Linkage Between miR-218-2 (rs11134527) Genetic Polymorphism and Breast Cancer Risk: A Case-Control Study in the Bangladeshi Women A. M. Shamim, Aiman Hossan, Md. Shafiul Hossen, Md Abdul Barek, Mohammad A. Rashid, et al. Health Science Reports, 2026 Background and Aims The growth and spread of breast carcinoma are influenced by genetic factors. Diverse forms of cancer have been reported to display multiple subtypes of the microRNA gene. Therefore, the current study aimed to explore the connection between the miR‐218‐2 (rs11134527) and breast cancer risk. Methods A total of 303 participants (158 breast cancer patients and 145 healthy controls) were enrolled. Clinical and demographic data were collected through structured questionnaires and hospital records. Genotyping of miR‐218‐2 rs11134527 was performed using the T‐ARMS‐PCR technique. Statistical analyses were conducted with SPSS v25.0 and MedCalc v19.0.7. The adjusted odds ratio (aOR) using binary logistic regression that controls for age and BMI was employed to investigate the relationship between the targeted SNPs and the risk of breast cancer. Results Among the patients, invasive ductal carcinoma was the most frequent histological type (49.61%), followed by lobular carcinoma (17.22%). Grade II tumors (63.75%) were predominant. Ultrasound (64.18%) and biopsy (68.66%) were the most common diagnostic tools. Chemotherapy was the principal treatment (62.12%), with cyclophosphamide (69.62%), doxorubicin (53.80%), and paclitaxel (56.33%) as the most prescribed agents. Genotype analysis revealed that individuals carrying the AA genotype had a significantly higher risk of breast cancer than those with GG (additive model 2: OR = 2.48, 95% CI = 1.12–5.48, p = 0.025). Significant associations were also observed under the recessive model (AA vs. GG + AG: OR = 1.96, 95% CI = 1.0–3.86, p = 0.051) and the allelic model (A vs G: OR = 1.59, 95% CI = 1.06–2.39, p = 0.026). Conclusion The miR‐218‐2 rs11134527 A allele confers an increased risk of breast cancer in Bangladeshi women, supporting its potential role as a population‐specific genetic biomarker for susceptibility assessment.
An Updated Narrative Review on the Therapeutic Potential of Resveratrol in the Treatment of Cancer Mohammad Ashraful Islam, Al Amin, Md. Abdul Aziz, Md. Mahabubur Rahaman, Jakir Hossain, et al. Health Science Reports, 2026 Background Cancer is a significant global health challenge, affecting millions of people every year. Overall survival rates have improved over time, but some patients exhibit treatment resistance, prompting ongoing research to find suitable and effective sensitizers. Resveratrol, a natural polyphenolic compound, has demonstrated significant effects in inhibiting the growth and spread of cancer. However, the molecular mechanisms and applications of resveratrol remain unclear. Objective In this updated narrative review, we aimed at discussing the role and related molecular mechanisms of resveratrol in various cancers and providing an overview of its therapeutic potential for the treatment and prevention of these cancers. Methodology We conducted an extensive literature search across four major databases, including PubMed, Google Scholar, Web of Science, and ScienceDirect, to identify all relevant articles. Result Resveratrol is a naturally occurring polyphenolic compound, specifically a stilbene, found in significant quantities in grapes, berries, peanuts, and various other plants. Resveratrol significantly contributes to the reduction of various human cancers, including those of the breast, cervix, thyroid, prostate, brain, skin, colon, bone, and ovarian cancers. Resveratrol has been shown to influence cell cycle arrest, activate apoptosis, and suppress metastasis, all of which are achieved through various signaling pathways. Additionally, several in vivo studies have shown promising results suggesting it may reduce tumor development and extend lifespan in animal cancer models, among other benefits. Conclusion This review indicates that resveratrol could serve as a prototype for developing more efficacious and less toxic therapeutic agents for the treatment of various cancers.
Association of NUDT17 rs9286836 and rs2004659 variants with breast cancer risk in Bangladeshi Women Md. Shajid Hossain Rafi, Md. Shalahuddin Millat, Md Abdul Barek, Syed Masudur Rahman Dewan, Mohammad Shahriar, et al. Plos One, 2026 Breast cancer is a multifaceted illness impacted by genetic factors as well as environmental influences. While variants in the NUDT17 gene have been associated with cancer biology, their involvement in breast cancer is still inadequately investigated, especially within South Asian populations. This study investigated the association between two NUDT17 polymorphisms, rs9286836 and rs2004659, and breast cancer risk in Bangladeshi women using a case–control design. A total of 240 breast cancer patients and 240 age-, sex-, and BMI-matched healthy controls were enrolled. Genomic DNA was extracted from blood samples, and genotyping was performed using tetra-primer ARMS-PCR for rs9286836 and PCR–RFLP for rs2004659. The statistical methods employed included chi-square tests for genotype distributions and logistic regression to calculate odds ratios (ORs) with 95% confidence intervals (CIs). Genotyping for NUDT17 rs9286836 was successfully completed for all recruited participants. However, for rs2004659, high-quality genotyping data were available for 204 breast cancer cases and 204 controls after quality control procedures. No significant association was observed between rs9286836 and breast cancer risk across the tested genetic models. In contrast, rs2004659 showed a robust protective association with breast cancer, particularly among heterozygous individuals, and this protective effect was consistently observed across the dominant, over-dominant, and allelic models. Haplotype analysis revealed that the AA haplotype was associated with an increased risk of breast cancer, whereas the AG and GA haplotypes were associated with a reduced risk. Expression analysis further demonstrated elevated NUDT17 levels in breast cancer tissues and genotype-dependent expression effects for both variants. These findings suggest a protective role of rs2004659 in breast cancer susceptibility and highlight the potential of NUDT17 polymorphisms as biomarkers in Bangladeshi women.
Protective Role of Vitamins C, D, and K in the Management of Dengue: A Narrative Review to Combat the Dengue Outbreak Shah Md Muztahid Hasan Chowdhury, Md. Shafiul Hossen, Mohammad A. Rashid, Mahammed Shafin Ul Islam, Arafat Miah, et al. Health Science Reports, 2026 Background and Aims Dengue fever is mostly found in tropical and subtropical regions and is spread by mosquitoes. Still now, no specific antiviral medication is available against the disease. However, several vitamins have been identified as potential dengue therapy supplements. Therefore, this study aimed to comprehensively gather data on the protective role of vitamins C, D, and K in the treatment of dengue fever. Methods To conduct the present narrative review, we retrieved data from Google Scholar, Web of Science, PubMed, Cochrane Library, BanglaJOL, Embase, and Scopus regarding the influence of vitamin supplements in dengue treatment. Articles published in English before March 2025 were included in the study. Results and Discussion This review explored how vitamin C neutralizes reactive oxygen species and reduces inflammation and oxidative damage in dengue infection. It stimulates chemotaxis and NK cell activity and controls the activities of monocytes, macrophages, phagocytosis, and the release of cytokines that promote inflammation. While shielding neutrophils from oxidative damage, it also promotes ROS production, which is essential for pathogen removal. Additionally, vitamin D possesses antiviral and immunomodulatory properties that help to fight dengue virus (DENV). It regulates the course of the disease in DENV‐infected individuals by modifying immunological responses. It can limit viral replication, decrease the expression of DENV entry receptors, and alter the expression of inflammatory cytokines in cells infected with the virus. Moreover, vitamin K is recommended in cases of dengue‐related hepatic failure and encephalopathy. The administration of vitamin K in early dengue hemorrhagic fever (DHF) may help to avoid anemia and lessen the need for transfusions. Conclusion By targeting important pathogenic processes, the adjunctive use of vitamins C, D, and K together provides an effective supplemental strategy in the dengue management and provides a good patient outcome in future dengue outbreak.
Exploration of the Obesity Researches in Bangladesh: A Scoping Review With 76 Studies Susmita Das, Md. Shafiul Hossen, Md. Abdul Barek, Mohammed Safiqul Islam, Mohammad A. Rashid, et al. Health Science Reports, 2026 Background and Aims Obesity is now considered a global epidemic in many parts of the world. Bangladesh is now affected by obesity, which was formerly thought to be a problem of developed countries. Several studies have been conducted to investigate obesity in Bangladesh. However, individual studies may not represent the variability across populations, regions, age groups, or study designs. To map all the variables examined, the current study focused on examining the results of the original researches on obesity in Bangladesh. Methods and Materials We retrieved articles from PubMed, Web of Science, Google Scholar, Scopus, and so forth by following the PRISMA guidelines that were published between 2008 and 2025. This study thematically analyzed the findings of the 76 included studies in terms of prevalence, risk factors, and comorbidities associated with obesity. Results The prevalence of obesity in Bangladeshi adults varied, ranging from 3.2% to 50.23%. It was more prevalent in urban areas. Abdominal obesity was more common, affecting up to 21% of individuals. Additionally, females were more likely to be obese than males. Family history, sleep disturbances, age, being female, higher education, and income were the most common risk factors for obesity in adults. Unhealthy eating habits, physical inactivity, urban areas, high income, watching TV and using computers, and heredity were associated with childhood obesity. In addition, increased age, high educational level and socioeconomic status, and physical inactivity were the major risk factors in women. Moreover, some comorbidities, such as diabetes, hypertension, and aberrant lipid profiles, are strongly linked to obesity in Bangladesh. Conclusion This study revealed a higher prevalence of obesity in urban dwellers and females, obesity‐associated risk factors and comorbidities in Bangladesh. Awareness initiatives should be given top priority in government policies to reduce the burden. Therefore, future research should focus on Bangladesh's healthcare system to ensure obesity awareness.
Association of NF-kappaBIA rs696 gene polymorphism with breast cancer risk in Bangladeshi women: A case-control study Sara Shahid Meem, Sakif Ahamed Khan, Mohiuddin Ahmed Bhuiyan, Mohammad Safiqul Islam, Md. Rezaul Islam, et al. International Journal of Biological Markers, 2026 Background Breast cancer is the leading cause of cancer-related mortality among women in developing nations. NFKBIA encodes the inhibitors of nuclear factor-kappaB (NF-κB), which plays a critical role in modulating inflammation and carcinogenic processes. However, no prior studies were conducted to determine the association between NFKBIA polymorphisms and breast cancer susceptibility in the Bangladeshi population. Therefore, we aimed to examine the association of the NFKBIA (rs696) polymorphism with breast cancer risk in Bangladeshi women. Methods This case-control study involved 168 breast cancer patients and 150 healthy volunteers, utilizing polymerase chain reaction-restriction fragment length polymorphism. We assessed the p -value, odds ratio (OR), and 95% confidence interval (CI) to analyze the level of risk association of rs696. Results The cancer patients exhibited a higher mutant allele frequency than the controls. Breast cancer patients who are carriers of the mutant allele demonstrated a markedly elevated risk in two genetic models, including the additive model 2 (GG vs. AA: OR = 2.09, 95% CI = 1.03–4.23, p -value=0.042) and the dominant model (AG + GG vs. AA: OR = 1.73, 95% CI = 1.07–2.78, p -value=0.025). Moreover, the analysis of allele frequency indicated that carriers of the mutant allele G among breast cancer patients exhibited a significantly elevated risk compared to carriers of the wild-type A allele (G vs. A: OR = 1.42, 95% CI = 1.04–1.96, p -value=0.029). Conclusion Our results suggest that NFKBIA (rs696) might be associated with an increased risk of breast cancer in Bangladeshi women. However, we recommend studies in the future with a larger sample size to validate these findings.
WDFY4 gene polymorphisms (rs11101565 and rs2671702) are not associated with breast cancer risk in Bangladeshi women: a case-control study T Akter, MA Aziz, AB Shahid, KK Keya, A Datta, MS Islam, MS Sarwar BMC Research Notes , 2026 2026
Linkage Between miR‐218‐2 (rs11134527) Genetic Polymorphism and Breast Cancer Risk: A Case‐Control Study in the Bangladeshi Women AM Shamim, A Hossan, MS Hossen, MA Barek, MA Rashid, MS Islam Health Science Reports 9 (4), e72092 , 2026 2026
Association of NUDT17 rs9286836 and rs2004659 variants with breast cancer risk in Bangladeshi Women MSH Rafi, MS Millat, MA Barek, SMR Dewan, M Shahriar, Z Nahar, ... PLOS ONE 21 (3), e0344584 , 2026 2026
An Updated Narrative Review on the Therapeutic Potential of Resveratrol in the Treatment of Cancer MA Islam, A Amin, MA Aziz, MM Rahaman, J Hossain, JA Chowdhury, ... Health Science Reports 9 (3), e71995 , 2026 2026 Citations: 1
Association of XPC rs2228001, and ESR2 rs1256030 and rs4986938 Gene Polymorphisms with Breast Cancer Risk in Bangladeshi Women: A Case-Control Study MT Alam, J Fardaush, SA Khan, AY Proma, S Reza, MA Barek, ... Clinical Breast Cancer , 2026 2026
Evaluation of ERCC4 (XPF) gene rs6498486 polymorphism and its potential role in breast cancer risk among Bangladeshi women I Hossain, SC Ivy, MS Islam, M Shahriar BMC cancer , 2026 2026
Exploration of the Obesity Researches in Bangladesh: A Scoping Review With 76 Studies S Das, MS Hossen, MA Barek, MS Islam, MA Rashid, M Haque, R Kundu Health Science Reports 9 (2), e71833 , 2026 2026
Protective Role of Vitamins C, D, and K in the Management of Dengue: A Narrative Review to Combat the Dengue Outbreak SMMH Chowdhury, MS Hossen, MA Rashid, MSU Islam, A Miah, ... Health Science Reports 9 (2), e71823 , 2026 2026
Genotype and Haplotype Analysis Between ESR1 Variants and Breast Cancer in the Bangladeshi Patients: A PCR‐RFLP‐Based Genetic Association Study MSI Md Shafiul Hossen, Md Abdul Aziz, Md Abdul Barek, Nusrat Jahan, Nahida ... Health Science Reports 8 (12), e71622 , 2025 2025 Citations: 3
Evaluation of the Association of TNF‐α rs361525 Gene Polymorphism in Bangladeshi Patients With Breast and Cervical Cancer: A Case‐Control Study and Meta‐Analysis SMR Dewan, AY Proma, SA Khan, SS Meem, MT Alam, MA Barek, ... Health Science Reports 8 (12), e71653 , 2025 2025
MMP2 rs243865 and MMP8 rs11225395 Gene Polymorphisms Are Correlated With Breast Cancer Risk in Bangladeshi Women: Evidence From a Case-Control Study A Datta, SB Mohammad, KK Bhowmik, MA Barek, A Miah, MS Hossen, ... Breast Cancer: Basic and Clinical Research 19, 11782234251392714 , 2025 2025
Exploring the toxicity and clinical outcomes of doxorubicin, cyclophosphamide, and taxane-based chemotherapies in women with breast cancer in Bangladesh MS Millat, MS Hussain, A Miah, MA Barek, MS Uddin, M Ferdous, MA Aziz, ... Journal of Oncology Pharmacy Practice , 2025 2025
Link between the ESR2 (rs3020449) polymorphism and breast cancer risk in Bangladeshi women TA Shayla, SR Arthi, SC Ivy, MS Islam, M Shahriar Scientific Reports 15 (1), 33471 , 2025 2025
Association of missense variant DCLRE1B rs3761936 with breast and cervical cancer risk—A case-control study S Jafrin, MA Aziz, MA Barek, MS Reza, NE Naznin, MS Islam PloS one 20 (9), e0331492 , 2025 2025 Citations: 1
A Case‐Control Study on the Association Between MMP2 and MMP9 Genetic Polymorphisms and Breast Cancer P Chowdhury, MA Aziz, T Akter, MS Islam, MS Sarwar Health Science Reports 8 (8), e71123 , 2025 2025 Citations: 2
Screening of Antioxidant, Analgesic, Antipyretic and Anti-inflammatory Effect of Zingiber barbatum Methanolic Extracts in Mice Model: In Vitro & In Vivo Study SM Rahman, FS Gowrab, S Islam, S Tabassum, MS Hossen, A Miah, ... Biomedical & Pharmacology Journal 18 (2), 1731-1745 , 2025 2025
Mosquito repellent and larvicidal activity of essential oils of aromatic plant growing in Bangladesh: a review F Nazmin, MA Barek, A Miah, MS Hossen, MS Islam, J Ahmed Clinical Phytoscience 11 (1), 7 , 2025 2025 Citations: 6
Inflammatory cytokines and specific factors influencing lung cancer progression MS Millat, MM Hasan, MS Uddin, MA Salam, MA Aziz, I Akhter, ... Cancer Pathogenesis and Therapy , 2025 2025 Citations: 8
A systematic review and meta-analysis of the association between endothelial nitric oxide synthase (eNOS) rs2070744 polymorphism and preeclampsia MS Hossen, MA Aziz, MA Barek, MS Islam Cytokine 187, 156870 , 2025 2025 Citations: 3
Interleukin-1β rs16944 and rs1143627 polymorphisms and risk of developing major depressive disorder: A case-control study among Bangladeshi population FM Toma, KT Kalam, MA Haque, S Reza, R Akter, MS Islam, MR Islam, ... PloS one 20 (1), e0317665 , 2025 2025 Citations: 2
MOST CITED SCHOLAR PUBLICATIONS
Impact of age, sex, comorbidities and clinical symptoms on the severity of COVID-19 cases: A meta-analysis with 55 studies and 10014 cases MA Barek, MA Aziz, MS Islam Heliyon 6 (12) , 2020 2020 Citations: 324
Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy EK Ruzzo, JM Capo-Chichi, B Ben-Zeev, D Chitayat, H Mao, AL Pappas, ... Neuron 80 (2), 429-441 , 2013 2013 Citations: 212
How the association between obesity and inflammation may lead to insulin resistance and cancer MN Amin, MS Hussain, MS Sarwar, MMR Moghal, A Das, MZ Hossain, ... Diabetes & Metabolic Syndrome: Clinical Research & Reviews 13 (2), 1213-1224 , 2019 2019 Citations: 187
In vivo analgesic, antipyretic, and anti-inflammatory potential in Swiss albino mice and in vitro thrombolytic activity of hydroalcoholic extract from Litsea glutinosa leaves R Bhowmick, MS Sarwar, SM RahmanDewan, A Das, B Das, ... Biological research 47 (1), 56 , 2014 2014 Citations: 148
Alterations of serum macro-minerals and trace elements are associated with major depressive disorder: a case-control study MR Islam, MR Islam, MMA Shalahuddin Qusar, MS Islam, MH Kabir, ... BMC psychiatry 18 (1), 94 , 2018 2018 Citations: 136
Comparative study of serum zinc, copper, manganese, and iron in preeclamptic pregnant women MS Sarwar, S Ahmed, MS Ullah, H Kabir, GKMM Rahman, A Hasnat, ... Biological trace element research 154, 14-20 , 2013 2013 Citations: 129
Elevated serum levels of malondialdehyde and cortisol are associated with major depressive disorder: A case-control study MR Islam, MR Islam, I Ahmed, AA Moktadir, Z Nahar, MS Islam, ... SAGE open medicine 6, 2050312118773953 , 2018 2018 Citations: 111
Evaluation of total phenolic content, free radical scavenging activity and phytochemical screening of different extracts of Averrhoa bilimbi (fruits) M Hasanuzzaman, MR Ali, M Hossain, S Kuri, MS Islam International Current Pharmaceutical Journal 2 (4), 92-96 , 2013 2013 Citations: 98
A review on current repurposing drugs for the treatment of COVID-19: reality and challenges MS Hossen, MA Barek, N Jahan, MS Islam SN comprehensive clinical medicine, 1-13 , 2020 2020 Citations: 90
Evaluation of serum amino acids and non-enzymatic antioxidants in drug-naïve first-episode major depressive disorder AHMSI Md. Rabiul Islam, Samia Ali, James Regun Karmoker, Mohammad Fahim ... BMC Psychiatry 20 , 2020 2020 Citations: 84
Lung cancer risk in relation to nicotinic acetylcholine receptor, CYP2A6 and CYP1A1 genotypes in the Bangladeshi population MS Islam, MU Ahmed, MSB Sayeed, A Al Maruf, AGM Mostofa, ... Clinica Chimica Acta 416, 11-19 , 2013 2013 Citations: 83
Effect of lipid peroxidation, antioxidants, macro minerals and trace elements on eczema MN Amin, KF Liza, MS Sarwar, J Ahmed, MT Adnan, MI Chowdhury, ... Archives of Dermatological Research 307, 617-623 , 2015 2015 Citations: 77
Increased concentration of serum MDA, decreased antioxidants and altered trace elements and macro-minerals are linked to obesity among Bangladeshi population MSI Md Tarek Adnan, Mohammad Nurul Amin, Md Giash Uddin, Md Saddam Hussain ... Diabetes & Metabolic Syndrome: Clinical Research & Reviews 13 (2), 933-938 , 2019 2019 Citations: 76
Increased Oxidative Stress, Altered Trace Elements, and Macro-Minerals Are Associated with Female Obesity MSI Mohammad Nurul Amin, Shafayet Ahmed Siddiqui, Md. Giash Uddin, Md ... Biological Trace Element Research , 2020 2020 Citations: 70
A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatment PP Ray, MS Islam, A Han, P Geng, MA Aziz, AA Mamun Frontiers in Pharmacology 15, 1349745 , 2024 2024 Citations: 62
A review on monkeypox virus outbreak: New challenge for world J Ferdous, MA Barek, MS Hossen, KK Bhowmik, MS Islam Health Science Reports 6 (1), e1007 , 2022 2022 Citations: 62
Elevated serum MDA and depleted non-enzymatic antioxidants, macro-minerals and trace elements are associated with bipolar disorder MI Chowdhury, M Hasan, MS Islam, MS Sarwar, MN Amin, SMN Uddin, ... Journal of Trace Elements in Medicine and Biology 39, 162-168 , 2017 2017 Citations: 62
Comparative analysis of serum zinc, copper, manganese, iron, calcium, and magnesium level and complexity of interelement relations in generalized anxiety disorder patients MR Islam, MU Ahmed, SA Mitu, MS Islam, GKMM Rahman, MMAS Qusar, ... Biological trace element research 154 (1), 21-27 , 2013 2013 Citations: 61
In vivo antipyretic, antiemetic, in vitro membrane stabilization, antimicrobial, and cytotoxic activities of different extracts from Spilanthes paniculata leaves MM Hossain, SK Ahamed, SMR Dewan, MM Hassan, A Istiaq, MS Islam, ... Biological Research 47, 1-9 , 2014 2014 Citations: 60
Recent outbreak of dengue in Bangladesh: A threat to public health KK Bhowmik, J Ferdous, PK Baral, MS Islam Health Science Reports 6 (4), e1210 , 2023 2023 Citations: 57