Hadeer Muhammed Morsy
@hadermohamed98_pg@science.bsu.edu.eg
Faculty of science, Zoology Department
Beni-Suef University
RESEARCH, TEACHING, or OTHER INTERESTS
Animal Science and Zoology, Molecular Biology, Cancer Research, Physiology
4
Scopus Publications
10
Scholar Citations
1
Scholar h-index
Scopus Publications
- Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals
Hadeer M. Morsy, Mohamed Y. Zaky, Nour Y.S. Yassin, and Ashraf Y.Z. Khalifa
Elsevier BV - Phytochemicals as Protective Agents for Brain Aging
Mohamed Y. Zaky, Hadeer M. Morsy, and Osama M. Ahmed
Springer Nature Singapore - The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: insight on the mechanisms of action
Hadeer M. Morsy, Osama M. Ahmed, Khairy M. A. Zoheir, and Adel Abdel-Moneim
Springer Science and Business Media LLC
AbstractThis study was designed to assess the ameliorative effects of eugenol and to propose the possible mechanisms of action of eugenol in diethylnitrosamine (DENA)/acetylaminofluorene (AAF)-caused lung cancer in Wistar rats. To induce lung cancer, DENA at a dose of 150 mg/kg body weight (b.wt) for 2 weeks were intraperitoneally injected once each week and AAF was administered orally at a dose of 20 mg/kg b.wt. four times each week for the next 3 weeks. DENA/AAF-administered rats were orally supplemented with eugenol at a dose of 20 mg/kg b.wt administered once a day until 17 weeks starting from the 1st week of DENA administration. Lung histological lesions, including sheets of tumor cells, micropapillary adenocarcinoma, and apoptotic cells, resulting from the DENA/AAF dosage, were ameliorated by eugenol treatment. However, a significant drop in the levels of LPO in the lungs and a remarkable rise in GSH content and GPx and SOD activities were observed in DENA/AAF-administered rats treated with eugenol compared with those in DENA/AAF-administered controls. Moreover, in DENA/AAF-administered rats, eugenol supplementation significantly reduced TNF-α and IL-1β levels and mRNA expression levels of NF-κB, NF-κB p65, and MCP-1 but significantly elevated the level of Nrf2. Furthermore, the DENA/AAF-administered rats treated with eugenol exhibited a significant downregulation of Bcl-2 expression levels in addition to a significant upregulation in P53 and Bax expression levels. Otherwise, the administration of DENA/AAF elevated the protein expression level of Ki-67, and this elevation was reversed by eugenol treatment. In conclusion, eugenol has effective antioxidant, anti-inflammatory, proapoptotic, and antiproliferative properties against lung cancer. Graphical abstract - An overview of hepatocellular carcinoma stem cells and potential targeted therapies
Mohamed Y. Zaky, Hadeer M. Morsy, and Osama M. Ahmed
Elsevier
RECENT SCHOLAR PUBLICATIONS
- Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals
HM Morsy, MY Zaky, NYS Yassin, AYZ Khalifa
International Journal of Pharmaceutics, 125135 2024 - Phytochemicals as Protective Agents for Brain Aging
MY Zaky, HM Morsy, OM Ahmed
Neuroprotective Effects of Phytochemicals in Brain Ageing, 1-16 2024 - An overview of hepatocellular carcinoma stem cells and potential targeted therapies
MY Zaky, HM Morsy, OM Ahmed
Cancer Stem Cells and Signaling Pathways, 581-590 2024 - The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: Insight on the mechanisms of action
HM Morsy, OM Ahmed, KMA Zoheir, A Abdel-Moneim
Apoptosis 28 (7), 1184-1197 2023
MOST CITED SCHOLAR PUBLICATIONS
- The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: Insight on the mechanisms of action
HM Morsy, OM Ahmed, KMA Zoheir, A Abdel-Moneim
Apoptosis 28 (7), 1184-1197 2023
Citations: 8 - Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals
HM Morsy, MY Zaky, NYS Yassin, AYZ Khalifa
International Journal of Pharmaceutics, 125135 2024
Citations: 1 - An overview of hepatocellular carcinoma stem cells and potential targeted therapies
MY Zaky, HM Morsy, OM Ahmed
Cancer Stem Cells and Signaling Pathways, 581-590 2024
Citations: 1