R Karthik Raja
Verified @gmail.com
Associate Professor, Department of Research and Innovation
Saveetha School of Engineering
EDUCATION
M. Sc., Ph.D
RESEARCH INTERESTS
Agricultural Microbiology
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Abhispa Bora, Sivaprakash Gurusamy, Ananthi Veleeswaran, Angelin Swetha Thondi Rajan, Yuvakkumar Rathinam, Karthik Raja Ramalingam, and Arun Alagarsamy
Elsevier BV
Marwa Ghallab, Najat Bukhari, El-Araby Salem, Mohamed El-Zaidy, Amr El-Sheikh, and Ramalingam Raja
MDPI AG
This study was conducted at El-Sabahia Research Station (latitude 31°12′ N, longitude 29°58′ E) in Alexandria, Egypt to evaluate the effect of Spirulina platensis algae extract on the growth, yield, and juice quality of four sugarcane genotypes during the 2020/2021 and 2021/2022 seasons. The sugarcane genotypes tested (G.T. 54-9, G. 2003-47, G. 84-47, and G. 2004-27) were treated with four concentrations (0, 0.1, 0.2, and 0.3%) of spirulina algae extract (SE) during their development as plant cane and first ratoon crops. At harvest, the growth, physiological, and juice quality characteristics were documented, while relative chlorophyll content was measured 210 days after sowing. Spraying canes with 0.2% of SE was the most effective treatment in enhancing all of the evaluated characteristics compared to those left without SE. Cane yield was more closely correlated with stalk weight (r = 0.88), followed by leaf area index (r = 0.82), relative chlorophyll content (r = 0.82), stalk length (r = 0.76), and number of tillers (r = 0.73), while recoverable sugar yield was closely correlated (p < 0.01) with sugar content % (r = 0.76).
V. Ananthi, Abhispa Bora, U. Ramesh, R. Yuvakkumar, Karthik Raja, Kumar Ponnuchamy, Govarthanan Muthusamy, and A. Arun
Elsevier BV
James Obeth Ebenezer Samuel, Nithya Rathinavel, Ananthi Veleeswaran, Boobalan Thulasinathan, Karthik Raja Ramalingam, Yuvakkumar Rathinam, and Arun Alagarsamy
Elsevier BV
Balakrishnan Jayanthi, Sadasivam Vinoth, Mohan Hariharan, Ramalingam Karthik Raja, Chinnaperumal Kamaraj, and Mathiyazhagan Narayanan
Elsevier BV
Selvam Naveenkumar, Chinnaperumal Kamaraj, Pradisha Prem, Ramalingam Karthik Raja, Arumugam Priyadharsan, Abdulwahed Fahad Alrefaei, Rasiravathanahalli Kaveriyappan Govindarajan, Rajkumar Thamarai, and Vetriselvan Subramaniyan
Elsevier BV
Ramalingam Karthik Raja, Prabu Kumar Seetharaman, Bharathi Kalidass, Siva Ananth, Liu Bo, Chinnaperumal Kamaraj, Harun Cimen, and Selcuk Hazir
Elsevier BV
Prabu Kumar Seetharaman, Ananth Sivapunniyam, Parthasarathy Ramalingam, Karthik Raja Ramalingam, and Bo Liu
Elsevier BV
Arumugam Priyadharsan, Chinnasamy Ragavendran, Chinnaperumal Kamaraj, Shine Kadaikunnan, Ramalingam Karthik Raja, and Muthu Thiruvengadam
Elsevier BV
Ramya Mohan, Arunmozhi Rama, Ramalingam Karthik Raja, Mohammed Rafi Shaik, Mujeeb Khan, Baji Shaik, and Venkatesan Rajinikanth
MDPI AG
Humankind is witnessing a gradual increase in cancer incidence, emphasizing the importance of early diagnosis and treatment, and follow-up clinical protocols. Oral or mouth cancer, categorized under head and neck cancers, requires effective screening for timely detection. This study proposes a framework, OralNet, for oral cancer detection using histopathology images. The research encompasses four stages: (i) Image collection and preprocessing, gathering and preparing histopathology images for analysis; (ii) feature extraction using deep and handcrafted scheme, extracting relevant features from images using deep learning techniques and traditional methods; (iii) feature reduction artificial hummingbird algorithm (AHA) and concatenation: Reducing feature dimensionality using AHA and concatenating them serially and (iv) binary classification and performance validation with three-fold cross-validation: Classifying images as healthy or oral squamous cell carcinoma and evaluating the framework’s performance using three-fold cross-validation. The current study examined whole slide biopsy images at 100× and 400× magnifications. To establish OralNet’s validity, 3000 cropped and resized images were reviewed, comprising 1500 healthy and 1500 oral squamous cell carcinoma images. Experimental results using OralNet achieved an oral cancer detection accuracy exceeding 99.5%. These findings confirm the clinical significance of the proposed technique in detecting oral cancer presence in histology slides.
Moorthy Muruganandham, Fatimah Oleyan Al-Otibi, Raedah Ibrahim Alharbi, Kanagasabapathy Sivasubramanian, Ramalingam Karthik Raja, Palanivel Velmurugan, and Nagaraj Basavegowda
Walter de Gruyter GmbH
Abstract The synthesis of silver nanoparticles using plant-based materials has seen a surge in recent years. This study used the Syzygium aromaticum (clove) buds extract as a reducing agent for synthesizing silver nanoparticles (Sa-AgNPs). The presence of Sa-AgNPs (440 nm) was confirmed by UV-Vis spectroscopy. The optimization of nanoparticle production with pH, metal ions, and substrate concentration (clove extract) was studied. The transmission electron microscopy analysis revealed that Sa-AgNPs had a size distribution predominantly below the range of 10–100 nm. The investigation of Sa-AgNPs using EDX revealed the presence of an optical absorption silver peak at 3 keV. The involvement of phenolic chemicals and carboxylic acids in stretching O–H, N–O, and C═O bonds, forming Sa-AgNPs has been identified by Fourier transform infrared spectroscopy. Klebsiella pneumoniae and Trichophyton rubrum exhibited a higher inhibition zone of 26 ± 0.48 mm and 21 ± 0.48 mm in antibacterial and antifungal activity, respectively. In the 2,2-diphenyl-1-picrylhydrazyl experiment, at a maximum concentration of 500 μg·mL−1, Sa-AgNPs exhibited a scavenging efficiency of 79.98%. Cytotoxicity was observed in the treated cells due to the presence of biologically synthesized Sa-AgNPs. An IC50 value of 48 μg·mL−1 was determined by treating L929 human fibroblast cells.
Chandrabose Selvaraj, Karthik Raja Ramalingam, Devadasan Velmurugan, and Sanjeev Kumar Singh
Elsevier
Chandrabose Selvaraj, Umesh Panwar, Karthik Raja Ramalingam, Rajendran Vijayakumar, and Sanjeev Kumar Singh
Elsevier
Ramalingam Karthik Raja, Phuong Nguyen-Tri, Govindasamy Balasubramani, Arun Alagarsamy, Selcuk Hazir, Safa Ladhari, Alireza Saidi, Arivalagan Pugazhendhi, and Arulandhu Anthoni Samy
Springer Science and Business Media LLC
Arul Dhayalan, Balasubramanian Velramar, Balasubramani Govindasamy, Karthik Raja Ramalingam, Aiswarya Dilipkumar, and Perumal Pachiappan
Elsevier BV
G. Sivaprakash, R. Karthik Raja, K. Mohanrasu, G.H. Dinesh, and A. Arun
Elsevier
R. Karthik Raja, Selcuk Hazir, Govindan Balasubramani, G Sivaprakash, Ebenezer Samuel James Obeth, Thulasinathan Boobalan, Arivalagan Pugazhendhi, R Hari Krishna Raj, and A Arun
Elsevier
Arumugam Priya, Anthonymuthu Selvaraj, Dass Divya, Ramalingam Karthik Raja, and Shunmugiah Karutha Pandian
Frontiers Media SA
Early childhood caries (ECC), a severe form of caries due to cross-kingdom interaction of Candida albicans and Streptococcus mutans, is a serious childhood dental disease that affects majority of the children with poor background. The present study investigated the anti-infective potential of thymol against C. albicans and S. mutans dual species for the management of ECC. Thymol, a plant derivative of the monoterpene group, has been well known for its numerous biological activities. Thymol at 300 μg/ml concentration completely arrested growth and proliferation of dual species of C. albicans and S. mutans. Rapid killing efficacy of pathogens, within a span of 2 min, was observed in the time kill assay. In addition, at sub-inhibitory concentrations, thymol effectively diminished the biofilm formation and virulence of both C. albicans and S. mutans such as yeast-to-hyphal transition, hyphal-to-yeast transition, filamentation, and acidogenicity and acidurity, respectively, in single and dual species state. qPCR analysis was consistent with virulence assays. Also, through the invertebrate model system Galleria mellonella, in vivo toxicity and efficacy of the phytocompound was assessed, and it was found that no significant toxic effect was observed. Moreover, thymol was found to be proficient in diminishing the infection under single and dual state in in vivo condition. Overall, the results from the present study illustrate the anti-infective potential of thymol against the ECC-causing dual species, C. albicans and S. mutans, and the applicability of thymol in medicated dentifrice formulation.
Arivalagan Pugazhendhi, Seerangaraj Vasantharaj, Selvam Sathiyavimal, Ramalingam Karthik Raja, Indira Karuppusamy, Mathiyazhagan Narayanan, Sabariswaran Kandasamy, and Kathirvel Brindhadevi
Elsevier BV
Ramu Satheesh Murugan, Gujuluva Hari Dinesh, Ramalingam Karthik Raja, Ebenezer Samuel James Obeth, Abhispa Bora, Naina Mohammed Samsudeen, Arivalagan Pugazhendhi, and Alagarsamy Arun
Elsevier BV
Ramalingam Karthik Raja, Alagarsamy Arun, Mustapha Touray, Sebnem Hazal Gulsen, Harun Cimen, Baris Gulcu, Canan Hazir, Dilipkumar Aiswarya, Derya Ulug, Ibrahim Cakmak,et al.
Elsevier BV
D. Aiswarya, R. K. Raja, C. Kamaraj, G. Balasubramani, P. Deepak, D. Arul, V. Amutha, C. Sankaranarayanan, S. Hazir, and P. Perumal
Springer Science and Business Media LLC
Aiswarya Dilipkumar, Karthik Raja Ramalingam, Kamaraj Chinnaperumal, Balasubramani Govindasamy, Deepak Paramasivam, Arul Dhayalan, and Perumal Pachiappan
Elsevier BV
Balasubramani Govindasamy, Deepak Paramasivam, Aiswarya Dilipkumar, Karthik Raja Ramalingam, Kamaraj Chinnaperumal, and Perumal Pachiappan
Springer Science and Business Media LLC
M. Raja, R. Raja, C. Kamaraj, V. Balasubramanian, M. Kavitha and P. Perumal
Introduction of alien parasitic nematodes to the wild fish species might result in a severe threat to native species biodiversity including native fish species and native parasitic fauna. In the present study, the invasive Asian nematode, C amallanus cotti (Nematoda: Camallanidae), has been reported for the first time in Giant Danio ( Devario aequipinnatus ) in the Cauvery river systems of Southern part of Western Ghats, India. The occurrence of this parasite in both aquarium-cultured fish as well as from the natural aquatic bodies dwelling fish is evident of the introduction of the alien organisms due to insufficient prophylactic measures during the transmission of non-native hosts between countries and also the spread of them by the anthropogenic introduction to natural systems.