Joao Manuel Cunha Rodrigues

@cqm.uma.pt

- Departamento de Química/Faculdade de Ciências Exactas e da Engenharia - Centro de Química da Madeira
Universidade da Madeira



                       

https://researchid.co/rodriguesjmcr
38

Scopus Publications

2236

Scholar Citations

13

Scholar h-index

28

Scholar i10-index

Scopus Publications

  • Stabilization of metal-doped magnesium oxide nanoparticles with PAMAM dendrimers to improve alpha-amylase enzyme inhibition
    Jaison Jeevanandam, Mara Gonçalves, Rita Castro, Juan Gallo, Manuel Bañobre-López, and João Rodrigues
    Elsevier BV

  • Conjugation of PDLA onto MgO microspheres: comparison between solution grafting and melt grafting methods
    Wenhao Yu, Dong Zhou, Fangrui Liu, Xu Li, Lan Xiao, Muhammad Rafique, Zhiyong Li, João Rodrigues, Ruilong Sheng, and Yulin Li
    Royal Society of Chemistry (RSC)
    MgO microspheres modified by solution and melt grafting methods were used to assess the effect of reaction temperature on the PDLA graft ratio, resulting in varied surface morphologies and controllable degradability when analyzed by kinetic modeling.

  • Bioinspired hybrid DNA/dendrimer-based films with supramolecular chirality
    Rita Castro, Pedro L. Granja, João Rodrigues, Ana Paula Pêgo, and Helena Tomás
    Royal Society of Chemistry (RSC)
    Hybrid DNA/dendrimer films were obtained by heating dsDNA above its Tm and, while in the denatured state, mixing it with dendrimers, followed by controlled cooling. Films are stable, cytocompatible and show evidence of supramolecular chirality.



  • Blood-brain barrier-crossing dendrimers for glioma theranostics
    Jinxia Wang, Zhiqiang Wang, Guixiang Zhang, João Rodrigues, Helena Tomás, Xiangyang Shi, and Mingwu Shen
    Royal Society of Chemistry (RSC)
    Blood–brain barrier-crossing dendrimers for glioma imaging diagnostics, chemotherapy, gene therapy, or imaging-guided therapy have been concisely reviewed with perspectives briefly discussed.

  • Poly(alkylideneamine) Dendrimer Nanogels Codeliver Drug and Nucleotide To Alleviate Anticancer Drug Resistance through Immunomodulation
    Yue Gao, Zhijun Ouyang, Gaoming Li, Qiuyu Yu, Waicong Dai, João Rodrigues, Andrij Pich, Meera Moydeen Abdul Hameed, Mingwu Shen, and Xiangyang Shi
    American Chemical Society (ACS)

  • Recent advances in nanogels composed of dendrimers to tackle cancer
    Xianghao Xiao, Yue Gao, Ivan Stoikov, Dzmitry Shcharbin, João Rodrigues, Mingwu Shen, and Xiangyang Shi
    Informa UK Limited

  • Natural alkaloids from Dicranostigma leptopodum (Maxim.) Fedde and their G5. NHAc-PBA dendrimer-alkaloid complexes for targeting chemotherapy in breast cancer MCF-7 cells
    Ye Tian, Zhiqiang Wang, Xu Xu, Yunqi Guo, Yanni Ma, Yanqi Lu, Mingwu Shen, Yang Geng, Helena Tomás, João Rodrigues,et al.
    Informa UK Limited
    Herein, we isolated five natural alkaloids, iso-corydine (iso-CORY), corydine (CORY), sanguinarine (SAN), chelerythrine (CHE) and magnoflorine (MAG), from traditional medicinal herb Dicranostigma leptopodum (Maxim.) Fedde (whole herb) and elucidated their structures. Then we synthesised G5. NHAc-PBA as targeting dendrimer platform to encapsulate the alkaloids into G5. NHAc-PBA-alkaloid complexes, which demonstrated alkaloid-dependent positive zeta potential and hydrodynamic particle size. G5. NHAc-PBA-alkaloid complexes demonstrated obvious breast cancer MCF-7 cell targeting effect. Among the G5. NHAc-PBA-alkaloid complexes, G5.NHAc-PBA-CHE (IC50=13.66 μM) demonstrated the highest MCF-7 cell inhibition capability and G5.NHAc-PBA-MAG (IC50=24.63 μM) had equivalent inhibitory effects on cell proliferation that comparable to the level of free MAG (IC50=23.74 μM), which made them the potential breast cancer targeting formulation for chemotherapeutic application. This work successfully demonstrated a pharmaceutical research model of 'natural bioactive product isolation-drug formulation preparation-breast cancer cell targeting inhibition'.

  • Smart stimuli-responsive strategies for titanium implant functionalization in bone regeneration and therapeutics
    Jinkai Zhang, Yu Zhuang, Ruilong Sheng, Helena Tomás, João Rodrigues, Guangyin Yuan, Xudong Wang, and Kaili Lin
    Royal Society of Chemistry (RSC)
    Schematic summary of various smart stimuli-responsive strategies applied for titanium implant functionalization.

  • Enhanced alpha-amylase inhibition activity of amine-terminated PAMAM dendrimer stabilized pure copper-doped magnesium oxide nanoparticles
    Jaison Jeevanandam, Mara Gonçalves, Rita Castro, Juan Gallo, Manuel Bañobre-López, and João Rodrigues
    Elsevier BV

  • Redox-Responsive Dendrimer Nanogels Enable Ultrasound-Enhanced Chemoimmunotherapy of Pancreatic Cancer via Endoplasmic Reticulum Stress Amplification and Macrophage Polarization
    Guizhi Zhang, Mengsi Zhan, Changchang Zhang, Zhiqiang Wang, Huxiao Sun, Yuchen Tao, Qiusheng Shi, Meijuan He, Han Wang, João Rodrigues,et al.
    Wiley
    Developing a multifunctional nanoplatform to achieve efficient theranostics of tumors through multi-pronged strategies remains to be challenging. Here, the design of the intelligent redox-responsive generation 3 (G3) poly(amidoamine) dendrimer nanogels (NGs) loaded with gold nanoparticles (Au NPs) and chemotherapeutic drug toyocamycin (Au/Toy@G3 NGs) for ultrasound-enhanced cancer theranostics is showcased. The constructed hybrid NGs with a size of 193 nm possess good colloidal stability under physiological conditions, and can be dissociated to release Au NPs and Toy in the reductive glutathione-rich tumor microenvironment (TME). The released Toy can promote the apoptosis of cancer cells through endoplasmic reticulum stress amplification and cause immunogenic cell death to maturate dendritic cells. The loaded Au NPs can induce the conversion of tumor-associated macrophages from M2-type to antitumor M1-type to remodulate the immunosuppressive TME. Combined with antibody-mediated immune checkpoint blockade, effective chemoimmunotherapy of a pancreatic tumor mouse model can be realized, and the chemoimmunotherapy effect can be further ultrasound enhanced due to the sonoporation-improved tumor permeability of NGs. The developed Au/Toy@G3 NGs also enable Au-mediated computed tomography imaging of tumors. The constructed responsive dendrimeric NGs tackle tumors through a multi-pronged chemoimmunotherapy strategy targeting both cancer cells and immune cells, which hold a promising potential for clinical translations.

  • Carbon dots and dendrimers nanohybrids: from synthesis to applications
    Ivo J. Martins, Helena Tomás, and João Rodrigues
    Elsevier BV

  • Toward public security monitoring: A perspective of optical molecular probes for phosgene and mustard gas detection
    Xichao Hu, Yingjun Ke, Huan Ye, Beitong Zhu, João Rodrigues, and Ruilong Sheng
    Elsevier BV

  • Target-Specific Delivery and Bioavailability of Pharmaceuticals via Janus and Dendrimer Particles
    Jaison Jeevanandam, Kei Xian Tan, João Rodrigues, and Michael K. Danquah
    MDPI AG
    Nanosized Janus and dendrimer particles have emerged as promising nanocarriers for the target-specific delivery and improved bioavailability of pharmaceuticals. Janus particles, with two distinct regions exhibiting different physical and chemical properties, provide a unique platform for the simultaneous delivery of multiple drugs or tissue-specific targeting. Conversely, dendrimers are branched, nanoscale polymers with well-defined surface functionalities that can be designed for improved drug targeting and release. Both Janus particles and dendrimers have demonstrated their potential to improve the solubility and stability of poorly water-soluble drugs, increase the intracellular uptake of drugs, and reduce their toxicity by controlling the release rate. The surface functionalities of these nanocarriers can be tailored to specific targets, such as overexpressed receptors on cancer cells, leading to enhanced drug efficacy The design of these nanocarriers can be optimized by tuning the size, shape, and surface functionalities, among other parameters. The incorporation of Janus and dendrimer particles into composite materials to create hybrid systems for enhancing drug delivery, leveraging the unique properties and functionalities of both materials, can offer promising outcomes. Nanosized Janus and dendrimer particles hold great promise for the delivery and improved bioavailability of pharmaceuticals. Further research is required to optimize these nanocarriers and bring them to the clinical setting to treat various diseases. This article discusses various nanosized Janus and dendrimer particles for target-specific delivery and bioavailability of pharmaceuticals. In addition, the development of Janus-dendrimer hybrid nanoparticles to address some limitations of standalone nanosized Janus and dendrimer particles is discussed.

  • Dendrimer-mediated gene delivery to boost cancer immunotherapy
    Mengsi Zhan, Huxiao Sun, Joao Rodrigues, Dzmitry Shcharbin, Mingwu Shen, and Xiangyang Shi
    Future Medicine Ltd

  • Biological Effects in Cancer Cells of Mono- and Bidentate Conjugation of Cisplatin on PAMAM Dendrimers: A Comparative Study
    Cláudia Camacho, Dina Maciel, Helena Tomás, and João Rodrigues
    MDPI AG
    Cisplatin (cis-diamminedichloroplatinum(II)) is a potent chemotherapeutic agent commonly used to treat cancer. However, its use also leads to serious side effects, such as nephrotoxicity, ototoxicity, and cardiotoxicity, which limit the dose that can be safely administered to patients. To minimize these problems, dendrimers may be used as carriers for cisplatin through the coordination of their terminal functional groups to platinum. Here, cisplatin was conjugated to half-generation anionic PAMAM dendrimers in mono- and bidentate forms, and their biological effects were assessed in vitro. After preparation and characterization of the metallodendrimers, their cytotoxicity was evaluated against several cancer cell lines (A2780, A2780cisR, MCF-7, and CACO-2 cells) and a non-cancer cell line (BJ cells). The results showed that all the metallodendrimers were cytotoxic and that the cytotoxicity level depended on the cell line and the type of coordination mode (mono- or bidentate). Although, in this study, a correlation between dendrimer generation (number of carried metallic fragments) and cytotoxicity could not be completely established, the monodentate coordination form of cisplatin resulted in lower IC50 values, thus revealing a more accessible cisplatin release from the dendritic scaffold. Moreover, most of the metallodendrimers were more potent than the cisplatin, especially for the A2780 and A2780cisR cell lines, which showed higher selectivity than for non-cancer cells (BJ cells). The monodentate G0.5COO(Pt(NH3)2Cl)8 and G2.5COO(Pt(NH3)2Cl)32 metallodendrimers, as well as the bidentate G2.5COO(Pt(NH3)2)16 metallodendrimer, were even more active towards the cisplatin-resistant cell line (A2780cisR cells) than the correspondent cisplatin-sensitive one (A2780 cells). Finally, the effect of the metallodendrimers on the hemolysis of human erythrocytes was neglectable, and metallodendrimers’ interaction with calf thymus DNA seemed to be stronger than that of free cisplatin.

  • Cellulose-based bionanocomposites: Synthesis, properties, and applications
    Jaison Jeevanandam, João Rodrigues, Sharadwata Pan, and Michael K. Danquah
    Elsevier

  • New insights into ruthenium(ii) metallodendrimers as anticancer drug nanocarriers: from synthesis to preclinic behaviour
    Dina Maciel, Nádia Nunes, Francisco Santos, Yu Fan, Gaoming Li, Mingwu Shen, Helena Tomás, Xiangyang Shi, and João Rodrigues
    Royal Society of Chemistry (RSC)
    Pre-clinical results highlight the potential of the low-generation poly(alkylidenamine)-based dendrimers as ruthenium metallodrug nanocarriers.

  • Modulation of Macrophages Using Nanoformulations with Curcumin to Treat Inflammatory Diseases: A Concise Review
    Huxiao Sun, Mengsi Zhan, Serge Mignani, Dzmitry Shcharbin, Jean-Pierre Majoral, João Rodrigues, Xiangyang Shi, and Mingwu Shen
    MDPI AG
    Curcumin (Cur), a traditional Chinese medicine extracted from natural plant rhizomes, has become a candidate drug for the treatment of diseases due to its anti-inflammatory, anticancer, antioxidant, and antibacterial activities. However, the poor water solubility and low bioavailability of Cur limit its therapeutic effects for clinical applications. A variety of nanocarriers have been successfully developed to improve the water solubility, in vivo distribution, and pharmacokinetics of Cur, as well as to enhance the ability of Cur to polarize macrophages and relieve macrophage oxidative stress or anti-apoptosis, thus accelerating the therapeutic effects of Cur on inflammatory diseases. Herein, we review the design and development of diverse Cur nanoformulations in recent years and introduce the biomedical applications and potential therapeutic mechanisms of Cur nanoformulations in common inflammatory diseases, such as arthritis, neurodegenerative diseases, respiratory diseases, and ulcerative colitis, by regulating macrophage behaviors. Finally, the perspectives of the design and preparation of future nanocarriers aimed at efficiently exerting the biological activity of Cur are briefly discussed.

  • Synthesis approach-dependent antiviral properties of silver nanoparticles and nanocomposites
    Jaison Jeevanandam, Saravanan Krishnan, Yiik Siang Hii, Sharadwata Pan, Yen San Chan, Caleb Acquah, Michael K. Danquah, and João Rodrigues
    Springer Science and Business Media LLC

  • Molecular engineered optical probes for chemical warfare agents and their mimics: Advances, challenges and perspectives
    Beitong Zhu, Ruilong Sheng, Tianhong Chen, João Rodrigues, Qin-Hua Song, Xichao Hu, and Lintao Zeng
    Elsevier BV

  • Medical applications of biopolymer nanofibers
    Jaison Jeevanandam, Sharadwata Pan, João Rodrigues, M. Abd Elkodous, and Michael K. Danquah
    Royal Society of Chemistry (RSC)
    This review is an overview of various biopolymer nanofibers and their distinct synthesis approaches. Further, the medical applications of biopolymer nanofibers, including drug delivery systems and biosensor fabrication, are also discussed.

  • Development and challenges of cells- and materials-based tooth regeneration
    Zeyu Fu, Yu Zhuang, Jinjie Cui, Ruilong Sheng, Helena Tomás, João Rodrigues, Bin Zhao, Xudong Wang, and Kaili Lin
    Elsevier BV

  • Dendrimer nanoplatforms for veterinary medicine applications: A concise overview
    Serge Mignani, Xiangyang Shi, João Rodrigues, Helena Tomás, and Jean-Pierre Majoral
    Elsevier BV

RECENT SCHOLAR PUBLICATIONS

  • Nanomedicines for the treatment of ischemic stroke: an overview of recent advances
    S Geng, C Zhang, J Rodrigues, D Shcharbin, S Mignani, JP Majoral, ...
    Precision Medicine and Engineering, 100022 2025

  • Stabilization of metal-doped magnesium oxide nanoparticles with PAMAM dendrimers to improve alpha-amylase enzyme inhibition
    J Jeevanandam, M Gonalves, R Castro, J Gallo, M Baobre-Lpez, ...
    Materials Today Bio, 101520 2025

  • Gelatin-based ballistic gel formulated with phytosynthesized nanocellulose from Arundo donax for alpha-amylase enzyme inhibition activity
    J Jeevanandam, R Castro, J Rodrigues
    Carbohydrate Polymer Technologies and Applications 8, 100575 2024

  • Recent advances in nanogels composed of dendrimers to tackle cancer
    X Xiao, Y Gao, I Stoikov, D Shcharbin, J Rodrigues, M Shen, X Shi
    Nanomedicine 19 (13), 1117-1121 2024

  • Sustainable synthesis of bionanomaterials using non-native plant extracts for maintaining ecological balance: A computational bibliography analysis
    J Jeevanandam, J Rodrigues
    Journal of Environmental Management 358, 120892 2024

  • Natural alkaloids from Dicranostigma leptopodum (Maxim.) Fedde and their G5. NHAc-PBA dendrimer-alkaloid complexes for targeting chemotherapy in breast
    Y Tian, Z Wang, X Xu, Y Guo, Y Ma, Y Lu, M Shen, Y Geng, H Toms, ...
    Natural Product Research, 1-18 2024

  • Poly (alkylideneamine) Dendrimer Nanogels Codeliver Drug and Nucleotide To Alleviate Anticancer Drug Resistance through Immunomodulation
    Y Gao, Z Ouyang, G Li, Q Yu, W Dai, J Rodrigues, A Pich, ...
    ACS Materials Letters 6 (2), 517-527 2024

  • Blood–brain barrier-crossing dendrimers for glioma theranostics
    J Wang, Z Wang, G Zhang, J Rodrigues, H Toms, X Shi, M Shen
    Biomaterials Science 2024

  • Smart stimuli-responsive strategies for titanium implant functionalization in bone regeneration and therapeutics
    J Zhang, Y Zhuang, R Sheng, H Toms, J Rodrigues, G Yuan, X Wang, ...
    Materials Horizons 11 (1), 12-36 2024

  • Cellulose-based bionanocomposites: Synthesis, properties, and applications
    J Jeevanandam, J Rodrigues, S Pan, MK Danquah
    Advances in Bionanocomposites, 191-210 2024

  • Carbon dots and dendrimers nanohybrids: From synthesis to applications
    IJ Martins, H Toms, J Rodrigues
    Materials Today Chemistry 32, 101662 2023

  • Redox-Responsive Dendrimer Nanogels Enable Ultrasound-Enhanced Chemoimmunotherapy of Pancreatic Cancer via Endoplasmic Reticulum Stress Amplification and Macrophage Polarization
    G Zhang, M Zhan, C Zhang, Z Wang, H Sun, Y Tao, Q Shi, M He, H Wang, ...
    Advanced Science, 2301759 2023

  • State-of-the-art rational nanodesign: from screening to theranostics and from bench to clinic
    A Fernandez-Fernandez, R Manchanda, JM Cunha Rodrigues, Y Tang
    Frontiers in Pharmacology 14, 1210185 2023

  • Biological Effects in Cancer Cells of Mono-and Bidentate Conjugation of Cisplatin on PAMAM Dendrimers: A Comparative Study
    C Camacho, D Maciel, H Toms, J Rodrigues
    Pharmaceutics 15 (2), 689 2023

  • Enhanced alpha-amylase inhibition activity of amine-terminated PAMAM dendrimer stabilized pure copper-doped magnesium oxide nanoparticles
    J Jeevanandam, M Gonalves, R Castro, J Gallo, M Baobre-Lpez, ...
    Biomaterials Advances 153, 213535 2023

  • Dendrimer-mediated gene delivery to boost cancer immunotherapy
    M Zhan, H Sun, J Rodrigues, D Shcharbin, M Shen, X Shi
    Nanomedicine, 0124 2023

  • Target-Specific Delivery and Bioavailability of Pharmaceuticals via Janus and Dendrimer Particles
    J Jeevanandam, KX Tan, J Rodrigues, MK Danquah
    Pharmaceutics 15, 1614 2023

  • Toward Public Security Monitoring: A Perspective of Optical Molecular Probes for Phosgene and Mustard Gas Detection
    X Hu, Y Ke, H Ye, B Zhu, J Rodrigues, R Sheng
    Dyes and Pigments 216, 111379 2023

  • Dendrimers and dendrimer-based nano-objects for oncology applications
    H Tomas, J Rodrigues
    New Trends in Smart Nanostructured Biomaterials in Health Sciences, 41-78 2023

  • Aptamer-Mediated Antiviral Approaches for SARS-CoV-2
    KX Tan, J Jeevanandam, J Rodrigues, MK Danquah
    Frontiers in Bioscience-Landmark 27 (11), 306 2022

MOST CITED SCHOLAR PUBLICATIONS

  • Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications
    Y Li, J Rodrigues, H Toms
    Chem. Soc. Rev. 41 (6), 2193-2221 2012
    Citations: 1501

  • Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery
    Y Li, D Maciel, J Rodrigues, X Shi, H Tomás
    Chemical Reviews 115, 8564–8608 2015
    Citations: 486

  • Laponite: A key nanoplatform for biomedical applications?
    H Toms, CS Alves, J Rodrigues
    Nanomedicine: Nanotechnology, Biology and Medicine 14, 2407-2420 2018
    Citations: 335

  • Green approaches for the synthesis of metal and metal oxide nanoparticles using microbial and plant extracts
    J Jeevanandam, SF Kiew, SB Ansah, SY Lau, A Barhoum, MK Danquah, ...
    Nanoscale 14, 2525-2533 2022
    Citations: 315

  • Functionalization of poly (amidoamine) dendrimers with hydrophobic chains for improved gene delivery in mesenchymal stem cells
    JL Santos, H Oliveira, D Pandita, J Rodrigues, AP Pgo, PL Granja, ...
    Journal of Controlled Release 144 (1), 55-64 2010
    Citations: 236

  • Dendrimers in combination with natural products and analogues as anti-cancer agents
    S Mignani, J Rodrigues, H Tomas, M Zablocka, X Shi, AM Caminade, ...
    Chemical Society Reviews 47, 514-532 2018
    Citations: 198

  • Non-viral gene delivery to mesenchymal stem cells: methods, strategies and application in bone tissue engineering and regeneration
    J L Santos, D Pandita, J Rodrigues, A P Pego, P L Granja, H Toms
    Current gene therapy 11 (1), 46-57 2011
    Citations: 177

  • Redox-responsive alginate nanogels with enhanced anticancer cytotoxicity
    D Maciel, P Figueira, S Xiao, D Hu, X Shi, J Rodrigues, H Toms, Y Li
    Biomacromolecules 14, 3140–3146 2013
    Citations: 175

  • Thermo/redox/pH-triple sensitive poly (N-isopropylacrylamide-co-acrylic acid) nanogels for anticancer drug delivery
    Y Zhan, M Gonalves, P Yi, D Capelo, Y Zhang, J Rodrigues, C Liu, ...
    Journal of Materials Chemistry B 3 (20), 4221-4230 2015
    Citations: 140

  • Receptor-mediated gene delivery using PAMAM dendrimers conjugated with peptides recognized by mesenchymal stem cells
    JL Santos, D Pandita, J Rodrigues, AP Pgo, PL Granja, G Balian, ...
    Molecular pharmaceutics 7 (3), 763-774 2010
    Citations: 133

  • Polysaccharide-based nanomedicines for cancer immunotherapy: A review
    Y Zeng, Y Xiang, R Sheng, H Toms, J Rodrigues, Z Gu, H Zhang, ...
    Bioactive Materials 6 (10), 3358-3382 2021
    Citations: 127

  • Present drug-likeness filters in medicinal chemistry during the hit and lead optimization process: how far can they be simplified?
    S Mignani, J Rodrigues, H Tomas, R Jalal, PP Singh, JP Majoral, ...
    Drug Discovery Today 23, 605-615 2018
    Citations: 127

  • RGD peptide-modified multifunctional dendrimer platform for drug encapsulation and targeted inhibition of cancer cells
    X He, CS Alves, N Oliveira, J Rodrigues, J Zhu, I Bnyai, H Toms, X Shi
    Colloids and Surfaces B: Biointerfaces 125, 82-89 2015
    Citations: 124

  • pH-sensitive Laponite/doxorubicin/alginate nanohybrids with improved anticancer efficacy
    M Gonalves, P Figueira, D Maciel, J Rodrigues, X Qu, C Liu, H Toms, ...
    Acta biomaterialia 10, 300-307 2014
    Citations: 112

  • Gene Delivery into Mesenchymal Stem Cells: A Biomimetic Approach Using RGD Nanoclusters Based on Poly (amidoamine) Dendrimers
    D Pandita, JL Santos, J Rodrigues, AP Pgo, PL Granja, H Toms
    Biomacromolecules 12 (2), 472-481 2011
    Citations: 110

  • Multifunctional Dendrimer-Entrapped Gold Nanoparticles Conjugated with Doxorubicin for pH-Responsive Drug Delivery and Targeted Computed Tomography Imaging
    J Zhu, G Wang, CS Alves, H Toms, Z Xiong, M Shen, J Rodrigues, S X.
    Langmuir 34 (41), 12428–12435 2018
    Citations: 107

  • Why and how have drug discovery strategies in pharma changed? What are the new mindsets?
    S Mignani, S Huber, H Toms, J Rodrigues, JP Majoral
    Drug discovery today 21 (2), 239-249 2016
    Citations: 107

  • Amphiphilic polymer-mediated formation of laponite-based nanohybrids with robust stability and pH sensitivity for anticancer drug delivery
    G Wang, D Maciel, Y Wu, J Rodrigues, X Shi, Y Yuan, C Liu, H Toms, ...
    ACS applied materials & interfaces 6 (19), 16687-16695 2014
    Citations: 98

  • PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal brain ischemia
    SD Santos, M Xavier, DM Leite, DA Moreira, B Custdio, M Torrado, ...
    Journal of Controlled Release 291, 65-79 2018
    Citations: 96

  • Dendrimer-Assisted Formation of Fluorescent Nanogels for Drug Delivery and Intracellular Imaging
    M Gonalves, D Maciel, D Caplo, S Xiao, W Sun, X Shi, J Rodrigues, ...
    Biomacromolecules 15, 492–499 2014
    Citations: 95