Giuseppa Mudò

Scopus Publications

The remarkable impact of Opuntia Ficus Indica fruit administration on metabolic syndrome: Correlations between cognitive functions, oxidative stress and lipid dysmetabolism in the high-fat, diet-fed rat model
Danila Di Majo, Nicolò Ricciardi, Valentina Di Liberto, Mario Allegra, Monica Frinchi, Giulia Urone, Miriana Scordino, Alessandro Massaro, Giuseppa Mudò, Giuseppe Ferraro, Pierangelo Sardo, Giuseppe Giglia, Giuditta Gambino
Biomedicine and Pharmacotherapy, 2024
BACKGROUND: A wealth of evidence underscores the bioactive properties of nutraceuticals and functional foods in addressing oxyinflammatory-based diseases with implications at both peripheral and central levels. Opuntia ficus-indica (OFI) is well-documented for its health-promoting attributes, though its fruit (OFIF) remains relatively understudied. Not only poses Metabolic Syndrome (MetS) cardiometabolic risks but also contributes significantly to cognitive impairment, especially in crucial brain areas such as hippocampus and hypothalamus. METHODS: Following 8 weeks of HFD to induce MetS, rats received OFIF oral supplementation for 4 weeks to evaluate cognitive and affective modifications using behavioural paradigms, i.e. open field, burrowing, white-dark box, novelty-suppressed feeding, and object recognition tests. Our investigation extended to biochemical evaluations of lipid homeostasis, central and peripheral oxidative stress and neurotrophic pathways, correlating these measures together with circulating leptin levels. RESULTS: Our data revealed that OFIF modulation of leptin positively correlates with systemic and brain oxidative stress, with markers of increased anxiety-like behaviour and impaired lipid homeostasis. On the other hand, leptin levels reduced by OFIF are associated with improved antioxidant barriers, declarative memory and neurotrophic signalling. DISCUSSION: This study underscores OFIF neuroactive potential in the context of MetS-associated cognitive impairment, offering insights into its mechanisms and implications for future therapeutic strategies.
The stunting effect of an oxylipins-containing macroalgae extract on sea urchin reproduction and neuroblastoma cells viability
Chiara Martino, Rosario Badalamenti, Monica Frinchi, Roberto Chiarelli, Antonio Palumbo Piccionello, Giulia Urone, Manuela Mauro, Vincenzo Arizza, Claudio Luparello, Valentina Di Liberto, Giuseppa Mudò, Mirella Vazzana
Chemosphere, 2024
An upstream enhancer and MEF2 transcription factors fine-tune the regulation of the Bdnf gene in cortical and hippocampal neurons
Annela Avarlaid, Kaisa Falkenberg, Karin Lehe, Giuseppa Mudò, Natale Belluardo, Valentina Di Liberto, Monica Frinchi, Jürgen Tuvikene, Tõnis Timmusk
Journal of Biological Chemistry, 2024
The myocyte enhancer factor (MEF2) family of transcription factors, originally discovered for its pivotal role in muscle development and function, has emerged as an essential regulator in various aspects of brain development and neuronal plasticity. The MEF2 transcription factors are known to regulate numerous important genes in the nervous system, including brain-derived neurotrophic factor (BDNF), a small secreted neurotrophin responsible for promoting the survival, growth, and differentiation of neurons. The expression of the Bdnf gene is spatiotemporally controlled by various transcription factors binding to both its proximal and distal regulatory regions. While previous studies have investigated the connection between MEF2 transcription factors and Bdnf, the endogenous function of MEF2 factors in the transcriptional regulation of Bdnf remains largely unknown. Here, we aimed to deepen the knowledge of MEF2 transcription factors and their role in the regulation of Bdnf comparatively in rat cortical and hippocampal neurons. As a result, we demonstrate that the MEF2 transcription factor-dependent enhancer located at -4.8 kb from the Bdnf gene regulates the endogenous expression of Bdnf in hippocampal neurons. In addition, we confirm neuronal activity-dependent activation of the -4.8 kb enhancer in vivo. Finally, we show that specific MEF2 family transcription factors have unique roles in the regulation of Bdnf, with the specific function varying based on the particular brain region and stimuli. Altogether, we present MEF2 family transcription factors as crucial regulators of Bdnf expression, fine-tuning Bdnf expression through both distal and proximal regulatory regions.
Anti-Apoptotic and Anti-Inflammatory Properties of Grapefruit IntegroPectin on Human Microglial HMC3 Cell Line
Miriana Scordino, Giulia Urone, Monica Frinchi, Chiara Valenza, Angela Bonura, Chiara Cipollina, Rosaria Ciriminna, Francesco Meneguzzo, Mario Pagliaro, Giuseppa Mudò, Valentina Di Liberto
Cells, 2024
In this study, we investigated the beneficial effects of grapefruit IntegroPectin, derived from industrial waste grapefruit peels via hydrodynamic cavitation, on microglia cells exposed to oxidative stress conditions. Grapefruit IntegroPectin fully counteracted cell death and the apoptotic process induced by cell exposure to tert-butyl hydroperoxide (TBH), a powerful hydroperoxide. The protective effects of the grapefruit IntegroPectin were accompanied with a decrease in the amount of ROS, and were strictly dependent on the activation of the phosphoinositide 3-kinase (PI3K)/Akt cascade. Finally, IntegroPectin treatment inhibited the neuroinflammatory response and the basal microglia activation by down-regulating the PI3K- nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB)- inducible nitric oxide synthase (iNOS) cascade. These data strongly support further investigations aimed at exploring IntegroPectin’s therapeutic role in in vivo models of neurodegenerative disorders, characterized by a combination of chronic neurodegeneration, oxidative stress and neuroinflammation.
CNPY2 protects against ER stress and is expressed by corticostriatal neurons together with CTIP2 in a mouse model of Huntington’s disease
Miriana Scordino, Polina Stepanova, Vignesh Srinivasan, Dan Duc Pham, Ove Eriksson, Maciej Lalowski, Giuseppa Mudò, Valentina Di Liberto, Laura Korhonen, Merja H. Voutilainen, Dan Lindholm
Frontiers in Molecular Neuroscience, 2024
Canopy Homolog 2 (CNPY2) is an endoplasmic reticulum (ER) localized protein belonging to the CNPY gene family. We show here that CNPY2 is protective against ER stress induced by tunicamycin in neuronal cells. Overexpression of CNPY2 enhanced, while downregulation of CNPY2 using shRNA expression, reduced the viability of neuroblastoma cells after tunicamycin. Likewise, recombinant CNPY2 increased survival of cortical neurons in culture after ER stress. CNPY2 reduced the activating transcription factor 6 (ATF6) branch of ER stress and decreased the expression of CCAT/Enhancer-Binding Protein Homologous Protein (CHOP) involved in cell death. Immunostaining using mouse brain sections revealed that CNPY2 is expressed by cortical and striatal neurons and is co-expressed with the transcription factor, COUPTF-interacting protein 2 (CTIP2). In transgenic N171-82Q mice, as a model for Huntington’s disease (HD), the number of CNPY2-immunopositive neurons was increased in the cortex together with CTIP2. In the striatum, however, the number of CNPY2 decreased at 19 weeks of age, representing a late-stage of pathology. Striatal cells in culture were shown to be more susceptible to ER stress after downregulation of CNPY2. These results demonstrate that CNPY2 is expressed by corticostriatal neurons involved in the regulation of movement. CNPY2 enhances neuronal survival by reducing ER stress and is a promising factor to consider in HD and possibly in other brain diseases.
Impact of “Golden” tomato juice on cognitive alterations in metabolic syndrome: Insights into behavioural and biochemical changes in a high-fat diet rat model
Giuditta Gambino, Monica Frinchi, Giuseppe Giglia, Miriana Scordino, Giulia Urone, Giuseppe Ferraro, Giuseppa Mudò, Pierangelo Sardo, Danila Di Majo, Valentina Di Liberto
Journal of Functional Foods, 2024
“Golden” tomato (GT) plays a protective role in metabolic dysfunction induced by High-Fat Diet (HFD). Our aim is to characterize the phytonutrient composition of the juice and explore the influence of GT, orally administered for one month, on cognitive impairment associated with Metabolic Syndrome (MetS) in male rats. We investigated reactivity, stress response and memory, together with brain neurotrophic/inflammatory signaling. Our data showed that HFD-induced functional modifications were ameliorated by GT nutritional supplementation. In particular, the behavioural reactivity improved in HFD/GT rats, that also showed a better performance in tests measuring anxiety and anhedonia. Furthermore, GT consumption rescued the declarative memory impairment. Lastly, GT supplementation counteracted HFD-induced brain alterations in PI3K\Akt and MAPK/ERK signalling pathways. In conclusion, this study provides evidence of the importance of food supplementation with GT in the protection from neuroinflammation and cognitive alterations associated with MetS.
Retraction Note: Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells (Purinergic Signalling, (2017), 13, 4, (429-442), 10.1007/s11302-017-9571-6)
Mariachiara Zuccarini, Patricia Giuliani, Silvana Buccella, Valentina Di Liberto, Giuseppa Mudò, Natale Belluardo, Marzia Carluccio, Margherita Rossini, Daniele Filippo Condorelli, Michel Piers Rathbone, Francesco Caciagli, Renata Ciccarelli, Patrizia Di Iorio
Purinergic Signalling, 2023
Neuroprotective and Antioxidant Role of Oxotremorine-M, a Non-selective Muscarinic Acetylcholine Receptors Agonist, in a Cellular Model of Alzheimer Disease
Domenico Nuzzo, Monica Frinchi, Costanza Giardina, Miriana Scordino, Mariachiara Zuccarini, Chiara De Simone, Marta Di Carlo, Natale Belluardo, Giuseppa Mudò, Valentina Di Liberto
Cellular and Molecular Neurobiology, 2023
Alzheimer disease (AD) is a multifactorial and age-dependent neurodegenerative disorder, whose pathogenesis, classically associated with the formation of senile plaques and neurofibrillary tangles, is also dependent on oxidative stress and neuroinflammation chronicization. Currently, the standard symptomatic therapy, based on acetylcholinesterase inhibitors, showed a limited therapeutic potential, whereas disease-modifying treatment strategies are still under extensive research. Previous studies have demonstrated that Oxotremorine-M (Oxo), a non-selective muscarinic acetylcholine receptors agonist, exerts neurotrophic functions in primary neurons, and modulates oxidative stress and neuroinflammation phenomena in rat brain. In the light of these findings, in this study, we aimed to investigate the neuroprotective effects of Oxo treatment in an in vitro model of AD, represented by differentiated SH-SY5Y neuroblastoma cells exposed to Aβ1-42 peptide. The results demonstrated that Oxo treatment enhances cell survival, increases neurite length, and counteracts DNA fragmentation induced by Aβ1-42 peptide. The same treatment was also able to block oxidative stress and mitochondria morphological/functional impairment associated with Aβ1-42 cell exposure. Overall, these results suggest that Oxo, by modulating cholinergic neurotransmission, survival, oxidative stress response, and mitochondria functionality, may represent a novel multi-target drug able to achieve a therapeutic synergy in AD. Graphical Abstract Illustration of the main pathological hallmarks and mechanisms underlying AD pathogenesis, including neurodegeneration and oxidative stress, efficiently counteracted by treatment with Oxo, which may represent a promising therapeutic molecule. Created with BioRender.com under academic license.
Manipulation of HSP70-SOD1 Expression Modulates SH-SY5Y Differentiation and Susceptibility to Oxidative Stress-Dependent Cell Damage: Involvement in Oxotremorine-M-Mediated Neuroprotective Effects
Miriana Scordino, Monica Frinchi, Giulia Urone, Domenico Nuzzo, Giuseppa Mudò, Valentina Di Liberto
Antioxidants, 2023
The differentiation of neural progenitors is a complex process that integrates different signals to drive transcriptional changes, which mediate metabolic, electrophysiological, and morphological cellular specializations. Understanding these adjustments is essential within the framework of stem cell and cancer research and therapy. Human neuroblastoma SH-SY5Y cells, widely used in neurobiology research, can be differentiated into neuronal-like cells through serum deprivation and retinoic acid (RA) supplementation. In our study, we observed that the differentiation process triggers the expression of Heat Shock Protein 70 (HSP70). Notably, inhibition of HSP70 expression by KNK437 causes a dramatic increase in cell death. While undifferentiated SH-SY5Y cells show a dose-dependent decrease in cell survival following exposure to hydrogen peroxide (H2O2), differentiated cells become resistant to H2O2-induced cell death. Interestingly, the differentiation process enhances the expression of SOD1 protein, and inhibition of HSP70 expression counteracts this effect and increases the susceptibility of differentiated cells to H2O2-induced cell death, suggesting that the cascade HSP70-SOD1 is involved in promoting survival against oxidative stress-dependent damage. Treatment of differentiated SH-SY5Y cells with Oxotremorine-M (Oxo), a muscarinic acetylcholine receptor agonist, enhances the expression of HSP70 and SOD1 and counteracts tert–Butyl hydroperoxide-induced cell death and reactive oxygen species (ROS) generation. It is worth noting that co-treatment with KNK437 reduces SOD1 expression and Oxo-induced protection against oxidative stress damage, suggesting the involvement of HSP70/SOD1 signaling in this beneficial effect. In conclusion, our findings demonstrate that manipulation of the HSP70 signal modulates SH-SY5Y differentiation and susceptibility to oxidative stress-dependent cell death and unravels novel mechanisms involved in Oxo neuroprotective functions. Altogether these data provide novel insights into the mechanisms underlying neuronal differentiation and preservation under stress conditions.
Downregulation of the Astroglial Connexin Expression and Neurodegeneration after Pilocarpine-Induced Status Epilepticus
Anna Andrioli, Paolo Francesco Fabene, Giuseppa Mudò, Vincenza Barresi, Valentina Di Liberto, Monica Frinchi, Marina Bentivoglio, Daniele Filippo Condorelli
International Journal of Molecular Sciences, 2023
Astrocytic networks and gap junctional communication mediated by connexins (Cxs) have been repeatedly implicated in seizures, epileptogenesis, and epilepsy. However, the effect of seizures on Cx expression is controversial. The present study focused on the response of Cxs to status epilepticus (SE), which is in turn an epileptogenic insult. The expression of neuronal Cx36 and astrocytic Cx30 and Cx43 mRNAs was investigated in the brain of rats in the first day after pilocarpine-induced SE. In situ hybridization revealed a progressive decrease in Cx43 and Cx30 mRNA levels, significantly marked 24 h after SE onset in neocortical areas and the hippocampus, and in most thalamic domains, whereas Cx36 mRNA did not exhibit obvious changes. Regional evaluation with quantitative real-time-RT-PCR confirmed Cx43 and Cx30 mRNA downregulation 24 h after SE, when ongoing neuronal cell death was found in the same brain regions. Immunolabeling showed at the same time point marked a decrease in Cx43, microglia activation, and interleukin-1β induction in some microglial cells. The data showed a transient downregulation of astroglial Cxs in the cortical and thalamic areas in which SE triggers neurodegenerative events in concomitance with microglia activation and cytokine expression. This could potentially represent a protective response of neuroglial networks to SE-induced acute damage.
Role of Bioactive Molecules on Neuroprotection, Oxidative Stress, and Neuroinflammation Modulation
Valentina Di Liberto, Giuseppa Mudò
International Journal of Molecular Sciences, 2022
Guanosine modulates K+ membrane currents in SH-SY5Y cells: involvement of adenosine receptors
Giuditta Gambino, Giuseppe Giglia, Daniele Gallo, Miriana Scordino, Costanza Giardina, Mariachiara Zuccarini, Patrizia Di Iorio, Patricia Giuliani, Francisco Ciruela, Giuseppe Ferraro, Giuseppa Mudò, Pierangelo Sardo, Valentina Di Liberto
Pflugers Archiv European Journal of Physiology, 2022
Guanine inhibits the growth of human glioma and melanoma cell lines by interacting with GPR23
Roberta Garozzo, Mariachiara Zuccarini, Patricia Giuliani, Valentina Di Liberto, Giuseppa Mudò, Francesco Caciagli, Renata Ciccarelli, Francisco Ciruela, Patrizia Di Iorio, Daniele F. Condorelli
Frontiers in Pharmacology, 2022
Bidirectional Control between Cholesterol Shuttle and Purine Signal at the Central Nervous System
Daniela Passarella, Maurizio Ronci, Valentina Di Liberto, Mariachiara Zuccarini, Giuseppa Mudò, Carola Porcile, Monica Frinchi, Patrizia Di Iorio, Henning Ulrich, Claudio Russo
International Journal of Molecular Sciences, 2022
Adipose Stromal/Stem Cell-Derived Extracellular Vesicles: Potential Next-Generation Anti-Obesity Agents
Mariachiara Zuccarini, Patricia Giuliani, Valentina Di Liberto, Monica Frinchi, Francesco Caciagli, Vanni Caruso, Renata Ciccarelli, Giuseppa Mudò, Patrizia Di Iorio
International Journal of Molecular Sciences, 2022
Protective, antioxidant and antiproliferative activity of grapefruit integropectin on sh-sy5y cells
Domenico Nuzzo, Miriana Scordino, Antonino Scurria, Costanza Giardina, Francesco Giordano, Francesco Meneguzzo, Giuseppa Mudò, Mario Pagliaro, Pasquale Picone, Alessandro Attanzio, Stefania Raimondo, Rosaria Ciriminna, Valentina Di Liberto
International Journal of Molecular Sciences, 2021
Serotonin heteroreceptor complexes and their integration of signals in neurons and astroglia—relevance for mental diseases
Dasiel O. Borroto-Escuela, Patrizia Ambrogini, Manuel Narvaez, Valentina Di Liberto, Sarah Beggiato, Luca Ferraro, Ramon Fores-Pons, Jose E. Alvarez-Contino, Alexander Lopez-Salas, Giuseppa Mudò, Zaida Díaz-Cabiale, Kjell Fuxe
Cells, 2021
New neuroprotective effect of lemon integropectin on neuronal cellular model
Domenico Nuzzo, Pasquale Picone, Costanza Giardina, Miriana Scordino, Giuseppa Mudò, Mario Pagliaro, Antonino Scurria, Francesco Meneguzzo, Laura M. Ilharco, Alexandra Fidalgo, Rosa Alduina, Alessandro Presentato, Rosaria Ciriminna, Valentina Di Liberto
Antioxidants, 2021
Investigating the Role of Guanosine on Human Neuroblastoma Cell Differentiation and the Underlying Molecular Mechanisms
Natale Belluardo, Giuseppa Mudò, Valentina Di Liberto, Monica Frinchi, Daniele F. Condorelli, Ugo Traversa, Francisco Ciruela, Renata Ciccarelli, Patrizia Di Iorio, Patricia Giuliani
Frontiers in Pharmacology, 2021
Beneficial role of exercise in the modulation of mdx muscle plastic remodeling and oxidative stress
Monica Frinchi, Giuseppe Morici, Giuseppa Mudó, Maria R. Bonsignore, Valentina Di Liberto
Antioxidants, 2021
Guanosine-mediated anxiolytic-like effect: Interplay with adenosine a1 and a2a receptors
Monica Frinchi, Vincenzo Verdi, Fulvio Plescia, Francisco Ciruela, Maria Grillo, Roberta Garozzo, Daniele F. Condorelli, Patrizia Di Iorio, Francesco Caciagli, Renata Ciccarelli, Natale Belluardo, Valentina Di Liberto, Giuseppa Mudò
International Journal of Molecular Sciences, 2020
Anti-inflammatory and antioxidant effects of muscarinic acetylcholine receptor (mAChR) activation in the rat hippocampus
Monica Frinchi, Domenico Nuzzo, Pietro Scaduto, Marta Di Carlo, Maria F. Massenti, Natale Belluardo, Giuseppa Mudò
Scientific Reports, 2019
Crosstalk between receptor tyrosine kinases (RTKs) and G protein-coupled receptors (GPCR) in the brain: Focus on heteroreceptor complexes and related functional neurotrophic effects
Valentina Di Liberto, Giuseppa Mudò, Natale Belluardo
Neuropharmacology, 2019
Anti-inflammatory and cognitive effects of interferon-?1a (IFN?1a) in a rat model of Alzheimer's disease
Giuseppa Mudò, Monica Frinchi, Domenico Nuzzo, Pietro Scaduto, Fulvio Plescia, Maria F. Massenti, Marta Di Carlo, Carla Cannizzaro, Giovanni Cassata, Luca Cicero, Maria Ruscica, Natale Belluardo, Luigi M. Grimaldi
Journal of Neuroinflammation, 2019
Heat shock protein (Hsp) regulation by muscarinic acetylcholine receptor (mAChR) activation in the rat hippocampus
Monica Frinchi, Pietro Scaduto, Francesco Cappello, Natale Belluardo, Giuseppa Mudò
Journal of Cellular Physiology, 2018
Altered gastrointestinal motility in an animal model of Lesch-Nyhan disease
Maria G. Zizzo, Monica Frinchi, Domenico Nuzzo, Hyder A. Jinnah, Giuseppa Mudò, Daniele F. Condorelli, Francesco Caciagli, Renata Ciccarelli, Patrizia Di Iorio, Flavia Mulè, Natale Belluardo, Rosa Serio
Autonomic Neuroscience Basic and Clinical, 2018
Uncovering the signaling pathway behind extracellular guanine-induced activation of NO System: New perspectives in memory-related disorders
Mariachiara Zuccarini, Patricia Giuliani, Monica Frinchi, Giuseppa Mudò, Rosa Maria Serio, Natale Belluardo, Silvana Buccella, Marzia Carluccio, Daniele F. Condorelli, Francesco Caciagli, Renata Ciccarelli, Patrizia Di Iorio
Frontiers in Pharmacology, 2018
Detection of fibroblast growth factor receptor 1 (FGFR1) transactivation by muscarinic acetylcholine receptors (mAChRs) in primary neuronal hippocampal cultures through use of biochemical and morphological approaches
Valentina Di Liberto, Giuseppa Mudó, Dasiel O. Borroto-Escuela, Kjell Fuxe, Natale Belluardo
Neuromethods, 2018
Detection, analysis, and quantification of GPCR homo- and heteroreceptor complexes in specific neuronal cell populations using the in situ proximity ligation assay
Dasiel O. Borroto-Escuela, Manuel Narvaez, Ismael Valladolid-Acebes, Kirill Shumilov, Michael Di Palma, Karolina Wydra, Thorsten Schaefer, Irene Reyes-Resina, Gemma Navarro, Giuseppa Mudó, Malgorzata Filip, Stefano Sartini, Kristina Friedland, Harriët Schellekens, Sarah Beggiato, Luca Ferraro, Sergio Tanganelli, Rafael Franco, Natale Belluardo, Patrizia Ambrogini, Miguel Pérez de la Mora, Kjell Fuxe
Neuromethods, 2018
Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells
Mariachiara Zuccarini, Patricia Giuliani, Silvana Buccella, Valentina Di Liberto, Giuseppa Mudò, Natale Belluardo, Marzia Carluccio, Margherita Rossini, Daniele Filippo Condorelli, Michel Piers Rathbone, Francesco Caciagli, Renata Ciccarelli, Patrizia Di Iorio
Purinergic Signalling, 2017
Mild Aerobic Exercise Training Hardly Affects the Diaphragm of mdx Mice
Giuseppe Morici, Monica Frinchi, Alessandro Pitruzzella, Valentina Di Liberto, Rosario Barone, Andrea Pace, Valentina Di Felice, Natale Belluardo, Francesco Cappello, Giuseppa Mudò, Maria R. Bonsignore
Journal of Cellular Physiology, 2017
Existence of muscarinic acetylcholine receptor (mAChR) and fibroblast growth factor receptor (FGFR) heteroreceptor complexes and their enhancement of neurite outgrowth in neural hippocampal cultures
V. Di Liberto, D.O. Borroto-Escuela, M. Frinchi, V. Verdi, K. Fuxe, N. Belluardo, G. Mudò
Biochimica Et Biophysica Acta General Subjects, 2017
Anxiolytic effects of muscarinic acetylcholine receptors agonist oxotremorine in chronically stressed rats and related changes in BDNF and FGF2 levels in the hippocampus and prefrontal cortex
Valentina Di Liberto, Monica Frinchi, Vincenzo Verdi, Angela Vitale, Fulvio Plescia, Carla Cannizzaro, Maria F. Massenti, Natale Belluardo, Giuseppa Mudò
Psychopharmacology, 2017
Lack of Dystrophin Affects Bronchial Epithelium in mdx Mice
Giuseppe Morici, Francesca Rappa, Francesco Cappello, Elisabetta Pace, Andrea Pace, Giuseppa Mudò, Grazia Crescimanno, Natale Belluardo, Maria R. Bonsignore
Journal of Cellular Physiology, 2016
The guanine-based purinergic system: The tale of an orphan neuromodulation
Valentina Di Liberto, Giuseppa Mudò, Roberta Garozzo, Monica Frinchi, Víctor Fernandez-Dueñas, Patrizia Di Iorio, Renata Ciccarelli, Francesco Caciagli, Daniele F. Condorelli, Francisco Ciruela, Natale Belluardo
Frontiers in Pharmacology, 2016
Current disease modifying approaches to treat Parkinson's disease
Dan Lindholm, Johanna Mäkelä, Valentina Di Liberto, Giuseppa Mudò, Natale Belluardo, Ove Eriksson, Mart Saarma
Cellular and Molecular Life Sciences, 2016
Parkinson's disease: Towards better preclinical models and personalized treatments
Dan Lindholm, Johanna Mäkelä, Valentina Di Liberto, Giuseppa Mudò, Natale Belluardo, Ove Eriksson, Mart Saarma
Cellular and Molecular Life Sciences, 2016
Peroxisome proliferator-activated receptor-γ coactivator-1α mediates neuroprotection against excitotoxic brain injury in transgenic mice: Role of mitochondria and X-linked inhibitor of apoptosis protein
Johanna Mäkelä, Giuseppa Mudò, Dan Duc Pham, Valentina Di Liberto, Ove Eriksson, Lauri Louhivuori, Céline Bruelle, Rabah Soliymani, Marc Baumann, Laura Korhonen, Maciej Lalowski, Natale Belluardo, Dan Lindholm
European Journal of Neuroscience, 2016
Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression
Dasiel O. Borroto-Escuela, Mileidys Pérez-Alea, Manuel Narvaez, Alexander O. Tarakanov, Giuseppa Mudó, Antonio Jiménez-Beristain, Luigi F. Agnati, Francisco Ciruela, Natale Belluardo, Kjell Fuxe
Biochemical and Biophysical Research Communications, 2015
Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system
Dasiel O. Borroto-Escuela, Manuel Narvaez, Mileidys Pérez-Alea, Alexander O. Tarakanov, Antonio Jiménez-Beristain, Giuseppa Mudó, Luigi F. Agnati, Francisco Ciruela, Natale Belluardo, Kjell Fuxe
Biochemical and Biophysical Research Communications, 2015
Reduction in mdx mouse muscle degeneration by low-intensity endurance exercise: A proteomic analysis in quadriceps muscle of exercised compared with sedentary mdx mice
Simona Fontana, Odessa Schillaci, Monica Frinchi, Marco Giallombardo, Giuseppe Morici, Valentina Di Liberto, Riccardo Alessandro, Giacomo De Leo, Vincenzo Perciavalle, Natale Belluardo, Giuseppa Mudò
Bioscience Reports, 2015
Interactions between cholinergic and fibroblast growth factor receptors in brain trophism and plasticity
Valentina Liberto, Giuseppa Mudo, Kjell Fuxe, Natale Belluardo
Current Protein and Peptide Science, 2014
Recovery of damaged skeletal muscle in mdx mice through low-intensity endurance exercise
M. Frinchi, F. Macaluso, A. Licciardi, V. Perciavalle, M. Coco, N. Belluardo, G. Morici, G. Mudò
International Journal of Sports Medicine, 2014
Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1
Johanna Mäkelä, Timofey V Tselykh, Francesca Maiorana, Ove Eriksson, Hai Do, Giuseppa Mudò, Laura T Korhonen, Natale Belluardo, Dan Lindholm
Springerplus, 2014
Guanosine negatively modulates the gastric motor function in mouse
Maria Grazia Zizzo, Flavia Mulè, Antonella Amato, Francesca Maiorana, Giuseppa Mudò, Natale Belluardo, Rosa Serio
Purinergic Signalling, 2013
Distribution and function of gap junction coupling in cortical GABAergic neurons
Daniele F. Condorelli, Giuseppa Mudò, Vincenza Barresi, Natale Belluardo
Gap Junctions in the Brain, 2013
Connexin36 (Cx36) expression and protein detection in the mouse carotid body and myenteric plexus
Monica Frinchi, Valentina Di Liberto, Sada Turimella, Francesca D’Antoni, Martin Theis, Natale Belluardo, Giuseppa Mudò
Acta Histochemica, 2013
Distribution and Function of Gap Junction Coupling in Cortical GABAergic Neurons
Daniele F. Condorelli, Giuseppa Mudò, Vincenza Barresi, Natale Belluardo
Gap Junctions in the Brain Physiological and Pathological Roles, 2012
The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: Relevance for neuroplasticity
Dasiel O. Borroto-Escuela, Wilber Romero-Fernandez, Mileidys Pérez-Alea, Manuel Narvaez, Alexander O. Tarakanov, Giuseppa Mudó, Luigi F. Agnati, Francisco Ciruela, Natale Belluardo, Kjell Fuxe
Journal of Neuroscience, 2012
Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinsons disease
Giuseppa Mudò, Johanna Mäkelä, Valentina Di Liberto, Timofey V. Tselykh, Melania Olivieri, Petteri Piepponen, Ove Eriksson, Annika Mälkiä, Alessandra Bonomo, Minna Kairisalo, Jose A. Aguirre, Laura Korhonen, Natale Belluardo, Dan Lindholm
Cellular and Molecular Life Sciences, 2012
Involvement of estrogen receptors in the resveratrol-mediated increase in dopamine transporter in human dopaminergic neurons and in striatum of female mice
Valentina Di Liberto, Johanna Mäkelä, Laura Korhonen, Melania Olivieri, Timofey Tselykh, Annika Mälkiä, Hai Do Thi, Natale Belluardo, Dan Lindholm, Giuseppa Mudò
Neuropharmacology, 2012
Fibroblast growth factor receptor 1 5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity
Dasiel O. Borroto-Escuela, Wilber Romero-Fernandez, Giuseppa Mudó, Mileidys Pérez-Alea, Francisco Ciruela, Alexander O. Tarakanov, Manuel Narvaez, Valentina Di Liberto, Luigi F. Agnati, Natale Belluardo, Kjell Fuxe
Biological Psychiatry, 2012
Involvement of cyclin-dependent kinase-5 in the kainic acid-mediated degeneration of glutamatergic synapses in the rat hippocampus
Noora Putkonen, Jyrki P. Kukkonen, Guiseppa Mudo, Jaana Putula, Natale Belluardo, Dan Lindholm, Laura Korhonen
European Journal of Neuroscience, 2011
MGluR2/3 agonist LY379268, by enhancing the production of GDNF, induces a time-related phosphorylation of RET receptor and intracellular signaling Erk1/2 in mouse striatum
Valentina Di Liberto, Giuseppa Mudò, Natale Belluardo
Neuropharmacology, 2011
Agonist-induced formation of FGFR1 homodimers and signaling differ among members of the FGF family
Wilber Romero-Fernandez, Dasiel O. Borroto-Escuela, Alexander O. Tarakanov, Giuseppa Mudó, Manuel Narvaez, Mileidys Pérez-Alea, Luigi F. Agnati, Francisco Ciruela, Natale Belluardo, Kjell Fuxe
Biochemical and Biophysical Research Communications, 2011
Resveratrol reduces oxidative stress and cell death and increases mitochondrial antioxidants and XIAP in PC6.3-cells
Minna Kairisalo, Alessandra Bonomo, Alise Hyrskyluoto, Giuseppa Mudò, Natale Belluardo, Laura Korhonen, Dan Lindholm
Neuroscience Letters, 2011
FGF-2/FGFR1 neurotrophic system expression level and its basal activation do not account for the age-dependent decline of precursor cell proliferation in the subventricular zone of rat brain
Monica Frinchi, Valentina Di Liberto, Melania Olivieri, Kjell Fuxe, Natale Belluardo, Giuseppa Mudò
Brain Research, 2010
Group II metabotropic glutamate receptor activation by agonist LY379268 treatment increases the expression of brain derived neurotrophic factor in the mouse brain
V. Di Liberto, A. Bonomo, M. Frinchi, N. Belluardo, G. Mudò
Neuroscience, 2010
Identification of calcium sensing receptor (CaSR) mRNA-expressing cells in normal and injured rat brain
Giuseppa Mudò, Angela Trovato-Salinaro, Vincenza Barresi, Natale Belluardo, Daniele F. Condorelli
Brain Research, 2009
Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons
Giuseppe Battaglia, Gemma Molinaro, Barbara Riozzi, Marianna Storto, Carla L. Busceti, Paola Spinsanti, Domenico Bucci, Valentina Di Liberto, Giuseppina Mudò, Corrado Corti, Mauro Corsi, Ferdinando Nicoletti, Natale Belluardo, Valeria Bruno
Plos One, 2009
The FGF-2/FGFRs neurotrophic system promotes neurogenesis in the adult brain
G. Mudò, A. Bonomo, V. Di Liberto, M. Frinchi, K. Fuxe, Natale Belluardo
Journal of Neural Transmission, 2009
Corrigendum to "Antiabsence effects of carbenoxolone in two genetic animal models of absence epilepsy (WAG/Rij rats and lh/lh mice)" (DOI:10.1016/j.neuropharm.2005.04.012)
Pietro Gareri, Daniele Condorelli, Natale Belluardo, Rita Citraro, Vincenza Barresi, Angela Trovato-Salinaro, Giuseppa Mudo‘, Guido Ferreri Ibbadu, Emilio Russo, Giovambattista De Sarro
Neuropharmacology, 2009
Regulation of connexin gene expression during skeletal muscle regeneration in the adult rat
A. Trovato-Salinaro, N. Belluardo, M. Frinchi, J. von Maltzahn, K. Willecke, D. F. Condorelli, G. Mudò
American Journal of Physiology Cell Physiology, 2009
Fibroblast growth factor-2 and its receptor expression in proliferating precursor cells of the subventricular zone in the adult rat brain
Monica Frinchi, Alessandra Bonomo, Angela Trovato-Salinaro, Daniele F. Condorelli, Kjell Fuxe, Marcello G. Spampinato, Giuseppa Mudò
Neuroscience Letters, 2008
Time-course of GDNF and its receptor expression after brain injury in the rat
Qingzhang Cheng, Valentina Di Liberto, Giuseppa Caniglia, Giuseppa Mudò
Neuroscience Letters, 2008
Nicotine-induced fibroblast growth factor-2 restores the age-related decline of precursor cell proliferation in the subventricular zone of rat brain
Natale Belluardo, Giuseppa Mudo', Alessandra Bonomo, Valentina Di Liberto, Monica Frinchi, Kjell Fuxe
Brain Research, 2008
Cellular localization of mGluR3 and mGluR5 mRNAs in normal and injured rat brain
Giuseppa Mudo, Angela Trovato-Salinaro, Giuseppa Caniglia, Qingzhang Cheng, Daniele F. Condorelli
Brain Research, 2007
Acute intermittent nicotine treatment induces fibroblast growth factor-2 in the subventricular zone of the adult rat brain and enhances neuronal precursor cell proliferation
G. Mudò, N. Belluardo, A. Mauro, K. Fuxe
Neuroscience, 2007
Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain
Anna-Leena Sokka, Noora Putkonen, Giuseppa Mudo, Evgeny Pryazhnikov, Sami Reijonen, Leonard Khiroug, Natale Belluardo, Dan Lindholm, Laura Korhonen
Journal of Neuroscience, 2007
Nicotinic receptor agonists as neuroprotective/neurotrophic drugs. Progress in molecular mechanisms
G. Mudo, N. Belluardo, K. Fuxe
Journal of Neural Transmission, 2007
Bruce/apollon promotes hippocampal neuron survival and is downregulated by kainic acid
Anna-Leena Sokka, Guiseppa Mudo, Johanna Aaltonen, Natale Belluardo, Dan Lindholm, Laura Korhonen
Biochemical and Biophysical Research Communications, 2005
Transcription factor gene expression profiling after acute intermittent nicotine treatment in the rat cerebral cortex
N. Belluardo, P.A. Olsson, G. Mudo’, W.H. Sommer, G. Amato, K. Fuxe
Neuroscience, 2005
Expression of the rat connexin 39 (rCx39) gene in myoblasts and myotubes in developing and regenerating skeletal muscles: An in situ hybridization study
N. Belluardo, A. Trovato-Salinaro, G. Mudò, D. F. Condorelli
Cell and Tissue Research, 2005
Antiabsence effects of carbenoxolone in two genetic animal models of absence epilepsy (WAG/Rij rats and lh/lh mice)
P GARERI, D CONDORELLI, N BELLUARDO, R CITRARO, V BARRESI, A TROVATOSALINATO, G MUDO, G IBBADU, E RUSSO, G DESARRO
Neuropharmacology, 2005
Nicotine-induced FGF-2 mRNA in rat brain is preserved during aging
Natale Belluardo, Giuseppa Mudò, Mariann Blum, Nobuyuki Itoh, Luigi Agnati, Kjell Fuxe
Neurobiology of Aging, 2004
Cellular expression of connexins in the rat brain: Neuronal localization, effects of kainate-induced seizures and expression in apoptotic neuronal cells
Daniele F. Condorelli, Angela Trovato‐Salinaro, Giuseppa Mudò, Melita B. Mirone, Natale Belluardo
European Journal of Neuroscience, 2003
Increase in Bcl-2 phosphorylation and reduced levels of BH3-only Bcl-2 family proteins in kainic acid-mediated neuronal death in the rat brain
Laura Korhonen, Natale Belluardo, Giuseppa Mudo, Dan Lindholm
European Journal of Neuroscience, 2003
Transplantation of prodrug-converting neural progenitor cells for brain tumor therapy
Vincenza Barresi, Natale Belluardo, Simonetta Sipione, Giuseppa Mudó, Elena Cattaneo, Daniele Filippo Condorelli
Cancer Gene Therapy, 2003
Neuronal expression and regulation of rat inhibitor of apoptosis protein-2 by kainic acid in the rat brain
Natale Belluardo, Laura Korhonen, Giuseppa Mudo, Dan Lindholm
European Journal of Neuroscience, 2002
Dendritic localization of mammalian neuralized mRNA encoding a protein with transcription repression activities
T Timmusk
Molecular and Cellular Neuroscience, 2002
Connexin-30 mRNA is up-regulated in astrocytes and expressed in apoptotic neuronal cells of rat brain following kainate-induced seizures
D.F. Condorelli, G. Mudò, A. Trovato-Salinaro, M.B. Mirone, G. Amato, N. Belluardo
Molecular and Cellular Neuroscience, 2002
Identification and functional expression of HCx31.9, a novel gap junction gene
N. Belluardo, T. W. White, M. Srinivas, A. Trovato-Salinaro, H. Ripps, G. Mudò, R. Bruzzone, D. F. Condorelli
Cell Communication and Adhesion, 2001
Neuromuscular junction disassembly and muscle fatigue in mice lacking neurotrophin-4
Natale Belluardo, Håkan Westerblad, Giusepa Mudó, Antonino Casabona, Joseph Bruton, Giuseppina Caniglia, Ornella Pastoris, Francesca Grassi, Carlos F. Ibáñez
Molecular and Cellular Neuroscience, 2001
Central nicotinic receptors, neurotrophic factors and neuroprotection
Natale Belluardo, Giuseppa Mudò, Mariann Blum, Kjell Fuxe
Behavioural Brain Research, 2000
Expression of Connexin36 in the adult and developing rat brain
Natale Belluardo, Giuseppa Mudò, Angela Trovato-Salinaro, Sabine Le Gurun, Anne Charollais, Véronique Serre-Beinier, Giuseppe Amato, Jacques-Antoine Haefliger, Paolo Meda, Daniele F Condorelli
Brain Research, 2000
Expression of Cx36 in mammalian neurons
Daniele F Condorelli, Natale Belluardo, Angela Trovato-Salinaro, Giuseppa Mudò
Brain Research Reviews, 2000
Neurotrophic effects of central nicotinic receptor activation
N. Belluardo, G. Mudo, M. Blum, G. Amato, K. Fuxe
Journal of Neural Transmission Supplement, 2000
The nicotinic acetylcholine receptor agonist ABT-594 increases FGF-2 expression in various rat brain regions
Natale Belluardo, Giuseppa Mudò, Giuseppa Caniglia, Qingzhang Cheng, Mariann Blum, Kjell Fuxe
Neuroreport, 1999
The nicotinic acetylcholine receptor agonist (±)-epibatidine increases FGF-2 mRNA and protein levels in the rat brain
Natale Belluardo, Giuseppa Mudò, Mariann Blum, Qingzhang Cheng, Giuseppa Caniglia, Paola Dell'Albani, Kjell Fuxe
Molecular Brain Research, 1999
Structure, chromosomal localization, and brain expression of human Cx36 gene
N. Belluardo, A. Trovato-Salinaro, G. Mudò, Y.L. Hurd, D.F. Condorelli
Journal of Neuroscience Research, 1999
Expression of neurotrophins, GDNF, and their receptors in rat thyroid tissue
N. Belluardo, G. Mudò, G. Caniglia, M. Corsaro, Q. Cheng, F. Frasca, A. Belfiore, D. F. Condorelli
Cell and Tissue Research, 1999
Acute intermittent nicotine treatment produces regional increases of basic fibroblast growth factor messenger RNA and protein in the tel- and diencephalon of the rat
N Belluardo, M Blum, G Mudo, B Andbjer, K Fuxe
Neuroscience, 1998
Differential regulation of BDNF and NT-3 mRNA levels in primary cultures of rat cerebellar neurons
D Condorelli
Neurochemistry International, 1998
Thymotrophic effect of ether lipid 1-O-octadecyl-2-O-methoxy-rac- glicero-3-phosphocholine in the mouse
Venera Cardile, Giuseppa Mudò, Xinghong Jiang, Francesca Casella, Mauro Bindoni, Natale Belluardo
Immunopharmacology, 1997
Comparative localization of fibroblast growth factor receptor-1, -2, and -3 mRNAs in the rat brain: In situ hybridization analysis
N. Belluardo, G. Wu, G. Mudo, A.C. Hansson, R. Pettersson, K. Fuxe
Journal of Comparative Neurology, 1997
Induction of astroglial gene expression by experimental seizures in the rat: Spatio-temporal patterns of the early stages
N. Belluardo, G. Mudo, X.H. Jiang, D.F. Condorelli
GLIA, 1996
Change in neurotrophins and their receptor mRNAs in the rat forebrain after status epilepticus induced by pilocarpine
Giuseppa Mudò, Xing H. Jiang, Tõnis Timmusk, Mauro Bindoni, Natale Belluardo
Epilepsia, 1996
Chronic continuous infusion of (-)nicotine reduces basic fibroblast growth factor messenger RNA levels in the ventral midbrain of the intact but not of the 6-hydroxydopamine-lesioned rat
M. Blum, G. Wu, G. Mudo´, N. Belluardo, K. Andersson, L.F. Agnati, K. Fuxe
Neuroscience, 1996
Neurotrophins and their trk receptors in cultured cells of the glial lineage and in white matter of the central nervous system
Daniele F. Condorelli, Tuija Salin, Paola Dell’Albani, Giuseppa Mudò, Massimo Corsaro, Tonis Timmusk, Madis Metsis, Natale Belluardo
Journal of Molecular Neuroscience, 1995
Neurotoxic injury in rat hippocampus differentially affects multiple trkB and trkC transcripts
N. Belluardo, T. Salin, P. Dell'Albani, G. Mudò, M. Corsaro, X.H. Jiang, T. Timmusk, D.F. Condorelli
Neuroscience Letters, 1995
Up-regulation of trkB mRNA expression in the rat striatum after seizures
Tuija Salin, Giuseppa Mudò, Xing H. Jiang, Tõnis Timmusk, Madis. Metsis, Natale Belluardo
Neuroscience Letters, 1995
Seizures increase trkC mRNA expression in the dentate gyrus of rat hippocampus - Role of glutamate receptor activation
Giuseppa Mudò, Tuija Salin, Daniele F. Condorelli, Xing H. Jiang, Paola Dell’Albani, Tõnis Timmusk, Madis Metsis, Hiroshi Funakoshi, Natale Belluardo
Journal of Molecular Neuroscience, 1995
Expression of mRNAs for neurotrophins and their receptors in the rat choroid plexus and dura mater
Tönis Timmusk, Giuseppa Mudò, Madis Metsis, Natale Belluardo
Neuroreport, 1995
NMDA receptor-dependent and -independent immediate early gene expression induced by focal mechanical brain injury
N. Belluardo, G. Mudò, P. Dell'albani, X.H. Hang, D.F. Condorelli
Neurochemistry International, 1995
Neuroregulation of natural suppressor cell activity
G. Mudò, M. Bindoni, N. Belluardo
International Journal of Neuroscience, 1994
Expression of neurotrophins and their receptors in primary astroglial cultures: Induction by cyclic AMP-elevating agents
D. F. Condorelli, P. Dell'Albani, G. Mudò, T. Timmusk, N. Belluardo
Journal of Neurochemistry, 1994
Changes in gene expression of AMPA-selective glutamate receptor subunits induced by status epilepticus in rat brain
D.F. Condorelli, N. Belluardo, G. Mudò, P. Dell'Albani, X. Jiang, A.M. Giuffrida-Stella
Neurochemistry International, 1994
Platelet-activating factor and its methoxy-analogue et-18-OCH3 stimulate immediate early gene expression in rat astroglial cultures
P. Dell' Albani, D.F. Condorelli, G. Mudò, C. Amico, M. Bindoni, N. Belluardo
Neurochemistry International, 1993
Increased expression of trkB and trkC messenger RNAS in the rat forebrain after focal mechanical injury
G. Mudó, H. Persson, T. Timmusk, H. Funakoshi, M. Bindoni, N. Belluardo
Neuroscience, 1993
Crossfostering and early development of natural killer cytotoxic activity in various inbred mouse strains
N. Belluardo, G. Mudó, A. Campisi, A. Vanella, J. Russo, M. Bindoni
Physiology and Behavior, 1993
Effects of early destruction of the mouse arcuate nucleus by monosodium glutamate on age-dependent natural killer activity
Natale Belluardo, Giuseppa Mudo`, Mauro Bindoni
Brain Research, 1990
Effect of cerebral hemisphere decortication on the cytotoxic activity of natural killer and natural cytotoxic lymphocytes in the mouse
Natale Belluardo, Giuseppa Mudo`, Silvano Cella, Mauro Bindoni
Brain Research, 1990
Hypothalamic control of the generation of mature natural killer lymphocytes in bone marrow and spleen of the mouse
Natural Immunity and Cell Growth Regulation, 1990
The development of the age-dependent natural killer (NK) activity in mouse is controlled by hypothalamus
N. Belluardo, G. Mudò, M. Bindoni
International Journal of Neuroscience, 1990
Hypothalamic control of certain aspects of natural immunity in the mouse
Immunology, 1987
Increased tumor cell multiplication after radiofrequency lesions in median hypothalamus in the mouse and rat1
Mauro Bindoni, Natale Belluardo, Anna E. Marchese, Venera Cardile, Giuseppa Mudò, Silvano Cella, Antonio Laguidara, Giuseppe Denatale
Neuroendocrinology, 1986
Labeling index and mean number of labeled cells in glandular tubules of the small intestine in DBA/2 mice after electrothermocoagulation of nuclei of the median hypothalamus
Bollettino Della Societa Italiana Di Biologia Sperimentale, 1985
Polyamines content in liver, spleen and L1210 ascites tumor after radiofrequency destruction of the tuberoinfundibular region of hypothalamus in DBA/2 mice
Italian Journal of Biochemistry, 1985
Dental caries study in rats exposed to electrothermocoagulation of the ventromedial area of the hypothalamus
Minerva Stomatologica, 1983
Growth and doubling time of the L1210 ascites tumor in DBA/2 mice after electrothermocoagulation of the tuberoinfundibular region of the hypothalamus
Bollettino Della Societa Italiana Di Biologia Sperimentale, 1983

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