Akram Hoseinzadeh

@auto.semums.ac.ir

Department of Immunology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Department of Immunology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.

https://researchid.co/anahita2024

RESEARCH, TEACHING, or OTHER INTERESTS

Immunology and Allergy, Immunology, Rheumatology, Biophysics

Scopus Publications

Scholar Citations

Scholar h-index

Scholar i10-index

Scopus Publications

Effects of Probiotics on Liver Diseases: Current In Vitro and In Vivo Studies
Maryam Sadri, Zahra Shafaghat, Mona Roozbehani, Akram Hoseinzadeh, Fatemeh Mohammadi, Fahimeh Lavi Arab, Sara Minaeian, Soheil Rahmani Fard, and Fatemeh Faraji
Springer Science and Business Media LLC

Potential applications of macrophages in cancer immunotherapy
Maryam Sadri, Sahel Heidari, Arezoo Faridzadeh, Mona Roozbehani, Shirin Toosi, Reihaneh Alsadat Mahmoudian, Akram Hoseinzadeh, Mohammad Taha Salmani Fard, Fahimeh Lavi Arab, Soheil Rahmani Fard,et al.
Elsevier BV

Mesenchymal stem cell-derived exosomes for management of prostate cancer: An updated view
Fahimeh Lavi Arab, Akram Hoseinzadeh, Fatemeh Hafezi, Fatemeh Sadat Mohammadi, Farid Zeynali, Melika Hadad Tehran, and Amirreza Rostami
Elsevier BV

Immunoregulatory effects of nanocurcumin in inflammatory milieu: Focus on COVID-19
Fahimeh Lavi Arab, Akram Hoseinzadeh, Fatemeh Sadat Mohammadi, Arezoo Rajabian, Arezoo Faridzadeh, and Mahmoud Mahmoudi
Elsevier BV

A new generation of mesenchymal stromal/stem cells differentially trained by immunoregulatory probiotics in a lupus microenvironment
Akram Hoseinzadeh, Mahmoud Mahmoudi, Houshang Rafatpanah, Zahra Rezaieyazdi, Jalil Tavakol Afshari, Sara Hosseini, and Seyed-Alireza Esmaeili
Springer Science and Business Media LLC
Abstract Background Increasing evidence suggests that multipotent mesenchymal stem/stromal cells (MSCs) are a promising intervention strategy in treating autoimmune inflammatory diseases. It should be stated that systemic immunoregulation is increasingly recognized among the beneficial effects of MSCs and probiotics in treating morbid autoimmune disorders such as lupus. This study aimed to determine if immunoregulatory probiotics L. rhamnosus or L. delbrueckii can change the immunomodulatory effects of MSCs in lupus-like disease. Methods Pristane-induced lupus (PIL) mice model was created via intraperitoneal injection of Pristane and then confirmed. Naïve MSCs (N-MSCs) were coincubated with two Lactobacillus strains, rhamnosus (R-MSCs) or delbrueckii (D-MSCs), and/or a combination of both (DR-MSCs) for 48 h, then administrated intravenously in separate groups. Negative (PBS-treated normal mice) and positive control groups (PBS-treated lupus mice) were also investigated. At the end of the study, flow cytometry and enzyme-linked immunosorbent assay (ELISA) analysis were used to determine the percentage of Th cell subpopulations in splenocytes and the level of their master cytokines in sera, respectively. Moreover, lupus nephritis was investigated and compared. Analysis of variance (ANOVA) was used for multiple comparisons. Results Abnormalities in serum levels of anti-dsDNA antibodies, creatinine, and urine proteinuria were significantly suppressed by MSCs transplantation, whereas engrafted MSCs coincubation with both L. strains did a lesser effect on anti-dsDNA antibodies. L. rhamnosus significantly escalated the ability of MSCs to scale down the inflammatory cytokines (IFN-ɣ, IL-17), while L. delbrueckii significantly elevated the capacity of MSCs to scale down the percentage of Th cell subpopulations. However, incubation with both strains induced MSCs with augmented capacity in introducing inflammatory cytokines (IFN-ɣ, IL-17). Strikingly, R-MSCs directly restored the serum level of TGF-β more effectively and showed more significant improvement in disease parameters than N-MSCs. These results suggest that R-MSCs significantly attenuate lupus disease by further skew the immune phenotype of MSCs toward increased immunoregulation. Conclusions Results demonstrated that Lactobacillus strains showed different capabilities in training/inducing new abilities in MSCs, in such a way that pretreated MSCs with L. rhamnosus might benefit the treatment of lupus-like symptoms, given their desirable properties. Graphical abstract

Dysregulated balance in Th17/Treg axis of Pristane-induced lupus mouse model, are mesenchymal stem cells therapeutic?
Akram Hoseinzadeh, Zahra Rezaieyazdi, Mahmoud Mahmoudi, Jalil Tavakol Afshari, Fahimeh Lavi Arab, Seyed-Alireza Esmaeili, Arezoo Faridzadeh, Amin Rezaeian, Sara Hoseini, Mehdi Barati,et al.
Elsevier BV

Modulation of Mesenchymal Stem Cells-Mediated Adaptive Immune Effectors’ Repertoire in the Recovery of Systemic Lupus Erythematosus
Akram Hoseinzadeh, Zahra Rezaieyazdi, Jalil Tavakol Afshari, Ali Mahmoudi, Sahar Heydari, Reza Moradi, Seyed-Alireza Esmaeili, and Mahmoud Mahmoudi
Springer Science and Business Media LLC

Cross Talk between Mesenchymal Stem/Stromal Cells and Innate Immunocytes Concerning Lupus Disease
Mahmoud Mahmoudi, Akram Hoseinzadeh, Zahra Rezaieyazdi, Jalil Tavakol Afshari, Ali Mahmoudi, and Sahar Heydari
Springer Science and Business Media LLC

The role of ACE1 I/D and ACE2 polymorphism in the outcome of Iranian COVID-19 patients: A case-control study
Arezoo Faridzadeh, Mahmoud Mahmoudi, Sara Ghaffarpour, Mohammad Saber Zamani, Akram Hoseinzadeh, Mohammad Mehdi Naghizadeh, and Tooba Ghazanfari
Frontiers Media SA
Background: Since the beginning of the pandemic of coronavirus disease 2019 (COVID-19), many countries have experienced a considerable number of COVID-19 cases and deaths. The etiology of a broad spectrum of symptoms is still debated. Host genetic variants might also significantly influence the outcome of the disease. This study aimed to evaluate the association of angiotensin-converting enzyme (ACE1) gene Insertion/Deletion (I/D) polymorphism (rs1799752) and ACE2 gene rs1978124 single nucleotide polymorphism with the COVID-19 severity.Methods: This study was conducted on 470 COVID-19 patients and a control group of 56 healthy individuals across several major cities in Iran. The blood sample and clinical data were collected from the participants, and their ACE1 I/D and ACE2 rs1978124 polymorphisms were determined using polymerase chain reaction and PCR-RFLP, respectively. Serum levels of C-reactive protein (CRP), interleukin 6 (IL-6), and ACE1 were measured in the blood samples.Results: We found that the ACE1 DD genotype frequency was inversely correlated with the risk of intubation (p = 0.017) and mortality in COVID-19 patients (p = 0.049). Even after adjustment, logistic regression demonstrated that this significant inverse association remained constant for the above variables at odds ratios of (OR) = 0.35 and Odds Ratio = 0.49, respectively. Also, in the expired (p = 0.042) and intubated (p = 0.048) groups with II + ID genotypes, the mean level of CRP was significantly higher than in the DD genotype group. Furthermore, in both intubated and expired groups, the mean serum level of ACE1 was higher compared with non-intubated and survived groups with II or II + ID genotypes. The results also indicated that ACE2 rs1978124 TT + CT genotypes in females have a significant positive role in susceptibility to COVID-19; however, in females, the TT + CT genotypes had a protective effect (OR = 0.098) against the severity of COVID-19.Conclusion: These findings suggest that ACE1 I/D and ACE2 rs1978124 polymorphism could potentially influence the outcome of COVID-19 in the Iranian population.

RECENT SCHOLAR PUBLICATIONS

Fate and long-lasting therapeutic effects of mesenchymal stromal/stem-like cells: mechanistic insights
A Hoseinzadeh, SA Esmaeili, R Sahebi, AM Melak, M Mahmoudi, ...
Stem Cell Research & Therapy 16 (1), 33 2025

Effects of Probiotics on Liver Diseases: Current In Vitro and In Vivo Studies
M Sadri, Z Shafaghat, M Roozbehani, A Hoseinzadeh, F Mohammadi, ...
Probiotics and Antimicrobial Proteins, 1-23 2024

Potential applications of macrophages in cancer immunotherapy
M Sadri, S Heidari, A Faridzadeh, M Roozbehani, S Toosi, ...
Biomedicine & Pharmacotherapy 178, 117161 2024

Mesenchymal stem cell-derived exosomes for management of prostate cancer: An updated view
FL Arab, A Hoseinzadeh, F Hafezi, FS Mohammadi, F Zeynali, A Rostami
International Immunopharmacology 134, 112171 2024

Immunoregulatory effects of nanocurcumin in inflammatory milieu: Focus on COVID-19
FL Arab, A Hoseinzadeh, FS Mohammadi, A Rajabian, A Faridzadeh, ...
Biomedicine & Pharmacotherapy 171, 116131 2024

A new generation of mesenchymal stromal/stem cells differentially trained by immunoregulatory probiotics in a lupus microenvironment
A Hoseinzadeh, M Mahmoudi, H Rafatpanah, Z Rezaieyazdi, ...
Stem Cell Research & Therapy 14 (1), 358 2023

Dysregulated balance in Th17/Treg axis of Pristane-induced lupus mouse model, are mesenchymal stem cells therapeutic?
A Hoseinzadeh, Z Rezaieyazdi, M Mahmoudi, JT Afshari, FL Arab, ...
International immunopharmacology 117, 109699 2023

Modulation of mesenchymal stem cells-mediated adaptive immune effectors’ repertoire in the recovery of systemic lupus erythematosus
A Hoseinzadeh, Z Rezaieyazdi, JT Afshari, A Mahmoudi, S Heydari, ...
Stem Cell Reviews and Reports 19 (2), 322-344 2023

Cross talk between mesenchymal stem/stromal cells and innate immunocytes concerning lupus disease
M Mahmoudi, A Hoseinzadeh, Z Rezaieyazdi, JT Afshari, A Mahmoudi, ...
Stem Cell Reviews and Reports 18 (8), 2781-2796 2022

The role of ACE1 I/D and ACE2 polymorphism in the outcome of Iranian COVID-19 patients: A case-control study
A Faridzadeh, M Mahmoudi, S Ghaffarpour, MS Zamani, A Hoseinzadeh, ...
Frontiers in Genetics 13, 955965 2022

Evaluation of immunomodulatory effects of mesenchymal stem cell on pristane-induced lupus mouse model
A Hoseinzadeh, ZR Yazdi, FL Arab, M Mahmoudi
Cytotherapy 23 (5), S71 2021

MOST CITED SCHOLAR PUBLICATIONS

Immunoregulatory effects of nanocurcumin in inflammatory milieu: Focus on COVID-19
FL Arab, A Hoseinzadeh, FS Mohammadi, A Rajabian, A Faridzadeh, ...
Biomedicine & Pharmacotherapy 171, 116131 2024
Citations: 5

Potential applications of macrophages in cancer immunotherapy
M Sadri, S Heidari, A Faridzadeh, M Roozbehani, S Toosi, ...
Biomedicine & Pharmacotherapy 178, 117161 2024
Citations: 2