Hadeer Muhammed Morsy

RESEARCH, TEACHING, or OTHER INTERESTS

Animal Science and Zoology, Molecular Biology, Cancer Research, Physiology

Scopus Publications

The Role of MicroRNAs as Hepatocellular Carcinoma Biomarkers and Therapeutic Targets
Hadeer M. Morsy, Mohamed Y. Zaky, Osama M. Ahmed
Advances in Biochemistry in Health and Disease, 2026
Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms
Mohamed Y. Zaky, Hadeer M. Morsy, Adel Abdel-Moneim, Khairy M. A. Zoheir, Anthony Bragoli, et al.
Discover Oncology, 2025
Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals
Hadeer M. Morsy, Mohamed Y. Zaky, Nour Y.S. Yassin, Ashraf Y.Z. Khalifa
International Journal of Pharmaceutics, 2025
Phytochemicals as Protective Agents for Brain Aging
Mohamed Y. Zaky, Hadeer M. Morsy, Osama M. Ahmed
Neuroprotective Effects of Phytochemicals in Brain Ageing, 2024
The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: insight on the mechanisms of action
Hadeer M. Morsy, Osama M. Ahmed, Khairy M. A. Zoheir, Adel Abdel-Moneim
Apoptosis, 2023
This study was designed to assess the ameliorative effects of eugenol and to propose the possible mechanisms of action of eugenol in diethylnitrosamine (DENA)/acetylaminofluorene (AAF)-caused lung cancer in Wistar rats. To induce lung cancer, DENA at a dose of 150 mg/kg body weight (b.wt) for 2 weeks were intraperitoneally injected once each week and AAF was administered orally at a dose of 20 mg/kg b.wt. four times each week for the next 3 weeks. DENA/AAF-administered rats were orally supplemented with eugenol at a dose of 20 mg/kg b.wt administered once a day until 17 weeks starting from the 1st week of DENA administration. Lung histological lesions, including sheets of tumor cells, micropapillary adenocarcinoma, and apoptotic cells, resulting from the DENA/AAF dosage, were ameliorated by eugenol treatment. However, a significant drop in the levels of LPO in the lungs and a remarkable rise in GSH content and GPx and SOD activities were observed in DENA/AAF-administered rats treated with eugenol compared with those in DENA/AAF-administered controls. Moreover, in DENA/AAF-administered rats, eugenol supplementation significantly reduced TNF-α and IL-1β levels and mRNA expression levels of NF-κB, NF-κB p65, and MCP-1 but significantly elevated the level of Nrf2. Furthermore, the DENA/AAF-administered rats treated with eugenol exhibited a significant downregulation of Bcl-2 expression levels in addition to a significant upregulation in P53 and Bax expression levels. Otherwise, the administration of DENA/AAF elevated the protein expression level of Ki-67, and this elevation was reversed by eugenol treatment. In conclusion, eugenol has effective antioxidant, anti-inflammatory, proapoptotic, and antiproliferative properties against lung cancer. Graphical abstract
An overview of hepatocellular carcinoma stem cells and potential targeted therapies
Mohamed Y. Zaky, Hadeer M. Morsy, Osama M. Ahmed
Cancer Stem Cells and Signaling Pathways, 2023

RECENT SCHOLAR PUBLICATIONS

The Role of MicroRNAs as Hepatocellular Carcinoma Biomarkers and Therapeutic Targets
HM Morsy, MY Zaky, OM Ahmed
MicroRNAs: Role in Cancer Progression, Diagnostics and Therapy, 451-468 , 2026
2026
Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms
MY Zaky, HM Morsy, A Abdel-Moneim, KMA Zoheir, A Bragoli, ...
Discover Oncology 16 (1), 1080 , 2025
2025
Citations: 6
Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals
HM Morsy, MY Zaky, NYS Yassin, AYZ Khalifa
International Journal of Pharmaceutics 670, 125135 , 2025
2025
Citations: 21
Phytochemicals as Protective Agents for Brain Aging
MY Zaky, HM Morsy, OM Ahmed
Neuroprotective Effects of Phytochemicals in Brain Ageing, 1-16 , 2024
2024
An overview of hepatocellular carcinoma stem cells and potential targeted therapies
MY Zaky, HM Morsy, OM Ahmed
Cancer Stem Cells and Signaling Pathways, 581-590 , 2024
2024
Citations: 2
The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: insight on the mechanisms of action
HM Morsy, OM Ahmed, KMA Zoheir, A Abdel-Moneim
Apoptosis 28 (7), 1184-1197 , 2023
2023
Citations: 13

MOST CITED SCHOLAR PUBLICATIONS

Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals
HM Morsy, MY Zaky, NYS Yassin, AYZ Khalifa
International Journal of Pharmaceutics 670, 125135 , 2025
2025
Citations: 21
The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: insight on the mechanisms of action
HM Morsy, OM Ahmed, KMA Zoheir, A Abdel-Moneim
Apoptosis 28 (7), 1184-1197 , 2023
2023
Citations: 13
Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms
MY Zaky, HM Morsy, A Abdel-Moneim, KMA Zoheir, A Bragoli, ...
Discover Oncology 16 (1), 1080 , 2025
2025
Citations: 6
An overview of hepatocellular carcinoma stem cells and potential targeted therapies
MY Zaky, HM Morsy, OM Ahmed
Cancer Stem Cells and Signaling Pathways, 581-590 , 2024
2024
Citations: 2
The Role of MicroRNAs as Hepatocellular Carcinoma Biomarkers and Therapeutic Targets
HM Morsy, MY Zaky, OM Ahmed
MicroRNAs: Role in Cancer Progression, Diagnostics and Therapy, 451-468 , 2026
2026
Phytochemicals as Protective Agents for Brain Aging
MY Zaky, HM Morsy, OM Ahmed
Neuroprotective Effects of Phytochemicals in Brain Ageing, 1-16 , 2024
2024