Zhixia Liu

@gmail.com

Chemistry
The Scripps Research Institute



               

http://researchid.co/zhixialiu

RESEARCH INTERESTS

Protein folding, Protein engineering, Aptamer discovery, Drug delivery

15

Scopus Publications

503

Google Scholar Citations

11

Google Scholar h-index

11

Google Scholar i10-index

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

  • Evolved polymerases facilitate selection of fully 2’-OMe-modified aptamers
    Z Liu, T Chen, FE Romesberg
    Chemical Science, DOI: 10.1039/c7sc03747c 2017

  • Selection of 2′-Fluoro-Modified Aptamers with Optimized Properties
    D Thirunavukarasu, T Chen, Z Liu, N Hongdilokkul, FE Romesberg
    Journal of the American Chemical Society 139, 2892−2895 2017

  • The expanding world of DNA and RNA
    T Chen, N Hongdilokkul, Z Liu, D Thirunavukarasu, FE Romesberg
    Current Opinion in Chemical Biology 34, 80–87 2016

  • Evolution of thermophilic DNA polymerases for the recognition and amplification of C2′-modified DNA
    T Chen, N Hongdilokkul, Z Liu, SS Tsuen, FE Romesberg
    Nature Chemistry 8 (6), 556-562 2016

  • Capture and enumeration of mRNA transcripts from single cells using a microfluidic device
    MT Walsh, AP Hsiao, HS Lee, Z Liu, X Huang
    Lab on a Chip 15, 2968–2980 2015

  • DIRECT REAL-TIME SINGLE MOLECULE DNA SEQUENCING
    Z Liu, M Walsh, X Huang
    NHGRI Advanced Sequencing Technology Development Meeting, San Diego, CA, USA 2013

  • Direct real-time single molecule DNA sequencing
    Z Liu, E Roller, M Walsh, X Huang
    NHGRI Advanced Sequencing Technology Development Meeting, San Diego, CA, USA 2012

  • Strengthening the stability of a tunnel-shaped homotetramer protein with nanogels
    Z Liu, D Lu, L Yin, J Li, Y Cui, W Chen, Z Liu
    The Journal of Physical Chemistry B 115 (28), 8875-8882 2011

  • Engineering DNA polymerases as chemo-mechanical nanosensors for real-time DNA sequencing
    Z Liu, E Roller, M Chandrangsu, X Huang
    NHGRI Advanced Sequencing Technology Development Meeting, San Diego, CA, USA 2011

  • Preparation and characterization of single-enzyme nanogels
    J Ge, M Yan, D Lu, Z Liu, Z Liu
    Nanoscale Biocatalysis, 119-130 2011

  • Genome sequencing by natural DNA synthesis
    EE Roller, KS Ko, Z Liu, M Walsh, X Huang
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 240 2010

  • Engineering DNA polymerases as chemo-mechanical nanosensors for real-time DNA sequencing
    Z Liu, E Roller, X Huang
    International Symposium on Advanced Biological Engineering, Beijing, China 2010

  • Genome sequencing by natural DNA synthesis
    E Roller, KS Ko, Z Liu, M Walsh, X Huang
    NHGRI Advanced Sequencing Technology Development Meeting, Chapel Hill, NC, USA 2010

  • Recent advances in nanostructured biocatalysts
    J Ge, D Lu, Z Liu, Z Liu
    Biochemical Engineering Journal 44 (1), 53-59 2009

  • Method for manufacturing nanoscale macromolecular biocatalytic particles containing horseradish peroxidase
    PO Ming Yan, Zheng Liu, Jun Ge, Zhixia Liu, Minlian Zhang
    CN Patent CN100469873; CN1,904,042 2009

  • Strengthening intersubunit hydrogen bonds for enhanced stability of recombinant urate oxidase from Aspergillus flavus: molecular simulations and experimental validation
    Z Liu, D Lu, J Li, W Chen, Z Liu
    Physical Chemistry Chemical Physics 11 (2), 333-340 2009

  • Study of temperature-induced structural transition of urate oxidase and fabrication of urate oxidase nanogel
    Z Liu, D Lu, J Li, Z Liu, W Chen
    The 2nd International Symposium on Advanced Biological Engineering and 2008

  • Role of intersubunit hydrogen bond to urate oxidase stability: molecular simulation and experimental validation
    Z Liu, D Lu, Z Liu
    AICHE Annual Meeting, Philadelphia, PA, USA 2008

  • Robust Biocatalytic Single Enzyme Nanogels by Versatile Strategies
    M Yan, S Li, Z Liu, Z Liu
    The 2007 Annual Meeting 2007

  • Fabrication of single carbonic anhydrase nanogel against denaturation and aggregation at high temperature
    M Yan, Z Liu, D Lu, Z Liu
    Biomacromolecules 8 (2), 560-565 2007

MOST CITED SCHOLAR PUBLICATIONS

  • Recent advances in nanostructured biocatalysts
    J Ge, D Lu, Z Liu, Z Liu
    Biochemical Engineering Journal 44 (1), 53-59 2009
    Citations: 131

  • Fabrication of single carbonic anhydrase nanogel against denaturation and aggregation at high temperature
    M Yan, Z Liu, D Lu, Z Liu
    Biomacromolecules 8 (2), 560-565 2007
    Citations: 99

  • Evolution of thermophilic DNA polymerases for the recognition and amplification of C2′-modified DNA
    T Chen, N Hongdilokkul, Z Liu, SS Tsuen, FE Romesberg
    Nature Chemistry 8 (6), 556-562 2016
    Citations: 60

  • Dextran-grafted-PNIPAAm as an artificial chaperone for protein refolding
    D Lu, Z Liu, M Zhang, X Wang, Z Liu
    Biochemical engineering journal 27 (3), 336-343 2006
    Citations: 42

  • The expanding world of DNA and RNA
    T Chen, N Hongdilokkul, Z Liu, D Thirunavukarasu, FE Romesberg
    Current Opinion in Chemical Biology 34, 80–87 2016
    Citations: 40

  • The mechanism of PNIPAAm-assisted refolding of lysozyme denatured by urea
    D Lu, Z Liu, M Zhang, Z Liu, H Zhou
    Biochemical engineering journal 24 (1), 55-64 2005
    Citations: 40

  • Selection of 2′-Fluoro-Modified Aptamers with Optimized Properties
    D Thirunavukarasu, T Chen, Z Liu, N Hongdilokkul, FE Romesberg
    Journal of the American Chemical Society 139, 2892−2895 2017
    Citations: 28

  • Molecular simulation of surfactant-assisted protein refolding
    D Lu, Z Liu, Z Liu, M Zhang, P Ouyang
    The Journal of chemical physics 122 (13), 134902 2005
    Citations: 17

  • Strengthening intersubunit hydrogen bonds for enhanced stability of recombinant urate oxidase from Aspergillus flavus: molecular simulations and experimental validation
    Z Liu, D Lu, J Li, W Chen, Z Liu
    Physical Chemistry Chemical Physics 11 (2), 333-340 2009
    Citations: 14

  • Evolved polymerases facilitate selection of fully 2’-OMe-modified aptamers
    Z Liu, T Chen, FE Romesberg
    Chemical Science, DOI: 10.1039/c7sc03747c 2017
    Citations: 12

  • Strengthening the stability of a tunnel-shaped homotetramer protein with nanogels
    Z Liu, D Lu, L Yin, J Li, Y Cui, W Chen, Z Liu
    The Journal of Physical Chemistry B 115 (28), 8875-8882 2011
    Citations: 12

  • Preparation and characterization of single-enzyme nanogels
    J Ge, M Yan, D Lu, Z Liu, Z Liu
    Nanoscale Biocatalysis, 119-130 2011
    Citations: 6

  • Surfactant assisted protein refolding in vitro: molecular simulation
    D Lu, J Wang, Z Liu, M Zhang, Z Liu
    JOURNAL OF CHEMICAL INDUSTRY AND ENGINEERING-CHINA- 56 (6), 1063 2005
    Citations: 2

Publications

Liu Z, Chen T, Romesberg FE, Evolved polymerases facilitate selection of fully 2’-OMe-modified aptamers, Chemical Science, 2017, 8: 8179
Thirunavukarasu D, Chen T, Liu Z, Hongdilokkul N, Romesberg FE, Selection of 2’-Fluoro-Modified Aptamers with Optimized Properties, Journal of the American Chemical Society, 2017, 139: 2892
Chen T, Hongdilokkul N, Liu Z, Thirunavukarasu D, Romesberg FE, The expanding world of DNA and RNA, Current Opinion in Chemical Biology, 2016, 34: 80
Chen T, Hongdilokkul N, Liu Z, Adhikary R, Tsuen SS, Romesberg FE, Evolution of thermophilic DNA polymerases for the recognition and amplification of C2ʹ-modified DNA, Nature Chemistry, 2016, 8: 556
Walsh M, Hsiao A, Lee HS, Liu Z, Huang X, Capture and enumeration of mRNA transcripts from single cells using a microfluidic device, Lab on a Chip, 2015, 15: 2968
Liu Z, Lu D, Yin L, Li J, Cui Y, Chen W, Liu Z, Strengthening the stability of a tunnel-shaped homotetramer protein with nanogels, The Journal of Physical Chemistry B, 2011, 115: 8875
Liu Z, Lu D, Li J, Chen W, Liu Z, Strengthening intersubunit hydrogen bonds for enhanced stability of recombinant urate oxidase from Aspergillus flavus: Molecular simulations and experimental validation, Physical Chemistry Chemical Physics, 2009, 11: 333
Ge J, Lu D, Liu Z, Liu Z, Recent advances in nanostructured biocatalysts, Biochemical Engineering Journal, 2009, 44: 53
Yan M, Liu Z, Lu D, Liu Z, Fabrication of single carbonic anhydrase nanogel against denaturation and aggregation at high temperature, Biomacromolecules, 2007, 8: 560
Lu D, Liu Z, Zhang M, Wang X, Liu Z, Dextran-grafted-PNIPAAm as an artificial chaperone for protein refolding, Biochemical Engineering Journal, 2006, 27: 336
Lu D, Liu Z, Zhang M, Liu Z, Zhou H, The mechanism of PNIPAAm-assisted refolding of lysozyme denatured by urea, Biochemical Engineering Journal, 2005, 24: 55
Lu D, Liu Z, Liu Z, Zhang M, Ouyang P, Molecular simulation of surfactant-assisted protein refolding, The Journal of Chemical Physics, 2005, 122: Art No.134902(1-11)
Lu D, Wang J, Liu Z, Zhang M, Liu Z, Surfactant assisted protein refolding in vitro: molecular simulation, Journal of Chemical Industry and Engineering-China, 2005, 56: 1063
Ge J, Yan M, Lu D, Liu Z, Liu Z, Preparation and Characterization of Single-Enzyme Nanogels, In: Wang P. (eds) Nanoscale Biocatalysis. Methods in Molecular Biology (Methods and Protocols), vol 743. Humana Press, 2011

RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

Yan M, Liu Z, Ge J, Liu Z, Zhang M, Ouyang P, Method for manufacturing nanoscale macromolecular biocatalytic particles containing horseradish peroxidase, Patent No. CN1904042; CN 100469873