Michael Oluwole Osungunna

@oauife.edu.ng

Associate Professor/Department of Pharmaceutical Microbiology/Faculty of Pharmacy
Obafemi Awolowo University

Michael Oluwole Osungunna


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https://researchid.co/yomosun2002

RESEARCH, TEACHING, or OTHER INTERESTS

Microbiology, Applied Microbiology and Biotechnology, Immunology and Microbiology
12

Scopus Publications

Scopus Publications

  • BIOFILM: FORMATION AND NATURAL PRODUCTS’ APPROACH TO CONTROL - A REVIEW
    Michael Oluwole OSUNGUNNA
    African Journal of Infectious Diseases, 2022
    Biofilm formation, especially on indwelling medical devices such as catheters, can result in infections and substantially affect patients' quality of life. Biofilm-associated infections have led to increased morbidity and mortality, increased cost of treatment, and length of hospital stay. However, all of the identified consequences of the biofilm-associated infections had been attributed to the reduced susceptibility of biofilm to conventional antimicrobial agents which has necessitated the development of a new strategy for biofilm infections control, thereby making a search for more effective antimicrobial agents from plant source inevitable. So far, some antimicrobial agents (crude or isolated compounds) from plant sources affect a specific stage of biofilm development while a few of them have been developed into a suitable dosage form for biofilm control. In this review, an attempt is made to look into some definitions of biofilm by "biofilmologists", stages in biofilm formation, mechanisms of resistance in biofilm, biofilm control strategies, the use of some natural products in biofilm control and concepts of probiotics as agents of biofilm control.
  • Effect of Chitosan-Coated Nanostructured Lipid Carrier on Escherichia coli Biofilms
    Michael Oluwole Osungunna, André Pitondo-Silva, Letícia Bueno Silva, Ana Carolina S. Ré, Priscyla D. Marcato, et al.
    Bionanoscience, 2021
  • Spray-Dried Proliposomes: an Innovative Method for Encapsulation of Rosmarinus officinalis L. Polyphenols
    Victor Oloruntoba Bankole, Michael Oluwole Osungunna, Claudia Regina Fernandes Souza, Sergio Luiz Salvador, Wanderley Pereira Oliveira
    AAPS Pharmscitech, 2020
    This work aims to improve the functionality of Rosmarinus officinalis L. (rosemary) polyphenols by encapsulation in an optimized proliposome formulation. A 23 Box-Wilson central composite design (CCD) was employed to determine lone and interaction effects of composition variables on moisture content (Xp); water activity (Aw); concentration and retention of rosemary polyphenols—rosmarinic acid (ROA), carnosol (CAR), and carnosic acid (CNA); and recovery of spray-dried proliposomes (SDP). Processing conditions which generate proliposomes with optimum physicochemical properties were determined by multi-response analysis (desirability approach). Antioxidant and antifungal activities were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH•) sequestering and minimum inhibitory concentration (MIC)/minimum fungicidal concentration (MFC) assays, respectively. SDP exhibited high polyphenol retention, ranging from 62.0 to 100.0% w/w, showing dependence on composition variables and polyphenol lipophilicity. SDP recovery ranged from 20.1 to 45.8%, with Xp and Aw of 1.7 ± 0.14–2.5 ± 0.23% w/w and 0.30 ± 0.004–0.47 ± 0.003, respectively, evidencing product with good chemical and microbiological stability. Optimum liposomal composition was determined, namely, lipid concentration (4.26% w/w), lyophilized extract (LE) concentration (4.48% w/w), and drying aid:(lipid+extract) ratio (7.55% w/w) on wet basis. Relative errors between experimental and predicted values for SDP properties showed concurrence for all responses except CAR retention, being 22% lower. SDP showed high antioxidant activity with IC50 of 9.2 ± 0.2 μg/mL, superior to results obtained for LE (10.8 μg/mL) and butylated hydroxytoluene (BHT), a synthetic antioxidant (12.5 μg/mL). MIC and MFC against Candida albicans (ATCC1023) were 312.5 μg/mL and 1250 μg/mL, respectively, a moderate antimicrobial activity for phytochemical-based products. SDP is shown as a veritable tool to encapsulate hydrophilic and lipophilic rosemary polyphenols generating a product with optimal physicochemical and biological properties.
  • Screening of medicinal plants for antimicrobial activity: Pharmacognosy and microbiological perspectives
    Michael Oluwole Osungunna
    Journal of Microbiology Biotechnology and Food Sciences, 2020
    The use of medicinal plants for human ailments precedes the introduction of conventional antibiotics. However, medicinal plants continue to enjoy human patronage because they are cheap, readily available and free from side effects often associated with conventional antibiotics. Reproducibility, on the part of screening plants for antimicrobial activity, has become a challenge both from the pharmacognosy and microbiology points of view. This review addresses the sampling techniques, phytochemical screening and the concept of metabolomics in relation to medicinal plants as well as the applicability and the advantages and disadvantages of some microbiological methodologies used in screening medicinal plants for their antimicrobial activity.
  • Anti-adhesion and antibiotic modulatory evaluation of grapefruit (citrus paradisi) juice and seed extract on bacteria isolated from urine and catheter
    Journal of Pharmacy and Pharmacognosy Research, 2016
  • Isolation and characterization of chemical constituents from Chrysophyllum albidum G. Don-Holl. stem-bark extracts and their antioxidant and antibacterial properties
    T. O. Idowu, Abiodun Oguntuga Ogundaini, S. A. Adesanya, G. O. Onawunmi, M. O. Osungunna, et al.
    African Journal of Traditional Complementary and Alternative Medicines, 2016
    Background: The plant, Chrysophyllum albidum is indigenous to Nigeria and its stem-bark has found relevance in folkloric
 medicine for infections and oxidative stress linked diseases medicaments. The study targets to isolate the chemical constituents
 accountable for the antioxidant and antibacterial actions of the plant stem-bark to substantiate some of its ethnomedicinal uses.
 Materials and Methods: Stem-bark extract of Chrysophyllum albidum was obtained from 80 % ethanol was partitioned in sequence
 with ethyl acetate (EtOAc) and n-butanol. The solvent fractions and isolated compounds were verified for antioxidant chattels
 utilizing 2-2-diphenyl-1-picrylhydrazyl. Antibacterial actions were also assessed by agency of agar-diffusion and broth micro
 dilution methods. EtOAc fraction was on many occasions chromatographed on silica and Sephadex LH-20 column to afford four
 compounds and their chemical structures were proven with the employment of NMR (1D and 2D) and MS.
 Results: Chromatographic fractionation of EtOAc fraction with the premier antioxidant and antimicrobial activities afforded
 stigmasterol (1), epicatechin (2), epigallocatechin (3) and procyanidin B5 (4). Procyanidin B5 isolated for the first time from
 Chrysophyllum genus proven the supreme antioxidant activity with IC50 values of 8.8 µM and 11.20 µM in DPPH and nitric oxide
 assays respectively and equally established the ultmost inhibitory activity against Escherichia coli (MIC 156.25 μg/mL),
 Staphylococcus aureus (MIC 156.25 μg/mL), Pseudomonas aeruginosa (MIC 625 μg/mL) and Bacillus subtilis (MIC 156.25
 μg/mL).
 Conclusion: The antibacterial and antioxidant activities of epicatechin, epigallocatechin and procyanidin B5 isolated from
 Chrysophyllum albidum stem-bark substantiate the folkloric uses
  • Erratum: Phytochemical and antimicrobial screening of Globimetula oreophila (Oliv) van Tiegh and Phragmanthera capitata (Spreng) Balle (International Journal of Green Pharmacy (2013) 7:2)
    RaviKant Upadhyay
    International Journal of Green Pharmacy, 2014
  • Phytochemical and antimicrobial screening of Globimetula oreophila (Oliv) van Tiegh and Phragmanthera capitata (Spreng) Balle
    Osungunna Oluwole, MO Osungunna, Y Abimbola
    International Journal of Green Pharmacy, 2013
  • Evaluation of anticaries activity of selected mouthwash marketed in Nigeria
    Tropical Journal of Pharmaceutical Research, 2010
  • Phytochemical and antimicrobial screening of the leaf extract of Diospyros barteri. Gurke
    B.B. Oluremi, M.O. Osungunna, O.O. Ogbole
    Pharmacognosy Journal, 2010
  • Bacteriological and antibiotic sensitivity patterns of bacterial isolates from creams and lotions hawked in Sagamu, Ogun State
    M.O. Osungunna, B.B. Oluremi, A. Adetuyi
    Pakistan Journal of Nutrition, 2010
  • Comparative microbial quality of jedi drinks sold in two major cities in Nigeria
    M.O. Osungunna, B.B. Oluremi, I. Talabi
    Pakistan Journal of Nutrition, 2010