Dr. Bhuvaneswari C
@pmchri.ac.in
Associate Professor and Anatomy
Panimalar Medical College Hospital and Reserach Institute
Mrs. Bhuvaneswari C has more than 17+ years of teaching, including 5 years of research experience in the field of Anatomy. I did my PhD in Medical Anatomy from SRM Medical college hospital and research institute, Chennai, MSc in Human Anatomy at Mudaliar PG institute of basic medical science (IBMS), Taramani, University Madras in the 2002. My field of interest includes Osteoporosis and herbal drug discovery. I worked in grades of Tutor, Assistant professor and Associate professor in Department of Anatomy, SRM medical college hospital and research centre, Potheri, Kanchipuram dist. and working at Panimalar Medical College and reserach institute. Currently I'm fascinated towards research on the effect of medicinal plants on osteoporosis, which made me to take over this research area.
EDUCATION
Ph.D in Medical Anatomy
MSc in Anatomy
BSc in Zooology
RESEARCH, TEACHING, or OTHER INTERESTS
Anatomy, Multidisciplinary, Drug Guides, Plant Science
FUTURE PROJECTS
IMMUNO HISTOLOGICAL EVIDENCE OF ORMOCARPUM SENNOIDES EXTRACT IN THE EXPRESSION OF BAX AND BCL2 IN WISTER RATS WITH GLUCOCORTICOID INDUCED OSTEOPOROSIS
Objective: Evaluate the effect of Ormocarpum sennoides through immunohistological evidence in the expression of Bax and Bcl2 in glucocorticoid induced Osteoporosis in Wister rats Method: Rats were divided into five groups (Control, MPA(Osteoporosis), Alendronate (2mg/kg), 100mg (EOS) and 200mg (EOS). The treatment were conducted for 45 days the Bax and Bcl2 expression were evaluated in osteoclast of distal femur diaphysis.
Applications Invited
Funding / Research fellow
Scopus Publications
Scholar Citations
Scholar h-index
Scopus Publications
K. Pugazharasi, Bhuvaneswari Srinivasan, Anandh Nagarajan, and I. Govindharaj
Elsevier BV
Bhuvaneswari C. Srinivasan and Radhika Krishnan
Medknow
Introduction: Glucocorticoid therapy is the most common cause for secondary osteoporosis leading to a resurgence of interest in traditional medicine that could have bone sparing effects by naturally occurring bioactive molecules. Therefore, this study was done to evaluate the effect of Ormocarpum sennoides DC through immunohistological evidence in the expression of Bax and Bcl2 in glucocorticoid-induced Osteoporosis in Wister albino rats. Materials and Methods: Rats were divided into five groups (Control, MPA (Osteoporosis), Alendronate (2 mg/kg), 100 mg (EOS), and 200 mg (EOS). The treatment was conducted for 45 days the Bax and Bcl2 expressions were evaluated in osteoclast of distal femur diaphysis. Results: When compared the MPA to control group (P < 0.05) Bax increased and Bcl2 reduced, when compared with MPA (P < 0.05) Alendronate, EOS 100 mg and EOS 200 mg increased the Bcl2 expressions, Alendronate, EOS 100 mg, and EOS 200 mg reduced the Bax expression. Discussion and Conclusion: EOS 100 mg and EOS 200 mg increased Bcl2 expression and reduced the Bax expression Ormocarpum sennoides prevents glucocorticoid-induced Apoptosis of preosteoblast; therefore, Bcl2 may be an important regulator of bone growth thus reporting antiapoptotic property of Ormocarpum sennoides DC.