@iimtu.edu.in
Professor and Dean, Department of Pharmacy
IIMT College of Medical Science, IIMT University, Meerut, U.P.
M. Pharm., Ph.D., MBA, FRHS, FAGE
Formulation Development, Herbal Formulations, Novel Drug Delivery System,
Scopus Publications
Gyanendra Kumar Sharma, Gurvinder Pal Singh, Harsh Bhardwaj, Umesh Kumar Sharma, Manish Pal Singh, Himanshu Bhardwaj, and Akhileshar Prasad Mishra
Connect Journals
In the present investigation, we have synthesized some new 2-(substituted phenyl)-3-(thiazol-2-yl) imidazo[4,5-b]indoles (1b-8b) of biological interest. In the last step of the synthesis, N-(substituted benzylidene)thiazole-2- amines (1a-8a) were reacted with isatin and ammonium acetate using silica gel as the solid support to yield the corresponding substituted thiazolyl imidazo indole derivatives (1b-8b). The reactions were carried out by two different techniques - conventional and microwave irradiation. The microwave irradiation method offers excellent yield, lesser reaction time, and eco-environmental friendly reaction. All the synthesized compounds showed anticancer (Dalton lymphoma ascites cell line and EAC cell line method) and antibacterial activity (cup plate method).. KEYWORDS :Thiazolyl imidazo indole, Microwave-assisted synthesis, Anticancer, Antibacterial.
Suraj Mandal, Bhumika Km Bhumika, Mukesh Kumar, Jiyaul Hak, Prabhakar Vishvakarma, and Umesh Kumar Sharma
EManuscript Technologies
Umender Sharma, Aradhana Vipra, and Shankaramurthy Channabasappa
Elsevier BV