SUNDARAMAHALINGAM M A
@nitt.edu
Research Scholar, Department of Chemical Engineering
National Institute of Technology Tiruchirappalli
RESEARCH INTERESTS
Bioenergy
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
M.A. Sundaramahalingam and P. Sivashanmugam
Elsevier BV
M. A. Sundaramahalingam, Pavithra Vijayachandran, J. Rajeshbanu, and P. Sivashanmugam
Springer Science and Business Media LLC
Ponmanian M, Vishnuprasad S, Suriiyakumar R, Gokulakrishnan S A, Ganeshmoorthy I, and Sundaramahalingam M A
Springer Science and Business Media LLC
Sundaramahalingam M A, Relli Teja, and Sivashanmugam P
CRC Press
A.V. Snehya, M.A. Sundaramahalingam, J. Rajesh Banu, and P. Sivashanmugam
Springer Science and Business Media LLC
M.A. Sundaramahalingam and P. Sivashanmugam
Elsevier BV
M.A. Sundaramahalingam and P. Sivashanmugam
Elsevier BV
M.A. Sundaramahalingam and P. Sivashanmugam
Elsevier BV
M. Shanthi, M.A. Sundaramahalingam, J. Rajeshbanu, and P.Sivashanmugam
Elsevier BV
M. A. Sundaramahalingam, A. V. Snehya, P. Sivashanmugam, J. Rajeshbanu, and S. Anandan
Springer Science and Business Media LLC
M.A. Sundaramahalingam, C. Amrutha, J. Rajeshbanu, K. Thirukumaran, S. Manibalan, Muthupandian Ashokkumar, and P. Sivashanmugam
Informa UK Limited
Abstract Yarrowia lipolytica is used as a model in this study to screen the potential candidates for inflating the innate lipid content of the cell. This study focuses on reducing the lipid degradation that occurs by the β-oxidation process and discursively increasing the innate lipid content. Acyl-CoA oxidase-1, the primary and initial enzyme involved in the lipid degradation pathway, was selected as a target and blocked using various lipid analogous compounds. The blocking study was carried out using molecular docking and dynamic studies using computation tools. The largest active site pocket located around the Phe-394 amino acid of the target protein is taken as a site for docking. The molecular docking was performed for the selected compounds (citric acid, Finsolv, lactic acid, oxalic acid, Tween-80 and Triton X-100) and the docking results were compared with the outcome of the standard molecule (octadecatrienoic acid). Citric acid, Finsolv, Tween-80 and Triton X-100 were found to be the potential candidates for blocking the target molecule in the static condition using docking studies, revealing a minimum binding energy requirement than the standard molecule. They were further taken for a dynamics study using GROMACS software. The RMSD, RMSF, number of hydrogen bond interactions and radius of gyration of the complex molecules were studied in a dynamic approach for 100 ns. Citric acid has been found to be the potential hit compound to block acyl-CoA oxidase-1 enzyme with its maximum hydrogen interaction and minimum fluctuations. It also revealed out the minimum total energy requirement for the complex formation. Graphical Abstract HIGHLIGHTS Suggesting a discursive strategy for inflating innate lipid content in Yarrowia lipolytica Molecular docking dynamics study of acyl-CoA oxidase-1 of Y. lipolytica with lipid analogous compounds. Molecular dynamics study of lipid analogous with acyl-CoA oxidase-1 of Y. lipolytica In silico strategy for bioenergy compounds Communicated by Ramaswamy H. Sarma
A.V. Snehya, M.A. Sundaramahalingam, J. Rajeshbanu, and P. Sivashanmugam
Elsevier BV
M.A. Sundaramahalingam, P. Sivashanmugam, J. Rajeshbanu, and Muthupandian Ashokkumar
Elsevier BV
M. A. Sundaramahalingam, Ritika Kabra, and Shailza Singh
Springer Nature Singapore
A.V. Snehya, M.A. Sundaramahalingam, J. Rajeshbanu, S. Anandan, and P. Sivashanmugam
Elsevier BV
M. A. Sundaramahalingam, C. Amrutha, P. Sivashanmugam, and J. Rajeshbanu
Springer Science and Business Media LLC
Michael Rahul S, Sundaramahalingam MA, Shivamthi CS, Shyam Kumar R, Varalakshmi P, Karthikumar S, Kanimozhi J, Vinoth Kumar R, Sabarathinam S, Ganesh Moorthy I,et al.
Hindawi Limited
Production of biodiesel from microalgae can be categorized as a symbiotic engineering solution focusing on energy and environmental problems. This review presents a collection of recent methods adopted for the production of biodiesel from microalgae. Microalgae are tiny cell factories which yield a large quantity of biomass by employing different methods of cultivation and using different types of harvesting techniques. Different strategies like nutrient starvation and micronutrient supplementation for hyper lipid accumulation to produce biodiesel for competing with the high market demand for fossil fuel are discussed. The use of different cultivation techniques for increasing the algal biomass in the recent scenario is focused. Also, improvement in the design strategies of bioreactors like the open pond, photobioreactors, and hybrid systems is included in the review. Further, diverse technologies for lipid improvement, including manipulating the bioprocess parameters and genetic engineering, are addressed. Also, microalgae for biorefinery approaches solve pollution problems, and its biomass can be used for biodiesel production which is elaborated in detail. The possibility of production of biodiesel from microalgae at a larger scale by overcoming the main bottlenecks in different steps of algal growth like high biomass cultivation, investment factor, and implementation of biorefinery approaches to address the current energy demand is also proposed.
M.A. Sundaramahalingam, S. Karthikumar, R. Shyam Kumar, Karl J. Samuel, S. Shajahan, V. Sivasubramanian, P. Sivashanmugam, P. Varalakshmi, Asad Syed, Najat Marraiki,et al.
Elsevier BV
V.S. Sivasankarapillai, S.S. Das, F. Sabir, M.A. Sundaramahalingam, J.C. Colmenares, S. Prasannakumar, M. Rajan, A. Rahdar, and G.Z. Kyzas
Elsevier BV