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Biotechnology
Rama Devi Women's University, Bhubaneswar
M.Sc (Life Sciences), M.Phil (Life Sciences)
Scopus Publications
Dillip Kumar Bishi, Priyadarshini Padhi, Chhabi Rani Panigrahi, Bibudhendu Pati, and Chandi Charan Rath
Elsevier
S.C. Chabattula, P.K. Gupta, S.K. Tripathi, R. Gahtori, P. Padhi, S. Mahapatra, B.K. Biswal, S.K. Singh, K. Dua, J. Ruokolainen,et al.
Elsevier BV
Priyadarshini Padhi, Manasa Kumar Panda, Yengkhom Disco Singh, Kaushik Kumar Bharadwaj, Kausika Kumar Malik, and Binata Nayak
Springer Singapore
Dillip Kumar Bishi, Santosh S. Mathapati, Priyadarshini Padhi, K.S. Venkataprasanna, Hariharan Ezhilarasu, Raghavendra Ramalingam, Mohd Hasbi Ab. Rahim, and Jayarama Reddy Venugopal
Elsevier
Srimanta Patra, Prashanta Kumar Panda, Prajna Paramita Naik, Debasna Pritimanjari Panigrahi, Prakash Priyadarshi Praharaj, Chandra Sekhar Bhol, Kewal Kumar Mahapatra, Priyadarshini Padhi, Mrutyunjay Jena, Shankargouda Patil,et al.
Elsevier BV
Terminalia bellirica (TB) has been used in traditional Indian medical system, Ayurveda. However, the mechanism underlying the efficacy of the TB extract against oral squamous cell carcinoma (OSCC) is yet to be explored. The present study established a connecting link between the TB extract induced apoptosis and autophagy in relation to reactive oxygen species (ROS). Our study revealed that gallic acid in the TB extract possess a strong free radical scavenging capacity contributing towards selective anti-proliferative activity. Furthermore, TB extract markedly enhanced the accumulation of ROS that facilitated mitochondrial apoptosis through DNA damage, indicating ROS as the vital component regulating apoptosis. This effect was effectively reversed by the use of a scavenger, N-acetyl cysteine (NAC). Moreover, it was observed to induce autophagy; however, it attenuated the autophagosome-lysosome fusion in Cal33 cells without altering the lysosomal activity. Pharmacological inhibitors of autophagy, namely, 3-methyladenine and chloroquine, were observed to regulate the stage-specific progression of autophagy post treatment with the TB extract, favouring subsequent activation of apoptosis. These findings revealed presence of gallic acid in TB extract below NOAEL value causes oxidative upset in oral cancer cells and promote programmed cell death which has a potential therapeutic value against oral squamous cell carcinoma.