Adeniyi Temidayo Daniel
@unilorin.edu.ng
Lecturer, Faculty of Basic Clinical Sciences
University of Ilorin
RESEARCH, TEACHING, or OTHER INTERESTS
Medical Laboratory Technology, Histology, Anatomy, Cellular and Molecular Neuroscience
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Damilare Adedayo Adekomi, Olamide Janet Olajide, Omowumi Oyeronke Adewale, Akeem Ayodeji Okesina, John Olabode Fatoki, Benedict Abiola Falana, Temidayo Daniel Adeniyi, Adebiyi Aderinola Adegoke, Waliu Adetunji Ojo, and Sheriffdeen Oluwabusayo Alabi
Informa UK Limited
Abstract Alcohol exposure to the cerebellum has been known to trigger cerebellar dysfunctions through several mechanisms. This present study was designed to evaluate the repealing effect of D-ribose-L-cysteine (DRLC) on alcohol-induced cerebellar dysfunctions in juvenile BALB/c mice. The animals were randomly divided into 4 groups (n = 10 per group). Mice were given oral administration of normal saline (control), DRLC (100 mg/kg, p.o), ethanol (0.2 mL of 10% w/v), or DRLC (100 mg/kg, p.o) + ethanol (0.2 mL of 10% w/v). On day 29 of the study (i.e., 24 h after the administration of the last respective doses), neurochemical quantification of the respective levels of serotonin and dopamine, lipid peroxidation, total antioxidant, superoxide dismutase, and glutathione peroxidase in the cerebellar tissues of the mice were analyzed. Compared with the saline-treated group, the studied neurochemical indices were modulated across the various experimental groups. The administration of ethanol significantly modulates the levels of monoamine neurotransmitters (serotonin and dopamine) as well as contents of total antioxidants, activities of superoxide dismutase, and glutathione peroxidase, with a concurrently increased level of lipid peroxidase in the cerebellar tissue of the mice. DRLC significantly reverses these effects in the DRLC + ethanol co-treated group. Combined exposure to DRLC + ethanol counteracts the deleterious effect of ethanol in the cerebellum of juvenile BALB/c mice via monoamine neurotransmitter, lipid peroxidation, total antioxidant status, superoxide dismutase, and glutathione peroxidase action pathways. Therefore, DRLC could be a pharmacologic or therapeutic agent in attenuating the deleterious effects of alcohol on the cerebellum.
Taiwo Abayomi, Olorunfemi Tokunbo, Oluwatobiloba Oroyemi, Olawale Abayomi, Opeyemi Osuntokun, Benedict Falana, and Temidayo Adeniyi
Informa UK Limited
ABSTRACT This study evaluated the anxiolytic and antioxidative potential of DRLC on behavioral deficits, and neuronal perturbations in the hippocampus following paradoxical sleep deprivation in adult Wistar rats. Animals were paradoxically sleep deprived for 7 days ; DRLC (75 mg/kg b.w of RiboceineTM) was pre- and post-administered for 21 days before and after paradoxical sleep deprivation. Thereafter, behavioral study was conducted to assess fear and anxiety , animals were sacrificed and biochemical analysis of oxidative stress markers and histomorphology of the hippocampus was performed. Behavioral assessments revealed that PSD elicited increased anxiety levels as demonstrated by reduced line crossing, reduced habituation time, and increased freezing time in OFT as well as increased time spent in closed arms of EPM. Also, oxidative stress levels were elevated by PSD with significantly decreased activities of catalase (CAT), superoxide dismutase (SOD) and glutathione (GSH) concentration as well as increased Malondialdehyde concentrations in the blood serum. However, pre-and post-treatment with DRLC significantly prevented and reduced anxiety levels and oxidative stress levels as well as prevented and repaired neuronal hippocampal damage associated with PSD respectively. In conclusion, DRLC was able to modulate oxidative stress-driven alterations and perturbed emotionality linked with PSDthrough its anxiolytic and antioxidative properties. Abbreviations: D-ribose-L-cysteine(DRLC); Catalase(CAT); Glutathione transferase(GSH); Superoxide dismutase(SOD); Non-rapid eye movement(NREM); Rapid eye movement(REM); Paradoxical sleep deprivation(PSD); Elevated plus maze(EPM); Open Field test(OFT)
Abdulazeez A. Abubakar, Temidayo D. Adeniyi, Ismaila O. Nurain, Ayoade B. Olanrewaju, and Kareemat E. Uthman
Elsevier BV
Temidayo Adeniyi, Ahmad Tijani, Damilare Adekomi, and Taiwo Abayomi
Canadian Center of Science and Education
In this study, the lateral geniculate bodies (LGB) of rats, bats and pangolins were compared using histological and quantitative histochemical parameters to observe possible modifications that enable these mammals to cope with their habitation particularly with respect to their diet. The study was conducted using ten adult Wistar rats, ten fruit bats and eight pangolins comprising of both sexes. After being sacrificed by cervical dislocation, their skulls were opened using bone forceps to expose the brains. The lateral geniculate bodies were excised from each brain tissue, homogenized and homogenate studied spectrophotometrically for the activities of lactate dehydrogenase (LDH), glucose-6-phosphate dehydrogenase (G-6-PDH), acid phosphatase (ACP), alkaline phosphatase (ALP) and acetylcholinesterase (AChE). The LGB tissue samples meant for histological studies were fixed in 10% formol calcium and processed for paraffin wax embedding. Serial sections of 3μm thickness were stained with Hematoxylin and Eosin (H & E) and Cresyl fast violet (CFV) stains. The stained tissues were studied under the light microscope. Application of one-way ANOVA statistical method showed that there were significant differences (p<0.05) in the activities of LDH, G-6-PDH, ACP, ALP and AChE of the LGB of the three mammals as revealed in the quantitative histochemistry of these enzymes and markers. Histological observations revealed no observable differences in the relative distribution of neurons and their supporting glial cells within the LGB of the three mammalian species. The comparison of the differences observed in the histological and the quantitative histochemical activities in these mammalian species revealed a variation in the visual perception and their individual peculiarities in relation to their mode and pattern of living.