Ryosuke Hanaya

Verified email at m2.kufm.kagoshima-u.ac.jp

Department of Neurosurgery
Kagoshima University



                       

https://researchid.co/ryosukehanaya

RESEARCH INTERESTS

neurosurgery, epilepsy surgery

103

Scopus Publications

Scopus Publications

  • Risk factors for psychological distress in electroencephalography technicians during the COVID-19 pandemic: A national-level cross-sectional survey in Japan
    Naoto Kuroda, Takafumi Kubota, Toru Horinouchi, Naoki Ikegaya, Yu Kitazawa, Satoshi Kodama, Teppei Matsubara, Naoto Nagino, Shuichiro Neshige, Temma Soga, Daichi Sone, Yutaro Takayama, Izumi Kuramochi, Kousuke Kanemoto, Akio Ikeda, Kiyohito Terada, Hiroko Goji, Shinji Ohara, Koichi Hagiwara, Takashi Kamada, Koji Iida, Nobutsune Ishikawa, Hideaki Shiraishi, Osato Iwata, Hidenori Sugano, Yasushi Iimura, Takuichiro Higashi, Hiroshi Hosoyama, Ryosuke Hanaya, Akihiro Shimotake, Takayuki Kikuchi, Takeshi Yoshida, Hiroshi Shigeto, Jun Yokoyama, Takahiko Mukaino, Masaaki Kato, Masanori Sekimoto, Masahiro Mizobuchi, Yoko Aburakawa, Masaki Iwasaki, Eiji Nakagawa, Tomohiro Iwata, Kentaro Tokumoto, Takuji Nishida, Yukitoshi Takahashi, Kenjiro Kikuchi, Ryuki Matsuura, Shin-ichiro Hamano, Hideo Yamanouchi, Satsuki Watanabe, Ayataka Fujimoto, Hideo Enoki, Kyoichi Tomoto, Masako Watanabe, Youji Takubo, Toshihiko Fukuchi, Hidetoshi Nakamoto, Yuichi Kubota, Naoto Kunii, Yuichiro Shirota, Eiichi Ishikawa, Nobukazu Nakasato, Taketoshi Maehara, Motoki Inaji, Shunsuke Takagi, Takashi Enokizono, Yosuke Masuda, and Takahiro Hayashi

    Epilepsy and Behavior, ISSN: 15255050, eISSN: 15255069, Volume: 125, Published: December 2021 Elsevier BV

  • Radiological comparison of the midpoint of the nasion-inion line and the external auditory canal for measuring the cranial center of the gravity-sagittal vertical axis
    Ryutaro Makino, Hitoshi Yamahata, Masanori Yonenaga, Shingo Fujio, Nayuta Higa, Ryosuke Hanaya, and Koji Yoshimoto

    Interdisciplinary Neurosurgery: Advanced Techniques and Case Management, eISSN: 22147519, Published: December 2021 Elsevier BV

  • Initiating an epilepsy surgery program with limited resources in Indonesia
    Muhamad Thohar Arifin, Ryosuke Hanaya, Yuriz Bakhtiar, Aris Catur Bintoro, Koji Iida, Kaoru Kurisu, Kazunori Arita, Jacob Bunyamin, Rofat Askoro, Surya Pratama Brilliantika, Novita Ikbar Khairunnisa, and Zainal Muttaqin

    Scientific Reports, eISSN: 20452322, Published: December 2021 Springer Science and Business Media LLC
    AbstractTo share the experiences of organizing the epilepsy surgery program in Indonesia. This study was divided into two periods based on the presurgical evaluation method: the first period (1999–2004), when interictal electroencephalogram (EEG) and magnetic resonance imaging (MRI) were used mainly for confirmation, and the second period (2005–2017), when long-term non-invasive and invasive video-EEG was involved in the evaluation. Long-term outcomes were recorded up to December 2019 based on the Engel scale. All 65 surgical recruits in the first period possessed temporal lobe epilepsy (TLE), while 524 patients were treated in the second period. In the first period, 76.8%, 16.1%, and 7.1% of patients with TLE achieved Classes I, II, and III, respectively, and in the second period, 89.4%, 5.5%, and 4.9% achieved Classes I, II, and III, respectively, alongside Class IV, at 0.3%. The overall median survival times for patients with focal impaired awareness seizures (FIAS), focal to bilateral tonic–clonic seizures and generalized tonic–clonic seizures were 9, 11 and 11 years (95% CI: 8.170–9.830, 10.170–11.830, and 7.265–14.735), respectively, with p = 0.04. The utilization of stringent and selective criteria to reserve surgeries is important for a successful epilepsy program with limited resources.

  • The Incidence of Depressed Skull Fractures Due to the Use of Pin-Type Head Frame Systems in the Adult Population: 10-year Experience of a Single Neurosurgical Center
    Takaaki Hiwatari, Hitoshi Yamahata, Masanori Yonenaga, Shingo Fujio, Nayuta Higa, Ryosuke Hanaya, Kazunori Arita, and Koji Yoshimoto

    World Neurosurgery, ISSN: 18788750, eISSN: 18788769, Volume: 155, Pages: e395-e401, Published: November 2021 Elsevier BV

  • Microvascular Decompression for Trigeminal Neuralgia: A Prospective, Multicenter Study
    Yoshifumi Mizobuchi, Shinji Nagahiro, Akinori Kondo, Kazunori Arita, Isao Date, Yukihiko Fujii, Takamitsu Fujimaki, Ryosuke Hanaya, Mitsuhiro Hasegawa, Toru Hatayama, Tooru Inoue, Hidetoshi Kasuya, Masahito Kobayashi, Eiji Kohmura, Toshio Matsushima, Jun Masuoka, Akio Morita, Shigeru Nishizawa, Yoshihiro Okayama, Taku Shigeno, Hiroshi Shimano, Hideo Takeshima, and Iwao Yamakami

    Neurosurgery, ISSN: 0148396X, eISSN: 15244040, Pages: 557-564, Published: 1 October 2021 Ovid Technologies (Wolters Kluwer Health)
    BACKGROUND Microvascular decompression (MVD) is the most effective procedure for the long-term management of trigeminal neuralgia (TGN). However, retrospective and single-center studies are inherently biased, and there are currently no prospective, multicenter studies. OBJECTIVE To evaluate the short- and long-term outcomes and complications in patients with TGN who underwent MVD at specialized Japanese institutions. METHODS We enrolled patients with TGN who underwent MVD between April 2012 and March 2015. We recorded their facial pain grade and complications at 7 d (short term), 1 yr (mid-term), and 3 yr (long term) postoperatively. RESULTS There were 166 patients, comprising 60 men and 106 women (mean age 62.7 yr). Furthermore, 105 patients were aged over 60 yr. We conducted neuromonitoring in 84.3% of the cases. The complete pain relief, mortality, and complication rates at the short-term follow-up were 78.9%, 0%, and 16.3%, respectively. Overall, 155 patients (93.4%) completed the long-term follow-up, with the complete pain relief and complication rates of 80.0% and 5.2%, respectively. CONCLUSION In the hands of experienced neurosurgeons, MVD for TGN can achieve high long-term curative effects. In addition, complications are uncommon and usually transient. Our results indicate that MVD is an effective and safe treatment for patients with TGN, including elderly patients.

  • Dural sac shrinkage signs on magnetic resonance imaging at the thoracic level in spontaneous intracranial hypotension—its clinical significance
    Takashi Kawahara, Kazunori Arita, Shingo Fujio, Ryosuke Hanaya, Masamichi Atsuchi, FM Moinuddin, Muhammad Kamil, Tomohisa Okada, Hirofumi Hirano, Naoyuki Kitamura, Naoaki Kanda, Hitoshi Yamahata, and Koji Yoshimoto

    Acta Neurochirurgica, ISSN: 00016268, eISSN: 09420940, Volume: 163, Pages: 2685-2694, Published: October 2021 Springer Science and Business Media LLC
    Spontaneous intracranial hypotension (SIH) is secondary to a cerebrospinal fluid leak at the spinal level without obvious causative events. Several signs on brain and cervical spine magnetic resonance (MR) imaging (MRI) have been associated with SIH but can be equivocal or negative. This retrospective study sought to identify characteristic SIH signs on thoracic spinal MRI. Cranial and spinal MR images of 27 consecutive patients with classic SIH symptoms, who eventually received epidural autologous blood patches (EBPs), were analyzed. The most prevalent findings on T2-weighted MRI at the thoracic level were anterior shift of the spinal cord (96.3%) and dorsal dura mater (81.5%), probably caused by dural sac shrinkage. These dural sac shrinkage signs (DSSS) were frequently accompanied by cerebrospinal fluid collection in the posterior epidural space (77.8%) and a prominent epidural venous plexus (77.8%). These findings disappeared in all six patients who underwent post-EBP spinal MRI. Dural enhancement and brain sagging were minimum or absent on the cranial MR images of seven patients, although DSSS were obvious in these seven patients. For 23 patients with SIH and 28 healthy volunteers, a diagnostic test using thoracic MRI was performed by 13 experts to validate the usefulness of DSSS. The median sensitivity, specificity, positive-predictive value, negative-predictive value, and accuracy of the DSSS were high (range, 0.913–0.931). Detection of DSSS on thoracic MRI facilitates an SIH diagnosis without the use of invasive imaging modalities. The DSSS were positive even in patients in whom classic cranial MRI signs for SIH were equivocal or minimal.

  • Interpersonal communication skills related to seizure outcomes in pediatric patients with vagus nerve stimulation
    Masaya Katagiri, Hiroshi Otsubo, Kota Kagawa, Go Seyama, Akira Hashizume, Akitake Okamura, Nobutsune Ishikawa, Ryosuke Hanaya, Kazunori Arita, Kaoru Kurisu, and Koji Iida

    Interdisciplinary Neurosurgery: Advanced Techniques and Case Management, eISSN: 22147519, Published: June 2021 Elsevier BV
    Abstract Objective Various clinical parameters have been reported to be associated with favorable seizure outcomes after vagus nerve stimulation (VNS); however, none of these parameters have been conclusively validated. Here, we evaluated interpersonal communication skills (IPCS) and seizure outcomes in pediatric patients treated with VNS. Methods We enrolled 31 Japanese pediatric patients (mean ± SD: 9.0 ± 3.4 years old, range: 3–15 years old) who were treated with VNS and had at least 2 years of follow-up. We divided the patients into two groups: a responder group with ≥50% seizure reduction from the average number of seizures 2 months before VNS; and a nonresponder group with Results We found significantly favorable seizure outcomes (≥50% seizure reduction) in 12 of 19 (63.2%) patients with IPCS after 2-year VNS compared with one of 12 (8.3%) patients without ICPS (p = 0.0031, Fisher exact test). IPCS showed an odds ratio of 14.6 (95% CI, 1.9–318) and a significant correlation with a favorable seizure outcome (p = 0.0077) in binominal logistic regression analysis. Conclusion Feasible evaluation of IPCS by clinicians might predict the seizure outcome more than 2 years after VNS implantation in a pediatric population.

  • Prospective, Multicenter Clinical Study of Microvascular Decompression for Hemifacial Spasm
    Yoshifumi Mizobuchi, Shinji Nagahiro, Akinori Kondo, Kazunori Arita, Isao Date, Yukihiko Fujii, Takamitsu Fujimaki, Ryosuke Hanaya, Mitsuhiro Hasegawa, Toru Hatayama, Kazuhiro Hongo, Tooru Inoue, Hidetoshi Kasuya, Masahito Kobayashi, Eiji Kohmura, Toshio Matsushima, Jun Masuoka, Akio Morita, Shigeru Munemoto, Shigeru Nishizawa, Yoshihiro Okayama, Kimitoshi Sato, Taku Shigeno, Hiroshi Shimano, Hideo Takeshima, Hideki Tanabe, and Iwao Yamakami

    Neurosurgery, ISSN: 0148396X, eISSN: 15244040, Pages: 846-854, Published: 1 April 2021 Oxford University Press (OUP)
    Abstract BACKGROUND Microvascular decompression (MVD) is the most effective procedure for hemifacial spasm (HFS). MVD results from nonspecialized or low-volume institutes are not always reliable. Most studies on MVD for HFS are retrospective and single centered; to the best of our knowledge, no prospective, multicenter studies exist. OBJECTIVE To evaluate short- and long-term outcomes and complications in patients who underwent MVD for HFS in specialized Japanese institutions, in this multicenter, prospective, cohort study. METHODS Included patients had undergone MVD for HFS in study centers between April 2012 and March 2015. Patients’ postoperative grade of involuntary movements and complications were recorded postoperatively at 7 d (short-term) and at 1 (mid-term) and 3 (long-term) yr. RESULTS A total of 486 patients (150 men, 336 women; mean age 53.9 yr with 181 patients over 60 yr) were enrolled during the study period. Neuromonitoring was used in 96.3% of the cases. The complete cure rate of symptom relief, mortality rate, and complication rate at short-term follow-up were 70.6%, 0%, and 15%, respectively. The long-term follow-up was completed by 463 patients (95.3%); the complete cure rate of symptom relief and complication rate were 87.1% and 3.0%, respectively. CONCLUSION Our study revealed that under expert guidance and intraoperative neuromonitoring, the long-term curative effect rate of MVD for HFS is high, while complications are uncommon and usually transient. Our results indicate that MVD is an effective and safe treatment for patients with HFS, including elderly patients.

  • Surgery for Radiologically Normal-Appearing Temporal Lobe Epilepsy in a Centre with Limited Resources
    Muhamad Thohar Arifin, Yuriz Bakhtiar, Erie B. P. S. Andar, Happy Kurnia B., Dody Priambada, Ajid Risdianto, Gunadi Kusnarto, Krisna Tsaniadi, Jacob Bunyamin, Ryosuke Hanaya, Kazunori Arita, Aris Catur Bintoro, Koji Iida, Kaoru Kurisu, Rofat Askoro, Surya P. Briliantika, and Zainal Muttaqin

    Scientific Reports, eISSN: 20452322, Published: 1 December 2020 Springer Science and Business Media LLC
    Approximately 26–30% of temporal lobe epilepsy (TLE) cases display a normal-appearing magnetic resonance image (MRI) leading to difficulty in determining the epileptogenic focus. This causes challenges in surgical management, especially in countries with limited resources. The medical records of 154 patients with normal-appearing MRI TLE who underwent epilepsy surgery between July 1999 and July 2019 in our epilepsy centre in Indonesia were examined. The primary outcome was the Engel classification of seizures. Anterior temporal lobectomy was performed in 85.1% of the 154 patients, followed by selective amygdalo-hippocampectomy and resection surgery. Of 82 patients (53.2%), Engel Class I result was reported in 69.5% and Class II in 25.6%. The median seizure-free period was 13 (95% CI,12.550–13.450) years, while the seizure-free rate at 5 and 12 years follow-up was 96.3% and 69.0%, respectively. Patients with a sensory aura had better seizure-free outcome 15 (11.575–18.425) years. Anterior temporal lobectomy and selective amygdala-hippocampectomy gave the same favourable outcome. Despite the challenges of surgical procedures for normal MRI TLE, our outcome has been favourable. This study suggests that epilepsy surgery in normal MRI TLE can be performed in centres with limited resources.

  • Preoperative sensory aura predicts risk for seizure in temporal lobe epilepsy surgery
    Muhamad Thohar Arifin, Ryosuke Hanaya, Yuriz Bakhtiar, Aris Catur Bintoro, Koji Iida, Kaoru Kurisu, Kazunori Arita, Jacob Bunyamin, Rofat Askoro, Surya P. Brillantika, and Zainal Muttaqin

    Epilepsy and Behavior, ISSN: 15255050, eISSN: 15255069, Volume: 111, Published: October 2020 Elsevier BV
    BACKGROUND Patients with temporal lobe epilepsy (TLE) often report viscerosensory and experiential auras, with substantial epilepsy localization. However, few previous studies have investigated the epileptic preoperative aura, particularly with regard to its effect on surgical outcomes in patients with drug-resistant epilepsy. OBJECTIVE This study investigated the potential role of preoperative aura in predicting outcomes after surgery for TLE. MATERIAL AND METHODS This study included consecutive patients diagnosed with TLE who underwent anterior temporal lobectomy (ATL) for drug-resistant TLE during the period from January 1999 to December 2017. Data pertaining to patient age at the time of surgery, sex, age at initial seizure onset, duration of epilepsy, presence of preoperative aura, comprehensive clinical semiology, side of surgery, and type of pathology were analyzed. Preoperative auras were classified as autonomic, sensory, mental and affective, or multiple manifestations. Patients were followed at 3 and 12 months after surgery and at regular intervals thereafter. RESULTS AND CONCLUSIONS A total of 498 patients were included in the study. Positive preoperative aura was observed in 386 patients (77.51%). The correlation of each variable with seizure outcomes was analyzed, and the only variable found to correlate with seizure outcome was the presence of preoperative aura. Compared with those with negative preoperative aura, those with positive preoperative aura were 1.74-fold more likely to be seizure-free after surgery for TLE. The analysis of patient data suggested a later onset of initial seizure in those with positive preoperative aura, compared with those without (p = 0.04, 95% confidence interval (CI): 0.55-3.24). Patients with a shorter duration of disease prior to TLE surgery were more likely to achieve seizure-free status postoperatively. Preoperative sensory aura was a good predictor that a patient would be seizure-free during follow-up (p = 0.022).

  • Corrigendum to ‘Prosthesis Used in Microvascular Decompressions: A Multicenter Survey in Japan Focusing on Adverse Events’ [World Neurosurgery 130 (2019) e251-e258](S1878875019315943)(10.1016/j.wneu.2019.06.053)
    Mitsuhiro Hasegawa, Toru Hatayama, Akinori Kondo, Shinji Nagahiro, Takamitsu Fujimaki, Kenichi Amagasaki, Kazunori Arita, Isao Date, Yukihiko Fujii, Takeo Goto, Ryosuke Hanaya, Yoshinori Higuchi, Kazuhiro Hongo, Toru Inoue, Hidetoshi Kasuya, Takamasa Kayama, Masatou Kawashima, Eiji Kohmura, Taketoshi Maehara, Toshio Matsushima, Yoshihumi Mizobuchi, Akio Morita, Shigeru Nishizawa, Shusaku Noro, Shinjiro Saito, Hirofumi Shimano, Reizo Shirane, Hideo Takeshima, Yuichiro Tanaka, Hidenori Tanabe, Hiroki Toda, Iwao Yamakami, Yuya Nishiyama, Shigeo Ohba, Yuichi Hirose, and Takeya Suzuki

    World Neurosurgery, ISSN: 18788750, eISSN: 18788769, Volume: 134, Pages: 685, Published: February 2020 Elsevier BV

  • Prosthesis Used in Microvascular Decompressions: A Multicenter Survey in Japan Focusing on Adverse Events
    Mitsuhiro Hasegawa, Toru Hatayama, Akinori Kondo, Shinji Nagahiro, Takamitsu Fujimaki, Kenichi Amagasaki, Kazunori Arita, Isao Date, Yukihiko Fujii, Takeo Goto, Ryosuke Hanaya, Yoshinori Higuchi, Kazuhiro Hongo, Toru Inoue, Hidetoshi Kasuya, Takamasa Kayama, Masatou Kawashima, Eiji Kohmura, Taketoshi Maehara, Toshio Matsushima, Yoshihumi Mizobuchi, Akio Morita, Shigeru Nishizawa, Shusaku Noro, Shinjiro Saito, Hirofumi Shimano, Reizo Shirane, Hideo Takeshima, Yuichiro Tanaka, Hidenori Tanabe, Hiroki Toda, Iwao Yamakami, Yuya Nishiyama, Shigeo Ohba, Yuichi Hirose, and Takeya Suzuki

    World Neurosurgery, ISSN: 18788750, eISSN: 18788769, Volume: 130, Pages: e251-e258, Published: October 2019 Elsevier BV
    The purpose of this study was to investigate the characteristics of materials used as prostheses for microvascular decompression surgery (MVDs) in Japan and their possible adverse events (AEs) to determine preferable materials for MVDs. A questionnaire was sent to all members of the Japanese Society for MVDs, and answers were obtained from 59 institutions. Among a total of 2789 MVDs, 1088 operations for trigeminal neuralgia, 1670 for hemifacial spasm, and 31 others, including 117 re-operations, were performed between April 2011 and March 2014. Non-absorbable material was used in 96.5% of MVDs, including polytetrafluoroethylene (PTFE) (80.5%), polyurethane (11.9%), expanded PTFE (2.1%), and silk thread (1.47%). The usage of absorbable materials, including fibrin glue (87.5%), cellulose (13.5%), gelatin (4,77%), and collagen (1.76%), was reported. The major combinations were PTFE with fibrin glue (58.7%) followed by PTFE alone (7.60%). Eighty-eight AEs in 85 (3.2%) cases were reported among 2672 first operations. AEs included 51 central nervous system dysfunctions, 15 wound infections/dehiscence, and 10 others, that were presumed to be related to the intraoperative procedure. Among relatively high-volume, moderate-volume, and low-volume centers, there were no significant differences in the frequency of AEs (P=0.077). Tissue-prosthesis adhesion and/or granuloma formation were reported in 13 cases out of 117 re-operations. The incidence of adhesion-related recurrence was 11.1% of all re-operations. In conclusion, the number of AEs was quite low in this survey, and intradural use of any prosthesis reported in this paper might be justified. However, further development of easily handled and less-adhesive prosthesis materials is awaited.

  • Sellar Xanthogranuloma: A Quest Based on Nine Cases Assessed with an Anterior Pituitary Provocation Test
    Shingo Fujio, Tomoko Takajo, Yasuyuki Kinoshita, Ryosuke Hanaya, Hiroshi Arimura, Jun Sugata, Sei Sugata, Manoj Bohara, Tsubasa Hiraki, Koji Yoshimoto, and Kazunori Arita

    World Neurosurgery, ISSN: 18788750, eISSN: 18788769, Volume: 130, Pages: e150-e159, Published: October 2019 Elsevier BV
    BACKGROUND Xanthogranuloma is a chronic inflammatory mass characterized by cholesterol crystal deposition, which is rarely seen in the sellar region. The objective of this study is to know the clinical features and etiology of sellar xanthogranulomas. METHODS We retrospectively analyzed manifestation, radiographic, and endocrinologic presentation in 9 patients (7 women; 2 men) we had previously treated. RESULTS The patients were between 26-73 years of age (median: 56 years). The chief complains were visual symptoms in 3, polyuria in 3, headache in 4, and tiredness in 4 patients. Perimetry found visual field deficit in 6 patients. Anterior pituitary provocation tests disclosed impairment of at least one hormone in all: growth hormone in 8 and adrenocorticotropic hormone-cortisol axis in 8 patients. The lesions were located in the suprasellar in 2, intrasellar in 2, and intra-suprasellar region in 5 patients. Three of the lesions were solid and 6 were single- to multi-cystic. Very low intensity area on T2-weighted magnetic resonance imaging was observed in 4 lesions. Post-contrast study performed in 7 lesions revealed enhancement in solid parts or cyst walls. Surgical decompression improved visual disturbance in half of the patients but rarely improved hormonal deficits. Follow-up (median: 47 months) found no recurrence of the lesion. In addition to these 9 cases, we found 2 xanthogranulomatous lesions pathologically associated with ciliated epithelia, which also presented severe hypopituitarism. CONCLUSIONS Xanthogranuloma appears to be the last stage of the chronic inflammation affecting Rathke's cleft cyst or craniopharyngioma presenting with severe anterior pituitary insufficiency.

  • Anti-seizure effect and neuronal activity change in the genetic-epileptic model rat with acute and chronic vagus nerve stimulation
    Masaya Katagiri, Koji Iida, Kumatoshi Ishihara, Dileep Nair, Kana Harada, Kota Kagawa, Go Seyama, Akira Hashizume, Takashi Kuramoto, Ryosuke Hanaya, Kazunori Arita, and Kaoru Kurisu

    Epilepsy Research, ISSN: 09201211, eISSN: 18726844, Volume: 155, Published: September 2019 Elsevier BV
    BACKGROUND VNS showed time-dependent anti-seizure effect. However, the precise mechanism of VNS in acute and chronic anti-seizure effect has not been fully elucidated. Noda epileptic rat (NER) is genetic epilepsy model rat which exhibits spontaneous generalized tonic-clonic seizure (GTC) approximately once per 30 h and frequent dialeptic seizure (DS). We performed acute and chronic VNS on NER to focus on the acute and chronic anti-epileptic effect and neuronal activity change by VNS. METHODS We performed acute VNS (2 h) on 22 NERs (VNS, n = 11, control, n = 11), then subsequently administered chronic (4 weeks) VNS on 10 of 22 NERs (VNS n = 5, control n = 5). We evaluated the acute and chronic anti-seizure effects of VNS on GTC and DS by behavioral and electroencephalographical observation (2 h every week). We carried out double immunofluorescence for biomarkers of short-term (c-Fos) and long-term (ΔFosB) neuronal activation to map regions in the brain that were activated by acute (VNS n = 6, control n = 6) or chronic VNS (VNS n = 5, control n = 5). Furthermore, we performed chronic VNS (4 w) on 12 NERs (VNS n = 6, control n = 6) with long-term observation (8 h a day, 5d per week) to obtain an adequate number of GTCs to elucidate the time dependent anti-epileptic effect on GTC. RESULTS Acute VNS treatment reduced GTC seizure frequency and total duration of the DS. Chronic VNS resulted in a time-dependent reduction of DS frequency and duration. However, chronic VNS did not show time-dependent reduction of GTC frequency. There were significant c-Fos expressions in the central medial nucleus (CM), mediodorsal thalamic nucleus (MDM), locus coeruleus (LC), and nucleus of solitary tract (NTS) after acute VNS. And there were significant ΔFosB expressions in the lateral septal nucleus (LSV), medial septal nucleus (MSV), MDM, and pontine reticular nucleus caudal (PnC) after chronic VNS. Any decrease in frequency of GTCs by chronic VNS could not be confirmed even with long-term observation. CONCLUSION We confirmed acute VNS significantly reduced the frequency of GTC and duration of DS. Chronic VNS decreased the frequency and duration of DS in a time-dependent manner. The brainstem and midline thalamus were activated after acute and chronic VNS. The forebrain was activated only after chronic VNS.

  • Is additional mesial temporal resection necessary for intractable epilepsy with cavernous malformations in the temporal neocortex?
    Yumi Kashida, Naotaka Usui, Kazumi Matsuda, Kiyohito Terada, Koichi Baba, Akihiko Kondo, Daisuke Hirozawa, Takayasu Tottori, Tadahiro Mihara, Ryosuke Hanaya, Kazunori Arita, and Yushi Inoue

    Epilepsy and Behavior, ISSN: 15255050, eISSN: 15255069, Pages: 145-153, Published: March 2019 Elsevier BV
    PURPOSE Cavernous malformation (CM) in the temporal neocortex causes intractable epilepsy. Whether to resect additional mesial temporal structures in addition to the lesionectomy is a still controversial issue. To clarify the need for the procedure, we retrospectively analyzed pre- and postoperative clinical data of patients with surgically removed CM. SUBJECTS AND METHODS We included data from 18 patients with CM in the temporal neocortex who presented with intractable epilepsy. Eleven patients of our early series were treated with extended resection, i.e., lesionectomy and the resection of additional mesial temporal structures. Seven patients underwent lesionectomy, i.e., removal of the CM and of hemosiderin-stained surrounding brain tissue. Pathological assessments of the resected hippocampus were performed. Chronic intracranial electroencephalography (EEG) recordings were obtained in 6 patients. We performed perioperative neuropsychological assessments in all patients. RESULTS The seizure outcome was recorded as Engel class I in 17 patients (94.4%); Ia = 12 (66.7%) Ib = 2 (11.1%), Ic = 1 (5.6%), Id = 2 (11.1%), and class IIb in one patient (5.6%). Adding resection of the mesial temporal structures to lesionectomy did not alter the seizure outcome. Pathology of hippocampus revealed limited neuronal loss in CA4. Ictal onsets in the ipsilateral lateral cortex were detected in all 6 patients who underwent intracranial EEG. In 4 patients each, we also detected ictal onsets from the ipsilateral mesial temporal structures and from the contralateral temporal lobe. Postoperatively, in the patients where their CM was located in the language-dominant hemisphere (n = 10), the full-scale intelligence quotient (IQ) and the performance IQ increased (p < 0.05), whereas the verbal memory (WMS-R) deteriorated in two of 5 patients. CONCLUSION Excellent seizure outcomes were obtained even the lesionectomy alone. To confirm appropriate surgical strategy for lateral temporal CM with intractable epilepsy, further studies in large sample size are needed.

  • Hemispherotomy for drug-resistant epilepsy in an Indonesian population
    Muhamad Thohar Arifin, Zainal Muttaqin, Ryosuke Hanaya, Yuriz Bakhtiar, Aris Catur Bintoro, Koji Iida, Kaoru Kurisu, Kazunori Arita, Erie B.P.S. Andar, Happy Kurnia B, Dody Priambada, Ajid Risdianto, Gunadi Kusnarto, and Jacob Bunyamin

    Epilepsy and Behavior Reports, eISSN: 25899864, Published: 2019 Elsevier BV
    Hemispherotomy is a surgical treatment indicated in patients with drug-resistant epilepsy due to unilateral hemispheric pathology. Hemispherotomy is less invasive compared with hemispherectomy. We reviewed our experience performing 24 hemispherotomy and report the results of 16 patients with prolonged follow-up of this relatively uncommon procedure in two centers in Indonesia. This is a retrospective observational study conducted from 1999 to July 2019 in two epilepsy neurosurgical centers in Semarang, Indonesia. Surgical techniques included vertical parasagittal hemispherotomy (VPH), peri-insular hemispherotomy (PIH), and modified PIH called the Shimizu approach (SA). The postoperative assessment was carried out using the Engel classification system of seizure outcome. Seizure freedom (Engel class I) outcome was achieved in 10 patients (62.5%), class II in 3 patients (18.7%), class III in 2 patients (12.5%), and class IV in 1 patient (6.3%) with follow-up duration spanning from 24 to 160 months. To the best of our knowledge, this series is the most extensive documentation of hemispherotomy in an Indonesian population.

  • A companion to the preclinical common data elements and case report forms for rodent EEG studies. A report of the TASK3 EEG Working Group of the ILAE/AES Joint Translational Task Force
    Tomonori Ono, Joost Wagenaar, Filippo S. Giorgi, Petr Fabera, Ryosuke Hanaya, John Jefferys, Jason T. Moyer, Lauren C. Harte-Hargrove, and Aristea S. Galanopoulou

    Epilepsia Open, eISSN: 24709239, Pages: 90-103, Published: November 2018 Wiley
    Electroencephalography (EEG) is commonly used in epilepsy and neuroscience research to study brain activity. The principles of EEG recording such as signal acquisition, digitization, and conditioning share similarities between animal and clinical EEG systems. In contrast, preclinical EEG studies demonstrate more variability and diversity than clinical studies in the types and locations of EEG electrodes, methods of data analysis, and scoring of EEG patterns and associated behaviors. The TASK3 EEG working group of the International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force has developed a set of preclinical common data elements (CDEs) and case report forms (CRFs) for recording, analysis, and scoring of animal EEG studies. This companion document accompanies the first set of proposed preclinical EEG CRFs and is intended to clarify the CDEs included in these worksheets. We provide 7 CRF and accompanying CDE modules for use by the research community, covering video acquisition, electrode information, experimental scheduling, and scoring of EEG activity. For ease of use, all data elements and input ranges are defined in supporting Excel charts (Appendix S1 ).

  • Cerebral Paragonimiasis With Hemorrhagic Stroke in a Developed Country
    Yumi Kashida, Masaki Niiro, Haruhiko Maruyama, and Ryosuke Hanaya

    Journal of Stroke and Cerebrovascular Diseases, ISSN: 10523057, eISSN: 15328511, Pages: 2648-2649, Published: October 2018 Elsevier BV
    Paragonimiasis is a food-borne parasitic disease caused by Paragonimus lung flukes, which are epidemic in Asia. Cerebral paragonimiasis accounts for <1% of symptomatic paragonimiasis but is the most common extrapulmonary infection. Cerebral paragonimiasis often mimics stroke and sometimes causes severe neurological sequelae. A 61-year-old woman was admitted to the hospital for severe headache. A head computed tomography scan revealed intracerebral hemorrhage with subarachnoid hemorrhage. The patient also had lesions in the lungs. She frequently ate Japanese mitten crab. Peripheral blood examination results of increased eosinophilia and immunological testing results confirmed the diagnosis of Paragonimus westermani infection. The patient was successfully treated with praziquantel as the first-line agent. Cerebral paragonimiasis is currently rare in developed countries; however, it is an important disease to consider.

  • Application of Rubber Band with Hooks on Both Ends for Vagus Nerve Stimulator Implantation
    Hiroshi Hosoyama, Ryosuke Hanaya, Toshiaki Otsubo, Masanori Sato, Yumi Kashida, Sei Sugata, Masaya Katagiri, Koji Iida, and Kazunori Arita

    World Neurosurgery, ISSN: 18788750, eISSN: 18788769, Volume: 111, Pages: 258-260, Published: March 2018 Elsevier BV
    BACKGROUND Vagus nerve stimulation (VNS) is a valuable therapeutic option for many types of drug-resistant epilepsy. Muscle hooks and carotid endarterectomy rings have been used for cervical delamination preceding the implantation of stimulation electrodes. The attachment on both sides of a rubber band of Kamiyama-style hanging needles, as are used for scalp and dural retraction during craniotomy, yields a useful tool for VNS implantation. Here we report our experience with this method. METHODS We present our method using a rubber band plus hooks and a review of 21 consecutive patients who underwent VNS implantation using our rubber band-plus-hooks method. RESULTS None of the 21 patients experienced intraoperative or perioperative complications. Hooks placed in connective tissue around the common carotid artery and jugular vein raised the vagus nerve by elevating the carotid sheath. A single surgeon was able to perform all cervical manipulations under a surgical microscope. The average operation time in this series of 21 patients was 137 minutes. CONCLUSIONS The use of hooks attached to both sides of a rubber band rendered VNS implantation safer by lifting the vagus nerve and standardizing the procedure.

  • Synaptic vesicle glycoprotein 2 A and epilepsy
    Ryosuke Hanaya, Hiroshi Hosoyama, and Kazunori Arita

    Journal of the Japan Epilepsy Society, ISSN: 09120890, eISSN: 13475509, Pages: 3-16, Published: 2018 The Japan Epilepsy Society

  • Long-term outcome after endovascular treatment of cavernous sinus dural arteriovenous fistula and a literature review
    Yosuke Nishimuta, Ryuji Awa, Sei Sugata, Tetsuya Nagayama, Tsuneo Makiuchi, Tetsuzo Tomosugi, Ryosuke Hanaya, Hiroshi Tokimura, Hirofumi Hirano, F. M. Moinuddin, Muhammad Kamil, Akari Kibe, and Kazunori Arita

    Acta Neurochirurgica, ISSN: 00016268, eISSN: 09420940, Volume: 159, Pages: 2113-2122, Published: 1 November 2017 Springer Science and Business Media LLC
    BackgroundThe long-term efficacy of endovascular treatment (EVT) for cavernous sinus dural arteriovenous fistulae (CS-dAVF) was assessed with a special focus on residual shunts after initial EVT.Patients and methodsThis retrospective survey included 50 patients who had undergone EVT and were followed for 1 month or longer (median follow-up 56 months).ResultsCommon preoperative symptoms were chemosis (78%), extra-ocular motor palsy (72%), exophthalmos (66%), and tinnitus (26%). CS-dAVF were addressed by transvenous embolization (tVE, n = 48), tVE only was used in 43 instances and tVE plus transarterial embolization (tAE) in five. Two patients underwent tAE only. Procedure-related morbidity (brainstem infarction) was recorded in one patient (2%) and transient symptom exacerbation (paradoxical worsening) in 12 patients (24%). Postoperative digital subtraction angiography showed no major retrograde shunt or cortical venous reflux in any of the 50 patients. Anterograde or minor retrograde residual shunt was observed in 17 patients (34%); three of these underwent additional tVE and four had Gamma Knife surgery. The shunt flow disappeared in all 17 patients 12.6 ± 13.4 (mean ± SD) months after initial EVT. At the latest follow-up, 65.7 ± 52.6 months after the initial operation, no shunt flow was observed in any of the 50 patients. None had remaining or newly developed chemosis or tinnitus on follow-up. The rate of persistent cavernous sinus symptoms at the latest follow-up was higher in patients with than without post-procedural paradoxical worsening (5/12, 41.7% vs. 2/38, 5.3%, p = 0.0059 by Fisher’s exact test).ConclusionsLong-term follow-up showed that EVT, especially tVE, is an efficient and safe treatment for CS-dAVF. It resulted in the eventual disappearance of shunt flow. Residual shunt without major retrograde flow or cortical venous reflux can be monitored without additional treatment.

  • Long-term outcomes of epilepsy surgery in 85 pediatric patients followed up for over 10 years: A retrospective survey
    Hiroshi Hosoyama, Kazumi Matsuda, Tadahiro Mihara, Naotaka Usui, Koichi Baba, Yushi Inoue, Takayasu Tottori, Toshiaki Otsubo, Yumi Kashida, Koji Iida, Hirofumi Hirano, Ryosuke Hanaya, and Kazunori Arita

    Journal of Neurosurgery: Pediatrics, ISSN: 19330707, eISSN: 19330715, Pages: 606-615, Published: May 2017 Journal of Neurosurgery Publishing Group (JNSPG)
    OBJECTIVEThe aim of this study was to investigate the treatment outcomes and social engagement of patients who had undergone pediatric epilepsy surgery more than 10 years earlier.METHODSBetween 1983 and 2005, 110 patients younger than 16 years underwent epilepsy surgery at the National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders. The authors sent a questionnaire to 103 patients who had undergone follow-up for more than 10 years after surgery; 85 patients (82.5%) responded. The survey contained 4 categories: seizure outcome, use of antiepileptic drugs, social participation, and general satisfaction with the surgical treatment (resection of the epileptic focus, including 4 hemispherectomies). The mean patient age at the time of surgery was 9.8 ± 4.2 (SD) years, and the mean duration of postoperative follow-up was 15.4 ± 5.0 years. Of the 85 patients, 79 (92.9%) presented with a lesional pathology, such as medial temporal sclerosis, developmental/neoplastic lesions, focal cortical dysplasia, and gliosis in a single lobe.RESULTSFor 65 of the 85 responders (76.5%), the outcome was recorded as Engel Class I (including 15 [93.8%] of 16 patients with medial temporal sclerosis, 20 [80.0%] of 25 with developmental/neoplastic lesions, and 27 [73.0%] of 37 with focal cortical dysplasia). Of these, 29 (44.6%) were not taking antiepileptic drugs at the time of our survey, 29 (44.6%) held full-time jobs, and 33 of 59 patients (55.9%) eligible to drive had a driver's license. Among 73 patients who reported their degree of satisfaction, 58 (79.5%) were very satisfied with the treatment outcome.CONCLUSIONSThe seizure outcome in patients who underwent resective surgery in childhood and underwent followup for more than 10 years was good. Of 85 respondents, 65 (76.5%) were classified in Engel Class I. The degree of social engagement was relatively high, and the satisfaction level with the treatment outcome was also high. From the perspective of seizure control and social adaptation, resective surgery yielded longitudinal benefits in children with intractable epilepsy, especially those with a lesional pathology in a single lobe.

  • Radiologic and histologic features of the T2 hyperintensity rim of meningiomas on magnetic resonance images
    Hiroyuki Uchida, Hirofumi Hirano, FM Moinuddin, Ryosuke Hanaya, Yuko Sadamura, Hiroshi Hosoyama, Hajime Yonezawa, Hiroshi Tokimura, Hitoshi Yamahata, and Kazunori Arita

    Neuroradiology Journal, ISSN: 19714009, Pages: 48-56, Published: 1 February 2017 SAGE Publications
    A hyperintensity rim is often seen at the brain–tumor interface of meningiomas upon T2-weighted (T2WI) magnetic resonance imaging (MRI), and it is referred to as the cerebrospinal fluid (CSF) space; however, the true nature of the rim remains unclear. We surveyed the MRI findings and the histopathologic characteristics of such rims. Our study population consisted of 53 consecutive patients who underwent meningioma removal at our hospital. The intensity of the rim on MRI scans obtained with different imaging sequences was assessed in all patients. We used 22 tumors for histopathologic investigation: tissue samples were acquired from both the tumor surface and from a deep intratumoral site. Of the 53 meningiomas, 37 (69.8%) manifested a hyperintensity rim on T2WI (T2-rim). The other 16 showed neither a hyperintense nor a hypointense rim on their T2WI. An enhancement effect corresponding to the rim was observed in 28 of the 37 (75.7%) T2-rim positive tumors. While 9 among the 37 tumors with a T2-rim (24.3%) did not show rim enhancement, they showed low intensity on fluid-attenuated inversion recovery (FLAIR) images. The microvascular density in the tumor capsule was significantly greater in the 12 T2-rim and rim enhancement positive tumors than in 10 tumors that were T2-rim negative or T2-rim positive, but rim enhancement-negative ( p &lt; 0.001, Mann–Whitney U test). We found that 75.7% of T2 hyperintense rims that were detected at the brain–meningioma interface reflected a microvascular-rich capsule layer, rather than the CSF space.

  • Preoperative and postoperative pituitary function in patients with tuberculum sellae meningioma: Based on pituitary provocation tests
    Shingo FUJIO, Hirofumi HIRANO, Mami YAMASHITA, Satoshi USUI, Yasuyuki KINOSHITA, Atsushi TOMINAGA, Tomoko HANADA, Hitoshi YAMAHATA, Hiroshi TOKIMURA, Ryosuke HANAYA, Kaoru KURISU, and Kazunori ARITA

    Neurologia Medico-Chirurgica, ISSN: 04708105, eISSN: 13498029, Pages: 548-556, Published: 2017 Japan Neurosurgical Society
    Given the anatomical proximity of tuberculum sellae meningioma (TSM) to the hypothalamo-pituitary system, pituitary function impairments are of great concern. We retrospectively investigated pituitary function changes following surgery in patients with TSM using pituitary provocation tests (PPTs). Thirty-one patients (27 females and 4 males) with TSM underwent initial transcranial surgery (29 patients) or transsphenoidal surgery (two patients); surgeries were performed carefully to avoid injuring the pituitary stalk. In 24 patients, the PPTs were performed via a triple bolus injection with regular insulin, thyrotropin-releasing hormone (TRH), and luteinizing hormone releasing hormone (LH-RH). Seven patients underwent a quadruple test (growth-hormone-releasing factor, corticotrophin-releasing hormone, TRH, and LH-RH). The preoperative and postoperative target hormone levels of the anterior pituitary were normal in 93.5% and 96.8% of patients, respectively. At least one hormonal axis demonstrated impaired PPT responses in two patients (6.5%) preoperatively and in one patient (3.2%) postoperatively. The growth hormone (GH) response was also well preserved. A compromised GH peak level was only observed in one patient (3.2%) preoperatively. Postoperatively, transient diabetes insipidus and transient hyponatremia were observed in four (12.9%) and eight (25.8%) patients, respectively. No patients needed permanent postoperative hormone replacement. The preoperative pituitary function was well preserved in most patients, including those with large tumors pushing against the pituitary stalk considerably or embedded in it. After careful surgery to avoid damaging the pituitary stalk, pituitary function was preserved. However, transient postoperative hyponatremia occurred in 25.8% of patients; thus, surgeons should pay careful attention to this issue.

  • Vagus nerve stimulation for genetic epilepsy with febrile seizures plus (GEFS<sup>+</sup>) accompanying seizures with impaired consciousness
    Ryosuke Hanaya, Fajar H Niantiarno, Yumi Kashida, Hiroshi Hosoyama, Shinsuke Maruyama, Sei Sugata, Toshiaki Otsubo, Kazumi Tanaka, Atsushi Ishii, Shinichi Hirose, and Kazunori Arita

    Epilepsy and Behavior Case Reports, ISSN: 22133232, Pages: 16-19, Published: 2017 Elsevier BV
    Genetic epilepsy with febrile seizures plus (GEFS+) is characterized by childhood-onset epilepsy syndrome. It involves febrile seizures and a variety of afebrile epileptic seizure types within the same pedigree with autosomal-dominant inheritance. Approximately 10% of individuals with GEFS+ harbor SCN1A, a gene mutation in one of the voltage-gated sodium channel subunits. Considerably less common are focal epilepsies including complex partial seizures. We report vagus nerve stimulation (VNS) in a 6-year-old girl with GEFS+ who exhibited refractory generalized tonic-clonic seizures and complex partial seizures.