SAURABH SHARMA
@kalingauniversity.ac.in
ASSISTANT PROFESSOR, Faculty of Pharmacy
Kalinga University
RESEARCH INTERESTS
NOVEL DRUG DELIVERY SYSTEMS
Scopus Publications
Scholar Citations
Scholar h-index
Scopus Publications
Sudhanshu Mishra, Smriti Ojha, and Saurabh Sharma
Bentham Science Publishers Ltd.
Abstract: Hydrogels are one of the most extensively studied novel drug delivery dosage forms owing to their satisfactory results in drug delivery in various conditions, including pain management, immunomodulation, carcinomas, healing of wounds, and cardiology. A crosslinked polymeric network and an optimum amount of water combine to form hydrogels. Due to their specific properties such as biocompatibility, biodegradability, hydrophilicity, and non-toxic to biological tissues, hydrogels are demanding biomaterials. Furthermore, due to their programmable physical characteristics, controlled degradation behavior, and capability to preserve unstable medicines from degradation, hydrogels serve as an advanced drug delivery system in which diverse physiochemical interactions with the polymeric matrix containing embedded medications control their release. Despite significant challenges remaining, there has been significant progress in recent years in overcoming the clinical and pharmacological constraints of hydrogels for drug delivery applications This review covers various hydrogel-forming polymers, strategies for crosslinking of gelling agents, and release mechanisms from the hydrogel. Moreover, the current work includes a few marketed hydrogel preparations and patent rights associated with it, describing its mechanism of action against the underlying diseases.
Sudhanshu Mishra, Akhalesh Kumar, Saurabh Sharma, Smriti Ojha, and Pawan Upadhyay
Bentham Science Publishers Ltd.
Abstract: Nature is the chief source of various remedies which are used to cure various diseases. Boswellic acid (BA) is a secondary metabolite from the pentacyclic terpenoid compound groups that are derived from the plant genus Boswellia. The oleo gum resins of these plants are primarily composed of polysaccharides, with the remaining amounts of resin (30-60%) and essential oils (5-10%) soluble in organic solvents. BA and its analogs are also reported to exhibit various in vivo and biological responses for example anti-inflammatory, anti-tumor, free radical scavenging activity, etc. Among all analogs, 11-keto-β-boswellic acid (KBA) and 3-O-acetyl-11-keto-β-boswellic acid (AKBA) has been demonstrated to be the most effective at reducing cytokine production and inhibiting the inflammatory responsecausing enzymes. In this review, we summarized the computational ADME prediction via the SwissADME computational tool and the structure-activity relationship of the Boswellic acid scaffold for the aspect of anticancer and antiinflammatory potency. In addition to these research findings which are associated with the therapy of acute inflammation and some cancers, the potential of boswellic acids against other disorders was also discussed.