Luis Alberto Gobbo
@fct.unesp.br
Associate Professor, Kinesiology Department, School of Technology and Science
São Paulo State University - UNESP
Post-doctor in Exercise Science and a PhD in Public Health, Professor Gobbo has a PhD internship (PDEE / CAPES) at the School of Human Motricity of the Technical University of Lisbon and is a Visiting Scholar at Harvard Medical School. He is currently an Associate Professor in the Department of Physical Education/Kinesiology at the School of Technology and Science (FCT) at Sao Paulo State University-UNESP, Presidente Prudente / SP, Brazil, and accredited in the Graduate Program in Movement Sciences at UNESP. He coordinates the Musculoskeletal System Assessment Laboratory (LABSIM), in partnerships with Brazilian, American, Italian and Portuguese institutions, and has supervised more than 20 master's and doctoral students, in addition to two postdoctoral supervisions. He has two book chapters published and more than 80 articles published in indexed journals.
EDUCATION
Mar 2024 – Aug 2024 Harvard Medical School
Visiting Scholar, Laboratory of Exercise Physiology and Physical Performance, Men's Health, Aging, and Metabolism Unit, Harvard Medical School, Harvard University, Boston, MA, USA
Feb 2017 – Jan 2018 Londrina State University - UEL
Post-Doctoral, Exercise Science
Londrina, Paraná, Brazil
Feb 2008 – Mar 2012 University of São Paulo – USP
Doctor of Philosophy, Nutrition in Public Health
São Paulo, São Paulo, Brazil
Feb 2006 – Sep 2007 Londrina State University - UEL
Master of Science, Physical Education
Londrina, Paraná, Brazil
Feb 2000 – Apr 2004 Londrina State University - UEL
Bachelor of Science, Physical Education
Londrina, Paraná, Brazil
RESEARCH, TEACHING, or OTHER INTERESTS
Aging, Public Health, Environmental and Occupational Health, Physiology, Statistics and Probability
FUTURE PROJECTS
BIA Brasil: a national multicenter collaboration project
The project "BIA Brasil: A National Multicenter Collaboration Study" aims to establish normative values and tolerance ellipses for bioelectrical impedance parameters, including phase angle (AngF) and bioelectrical impedance vector analysis (BIVA), in a comprehensive sample of Brazilian university staff and their immediate family members. Through a cross-sectional design, which will later serve as a basis for longitudinal studies, data will be collected at 25 research centers distributed across the five regions of Brazil. Body composition parameters will be assessed using bioelectrical impedance spectroscopy (BIS) and localized assessment methods (L-BIA), in addition to evaluating sociodemographic variables, lifestyle habits, mental health, physical activity, sedentary behavior, and quality of life.
Applications Invited
Partnerships, grants
Analysis of bioelectrical impedance parameters and association with health determinants in families with high and low social vulnerability: BIA Brasil project
The project aims to investigate bioelectrical impedance (BIA) parameters and their association with health determinants in families with different levels of social vulnerability. This study will compare two groups: university employees in Presidente Prudente, SP, and their direct relatives (low social vulnerability) and residents from a peripheral neighborhood in Álvares Machado, SP (high social vulnerability), matched by age and sex. In addition to BIA parameters, evaluations will include body composition, quality of life, nutritional habits, physical activity levels, and clinical outcomes. The analysis will seek to identify patterns associated with social vulnerability and provide support for public health interventions that promote equity and well-being.
Applications Invited
Partnerships, grants
Analysis of different volumes and intensities of training on bioelectrical impedance parameters in young university students and athletes
The present study compares the BIA and L-BIA parameters in physical training sessions with varying volumes and intensities in young adults with experience in physical activities. To this end, physically active young people of both sexes, aged between 18 and 40, will be recruited to perform RT sessions in different zones of training volume and intensities. The BIA and L-BIA parameters will be measured using electrical bioimpedance, using a 50 kHz frequency analyzer. Resistance and reactance measurements will be obtained to calculate the phase angle. L-BIA will be performed on muscles specific to the sports training modality. Acute assessments will be carried out pre-training, immediately post-training, and then at minutes 15', 30', 45' and 60' post-training, and 24 hours after the training session. Chronic assessments will be carried out in periods of 4 weeks after the start of training.
Applications Invited
Partnerships, grants
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Ewerton P. Antunes, Wagner L. Prado, Daniel Canhin, Claudiele C. M. Silva, Luis Alberto Gobbo, Gerson Ferrari, Jorge Mota, William R. Tebar, and Diego G. D. Christofaro
Wiley
ABSTRACTBackground and AimsLifelong physical activity (PA) engagement has been linked with several health benefits, such as the prevention of cardiovascular diseases. However, longitudinal studies investigating the association of lifelong PA with quality of life (QoL) needs to be more explored in literature.MethodsWe analyze the association of lifelong PA engagement with quality of life (QoL) ini = 842 community‐dwelling adults (56.5 ± 18.3 years, 61.7% of women). PA engagement during childhood and adolescence was retrospectively assessed considering supervised sports practice outside the school for at least 1 year. Current PA was assessed by Baecke score, and classified as highly active (4th quartile) and less active (1st–3rd quartile). QoL were assessed through by the SF‐36, and classified as high (4th quartile) and low (1st–3rd quartile) QoL for each domain. Multiple logistic regression models (adjusted by sex, age, socioeconomic status, and disabling chronic conditions) analyzed the association between lifelong PA engagement with QoL.ResultsParticipants who engaged in PA in childhood and those currently classified into the highest quartile of Baecke score were more likely to present high QoL in isolated statistical models. Specific combinations of PA engagement in childhood + adolescence, childhood + adulthood, and adolescence + adulthood were associated with high physical functioning (OR: 3.34; 3.39; and 2.82), vitality (OR: 2.63; 2.08; and 2.40). Clustering life stages of PA engagement showed an incremental association for high physical functioning (2 stages OR: 2.49; 3 stages OR: 5.53), general health status (2 stages OR: 2.09; 3 stages OR: 2.79), and mental health (1 stage OR: 1.42; 3 stages OR: 2.79).ConclusionLifelong PA engagement is positively associated with QoL in adults. Actions for QoL promotion should focus on adherence of PA practice at all life stages, but this specific sample profile limited the generalization of results.
Gianfranco Sganzerla, Luis Alberto Gobbo, André Luiz Bisel Mendonça, Fabricio Cesar de Paula Ravagnani, Silvio Assis de Oliveira-Junior, Vitor Cordeiro, and Christianne F. Coelho-Ravagnani
Elsevier BV
Giovanni Henrique Quizzini, Caroline Galan de Souza Pereira, Vanessa Ribeiro dos Santos, Vitor Cabrera Batista, Bruna Spolador de Alencar Silva, Fábio Santos Lira, Alex Silva Ribeiro, and Luís Alberto Gobbo
Wiley
AbstractThe objective of the present study is to analyze the changes in bioimpedance vector analysis (BIVA) and phase angle (PhA) in sarcopenic older people submitted to a 12‐week resistance training (RT) program according to classic and specific analyses. To this end, 20 sarcopenic older adults of both sexes, invited through media, underwent bioimpedance analysis before and after the RT carried out three times a week, for 12 weeks. The mean impedance vectors of the groups established for the confidence ellipses (95% of the confidence ellipse) are compared using Hotelling's T2 test. The distance D from Mahalanobis is also calculated. Classic and Specific BIVA are presented. The resistance values for the classical analyses (R/H) decreased across all groups (whole group, women and men, p < 0.05), with approximate decreases ranging from 9.4% to 10%, while the classic reactance (Xc/H) decreased (p < 0.05) only for the whole group (5.9%) and men (7.7%). For the specific BIVA, trends are verified for the whole sample, with a decrease in resistance (R.sp) and an increase in reactance (Xc.sp). In conclusion, the RT program in sarcopenic individuals promoted a reduction in resistance values in classical analyses, indicating a possible increase in hydration status and, consequently, musculoskeletal mass.
Karina Pozo, Luis Alberto Gobbo, Rafael Mello Fontolan Vieira, Amanda Mendes Cavalcante, Isis Grigoletto, and Ercy Mara Cipulo Ramos
Ovid Technologies (Wolters Kluwer Health)
Ricardo R. Agostinete, Pedro H. Narciso, Manuel João Coelho-e-Silva, Renata M. Bielemann, Luis Alberto Gobbo, Bruna Camilo Turi-Lynch, Romulo Araújo Fernandes, and Dimitris Vlachopoulos
Frontiers Media SA
Ricardo R. Agostinete, Pedro H. Narciso, Manuel João Coelho-e-Silva, Renata M. Bielemann, Luis Alberto Gobbo, Bruna Camilo Turi-Lynch, Romulo Araújo Fernandes, and Dimitris Vlachopoulos
Frontiers Media SA
IntroductionCompetitive swimming during adolescence has been linked to poor bone development, potentially influenced by training load, inflammation, hormones, and bone markers. However, this influence has been poorly investigated in the literature.ObjectiveTo compare whether competitive adolescent swimmers present differences in inflammatory, immunological, anabolic, and bone markers compared with non-sport group and to analyse whether inflammatory variables mediate the association between training load and areal bone mineral density (aBMD) in the swimmers group.MethodsThis cross-sectional study included 61 adolescents (20 females, 15.4±2.3 years), of which 30 were adolescent swimmers and 31 did not participate in sports (non-sports group). The daily training load was obtained by multiplying the perceived exertion score by the training volume of the swimmers. Lean soft tissue, fat mass and aBMD were estimated from whole-body scans using dual-energy X-ray absorptiometry and peak height velocity considering stature and body mass. Blood samples were collected to assess bone markers (calcium, 25-hydroxy vitamin D, C-terminal telopeptide, and osteocalcin), growth hormones, insulin-like growth factor 1 (IGF-1), lymphocytes, leukocytes, and inflammatory markers (interleukin-6 [IL-6] and C-reactive protein [CRP]). Statistical analyses applied a significance level at p&lt;0.05.ResultsBesides lower values in BMD (expect in upper limbs), swimmers had higher calcium (10.0 ± 0.30 vs 9.7 ± 0.44, p=0.007), vitamin D (42.6 ± 10.4 vs 24.2 ± 5.9, p&lt;0.001), and IGF-1 (397.2 ± 115.1 vs 220.3± 73.9, p&lt;0.001) concentrations than their non-sports peers. The mediation analysis found no indirect associations between training load and aBMD through inflammatory markers. Nevertheless, training load was directly and negatively associated with aBMD in the lower limbs (β=-0.1533, 95%CI:-0.2875, -0.0191) and total body less head (β=-0.0978, 95%CI:-0.1880, -0.0076) through IL-6 and directly and negatively associated with aBMD at all sites through CRP.ConclusionThe swimming and non-sports groups did not show differences in bone, inflammatory, or immunological markers. In contrast, swimmers had higher concentrations of IGF-1, calcium, and 25-hydroxy vitamin D. Although the training load was negatively associated with aBMD, inflammatory markers (IL-6 and CRP) did not mediate this association. Reinforcing the hypothesis that swimmers have lower aBMD due to the hypogravitational environment.
Ismael Figueiredo Rabelo, Shannon Farrell, Kieran F. Reid, Vanessa Ribeiro Dos Santos, Melissa Antunes, Vitor Cabrera Batista, Andreia Bauermann-Vieira, and Luís Alberto Gobbo
Frontiers Media SA
IndroductionBioelectrical Impedance Analysis (BIA) is a widely used method to assess body composition. Traditional BIA models use predictive equations without considering individual characteristics such as age, sex, and activity level. Classic Bioelectrical Impedance Vector Analysis (BIVA) standardizes raw BIA data by height, while specific BIVA (spBIVA) normalizes by body segment areas and lengths, offering a potentially more accurate assessment. With aging populations, there is growing interest in assessing age‐related body composition changes ‐ especially sarcopenia, characterized by reduced muscle mass and function. While BIVA is promising for such assessments, limited studies compare classic and specific BIVA approaches in older adults based on physical activity and muscle strength. Thus, the objective of the study is to compare classic and specific BIVA values in older adults according to their physical activity level and muscle strength.MethodsThis cross‐sectional study involved 187 community‐dwelling older adults (143 women and 44 men, ≥60 years), recruited via public advertisements. Exclusion criteria included medical conditions affecting muscle mass. The Assessments included: Anthropometry (weight, height, BMI, waist, arm and calf circumferences); BIA (resistance ‐ R, reactance ‐ Xc, and phase angle ‐ PhA), measured using a 50 kHz analyzer (classic BIVA was normalized by height and specific BIVA by segmental area/length using upper arm); physical activity (measured using the Baecke Habitual Physical Activity Questionnaire); muscle strength (measured by handgrip dynamometry, cut‐off values &lt;27 kg for men and &lt;16 kg for women indicated low strength). For the statistical analyses, differences in BIVA parameters were evaluated using Hotelling’s T2 test and Mahalanobis D distances (p &lt; 0.05).ResultsMen had significantly higher body weight, height, waist circumference, and handgrip strength (p &lt; 0.05). Classic BIVA consistently showed higher values of R and Xc than specific BIVA (differences up to 30%). PhA was higher in men, especially due to lower resistance values. Among women, those with higher physical activity levels had significantly higher PhA, indicating better cellular health. Among men, no significant differences in PhA were observed between activity levels. For muscle strength, stronger men had higher PhA values and significant vector displacement in both models; women did not show significant differences by strength level.Discussion and ConclusionBoth classic and specific BIVA approaches identified differences in impedance parameters related to physical activity and strength. Classic BIVA tends to overestimate resistance and reactance due to height normalization, while specific BIVA, using body segments, may better reflect individual morphological characteristics.
Melissa Antunes, Leandro dos Santos, Luís Alberto Gobbo, Analiza M. Silva, Paolo M. Cunha, Witalo Kassiano, Letícia T. Cyrino, Hellen C. G. Nabuco, Ricardo J. Rodrigues, Luís B. Sardinha,et al.
Springer Science and Business Media LLC
Bruna T. C. Saraiva, Emerson Franchini, Alex S. Ribeiro, Luís A. Gobbo, Marília A. Correia, Luiz C. M. Vanderlei, Gerson Ferrari, William R. Tebar, and Diego G. D. Christofaro
Springer Science and Business Media LLC
Ricardo R. Agostinete, André O. Werneck, Pedro H. Narciso, Esther Ubago-Guisado, Manuel J. Coelho-e-Silva, Renata M. Bielemann, Luis Alberto Gobbo, Bruna Turi Lynch, Romulo Araújo Fernandes, and Dimitris Vlachopoulos
Springer Science and Business Media LLC
Abstract Background Sports practice during adolescence is important to enhance bone development, although it may provide different effects depending on the mechanical impact present in the sport. Besides, resistance training (RT) may also induce bone changes directly (via muscle contractions) and indirectly (via myokines). However, there have been no studies analyzing the longitudinal influence of engaging in sport with and without added mechanical load. Thus, this study aims to analyze the combined effects of sports participation and resistance training on areal bone mineral density (aBMD) accrual in adolescent athletes participating in swimming and impact sports for 12-months. Methods This was a 12-month longitudinal study. The sample comprised 91 adolescents (21 females) aged 10 to 18 years, engaged in impact sports (basketball, tennis, track & field, baseball and gymnastics, n = 66) and non-impact sport (swimming, n = 25). The sample was divided according to resistance training participation: impact sports only (n = 45), impact sports + resistance training (n = 21), swimming-only (n = 17) and swimming + resistance training (n = 8). aBMD and soft tissues were measured using dual-energy X-ray absorptiometry. Generalized linear models analysis was used for the resistance training (RT) x type of sport interaction in predicting aBMD changes overtime, adjusting for maturation, sex and baseline aBMD. Results After 12-months, all groups showed a significant increase in aBMD, except for the swimming groups (regardless of resistant training), which showed a significant loss in spine aBMD (-0.045 [-0.085 to -0.004] g/cm2 in swimming-only and − 0.047 [-0.073 to -0.021] g/cm2 in swimming + RT). In comparisons between groups, only swimming + RT group, compared with swimming-only group presented higher upper limbs aBMD (0.096 g/cm2 [0.074 to 0.118] in swimming + RT vs. 0.046 [0.032 to 0.060] g/cm2 in swimming only; p < 0.05) and whole body less head (WBLH) aBMD (0.039 [0.024 to 0.054] g/cm2 in swimming + RT vs. 0.017 [0.007 to 0.027] g/cm2 swimming-only; p < 0.05). Conclusion Despite the significant gain in aBMD in all groups and body sites after 12-months, except for the spine site of swimmers, the results indicate that participation in RT seems to improve aBMD accrual in swimmers at the upper limbs and WBLH.
Marcos Raphael Pereira-Monteiro, José Carlos Aragão-Santos, Alan Bruno Silva Vasconcelos, Antônio Gomes de Resende-Neto, André Filipe Santos de Almeida, Luis Alberto Gobbo, Francisco Hermosilla-Perona, Juan Ramón Heredia-Elvar, Fabricio Boscolo Del Vecchio, Felipe J. Aidar,et al.
MDPI AG
Encouraging healthy aging in postmenopausal women involves advocating for lifestyle modifications, including regular physical exercise like combined training (CT) and functional training (FT). Regarding this population, age-related alterations in body composition, such as decreased muscle mass and heightened adipose tissue, impact health. The aim of this study was to analyze the effects of FT and CT on body recomposition in postmenopausal women. About the methods, we randomly allocated 96 post-menopausal women to the FT, CT, or control group (CG). We measured body composition by bioimpedance and lower limb muscle strength by sit-to-stand test in five repetitions, respectively. The training protocol lasted 16 weeks, and we measured body composition and lower limb muscle strength every 4 weeks, totaling five assessments. Regarding results, we notice that both training groups increased lean mass from the 8th week of training. In addition, a reduction was observed in total fat percentage and an increase in appendicular lean mass from the 12th week of intervention. No differences were found for body mass. Furthermore, only the experimental groups increase muscle strength, starting from the 4th week of training. The conclusion was that FT and CT promote similar adaptations in body recomposition without affecting body mass in postmenopausal women.
Rafael Orbolato, Rômulo Araújo Fernandes, Bruna Camilo Turi-Lynch, Monique Yndawe Castanho Araujo, Izabela dos Santos Ferro, Luis Alberto Gobbo, Everton Alex Carvalho Zanuto, and Jamile Sanches Codogno
FapUNIFESP (SciELO)
Abstract: Leisure-time physical activity seems relevant to prevent the development of chronic diseases and obesity. However, not much is known about the economic burden of these healthy behaviors, mainly in longitudinal designs. This study aimed to analyze the impact of walking and cycling on leisure-time on adiposity and healthcare costs among adults. This longitudinal study was conducted at a medium-size Brazilian city and included 198 participants with no missing data attended in the Brazilian Unified National Health System. Cycling and walking were assessed by a questionnaire with a face-to-face interview at four time-points (baseline, 6-month, 12-month, and 18-month). Healthcare costs were assessed using medical records. Adiposity markers included waist circumference and body fatness. Over the follow-up period, participants who were more engaged in cycling presented lower body fatness (p-value = 0.028) and healthcare costs (p-value = 0.038). However, in the multivariate model, the impact of cycling on costs was not significant (p-value = 0.507) due to the impact of number of chronic diseases (p-value = 0.001). Cycling on leisure-time is inversely related to adiposity in adults, whereas its role on preventing chronic diseases seems the main pathway linking it to cost mitigation.
Vanessa Ribeiro Dos Santos, Bruna Spolador de Alencar Silva, Ricardo Ribeiro Agostinete, Vitor Cabrera Batista, and Luís Alberto Gobbo
Springer Science and Business Media LLC
Analiza M. Silva, Francesco Campa, Silvia Stagi, Luís A. Gobbo, Roberto Buffa, Stefania Toselli, Diego Augusto Santos Silva, Ezequiel M. Gonçalves, Raquel D. Langer, Gil Guerra-Júnior,et al.
Springer Science and Business Media LLC
Pedro Gabriel Pito, Ezequiel Moreira Gonçalves, Vitor Hugo Fernando de Oliveira, Rafael Deminice, Luis Alberto Gobbo, and Débora Alves Guariglia
Elsevier BV
Francesco Campa, Lucas Antonio Colognesi, Tatiana Moro, Antonio Paoli, Andrea Casolo, Leandro Santos, Rafael Ribeiro Correia, Ítalo Ribeiro Lemes, Vinícius Flávio Milanez, Diego Destro Christofaro,et al.
Springer Science and Business Media LLC
AbstractResistance training has been proposed as a valid practice to counteract the aging effect on body mass and its components, which can be easily evaluated though the bioelectrical impedance analysis. This study aimed to achieve a systematic review with meta-analysis on the impact of resistance training on bioelectrical proprieties in older adults.A literature review was done in four electronic databases up to 1 January 2022. The inclusion criteria were: (i) participants aged ≥ 60 years; (ii) resistance training lasted ≥ 8 weeks; (iii) measurement of raw bioelectrical parameters in randomized controlled study designs.The outcomes of the trial had to be bioelectrical phase angle (PhA), resistance (R), and reactance (Xc). The methodological quality was assessed using the Rosendal scale.Overall, seven studies with a total of 344 participants were eligible for the analysis. The quality assessment yielded a score of 71.3%. Bioelectrical PhA (0.52 degree [95%CI 0.32, 0.71], p < 0.001) and Xc (3.58 ohms [95%CI 1.97, 5.19], p < 0.001) increased, whereas R decreased (-28.50 ohms [95%CI -41.39, -15.60], p < 0.001) after the resistance training programs.In this meta-analysis, resistance training promoted increases of PhA, which result from an increase in Xc concomitant with a reduction in R. According to the bioimpedance vector analysis, resistance-trained people experienced a beneficial leftward vector displacement, whilst inactivity induced a rightward vector displacement within the R-Xc graph. In future, more sophisticated and rigorous studies that address specific criteria, methods and targeted designs are required to identify which equipment and protocols allow for an optimization of the resistance training effects.Registration code in PROSPERO: CRD42020168057.
Jefferson M. de Souza, William R. Tebar, Leandro D. Delfino, Fernanda S.G. Tebar, Luis A. Gobbo, Marcia Franco, Claudiele C.M. da Silva, Crystian B.S. Oliveira, and Diego G.D. Christofaro
Elsevier BV
Josefina Bertoli, Ewertton de Souza Bezerra, Kerri M. Winters-Stone, Luis Alberto Gobbo, and Ismael Forte Freitas
Informa UK Limited
Abstract Purpose To evaluate the effects of 24 weeks of Mat Pilates in breast cancer survivors (BCS) undergoing hormone therapy on lower and upper body muscle strength parameters and flexibility. Materials and methods Forty-three BCS (≥40 years) with confirmed breast cancer stage 0–III undergoing hormone therapy were included. Participants were randomized into Mat Pilates (three times/week, 60 min session) or control group (relaxation activities every two weeks). The difficulty and number of exercise repetitions were increased over the weeks. Assessments were performed at three times points (baseline, 12 weeks, and 24 weeks). The generalized estimating equations (GEE) model was used to compare each outcome measure during the analysis of intention to treat (ITT) and “Per protocol analysis” (PPA). Results The Pilates group presented significantly increased (p < 0.05) isometric flexor–extensor PT, and concentric and eccentric flexor PT and mechanical work (MW) after the intervention. Most of the upper body strength parameters, time to achieve maximal force (TFmax), maximal force (F max), and rapid force index (RFI) and right-left upper and lower body flexibility (p < 0.05) also improved. Conclusions From our findings, we conclude that 24 and 12-weeks of Mat Pilates induced strength and flexibility gains for lower and upper body, respectively. Implications for rehabilitation Mat Pilates can be adapted to the fitness level of breast cancer survivors, with a great variety of exercises that can be performed using a mat only or a few pieces of equipment. Patients can practice at home to gain different health benefits (i.e., increasing strength, flexibility, and functional capacity level), which could positively impact on quality of life. Mat Pilates performed three times per week with systematized increments in exercise level, load, and volume throughout the intervention was effective to improve hip extensor–flexor muscles peak torque and mechanical work at different muscle contractions, as well as upper and lower body flexibility. Mat Pilates was also able to improve right-left shoulder abductor and trunk extensor muscles strength parameters after 12 weeks of intervention, as well as both surgery and non-surgery sides of the upper body.
Isis Grigoletto, Vinicius Cavalheri, Luis Alberto Gobbo, Karina Pozo, Enio Rodrigues Maia Filho, Diogo Gonçalves Ribeiro, Nara Ielo, Fabiano Francisco De Lima, and Ercy Mara Cipulo Ramos
JMIR Publications Inc.
Background Lung or head and neck cancers are known for their high prevalence and mortality rates. Chemotherapy and radiotherapy are usually recommended as cancer treatment for these malignancies; however, they can negatively impact both the physical and mental status of patients. Hence, it is reasonable to consider resistance and aerobic exercise training to prevent these negative health outcomes. Further, several factors prevent patients from attending outpatient exercise training programs, and, therefore, a semisupervised home-based exercise training program may be seen as a well-accepted alternative. Objective The aim of this study will be to investigate the effects of a semisupervised home-based exercise training program on physical performance, body composition, and self-reported outcomes; changes in the initial cancer treatment dose prescribed; number of hospitalizations at 3, 6, and 9 months; and 12-month survival in people with primary lung or head and neck cancer. Methods Participants will be randomly allocated to the training group (TG) or control group (CG). The TG will undergo semisupervised home-based resistance and aerobic exercise training throughout their cancer treatment. The resistance training will be performed using elastic bands (TheraBand) twice a week. The aerobic training (ie, brisk walk) will be performed for at least 20 minutes per day outdoors. The equipment and tools used during the training sessions will be provided. This intervention will start the week before treatment commencement, will be performed throughout the duration of the treatment, and will continue for 2 weeks after treatment completion. The CG will undergo usual care (ie, cancer treatment with no formal exercise prescription). Assessments will take place 2 weeks before the beginning of the usual cancer treatment and 2 weeks after treatment completion. The measures of physical function (peripheral muscle strength, functional exercise capacity, and physical activity), body composition, and self-reported outcomes (symptoms of anxiety and depression, health-related quality of life, and symptoms related to the disease and treatment) will be collected. We will report on any change in the initial cancer treatment dose prescribed; number of hospitalizations at 3, 6, and 9 months; and 12-month survival. Results In February 2021, the clinical trial registration was approved. Recruitment and data collection for the trial are ongoing (as of April 2023, 20 participants had already been randomized), and findings of this study are likely to be published late in 2024. Conclusions This exercise training as a complementary treatment for patients with cancer is likely to promote positive effects on the health outcomes assessed, over and above any change in the CG, and prevent the reduction of initial cancer treatment dose prescribed. If these positive effects are shown, they will likely impact long-term outcomes such as hospitalizations and 12-month survival. Trial Registration Brazilian Clinical Trials Registry (ReBEC) RBR-5cyvzh9; https://ensaiosclinicos.gov.br/rg/RBR-5cyvzh9. International Registered Report Identifier (IRRID) PRR1-10.2196/43547
Marcos Raphael Pereira Monteiro, Alan Pantoja Cardoso, Antônio Gomes de Resende-Neto, Alan Bruno Silva Vasconcelos, Enilton Aparecido Camargo, Luis Alberto Gobbo, José Luis Maté-Muñoz, Juan Ramón Heredia-Elvar, David George Behm, and Marzo Edir Da Silva-Grigoletto
Frontiers Media SA
Introduction: Increases in fat mass and reductions in lean mass are associated with the frailty and mortality of older people. In this context, Functional Training (FT) is an option to increase lean mass and reduce fat mass in older people. Thus, this systematic review aims to investigate the effects of FT on body fat and lean mass in older people.Methods: We included randomized controlled clinical trials, with at least one intervention group that employed FT, with the age of participants ≥60 years; and participants physically independent and healthy. We performed the systematic investigation in Pubmed MEDLINE, Scopus, Web of Science, Cochrane Library, and Google Scholar. We extracted the information and used the PEDro Scale to assess the methodological quality of each study.Results: Our research found 3,056 references with five appropriate studies. Of the five studies, three presented reductions in fat mass, all of them with interventions between three and 6 months, different training dose parameters, and 100% of the sample was composed of women. On the other hand, two studies with interventions between 10 and 12 weeks presented conflicting results.Conclusion: Despite the limited literature about lean mass, it appears that long-term FT interventions may reduce fat mass in older women.Clinical Trial Registration:https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=399257, identifier CRD42023399257
Catarina Covolo Scarabottolo, William Rodrigues Tebar, Luis Alberto Gobbo, David Ohara, Aline Duarte Ferreira, Daniel da Silva Canhin, and Diego Giulliano Destro Christofaro
Health and Quality of Life Outcomes Springer Science and Business Media LLC
Abstract Background It is estimated that, worldwide, 9% of deaths occur as a result of insufficient physical activity (PA) practice. Practicing PA can prevent and/or reduce the deleterious effects of different types of diseases and can improve general health aspects related to health-related quality of life (HRQoL). Purpose To analyze the relationship of different PA domains with different HRQoL domains over a two-year period. Methods This is an observational study with a two-year longitudinal design. The sample, composed of adults, was selected from a randomization of the streets of the different regions (north, south, east, west and center) covering individuals from all areas of the city. To assess the practice of PA, the Baecke questionnaire was used. The instrument Medical Outcomes Study SF-36-Item Short Form Health Survey was used to assess the HRQoL domains. Linear regression models were used to analyzed the association of different PA domains with changes in HRQoL. Multivariate statistical models were adjusted for gender, age, socioeconomic status, marital status, the respective PA score at baseline, smoking, body mass index, and morbidity. Results 331 adults were evaluated. There was a decrease in the practice of PA in the occupational domain and an increase in the leisure/locomotion domain. Regarding HRQoL, there was an increase in the scores of body pain and mental health, and a decrease in scores of general health, vitality, social aspects and emotional aspects. The PA practice in the occupational domain was inversely related to functional capacity (β = − 7.2 [CI 95% − 13.0; − 1.4]). The practice of PA through sports in leisure time was positively associated with vitality (β = 5.5 [CI 95% 0.2; 10.7]) and mental health (β = 15.2 [CI 95% 6.8; 23.7]). PA practice during leisure and locomotion was inversely associated with functional capacity (β = − 5.68 [CI 95% − 10.7; − 0.6]) and positively associated with vitality β = 4.8 [CI 95% 0.8; 8.7]) and mental health (β = 8.4 [CI 95% 2.0; 14.9]). The total PA practice was inversely associated with functional capacity (β = − 3.8 [CI 95% − 6.5; − 1.2]) and positively associated with pain in the body (β = 4.9 [CI 95% 0.3; 9.4]), vitality (β = 2.9 [CI 95% 0.7; 5.0]) and mental health (β = 5.7 [CI 95% 2.2; 9.2]). Conclusions It is suggested that practicing PA continuously within a period of two years can positively affect some physical aspects and some mental aspects related to HRQoL, but not all of them. A strategy for public policy actions is to explore these variables by domain and thus detect the real needs and improvements that can be made for the population.
Jefferson M. de Souza, William R. Tebar, Leandro D. Delfino, Fernanda S.G. Tebar, Luis A. Gobbo, Rafael Z. Pinto, Claudiele C.M. da Silva, Crystian B.S. Oliveira, and Diego G.D. Christofaro
Elsevier BV
Witalo Kassiano, Bruna Costa, João Pedro Nunes, Letícia T. Cyrino, Matheus A. Nascimento, Crisieli Tomeleri, Melissa Antunes, Luís A. Gobbo, Alex S. Ribeiro, Manuel J. Coelho-e-Silva,et al.
Elsevier BV
Josefina Bertoli, Ewertton de Souza Bezerra, Andréa Dias Reis, Êmili Amice da Costa Barros, Luis Alberto Gobbo, and Ismael Forte Freitas Júnior
Ovid Technologies (Wolters Kluwer Health)
Abstract Bertoli, J, de Souza Bezerra, E, Dias Reis, A, Amice da Costa Barros, E, Gobbo, LA, and Forte Freitas Júnior, I. Long-term side effects of breast cancer on force production parameters. J Strength Cond Res 36(5): 1450–1458, 2022—Breast cancer treatments have long-term side effects, which are associated with muscle strength reduction, negatively affecting the quality of life and increasing the chances of a sedentary life style. The aim of this study was to analyze the effects of types of surgery and hormone therapy on muscle strength parameters in breast cancer survivors compared to women without cancer (control). Eighty-three women, 42 breast cancer survivors and 41 control women, volunteered to participate in this study. Subjects performed maximal isometric voluntary contractions, so that force parameters of the right and left shoulder abductor, trunk extensor, and preferred knee extensor-flexor muscles could be evaluated. Overall, breast cancer survivors presented a lower absolute and normalized maximal force (Fmax) for all muscle groups compared with control. The right shoulder abductor muscles of breast cancer survivors presented a significantly lower absolute and normalized rapid force index (RFI) than control. When compared according to hormone therapy treatment, in breast cancer survivors undergoing aromatase inhibitor, all strength parameters except for normalized RFI demonstrated lower values for the right and left shoulder abductors, trunk, and knee extensors compared with control and tamoxifen. When separated by surgery type, breast cancer survivors who underwent quadrantectomy and radical mastectomy presented lower values for some strength parameters for the left and right shoulder abductors, except for trunk extensor muscles, in which quadrantectomy and total mastectomy presented lower strength parameters. It is recommended that breast cancer survivors should be encouraged to perform supervised strength training programs for different muscle groups to improve Fmax and RFI, aiming to reduce muscle weakness and pain, and improve functional capacity and quality of life.
Francesco Campa, Luis Alberto Gobbo, Silvia Stagi, Leticia Trindade Cyrino, Stefania Toselli, Elisabetta Marini, and Giuseppe Coratella
Springer Science and Business Media LLC