Vinayak Appasaheb Dhumale
@mituniversity.ac.in
Assistant Professor, Department of Applied Sciences and Humanities
MIT, Art Design and Technology University, Pune.
I am Dr. Vinayak A. Dhumale, is presently working as Assistant Professor at MIT Art Design and Technology University, Pune. I have obtained PhD from Defence Institute of Advanced Technology (Deemed University), Pune. My research interest includes synthesis of metal nanoparticles, antibacterial properties, sensors and biomedical applications. I have 14 international publication.
RESEARCH INTERESTS
Nanoscience and Nanotechnology
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Febrina Amelia Saputri, Eka Ulya Zubaidah, Amaranggani Wikan Puspita Kenanga, Catur Jatmika, Rimadani Pratiwi, and Vinayak A. Dhumale
MDPI AG
Hg2+ is one of the most dangerous pollutants that can cause damage to organs and the immune system. The common detection methods of Hg2+ require sophisticated instrumentation and a long time for analysis. The purpose of this study was to develop a sensor for the detection of Hg2+ using filter paper immobilized by gold nanoparticles (AuNPs) conjugated with cyanuric acid (CA). The clear color change from pink to bluish purple is the response of the CA-AuNPs filter paper sensor to exposure to Hg2+. Detection can be observed visually with the naked eye and/or with imageJ software; the detection limit is 0.05 µM. The colorimetric response of the sensor was also selective towards Hg2+ after testing with different metal ions. In addition, the response from the sensor was also consistent for lake water samples spiked with Hg2+. The results of this research provide a promising basic technology for the development of sensors that are affordable, fast, portable, and easy to use for the detection and monitoring of Hg2+ levels in water.
Vinayak A. Dhumale, Rajesh K. Gangwar, and Nishigandh Pande
Informa UK Limited
ABSTRACT In the last few decades gold nanoparticles have become an intense topic of research due to it's eminent size and morphology dependent optical, chemical, physical and electrical properties. Gold nanoparticles show useful technological applications in the province of nanoelectronics, optoelectronics, chemical and biological sensors. Due to the size- and shape-dependent properties, synthesis of gold nanoparticles with various methods is still an important area of research. Recent literature reports indicate that gold nanoparticles have vast biomedical applications such as biosensors, bio-imaging, targeted drug delivery and controlled drug release. Other than size and shape, the inter-particle distance dependent optical properties of gold nanoparticles have very interesting applications in the field of sensors. Gold nanoparticles show good selectivity and sensitivity for colorimetric identification of heavy toxic metal ions such as Hg2+, Cd2+, As3+, Pb2+ etc and various biomolecules. The concentration of such toxic metal ions in water can be identified by naked eye also.
Rajesh K Gangwar, Vinayak A Dhumale, Kalyani S Date, Prashant Alegaonkar, Rishi B Sharma, and Suwarna Datar
IOP Publishing
Thin multiwall carbon nanotubes (MWCNTs) have been decorated with gold nanoparticles (Au NPs) with polyaniline (PANI) as an inter-linker by a simple wet chemical method. The synthesized AuNPs:MWCNT:PANI composite was studied with UV–vis, FTIR, Raman spectroscopy, x-ray diffractometer, transmission electron microscopy (TEM) and atomic force microscopy (AFM). Conducting AFM (C-AFM) images of the composite reveal the role played by the two components in electrochemical reactions. The size of the Au NPs was found to be 13 ± 2 nm in the composite as observed from TEM. The synthesized AuNPs:MWCNT:PANI composite was further drop casted onto a glassy carbon electrode (GCE) for electrocatalytic study. The resulting composite exhibits good electrocatalytic activity towards reduction of H2O2 and O2. A glucose biosensor was developed by immobilizing glucose oxidase into AuNPs:MWCNT:PANI composite film on GCE. The fabricated sensor demonstrates good linear response to glucose (i.e. R = 0.9975) in the range of 2 to 12 mM.
Bindu Arora, Madhura Murar, and Vinayak Dhumale
Informa UK Limited
The present study aims to evaluate the inhibition effectiveness of titanium dioxide nanoparticles in combination with cell wall active antibiotics – ceftazidime and cefotaxime against the multi-drug resistant Pseudomonas aeroginosa isolated from pus, sputum, endo-tracheal tract and broncho-alveolar lavage. Commercial Degussa-P25 TiO2 nanoparticle, antibiotics ceftazidime and cefotaxime were used in this study against multi-drug-resistant nosocomial pathogen. The nanoparticle shows antimicrobial effect on the pathogen at concentrations more than 350 μg/mL, when exposed to ultraviolet (UV) light for an hour. Minimum inhibitory concentration values obtained for the antibiotic cefotaxime were sixfolds higher than the antibiotic ceftazidime. When these antibiotics were used in combination with UV-irradiated metal nanoparticle, ceftazidime resulted in enhanced antimicrobial activity whereas cefotaxime does not show any change.
Rajesh K. Gangwar, Geetanjali B. Tomar, Vinayak A. Dhumale, Smita Zinjarde, Rishi B. Sharma, and Suwarna Datar
American Chemical Society (ACS)
Curcumin, a yellow bioactive component of Indian spice turmeric, is known to have a wide spectrum of biological applications. In spite of various astounding therapeutic properties, it lacks in bioavailability mainly due to its poor solubility in water. In this work, we have conjugated curcumin with silica nanoparticles to improve its aqueous solubility and hence to make it more bioavailable. Conjugation and loading of curcumin with silica nanoparticles was further examined with transmission electron microscope (TEM) and thermogravimetric analyzer. Cytotoxicity analysis of synthesized silica:curcumin conjugate was studied against HeLa cell lines as well as normal fibroblast cell lines. This study shows that silica:curcumin conjugate has great potential for anticancer application.
Rajesh K Gangwar, Vinayak A Dhumale, S W Gosavi, Rishi B Sharma, and Suwarna S Datar
IOP Publishing
A simple and eco-friendly method has been developed for the synthesis of gold nanoparticles using allamanda flower extract. In this green synthesis method, chloroauric acid (HAuCl4) solution was reduced with the help of allamanda flower extract. The synthesized gold nanoparticles were characterized by atomic force microscopy (AFM), transmission electron microscopy (TEM) and x-ray diffraction technique for their morphological and structural analysis. The size of the spherical and triangular gold nanoparticles was found to be in the range of 5–40 and 20–70 nm, respectively. The x-ray diffraction analysis revealed that the crystallite size of face-centered cubic (FCC) gold nanoparticles was ∼ 11 nm. These synthesized gold nanoparticles exhibit good catalytic activity towards the reduction of H2O2. The fabricated sensor exhibits good sensitivity of 21.33 μA mM−1 cm−2 with linear relationship (R2 = 0.996) in the range from 2 to 10 mM of H2O2 concentration. This work can be extended further for potential applications such as antimicrobial studies, bio-imaging and drug-delivery owing to the known properties of the allamanda flower extract.
Vinayak A. Dhumale, Rajesh K. Gangwar, Suwarna S. Datar, and Rishi B. Sharma
American Scientific Publishers
A simple procedure has been developed for aggregation of polyvinylpyrrolidone (PVP) capped gold nanoparticles by controlling the pH of the solution. PVP-capped gold nanoparticles were synthesized via wet chemical method. Transmission electron microscopy (TEM) and UV-vis spectroscopy techniques were employed for determining the morphological features and surface plasmon resonance (SPR) of the gold nanoparticles. When the pH of the solution containing PVP-capped gold nanoparticles was changed from 6.7 to 1.0, the color of the solution changed from deep red to blue due to SPR weakening by particle aggregate formation. The color of the solution returned to its original red when the pH of the solution was brought back to 6.7. Furthermore, citrate protection of the gold nanoparticles was found to inhibit the reverse action. This reversible/irreversible-selectable structural control of gold nanoparticles with drastic changes in their optical absorption characteristics may find various nanophotonic applications including contactless pH detection.
Rajesh K. Gangwar, Vinayak A. Dhumale, Dimple Kumari, Umesh T. Nakate, S.W. Gosavi, Rishi B. Sharma, S.N. Kale, and Suwarna Datar
Elsevier BV
Rajesh K. Gangwar, Vinayak A. Dhumale, Arvind Kumar, Prashant Alegaonkar, Rishi B. Sharma, and Suwarna S. Datar
IEEE
Gold-graphene (Au-G) nanocomposite has been synthesized by wet chemical method. Synthesized Au-G nanocomposite was examined under the UV-vis spectroscopy and transmission electron microscopy (TEM). Further Au-G nanocomposite was drop casted onto the glassy carbon electrode (GCE) by immobilizing glucose oxidase (GOx) into it for the electrochemical detection of glucose. Fabricated sensor demonstrates good linear response to glucose in the range 3 to 18 mM with linearity coefficient 0.964.
VINAYAK A DHUMALE, PREETI V SHAH, RISHI B SHARMA, and KATSUAKI TANABE
Springer Science and Business Media LLC
Vinayak A. Dhumale, Rajesh K. Gangwar, Preeti V. Shah, Vasant N. Bhoraskar, Imtiaz S. Mulla, and Rishi B. Sharma
Elsevier BV
Vinayak A. Dhumale, Preeti V. Shah, Vasant N. Bhoraskar, and Rishi B. Sharma
Elsevier BV
Vinayak A. Dhumale, Preeti V. Shah, I.S. Mulla, and R.B. Sharma
Elsevier BV