Exploring Coumarin Derivatives for High-Performance Metal Ion Detection Yelyzaveta V. Antsybora, Viktoriia S. Moskvina, Volodymir P. Khilya Analysis and Sensing, 2026 The development of highly sensitive and selective chemosensors for metal ion detection is crucial for various applications in environmental monitoring, biological analysis, and clinical diagnostics. This review focuses on the design, synthesis, and application of coumarin‐based fluorescent and colorimetric chemosensors for the detection of a wide range of metal ions, including Mg 2+ , Al 3+ , Cr 3+ , Fe 2+ , Fe 3+ , Cu + , Cu 2+ , Zn 2+ , Ga 3+ , Pd 0 , Pd 2+ , Cd 2+ , La 3+ , Au 3+ , and Hg 2+ . Coumarin derivatives are highlighted for their excellent optical properties, including strong emission, high environmental stability, and low biological toxicity, making them ideal candidates for small‐molecule sensors. The review delves into the structural modifications of coumarin compounds that enhance their specificity and sensitivity towards target metal ions. We discuss critical parameters such as detection limits, naked‐eye and biological analysis potential, and detection mechanisms. This comprehensive overview emphasizes recent advancements in coumarin‐based probes, providing insights into their utility in real‐time monitoring, environmental protection, and medical diagnostics. By concentrating on the aqueous media applications and green chemistry principles, this paper serves as a valuable resource for researchers aiming to develop efficient and environmentally friendly metal ion sensors.
Synthesis of Enantioenriched 2-((Hetera)Cyclo) Alkylchromanols and their Spirocyclic Analogs through Enzymatic Resolution Oleksii S. Timokhin, Anastasiia M. Romanova, Viktoria S. Moskvina, Olexandr V. Kucher, Aleksandr I. Boiko, et al. European Journal of Organic Chemistry, 2025 An efficient approach to the multigram synthesis of 2‐((hetera) cyclo) alkylchromanols and their spirocyclic analogs based on enzymatic resolution is described. It is shown that enzymatic acylation could be used for the preparation of enantioenriched title compounds with primary alkyl substituents at the C‐2 position. Meanwhile, enzymatic hydrolysis of the corresponding acetates was optimal for the preparation of the target alcohols when significant steric hindrance is present, e. g., due to the α‐branching. The latter factor was demonstrated to be crucial for the enzymatic reaction rate in both cases. The synthetic utility of the obtained chiral alcohols was demonstrated through Mitsunobu configuration inversion, as well as by preparation of the corresponding primary amines – valuable sp3‐enriched building blocks for medicinal chemistry.
BENZODIAZEPINE DERIVATIVE – METRESDIAZENONE ELIMINATES BEHAVIORAL DISORDERS AND NORMALISES BILE PIGMENT CONTENT IN RATS WITH PARKINSONIAN SYNDROME L.Ya. Shtanova, S.P. Veselsky, O.O. Lukyanetz Fiziologichnyi Zhurnal, 2025 Parkinson's disease (PD) is associated not only with the death of dopaminergic neurons of the substantia nigra pars compacta but also with secondary mitochondrial dysfunction and oxidative stress. This study aimed to evaluate the neuroprotective effects of the benzodiazepine derivative Metresdiazenone on the manifestations of parkinsonian syndrome in a rotenone-induced rat model. Rats received rotenone (2.5 mg/kg, s.c.) for 14 days, followed by 14-day administration of Metresdiazenone (10 mg/kg, p.o.). Behavioral parameters were evaluated using the open field and rotarod tests. Rotenone caused motor disturbances, bradykinesia, and decreased locomotor activity, while Metresdiazenone treatment restored motor performance and exploratory behavior. Biochemically, the compound normalized glutathione levels and reduced lipid peroxidation markers in the striatum. Thus, Metresdiazenone exhibits pronounced neuroprotective and antioxidant properties, suggesting its potential as a therapeutic agent in Parkinson’s disease.
Synthetic strategies for 4-aroylisochromen-1-ones and isoquinolin-1-ones (microreview) KV Kukushkina, VS Moskvina Chemistry of Heterocyclic Compounds, 1-3 , 2026 2026
Expanding the biocatalytic toolbox: PLE-catalyzed kinetic resolution and lipophilicity modulation of 2-fluoroalkyl chroman-4-ols OS Timokhin, RS Andrii, OV Kucher, D Lesyk, Y Holota, P Borysko, ... Journal of Fluorine Chemistry, 110566 , 2026 2026
Front Cover: Exploring Coumarin Derivatives for High‐Performance Metal Ion Detection (Anal. Sens. 2/2026) YV Antsybora, VS Moskvina, VP Khilya Analysis & Sensing 6 (2), e70067 , 2026 2026
From Flavones to Flavanols: An Enzymatic Kinetic Resolution Approach to Enantioenriched 2-(Het) arylchroman-4-ols OS Timokhin, VV Hys, OV Kucher, AV Kozytskyi, RV Yizhak, VS Brovarets, ... Tetrahedron, 135174 , 2026 2026 Citations: 1
Exploring Coumarin Derivatives for High‐Performance Metal Ion Detection YV Antsybora, VS Moskvina, VP Khilya Analysis & Sensing 6 (1), e202500147 , 2026 2026
Chroman-4-one scaffolds as a platform for anticancer and antiviral lead discovery OS Timokhin, VS Moskvina, OV Kucher, KA Keith, EA Harden, CB Hartline, ... Ukrainica Bioorganica Acta 20 (1), 19-25 , 2025 2025
Design, synthesis and structural characterization of coumarin-1, 3, 4-thiadiazole hybrids bearing cycloalkyl and phenyl substituents: expanding the chemical space for medicinal … YY Rybina, VS Moskvina, VP Khilya Ukrainica Bioorganica Acta 20 (1), 10-18 , 2025 2025
Рециклізація 3-арил-1Н-ізохромен-4-карбальдегідів як ефективний підхід до синтезу функціоналізованих ізокумаринів та ізохінолінонів КВ Кукушкіна, ВС Москвіна Reports of the National Academy of Sciences of Ukraine, 49-57 , 2025 2025
Synthesis of Enantioenriched 2‐((Hetera) Cyclo) Alkylchromanols and their Spirocyclic Analogs through Enzymatic Resolution OS Timokhin, AM Romanova, VS Moskvina, OV Kucher, AI Boiko, ... European Journal of Organic Chemistry 28 (8), e202401247 , 2025 2025 Citations: 3
SYNTHETIC STRATEGIES FOR 4-AROYLISOCHROMEN-1-ONES AND ISOQUINOLIN-1-ONES KV Kukushkina, VS Moskvina Chemistry of Heterocyclic Compounds 61 (9/10), 438-440 , 2025 2025
Модифікації 7-гідрокси-3-(бензотіазол-2-іл) кумарину ТВ Шокол, АВ Супрун, ЄК Глібов, ВС Москвіна, ВП Хиля Reports of the National Academy of Sciences of Ukraine, 90-98 , 2025 2025
Рециклізація 3-(2-(морфолін-4-карбоніл)-феніл)-4Н-хромен-4-онів під дією 1, 2-та 1, 3-N, N-бінуклеофілів КВ Кукушкіна, ВС Москвіна Reports of the National Academy of Sciences of Ukraine, 11-18 , 2024 2024
Progress in the synthesis of 3-fluorochromones (microreview) YY Rybina, VS Moskvina Chemistry of Heterocyclic Compounds 60 (9), 430-432 , 2024 2024 Citations: 1
Modified Neoflavones Based on 7-Hydroxyneoflavone-6-Enamino Ketone and 7-Hydroxy-3-Hetarylbenzopyran-2-and 4-Ones Mannich Bases and Their Recyclization EK Hlibov, NV Gorbulenko, VS Moskvina, OV Shablykina, TV Shokol, ... Chemistry of Natural Compounds 60 (2), 223-228 , 2024 2024 Citations: 1
Synthesis and in vitro anticancer evaluation of functionalized 5-(4-piperazin-1-yl)-2-aryloxazoles and 5-[(4-arylsulfonyl)piperazin-1-yl]-2-phenyloxazoles OO Severin, SG Pilyo, VS Moskvina, OV Shablykina, YA Karpichev, ... Chemistry of Heterocyclic Compounds 60 (1), 68-74 , 2024 2024 Citations: 1
Energy metabolism in the liver of rats with rotenone-induced Parkinsonian syndrome under the influence of methanindiazenone LY Shtanova, SP Vesеlsky, PI Yanchuk, OV Tsymbalyuk, VS Moskvina, ... Fiziol Zh 70 (5), 79-87 , 2024 2024 Citations: 1
Exploring aminomethylcoumarins: versatile synthesis, structural diversity, and ADME prediction EK Hlibov, VS Moskvina, YS Malets, VP Khilya Ukrainica Bioorganica Acta 18 (2), 22-30 , 2023 2023
Synthesis of chromeno[2,3- c ]pyrrol-9(2 H )-ones (microreview) VS Moskvina, VP Khilya Chemistry of Heterocyclic Compounds 59 (11), 736-738 , 2023 2023
Benzodiazepinе derivative methanindiazenone modulates lipid metabolism in the liver of rats with rotenone-induced Parkinson’s syndrome LY Shtanova, SP Vesеlsky, PI Yanchuk, OV Tsymbalyuk, OF Moroz, ... Fiziol Zh 69 (6), 77-87 , 2023 2023 Citations: 2
Distinctive Features of 3‐Acetyl‐and 3‐Benzoyl‐Isocoumarins’ Interaction with Active Primary Amines AS Konovalenko, OV Shablykin, OV Shablykina, VS Moskvina, ... ChemistrySelect 8 (37), e202301380 , 2023 2023 Citations: 2
MOST CITED SCHOLAR PUBLICATIONS
Cycloadditions of alkenylboronic derivatives OO Grygorenko, VS Moskvina, OV Hryshchuk, AV Tymtsunik Synthesis 52 (19), 2761-2780 , 2020 2020 Citations: 26
Expanding the chemical space of 1, 2-difunctionalized cyclobutanes AV Chernykh, OV Kudryk, OS Olifir, AV Dobrydnev, E Rusanov, ... The Journal of Organic Chemistry 88 (5), 3109-3131 , 2023 2023 Citations: 18
2-(Dichloromethyl) pyrazolo [1, 5-a][1, 3, 5] triazines: synthesis and anticancer activity YS Velihina, SG Pil’o, VS Zyabrev, VS Moskvina, OV Shablykina, ... Biopolymers & Cell 36 (1), 60 , 2020 2020 Citations: 17
Synthesis of pyrano[2,3- f ]chromen-2,8-diones and pyrano[3,2- g ]chromen-2,8-diones based on o -hydroxyformyl(acyl)neoflavonoids VS Moskvina, VP Khilya Chemistry of Natural Compounds 44 (1), 16-23 , 2008 2008 Citations: 17
A Versatile Synthesis of Heterocyclic Analogues of Neoflavonoids from Enamino Ketones VS Moskvina, VP Khilya, OV Turov, UM Groth Synthesis 2009 (08), 1279-1286 , 2009 2009 Citations: 16
Inhibition of hyaluronan secretion by novel coumarin compounds and chitin synthesis inhibitors AA Tsitrina, IV Krasylov, DI Maltsev, IN Andreichenko, VS Moskvina, ... Glycobiology 31 (8), 959-974 , 2021 2021 Citations: 15
3‐Fluoroalkyl (CF 3 , CHF 2 , CH 2 F) Cyclobutane‐Derived Building Blocks for Medicinal Chemistry: Synthesis and Physicochemical Properties OP Demchuk, BV Bobovskyi, BV Vashchenko, OV Hryshchuk, ... European Journal of Organic Chemistry 26 (24), e202300292 , 2023 2023 Citations: 14
3-Hetarylisocoumarins in the synthesis of 1-functionalized 3-hetarylisoquinolines AS Konovalenko, OV Shablykin, VS Brovarets, OV Shablykina, ... Chemistry of Heterocyclic Compounds 56 (8), 1021-1029 , 2020 2020 Citations: 13
Recent Progress in the Synthesis of 4-Arylcoumarins VS Moskvina, VP Khilya Chemistry of Natural Compounds 55 (3), 401-427 , 2019 2019 Citations: 12
Condensation of 2-(4-chlorophenyl)-1-(2,4-dihydroxyphenyl) ethanone with N , N -dimethylformamide dimethyl acetal: an effective approach to 3-(4-chlorophenyl)-7-methoxy-4 … VS Moskvina, SV Shilin, VP Khilya Chemistry of Heterocyclic Compounds 51 (9), 799-803 , 2015 2015 Citations: 12
Synthesis of azachromones and azachromanones YS Malets, VS Moskvina, OO Grygorenko, VS Brovarets Chemistry of Heterocyclic Compounds 55 (11), 1007-1012 , 2019 2019 Citations: 11
Aryl alkynoates in the radical synthesis of coumarins VS Moskvina, VP Khilya Chemistry of Heterocyclic Compounds 55 (4), 300-306 , 2019 2019 Citations: 10
Reactions of 3-arylisocoumarins with N-nucleophiles–a route to novel azaheterocycles VS Moskvina, OV Shablykina, VP Khilya Current Topics in Medicinal Chemistry 17 (29), 3199-3212 , 2017 2017 Citations: 10
Synthesis and structure of 4-arylspirodihydro-pyranochromen-2-one derivatives VS Moskvina, YL Garazd, MM Garazd, AV Turov, VP Khilya Chemistry of Heterocyclic Compounds 43 (4), 421-429 , 2007 2007 Citations: 10
Functionalized 5‐Amino‐4‐cyanoxazoles, their Hetero‐and Macrocyclic Derivatives: Preparation and Synthetic Applications DO Merzhyievskyi, OV Shablykin, OV Shablykina, AV Kozytskiy, ... European Journal of Organic Chemistry 2021 (47), 6511-6523 , 2021 2021 Citations: 7
Pyranoneoflavonoids: Synthesis and structure VS Moskvina, DY Masich, VP Khilya, VP Khilya Dopov Nac akad nauk Ukr 12, 122-127 , 2014 2014 Citations: 7
8-(Methyl(phenyl)sulfonyl)-2,6-dihydroimidazo[1,2- c ]- pyrimidin-5(3 Н )-ones and 9-(methyl(phenyl)sulfonyl)- 2,3,4,7-dihydro-6 H -pyrimido[1,6- a ]pyrimidin-6-ones … RN Solomyannyi, OV Shablykina, VS Moskvina, VP Khilya, EB Rusanov, ... Chemistry of Heterocyclic Compounds 55 (4), 401-407 , 2019 2019 Citations: 6
Efficient synthesis of 1-oxo-3-aryl-1H-isochromene-4-carbaldehydes from enaminoketones of 2′-carboxamidodeoxybenzoins VS Moskvina, OV Shablykina, VV Ishchenko, VP Khilya Tetrahedron Letters 58 (3), 245-247 , 2017 2017 Citations: 6
Synthesis and NMR spectroscopy investigations of functionalized 8,8,10-trimethyl-4-phenyl-7,8-dihydro-2 H ,6 H -pyrano[3,2- g ]chromene-2,6-diones and their … VS Moskvina, OV Turov, VP Khilya, MM Garazd, UM Groth Monatshefte für Chemie-Chemical Monthly 139 (11), 1391-1396 , 2008 2008 Citations: 6
Anticancer activity of isoquinoline derivatives—products of 3-(2-(thien-2-yl) thiazol-4-yl isocoumarin recyclization AS Konovalenko, OV Shablykin, OV Shablykina, VS Moskvina, ... 2019 Citations: 5
