasileira De Ciencias, 2025
The highly lipophilic nature and low aqueous solubility of cannabidiol (CBD) limit its oral bioavailability, resulting in poor intestinal absorption. To overcome these limitations, we proposed the production of a nanoemulsion with CBD to be included in the therapeutic treatment of autism spectrum disorder. The current study aimed to evaluate the effect of CBD-rich corn oil nanoemulsion treatment in male rats born to females exposed to valproic acid (VPA) during pregnancy on autistic-like behaviors and hippocampal histology. Offspring rats were treated orally twice daily with CBD nanoemulsions at different doses (1 and 2 mg/animal). The endpoints evaluated were anxiety, grooming time, exploratory activity, sociability, the social preference index, and hippocampal and cerebral cortex histology. All formulations were characterized as nanoemulsions and showed a reduced vesicle size (107.6 - 72.6 nm), low PDI (0.290-0.432), negative zeta potential (-40.6 mv), and good stability. Prenatal exposure to VPA increased anxiety and grooming time, and reduced exploratory activity, sociability, and the social preference index in the animals. Furthermore, VPA-exposed animals exhibited elevated neuronal death and a reduction in viable cells in the hippocampus. In conclusion, CBD nanoemulsion treatment reversed autistic-like behaviors, potentially by protecting against hippocampal neuronal death. The highly lipophilic nature and low aqueous solubility of cannabidiol (CBD) limit its oral bioavailability, resulting in poor intestinal absorption. To overcome these limitations, we proposed the production of a nanoemulsion with CBD to be included in the therapeutic treatment of autism spectrum disorder. The current study aimed to evaluate the effect of CBD-rich corn oil nanoemulsion treatment in male rats born to females exposed to valproic acid (VPA) during pregnancy on autistic-like behaviors and hippocampal histology. Offspring rats were treated orally twice daily with CBD nanoemulsions at different doses (1 and 2 mg/animal). The endpoints evaluated were anxiety, grooming time, exploratory activity, sociability, the social preference index, and hippocampal and cerebral cortex histology. All formulations were characterized as nanoemulsions and showed a reduced vesicle size (107.6 - 72.6 nm), low PDI (0.290-0.432), negative zeta potential (-40.6 mv), and good stability. Prenatal exposure to VPA increased anxiety and grooming time, and reduced exploratory activity, sociability, and the social preference index in the animals. Furthermore, VPA-exposed animals exhibited elevated neuronal death and a reduction in viable cells in the hippocampus. In conclusion, CBD nanoemulsion treatment reversed autistic-like behaviors, potentially by protecting against hippocampal neuronal death.
Use of phytocanabinoids in animal models of Parkinson's disease: Systematic review
Amanda de Deus Ferreira Alves, Fernanda Carolina Ribeiro Dias, Pabyton Gonçalves Cadena, Valdemiro Amaro Silva-Jr
Neurotoxicology, 2024
Speckle statistics as a tool to distinguish collective behaviors of Zebrafish shoals
Adauto J. F. de Souza, Antonio. R. de C. Romaguera, João V. A. Vasconcelos, Luis G. Negreiros-Neto, Viviane M. de Oliveira, et al.
Scientific Reports, 2024
Zebrafish have become an important model animal for studying the emergence of collective behavior in nature. Here, we show how to properly analyze the polarization statistics to distinguish shoal regimes. In analogy with the statistical properties of optical speckles, we show that exponential and Rayleigh distributions emerge in shoals with many fish with uncorrelated velocity directions. In the opposite limit of just two fish, the polarization distribution peaks at high polarity, with the average value being a decreasing function of the shoal’s size, even in the absence of correlations. We also perform a set of experiments unveiling two shoaling regimes. Large shoals behave as small domains with strong intra-domain and weak inter-domain correlations. A strongly correlated regime develops for small shoals. The reported polarization statistical features shall guide future automated neuroscience, pharmacological, toxicological, and embryogenesis-motivated experiments aiming to explore the collective behavior of fish shoals.
Behavioral Effects of the Mixture and the Single Compounds Carbendazim, Fipronil, and Sulfentrazone on Zebrafish (Danio rerio) Larvae
Samara da Silva Gomes, Jadson Freitas da Silva, Renata Meireles Oliveira Padilha, João Victor Alves de Vasconcelos, Luís Gomes de Negreiros Neto, et al.
Biomedicines, 2024
Pesticides are often detected in freshwater, but their impact on the aquatic environment is commonly studied based on single compounds, underestimating the potential additive effects of these mixtures. Even at low concentrations, pesticides can negatively affect organisms, altering important behaviors that can have repercussions at the population level. This study used a multi-behavioral approach to evaluate the effects of zebrafish larvae exposure to carbendazim (C), fipronil (F), and sulfentrazone (S), individually and mixed. Five behavioral tests, thigmotaxis, touch sensitivity, optomotor response, bouncing ball test, and larval exploratory behavior, were performed to assess potential effects on anxiety, fear, and spatial and social interaction. Significant changes were observed in the performance of larvae exposed to all compounds and their mixtures. Among the single pesticides, exposure to S produced the most behavioral alterations, followed by F and C, respectively. A synergistic effect between the compounds was observed in the C + F group, which showed more behavioral effects than the groups exposed to pesticides individually. The use of behavioral tests to evaluate pesticide mixtures is important to standardize methods and associate behavioral changes with ecologically relevant events, thus creating a more realistic scenario for investigating the potential environmental impacts of these compounds.
Assessment of toxicity of pyriproxyfen, Bacillus thuringiensis, and malathion and their mixtures used for mosquito control on embryo-larval development and behavior of zebrafish
Renata Meireles Oliveira Padilha, Samara da Silva Gomes, Jadson Freitas da Silva, Renatta Priscilla Ferreira Silva, André Lucas Corrêa de Andrade, et al.
Environmental Science and Pollution Research, 2024
Multifractal fluctuations in zebrafish (Danio rerio) polarization time series
Antonio R. de C. Romaguera, João V. A. Vasconcelos, Luis G. Negreiros-Neto, Nathan L. Pessoa, Jadson F. da Silva, et al.
European Physical Journal E, 2024
Use of a fast toxicity test to determine whether carbendazim, fipronil, and sulfentrazone and their mixtures affect early zebrafish embryonic development
Samara da Silva Gomes, Bruno Andre Fernandes de Jesus da Silva Nunes, Pabyton Gonçalves Cadena
Revista Ambiente E Agua, 2024
Essential Oils Produce Developmental Toxicity in Zebrafish Embryos and Cause Behavior Changes in Zebrafish Larvae
Ivanildo Inacio da Silva, Niely Priscila Correia da Silva, James A. Marrs, Pabyton Gonçalves Cadena
Biomedicines, 2023
Efficacy and non-toxicity of ciclopirox olamine-loaded liposomes against Cryptococcus neoformans clinical isolates
Patrícia de Oliveira Kocerginsky, Pedro Henrique dos Santos Soares, Hannah Ferreira Soares Lyra, Pabyton Gonçalves Cadena, Reginaldo Gonçalves de Lima-Neto, et al.
Brazilian Journal of Microbiology, 2023
Single and joint toxic effects of thyroid hormone, levothyroxine, and amiodarone on embryo-larval stages of zebrafish (Danio rerio)
Thamiris Pinheiro Santos, Paulo Eduardo da Silva Bastos, Jadson Freitas da Silva, Stefânia Maria de Medeiros Vieira, Marília Cordeiro Galvão da Silva, et al.
Ecotoxicology, 2023
Testosterone nanoemulsion produced masculinized Nile tilapia (Oreochromis niloticus)
Amanda Rodrigues dos Santos Magnabosco, Ester Inácio Damião Quinova, Matheus Victor Viana de Melo, Paulo Eduardo da Silva Bastos, Thamiris Pinheiro Santos, et al.
Fish Physiology and Biochemistry, 2022
Aqueous extract of fresh leaves from Alternanthera brasiliana (L.) Kuntze: chemical evaluation and antimycobacterial and anticandidal activities
Amanda Dias de Araújo, Maria do Carmo de Barros Pimentel, Camila da Silva Santos, Roberto Afonso da Silva, Pabyton Gonçalves Cadena, et al.
Advances in Traditional Medicine, 2021
Zebrafish (Danio rerio) larvae show behavioral and embryonic development defects when exposed to opioids at embryo stage
Marilia R. Sales Cadena, Pabyton G. Cadena, Meredith R. Watson, Swapnalee Sarmah, Stephen L. Boehm II, et al.
Neurotoxicology and Teratology, 2021
Protective effects of quercetin, polydatin, and folic acid and their mixtures in a zebrafish (Danio rerio) fetal alcohol spectrum disorder model
Pabyton Gonçalves Cadena, Marilia Ribeiro Sales Cadena, Swapnalee Sarmah, James A. Marrs
Neurotoxicology and Teratology, 2020
Folic acid reduces the ethanol-induced morphological and behavioral defects in embryonic and larval zebrafish (Danio rerio) as a model for fetal alcohol spectrum disorder (FASD)
Pabyton Gonçalves Cadena, Marilia Ribeiro Sales Cadena, Swapnalee Sarmah, James A. Marrs
Reproductive Toxicology, 2020
Marijuana and opioid use during pregnancy: Using zebrafish to gain understanding of congenital anomalies caused by drug exposure during development
Swapnalee Sarmah, Marilia Ribeiro Sales Cadena, Pabyton Gonçalves Cadena, James A. Marrs
Biomedicines, 2020
Toxic effects of sediments of the Capibaribe estuary on zebrafish embryos (Danio rerio)
S.S. Gomes, A.C.C. Carvalho, C.M.V.A. Castro, P.G. Cadena
Arquivo Brasileiro De Medicina Veterinaria E Zootecnia, 2020
Values of plasma total proteins of free-living marmosets (Callithrix jacchus) in an urban forest
Juliana Ribeiro de Albuquerque, Fernanda Danielle Gomes da Silva, Pedro Ivo Aragão Rocha, Dênisson da Silva e Souza, Maria Adélia Borstelmann de Oliveira, et al.
Journal of Medical Primatology, 2020
Thyroxine, levothyroxine, and thyroxine complexed into cyclodextrin changed animal behavior, oxygen consumption, and photopic electroretinogram of Colossoma macropomum
Thamiris Pinheiro Santos, Priscila Rafaela Leão Soares, Marília Cordeiro Galvão da Silva, Stephannie Caroline Barros Lucas da Silva, André Lucas Correa de Andrade, et al.
Fish Physiology and Biochemistry, 2019
Chronic exposure to metformin chloridrate and glibenclamide causes behavioral, blood glucose and mortality changes of Hemigrammus caudovittatus and Danio rerio
E.Q. Souza, T.Q.M. Bittencourt, R.C.B. Ferreira, E.G.S. Oliveira, N.P.C. Silva, et al.
Arquivo Brasileiro De Medicina Veterinaria E Zootecnia, 2019
The complexation of steroid hormones into cyclodextrin alters the toxic effects on the biological parameters of zebrafish (Danio rerio)
Marília Cordeiro Galvão da Silva, Jadson Freitas da Silva, Thamiris Pinheiro Santos, Niely Priscila Correia da Silva, Amanda Rodrigues dos Santos, et al.
Chemosphere, 2019
Toxic effects of vanadium compounds on biological parameters of embryos and adults of zebrafish (Danio rerio)
T.Q.M. Bittencourt, A.R. Santos, M.C.G. Silva, J.F. Silva, N.P.C. Silva, et al.
Arquivo Brasileiro De Medicina Veterinaria E Zootecnia, 2018
Impact evaluation caused by disponibility of free and complexed 17β-estradiol into cyclodextrin in the aquatic environment in tilapia (Oreochromis niloticus)
M.C.G. Silva, S.C.B.L. Silva, T.P. Santos, P.R.L. Soares, A.L.C. Andrade, et al.
Arquivo Brasileiro De Medicina Veterinaria E Zootecnia, 2018
Evaluation of the toxic effect of endocrine disruptor Bisphenol A (BPA) in the acute and chronic toxicity tests with Pomacea lineata gastropod
André Lucas Correa de Andrade, Priscila Rafaela Leão Soares, Stephannie Caroline Barros Lucas da Silva, Marília Cordeiro Galvão da Silva, Thamiris Pinheiro Santos, et al.
Comparative Biochemistry and Physiology Part C Toxicology and Pharmacology, 2017
Acute and chronic toxicity of the benzoylurea pesticide, lufenuron, in the fish, Colossoma macropomum
Priscila Rafaela Leão Soares, André Lucas Corrêa de Andrade, Thamiris Pinheiro Santos, Stephannie Caroline Barros Lucas da Silva, Jadson Freitas da Silva, et al.
Chemosphere, 2016
Cationic liposomes containing antioxidants reduces pulmonary injury in experimental model of sepsis: Liposomes antioxidants reduces pulmonary damage
Andre Martins Galvão, Júlia Siqueira Galvão, Marcela Araújo Pereira, Pabyton Gonçalves Cadena, Nereide Stella Santos Magalhães, et al.
Respiratory Physiology and Neurobiology, 2016
Glutamine-Loaded Liposomes: Preliminary Investigation, Characterization, and Evaluation of Neutrophil Viability
Larissa Chaves Costa, Bárbara Nayane Rosário Fernandes Souza, Fábio Fidélis Almeida, Cláudia Jacques Lagranha, Pabyton Gonçalves Cadena, et al.
AAPS Pharmscitech, 2016
Effects of steroid hormones from combined oral contraceptives on the behavioral and physiological parameters of Betta splendens (Regan, 1909)
B.D. Santos, M.C.G. Silva, T.P. Santos, S.C.B.L. Silva, M.R.S. Cadena, et al.
Arquivo Brasileiro De Medicina Veterinaria E Zootecnia, 2016
Nanoencapsulation of quercetin and resveratrol into elastic liposomes
Pabyton G. Cadena, Marcela A. Pereira, Rafaela B.S. Cordeiro, Isabella M.F. Cavalcanti, Benício Barros Neto, et al.
Biochimica Et Biophysica Acta Biomembranes, 2013
Immobilized invertase studies on glass-ceramic support from coal fly ashes
A.V.P. Albertini, J.L. Silva, V.N. Freire, R.P. Santos, J.L. Martins, et al.
Chemical Engineering Journal, 2013
Performance of invertase immobilized on glass-ceramic supports in batch bioreactor
A.V.P. Albertini, P.G. Cadena, J.L. Silva, G.A. Nascimento, A.L.S. Reis, et al.
Chemical Engineering Journal, 2012
Physical-chemical parameters and validation of a colorimetric method for deoxycholic and ursodeoxycholic acids: Kit reagent and optical sensor
Pabyton G. Cadena, Alberto N. Araújo, Maria C.B.S.M. Montenegro, Maria C.B. Pimentel, José L. Lima Filho, et al.
Chemistry and Physics of Lipids, 2011
Kinetics and bioreactor studies of immobilized invertase on polyurethane rigid adhesive foam
Pabyton G. Cadena, Frank N. Wiggers, Roberto A. Silva, José L. Lima Filho, Maria C.B. Pimentel
Bioresource Technology, 2011
Covalent immobilization of invertase on polyurethane, plast-film and ferromagnetic Dacron
P.G. Cadena, R.A.S. Jeronimo, J.M. Melo, R.A. Silva, J.L. Lima Filho, et al.
Bioresource Technology, 2010
Simple determination of deoxycholic and ursodeoxycholic acids by phenolphthalein-β-cyclodextrin inclusion complex
Pabyton G. Cadena, Eric C. Oliveira, Alberto N. Araújo, Maria C. B. S. M. Montenegro, Maria C. B. Pimentel, et al.
Lipids, 2009

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Scopus Publications