ANTHROPOCENE IMPRINTS ON THE PERSIAN GULF (ARABIAN GULF): A COMPREHENSIVE REVIEW OF POLLUTION AND CONSERVATION CHALLENGES K.A. AL-MUTAIRI Applied Ecology and Environmental Research, 2025 The Persian Gulf, a shallow semi-enclosed sea bordered by eight nations, faces intensifying ecological degradation under the pressures of the Anthropocene.This review systematically examined pollution types, impacts, and conservation challenges in Persian Gulf from the Scopus database.A bibliometric analysis using VOSviewer identified six major thematic clusters, highlighting evolving research priorities.Chronic oil pollution from extraction, refining, and shipping activities remains a dominant threat, with cumulative impacts on microbial communities, benthic macrofauna, and coral reefs.Heavy metals, including mercury, cadmium, and lead, continue to bioaccumulate in sediments, marine biota, and food webs, posing serious risks to fisheries productivity, food security, and public health.Additionally, thermal pollution and hypersaline effluents from desalination plants are altering salinitytemperature regimes, exacerbating stress on coral reefs and seagrass beds.Rapid coastal development and land reclamation are driving habitat loss, especially for mangroves and mudflats, while microplastic debris is increasingly entangling marine megafauna and contaminating seafood species.The socio-ecological consequences include biodiversity decline, heightened public health threats from seafood contamination and airborne pollutants, economic vulnerabilities in fisheries and tourism sectors, and the cultural erosion of traditional livelihoods such as pearl diving and artisanal fishing.Despite the establishment of Marine Protected Areas and regional initiatives like the Kuwait Action Plan, conservation efforts remain fragmented due to weak governance, geopolitical tensions, and insufficient transboundary cooperation.Critical research gaps persist in cumulative impact assessments, socio-economic valuation, and the integration of climate change stressors into pollution risk models.Safeguarding the Persian Gulf's ecological integrity demands the urgent adoption of ecosystem-based management frameworks, legally binding regional agreements, strengthened science-policy integration, proactive public engagement, and a commitment to embedding planetary health principles into national and regional development strategies.
New Pyranopyrazole-Based Indolin-2,3-Dione Hybrid as Effective Inhibitors of Xanthine Oxidase: Synthesis, In Vitro, and Molecular Modeling Approaches Osama Alharbi, Khalid Awadh Al‐Mutairi, Munjed M. Ibrahim, Ramith Ramu, Mohammed Al‐Ghorbani Chemistry and Biodiversity, 2025 In the current study, new pyranopyrazole analogs (9a–d and 10a–d) were synthesized through a one‐pot condensation reaction of 2‐arylacetohydrazide. The inhibitory abilities were investigated against the xanthine oxidase (XO) enzyme through experimental and molecular docking analyses. The synthesis studies were based on ultrasound‐mediated condensation reactions of four‐component containing 2‐arylacetohydrazide, ethyl acetoacetate, indoline‐2,3‐dione, and ethyl 2‐cyanoacetate/malononitrile in various solvents and catalysts to yield pyranopyrazole analogs (9a–d and 10a–d) in a short reaction time and remarkably favorable yields ranging from 79% to 92%. On the basis of the XO inhibition study of compounds 9a–d and 10a–d, compound 10d was the most potent (IC50 = 0.09 ± 0.22 µM), followed by 9c (0.12 ± 0.11 µM). With IC50 values of 0.20 ± 0.27 and 0.17 ± 0.11 µM respectively, compounds 10a and 10c exhibited moderate activity. The other compounds have shown less activity compared to the allopurinol control (IC50 = 0.14 ± 0.10 µM). Furthermore, in the molecular docking analysis, compound 10d was predicted to have the highest binding affinity against the target XO enzyme.
From desert margins to global insights: floristic diversity and conservation strategies in the arid regions of Tabuk and Khulais, Saudi Arabia – a bibliometric and ecological synthesis Khalid Awadh Al-Mutairi Frontiers in Forests and Global Change, 2025 Climate change, hydrological alterations, and anthropogenic pressures are collectively driving rapid ecological shifts in Saudi Arabia’s arid regions, particularly in Tabuk and Khulais. This study evaluates the status and conservation strategies of floristic diversity in these regions through a bibliometric and ecological synthesis. Using bibliometric analysis of 102 selected publications from 1984 to 2025, major thematic clusters were identified, focusing on policy interventions, hydrological impacts, biodiversity loss, and vegetation dynamics. Among these, 20 studies specifically addressed the Tabuk region’s ecological challenges and conservation responses. The findings reveal that rising temperatures (0.70–1.30 °C) and drastic rainfall reduction (up to 85%) have intensified aridity, decreased soil moisture, and accelerated biodiversity degradation. Invasive species such as Prosopis juliflora exacerbate the situation by outcompeting native flora for scarce resources. While rocky ecosystems exhibit resilience due to microclimatic buffering, fragile valley ecosystems require urgent, targeted measures like artificial water input and soil stabilization. Hydrological projects, including dam construction, have yielded mixed outcomes—enhancing species richness in riparian zones while simultaneously disrupting natural seed dispersal and causing habitat fragmentation. Rare and endemic species such as Rheum palaestinum and Astragalus collenettiae serve as vital indicators of ecosystem health and genetic heritage, underscoring the need for species-specific conservation initiatives. The study recommends integrated strategies that combine habitat restoration, sustainable water management, and long-term biodiversity monitoring. Furthermore, ecotourism development and community participation are highlighted as valuable components in achieving conservation goals, aligning with Saudi Arabia’s Vision 2030 and national biodiversity targets. This work contributes a comprehensive framework for managing arid-region floristic diversity under changing climatic conditions. By bridging ecological research with socio-economic and policy dimensions, the study offers valuable insights for sustainable forest and landscape management in desert-margin ecosystems globally.
Chernobyl nuclear catastrophe: lessons for sustainability and UNSDGs in health, energy, and environmental recovery Chee Kong Yap, Khalid Awadh Al-Mutairi Frontiers in Public Health, 2025 This study provides a comprehensive review of the research surrounding the Chernobyl nuclear incident, focusing on its far-reaching impacts on human health, and environmental contamination. Based on the Scopus database, 258 relevant papers were identified using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. These papers were metal-analyzed and quantitatively analyzed using a similarity map generated through VOSViewer in order to visualize key themes and their interconnections. The research highlights critical areas such as radiation-induced health effects, ecological damage, and the implications for sustainable energy practices. Additionally, this review explores the alignment of these findings with several United Nations Sustainable Development Goals (UNSDGs), particularly UNSDG 3 (Good Health and Wellbeing), UNSDG 6 (Clean Water and Sanitation), UNSDG 7 (Affordable and Clean Energy), UNSDG 13 (Climate Action), and UNSDG 15 (Life on Land). By synthesizing existing research, this study emphasizes the importance of integrating safety protocols, environmental rehabilitation, and sustainable energy policies to prevent and to mitigate the impacts of future nuclear incidents.
Mangrove ecosystems in Western Asia: a literature review of trends, conservation gaps, and sustainable management strategies Chee Kong Yap, Khalid Awadh Al-Mutairi Frontiers in Forests and Global Change, 2025 This study conducts a comprehensive bibliometric and systematic literature review (SLR) of mangrove ecosystem research in Western Asia, adhering to PRISMA guidelines to ensure methodological rigor. A total of 168 eligible documents published between 1991 and 2025 were identified from key Middle Eastern countries, including Saudi Arabia, Iran, the United Arab Emirates, Oman, Qatar, and Bahrain. The analysis synthesizes key trends in mangrove research across themes such as biodiversity conservation, climate change adaptation, socio-economic impacts, and sustainable management. Using the SWOT (Strengths, Weaknesses, Opportunities, Threats) framework, four key strengths were identified: ecological resilience of Avicennia marina, growing research productivity, institutional collaboration, and policy interest. Weaknesses included fragmented governance, limited socio-economic valuation, and inadequate data integration. Opportunities were found in emerging technologies such as remote sensing, blue carbon finance, and regional restoration programs. Threats were dominated by climate change, industrial encroachment, and transboundary pollution. To translate these findings into actionable strategies, a TOWS matrix was developed. The Strength–Opportunity (SO) strategy proposed leveraging robust research capacity to access climate finance and promote innovation. The Weakness–Opportunity (WO) strategy emphasized applying geospatial tools to overcome governance gaps. The Strength–Threat (ST) strategy suggested using localized pollution data to enhance regulatory enforcement. Finally, the Weakness–Threat (WT) strategy advocated for the development of cross-border policy networks to mitigate shared ecological risks. By integrating bibliometric insights with strategic planning tools, this study provides evidence-based recommendations for improving mangrove governance, monitoring, and conservation in the arid coastal zones of Western Asia.
THE POTENTIALS OF PERNA VIRIDIS SHELLS AS BIOMONITORING TOOLS FOR CADMIUM CONTAMINATION IN COASTAL AREA OF PENINSULAR MALAYSIA C.K. YAP, K.A. AL-MUTAIRI Applied Ecology and Environmental Research, 2025 . This study evaluates the potential of Perna viridis shells as reliable biomonitoring materials for cadmium (Cd) contamination in coastal ecosystems across 16 sites in Peninsular Malaysia. Mussels were sampled from diverse environments, including industrial, aquaculture, and recreational areas, providing a comprehensive assessment of environmental Cd exposure. Each mussel’s shells and soft tissues were analyzed separately, with shells showing consistent, significant positive correlations with bioavailable and organic-oxidizable sediment-bound Cd fractions. These correlations were stronger in shell components, particularly in the periostracum, compared to soft tissues, suggesting that shells provide a more stable, long-term record of environmental Cd contamination. Multiple linear regression analysis further identified bioavailable Cd fractions as significant predictors of Cd accumulation in shells, indicating that shell-based monitoring can reliably reflect ambient Cd levels in sediments. Surface sediment samples were also analyzed, confirming the environmental Cd distribution across sites. Findings highlight that P. viridis shells are better than soft tissues in monitoring chronic Cd contamination, offering a durable, cost-effective solution for coastal pollution assessment. This approach aligns with the United Nations Sustainable Development Goals, by supporting sustainable marine conservation and pollution management practices.
ASSESSMENT OF COPPER AND ZINC CONTAMINATION IN PADDY SOILS AND GRAINS FROM KEMUNING AND KELAWEH, KELANTAN: IMPLICATIONS FOR SUSTAINABILITY AND PLANETARY HEALTH C.K. YAP, K.A. AL-MUTAIRI Applied Ecology and Environmental Research, 2025 . This study aimed to investigated the concentrations of copper (Cu) and zinc (Zn) in paddy tissues and associated topsoils from Kemuning and Kelaweh, Kelantan. It assessed the potential ecological and health risks linked to metal accumulation. The results revealed significantly (P< 0.05) higher Cu and Zn concentrations in Kelaweh than Kemuning, particularly in the outlet zones, where metal accumulation was the most pronounced. The contamination factor and ecological risk index indicated that Kelaweh has a greater contamination potential, with Cu target hazard quotient (THQ) values exceeding the safe threshold for adults, suggesting a potential health risk. Zn levels, though elevated, did not pose an immediate health concern, as THQ values remained below risk thresholds. These findings highlighted the need for sustainable agricultural practices, improved water management, and continuous monitoring to ensure food safety and protect planetary health. The study emphasized the critical link between soil health, food security, and ecosystem sustainability in the context of rising environmental pressures. By understanding the current levels of metal contamination and the associated risks, policymakers and farmers can implement targeted interventions to ensure that paddy cultivation remains sustainable and contributes positively to planetary health.
EVALUATION OF COPPER AND ZINC CONCENTRATIONS IN DRIED FRUITS COLLECTED FROM MARKETPLACES OF PENINSULAR MALAYSIA: HEALTH RISK ASSESSMENT, FOOD SECURITY IMPLICATIONS, AND THE NECESSITY FOR REGULAR MONITORING Chee Kong Yap, Khalid Awadh Al-Mutairi Applied Ecology and Environmental Research, 2025 This study investigates the concentrations of Copper (Cu) and Zinc (Zn) in five types of dried fruits (raisins, kiwis, dates, figs, and apricots) collected from marketplaces in Peninsular Malaysia, while assessing their potential health risks based on the maximum permissible limits (MPLs) set by Malaysian Food Regulations (1985).After converting from the dry weight basis, the results show that figs exhibited the highest levels of Cu (9 mg/kg wet weight) and Zn (9.95 mg/kg wet weight), while kiwis had the lowest concentrations for both metals.Estimated daily intake (EDI) and target hazard quotient (THQ) values were calculated for each metal, revealing low health risks, with THQs for all fruits remaining below 1. Figs had the highest THQs for Cu (0.61) and Zn (0.08), suggesting moderate caution in frequent consumption.The study also emphasizes the importance of regularly monitoring metal concentrations in dried fruits, improved agricultural and post-harvest practices, and the need for clear labelling to inform consumers about potential metal content.These findings provide critical insights into ensuring food safety, reducing metal exposure, and promoting dietary diversity for better public health outcomes.
Ecological–Health Risk of Antimony and Arsenic in Centella asiatica, Topsoils, and Mangrove Sediments: A Case Study of Peninsular Malaysia Chee Kong Yap, Wen Siang Tan, Wan Hee Cheng, Wan Mohd Syazwan, Noor Azrizal-Wahid, Kumar Krishnan, Rusea Go, Rosimah Nulit, Mohd. Hafiz Ibrahim, Muskhazli Mustafa, Hishamuddin Omar, Weiyun Chew, Franklin Berandah Edward, Hideo Okamura, Khalid Awadh Al-Mutairi, Salman Abdo Al-Shami, Moslem Sharifinia, Mehrzad Keshavarzifard, Chen Feng You, Alireza Riyahi Bakhtiari, Amin Bintal, Hesham M. H. Zakaly, Takaomi Arai, Abolfazl Naji, Muhammad Saleem, Mohd Amiruddin Abd Rahman, Ghim Hock Ong, Geetha Subramaniam, Ling Shing Wong Frontiers in Environmental Science, 2022
Congruence patterns of aquatic communities in a tropical river basin, Malaysia Salman Abdo Al-Shami, Che Salmah Md Rawi, Suhaila Abdul Hamid, Nurul Huda Abdul, Mariam Zhafarina Rusli, Wan Nur Asiah Wan Mohd Adnan, Nur Adibah Mohd Ishadi, Mohd Shafiq Zakeyuddin, Sanya Abdulkareem Al-Qormuti, Khalid A. Al-Mutairi, Yap Chee Kong Acta Ecologica Sinica, 2021
Floristic diversity of tabuk province, north Saudi Arabia Journal of Animal and Plant Sciences, 2016
Spatial and environmental determinants of plant diversity in farasan archipelago, Saudi Arabia Life Science Journal, 2014
RECENT SCHOLAR PUBLICATIONS
From desert margins to global insights : Floristic diversity and conservation strategies in the arid regions of Tabuk and Khulais, Saudi Arabia– a bibliometric and ecological … AM K A Frontiers in Forests and Global Change , 2025 2025 Citations: 4
Copper and vanadium induce oxidative stress and pyroptosis in the duck brain via activating the TLR4/NF-κB-p65 signaling pathway J Chen, Y Yang, F Yang, X Gao, G Hu, Z Xiong, KA Al-Mutairi, L Yan, J Li, ... BioMetals, 1-15 , 2025 2025 Citations: 3
Tissue-Specific Nickel Accumulation and Detoxification in Pomacea insularum: A Biomonitoring Tool for Freshwater Ecosystems CK Yap, KA Al-Mutairi Polish Journal of Environmental Studies , 2025 2025
LITERATURE ANALYSIS AND SYNTHESIS OF THE RED SEA MANGROVE ECOSYSTEM: DECADES OF HUMAN IMPACTS AND KNOWLEDGE GAPS. KA Al-Mutairi Applied Ecology & Environmental Research 23 (4) , 2025 2025
THE POTENTIALS OF PERNA VIRIDIS SHELLS AS BIOMONITORING TOOLS FOR CADMIUM CONTAMINATION IN COASTAL AREA OF PENINSULAR MALAYSIA. CK Yap, KA Al-Mutairi Applied Ecology & Environmental Research 23 (3) , 2025 2025
ASSESSMENT OF COPPER AND ZINC CONTAMINATION IN PADDY SOILS AND GRAINS FROM KEMUNING AND KELAWEH, KELANTAN: IMPLICATIONS FOR SUSTAINABILITY AND PLANETARY HEALTH. CK Yap, KA Al-Mutairi Applied Ecology & Environmental Research 23 (3) , 2025 2025
New Pyranopyrazole‐Based Indolin‐2, 3‐Dione Hybrid as Effective Inhibitors of Xanthine Oxidase: Synthesis, In Vitro, and Molecular Modeling Approaches O Alharbi, KA Al‐Mutairi, MM Ibrahim, R Ramu, M Al‐Ghorbani Chemistry & Biodiversity 22 (5), e202402104 , 2025 2025 Citations: 3
Mangrove ecosystems in Western Asia: a literature review of trends, conservation gaps, and sustainable management strategies CK Yap, KA Al-Mutairi Frontiers in Forests and Global Change 8, 1556158 , 2025 2025 Citations: 11
Cadmium bioaccumulation and detoxification mechanisms in Pomacea insularum : implications for biomonitoring in freshwater ecosystems CK Yap, KA Al-Mutairi Frontiers in Environmental Science 13, 1548453 , 2025 2025 Citations: 2
Chernobyl nuclear catastrophe: lessons for sustainability and UNSDGs in health, energy, and environmental recovery CK Yap, KA Al-Mutairi Frontiers in Public Health 13, 1552122 , 2025 2025 Citations: 3
Zinc Bioaccumulation and Detoxification Mechanisms in Pomacea insularum: Implications for Biomonitoring in Metal-Contaminated Ecosystems CK Yap, KA Al-Mutairi Turkish Journal of Fisheries and Aquatic Sciences 25 (8) , 2025 2025
Anthropocene Imprints on the Persian Gulf (arabian Gulf): a Comprehensive Review of Pollution and Conservation Challenges KA Al-Mutairi Applied Ecology and Environmental Research 23 (5), 9167-9196 , 2025 2025 Citations: 3
Evaluating Marine Mussels' Lithium, Strontium, and Vanadium Detoxification for Coastal Ecosystem Conservation KA Yap, C. K., & Al-Mutairi Polish journal of Environmental Studies , 2025 2025
LEAD CONTAMINATION IN PADDY SOILS AND RICE GRAINS FROM KELANTAN: ASSESSING RISKS TO FOOD SECURITY AND PUBLIC HEALTH KA Yap, C. K., & Al-Mutairi Carpathian Journal of Earth and Environmental Sciences , 2025 2025
EVALUATION OF COPPER AND ZINC CONCENTRATIONS IN DRIED FRUITS COLLECTED FROM MARKETPLACES OF PENINSULAR MALAYSIA: HEALTH RISK ASSESSMENT, FOOD SECURITY IMPLICATIONS, AND THE … KA Yap, C. K., & Al-Mutairi Applied Ecology and Environmental Research , 2025 2025
Synthesis and Biological Evaluation of New N -(4-Acetylphenyl)-2-cyanoacetamide Derivatives with Docking, and Molecular Dynamics Insights M Al-Ghorbani, MA Gouda, O Alharbi, KA Al-Mutairi, R Ramu Russian Journal of General Chemistry 95 (1), 155-172 , 2025 2025
Depuration kinetics of potentially toxic metals (Hg, Co and Cr) in Perna viridis: implications for biomonitoring, environmental management, and planetary health CK Yap, KA Al-Mutairi Journal of Fisheries 13 (1), 131202-131202 , 2025 2025 Citations: 3
Zinc in commercial marine fish from Peninsular Malaysia: Biomonitoring, health risks, and UNSDGs’ connection CK Yap, KA Al-Mutairi Journal of Fisheries 13 (1), 131201-131201 , 2025 2025 Citations: 1
CONTROL OF SEEDLING MORTALITY IN THE LONG-LEAVED SAUCER-BERRY CORDIA SINENSIS LAM. IN KHARGA OASIS, EGYPT: AN IN SITU PHYSIOLOGICAL, CHEMICAL, AND BIOLOGICAL APPROACH. TM Galal, SMA Kawey, MA El-Gamal, LM Hassan, KA Al-Mutairi, ... Applied Ecology & Environmental Research 22 (6) , 2024 2024
Therapeutic potential of Leea asiatica: Chemical isolation and validation of ethnomedicinal claims through in vitro and in silico assessment of antioxidant and anti … KR Joshi, HP Devkota, KA Al-Mutairi, K Sugimura, S Yahara, R Khadka, ... Heliyon 10 (19) , 2024 2024 Citations: 10
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Role of nanomaterials in plants under challenging environments MN Khan, M Mobin, ZK Abbas, KA AlMutairi, ZH Siddiqui Plant physiology and biochemistry 110, 194-209 , 2017 2017 Citations: 606
Earthworms effect on microbial population and soil fertility as well as their interaction with agriculture practices N Ahmed, KA Al-Mutairi Sustainability 14 (13), 7803 , 2022 2022 Citations: 177
Botanical insecticides are a non-toxic alternative to conventional pesticides in the control of insects and pests H Ullah, T Iqbal, KA Al-Mutairi, K Shahjeer, R Ullah, S Ahmed, N Ahmed, ... Global decline of insects 103 , 2022 2022 Citations: 119
Inhibitory effect of polyphenols from the whole green jackfruit flour against α-glucosidase, α-amylase, aldose reductase and glycation at multiple stages and their interaction … T Maradesha, SM Patil, KA Al-Mutairi, R Ramu, SRV Madhunapantula, ... Molecules 27 (6), 1888 , 2022 2022 Citations: 96
A commentary on the use of bivalve mollusks in monitoring metal pollution levels CK Yap, M Sharifinia, WH Cheng, SA Al-Shami, KW Wong, KA Al-Mutairi International journal of environmental research and public health 18 (7), 3386 , 2021 2021 Citations: 65
Botanical insecticides and their potential as anti-insect/pests: are they successful against insects and pests? T Iqbal, N Ahmed, K Shahjeer, S Ahmed, KA Al-Mutairi, HF Khater, RF Ali Global decline of insects , 2021 2021 Citations: 60
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A review of heavy metals in coastal surface sediments from the Red Sea: health-ecological risk assessments KA Al-Mutairi, CK Yap International journal of environmental research and public health 18 (6), 2798 , 2021 2021 Citations: 46
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Floristic diversity of Tabuk province, north Saudi Arabia. K Al-Mutairi, SA Al-Shaami, Z Khorshid, MM Moawed JAPS: Journal of Animal & Plant Sciences 26 (4) , 2016 2016 Citations: 42
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A Combined Use of Rhizobacteria and Moringa Leaf Extract Mitigates the Adverse Effects of Drought Stress in Wheat ( Triticum aestivum L.) I Lalarukh, SA Al-Dhumri, LKT Al-Ani, R Hussain, KA Al Mutairi, ... Frontiers in Microbiology 13, 813415 , 2022 2022 Citations: 39
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Publications
Importance of regional diversity and environmental conditions on local species richness of aquatic macro-invertebrates in tropical forested streams
Significance of sulfur in heat stressed cluster bean (Cymopsis tetragonoloba L. Taub) genotypes:responses of growth, sugar and antioxidative metabolism
Floristic diversity and phytogeographical distribution of plants in Tabuk region, Saudi Arabia
Role of nanomaterials in plants under challenging environments