Adeniyi Temidayo Daniel

@unilorin.edu.ng

Lecturer, Faculty of Basic Clinical Sciences
University of Ilorin

https://researchid.co/adeniyitemidayo

RESEARCH, TEACHING, or OTHER INTERESTS

Medical Laboratory Technology, Histology, Anatomy, Cellular and Molecular Neuroscience

Scopus Publications

172

Scholar Citations

Scholar h-index

Scholar i10-index

Scopus Publications

Oxidative stress response to gasoline generator exhaust emission in adult male wistar rats
Akinpelu Moronkeji, Ayodeji Olayanju, Temidayo Daniel Adeniyi, Atere Adedeji David, Moronkeji Adebimpe Iyanuoluwa, Igunbor Michael Chuks, Oyeleke Abiodun, and Akinbo Frederick Olusegun
The Korean Society of Environmental Health and Toxicology
Petroleum-powered generators are commonly used in many developing countries as an alternative to meet utility demands. Generator exhaust emission significantly contributes to air pollution, which remains a constant threat to human health due to the presence of aromatic hydrocarbons and other harmful gases. This study assessed oxidative stress parameters in response to exhaust emission from gasoline generator engine in adult male wistar rats. Forty-eight (48) adult wistar rats weighing between 180-200g were randomly allocated to four (4) groups (A-D) of twelve (12) rats each. After the acclimatization period, the control group (A) were kept unexposed, whereas rats in groups (C-D) were exposed daily at 2, 4, and 8-hour intervals for 4, 8, and 12 weeks, respectively. Tissue samples were obtained at four weeks intervals. Fresh lung tissues weighing 1g were rinsed twice in phosphate-buffered saline (PBS, pH 8.0), homogenized and centrifuged at 3000 revolutions per minute for 20 min at 4°C. Supernatant levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione S-transferase (GST), reduced glutathione (GSH), nitric oxide (NO), hydrogen peroxide (H2O2), catalase (CAT), and total antioxidant status (TAS) were determined using standard protocols. The findings revealed elevated oxidant levels of MDA, NO, and H2O2, whereas SOD, GPX, GST, GSH, CAT, and TAS were significantly reduced across the exposure time points compared to the unexposed control rats (p < 0.05). The research findings revealed that exposure to emissions from gasoline generators induced oxidative stress in the exposed rats, with the extent of disruption to their oxidative balance dependent on the duration and length of exposure time.

CYMBOPOGON CITRATUS: A MODULATOR OF TNF-Α AND IL-10 IN NSAID-INDUCED HEPATORENAL TOXICITY IN ADULT WISTAR RATS
Akinpelu MORONKEJI, Temidayo D Adeniyi, Abiodun Oyeleke, Chuks M Igunbor, Joy Olajumoke AYENI, Toluwanimi Olanike ADELABI, and Adebimpe Moronkeji
Egyptian Knowledge Bank

Mitigation of Diclofenac-Induced Hepatorenal Toxicity by Methanolic Extract of Cymbopogon citratus

D-ribose-L-cysteine exhibits neuroprotective activity through inhibition of oxido-behavioral dysfunctions and modulated activities of neurotransmitters in the cerebellum of Juvenile mice exposed to ethanol
Damilare Adedayo Adekomi, Olamide Janet Olajide, Omowumi Oyeronke Adewale, Akeem Ayodeji Okesina, John Olabode Fatoki, Benedict Abiola Falana, Temidayo Daniel Adeniyi, Adebiyi Aderinola Adegoke, Waliu Adetunji Ojo, and Sheriffdeen Oluwabusayo Alabi
Informa UK Limited
Abstract Alcohol exposure to the cerebellum has been known to trigger cerebellar dysfunctions through several mechanisms. This present study was designed to evaluate the repealing effect of D-ribose-L-cysteine (DRLC) on alcohol-induced cerebellar dysfunctions in juvenile BALB/c mice. The animals were randomly divided into 4 groups (n = 10 per group). Mice were given oral administration of normal saline (control), DRLC (100 mg/kg, p.o), ethanol (0.2 mL of 10% w/v), or DRLC (100 mg/kg, p.o) + ethanol (0.2 mL of 10% w/v). On day 29 of the study (i.e., 24 h after the administration of the last respective doses), neurochemical quantification of the respective levels of serotonin and dopamine, lipid peroxidation, total antioxidant, superoxide dismutase, and glutathione peroxidase in the cerebellar tissues of the mice were analyzed. Compared with the saline-treated group, the studied neurochemical indices were modulated across the various experimental groups. The administration of ethanol significantly modulates the levels of monoamine neurotransmitters (serotonin and dopamine) as well as contents of total antioxidants, activities of superoxide dismutase, and glutathione peroxidase, with a concurrently increased level of lipid peroxidase in the cerebellar tissue of the mice. DRLC significantly reverses these effects in the DRLC + ethanol co-treated group. Combined exposure to DRLC + ethanol counteracts the deleterious effect of ethanol in the cerebellum of juvenile BALB/c mice via monoamine neurotransmitter, lipid peroxidation, total antioxidant status, superoxide dismutase, and glutathione peroxidase action pathways. Therefore, DRLC could be a pharmacologic or therapeutic agent in attenuating the deleterious effects of alcohol on the cerebellum.

D-ribose-L-cysteine modulates paradoxical sleep deprivation-induced neurological impairments: anxiolytic and antioxidative study in rat model
Taiwo Abayomi, Olorunfemi Tokunbo, Oluwatobiloba Oroyemi, Olawale Abayomi, Opeyemi Osuntokun, Benedict Falana, and Temidayo Adeniyi
Informa UK Limited
ABSTRACT This study evaluated the anxiolytic and antioxidative potential of DRLC on behavioral deficits, and neuronal perturbations in the hippocampus following paradoxical sleep deprivation in adult Wistar rats. Animals were paradoxically sleep deprived for 7 days ; DRLC (75 mg/kg b.w of RiboceineTM) was pre- and post-administered for 21 days before and after paradoxical sleep deprivation. Thereafter, behavioral study was conducted to assess fear and anxiety , animals were sacrificed and biochemical analysis of oxidative stress markers and histomorphology of the hippocampus was performed. Behavioral assessments revealed that PSD elicited increased anxiety levels as demonstrated by reduced line crossing, reduced habituation time, and increased freezing time in OFT as well as increased time spent in closed arms of EPM. Also, oxidative stress levels were elevated by PSD with significantly decreased activities of catalase (CAT), superoxide dismutase (SOD) and glutathione (GSH) concentration as well as increased Malondialdehyde concentrations in the blood serum. However, pre-and post-treatment with DRLC significantly prevented and reduced anxiety levels and oxidative stress levels as well as prevented and repaired neuronal hippocampal damage associated with PSD respectively. In conclusion, DRLC was able to modulate oxidative stress-driven alterations and perturbed emotionality linked with PSDthrough its anxiolytic and antioxidative properties. Abbreviations: D-ribose-L-cysteine(DRLC); Catalase(CAT); Glutathione transferase(GSH); Superoxide dismutase(SOD); Non-rapid eye movement(NREM); Rapid eye movement(REM); Paradoxical sleep deprivation(PSD); Elevated plus maze(EPM); Open Field test(OFT)

Chromatographic and computational studies of ligands associated with bilharziasis
Abdulazeez A. Abubakar, Temidayo D. Adeniyi, Ismaila O. Nurain, Ayoade B. Olanrewaju, and Kareemat E. Uthman
Elsevier BV

A comparative study of the lateral geniculate body of rat (Rattus norvegicus), bat (Eidolon helvum) and pangolin (Manis tricuspis).
Temidayo Adeniyi, Ahmad Tijani, Damilare Adekomi, and Taiwo Abayomi
Canadian Center of Science and Education
In this study, the lateral geniculate bodies (LGB) of rats, bats and pangolins were compared using histological and quantitative histochemical parameters to observe possible modifications that enable these mammals to cope with their habitation particularly with respect to their diet. The study was conducted using ten adult Wistar rats, ten fruit bats and eight pangolins comprising of both sexes. After being sacrificed by cervical dislocation, their skulls were opened using bone forceps to expose the brains. The lateral geniculate bodies were excised from each brain tissue, homogenized and homogenate studied spectrophotometrically for the activities of lactate dehydrogenase (LDH), glucose-6-phosphate dehydrogenase (G-6-PDH), acid phosphatase (ACP), alkaline phosphatase (ALP) and acetylcholinesterase (AChE). The LGB tissue samples meant for histological studies were fixed in 10% formol calcium and processed for paraffin wax embedding. Serial sections of 3μm thickness were stained with Hematoxylin and Eosin (H & E) and Cresyl fast violet (CFV) stains. The stained tissues were studied under the light microscope. Application of one-way ANOVA statistical method showed that there were significant differences (p<0.05) in the activities of LDH, G-6-PDH, ACP, ALP and AChE of the LGB of the three mammals as revealed in the quantitative histochemistry of these enzymes and markers. Histological observations revealed no observable differences in the relative distribution of neurons and their supporting glial cells within the LGB of the three mammalian species. The comparison of the differences observed in the histological and the quantitative histochemical activities in these mammalian species revealed a variation in the visual perception and their individual peculiarities in relation to their mode and pattern of living.

Exposure to smoke extract of datura stramonium leaf: Some of its effects on the heart, liver, lungs, kidneys and testes of male sprague dawley rats

RECENT SCHOLAR PUBLICATIONS

Assessment of the oxidative potential of Citrus limon, Citrus aurantifolia juice extracts and counterstaining prospects of Hibiscus sabdariffa leaf extract to the conventional
TD Adeniyi, A Moronkeji, JA Abdulsalam, TO Oluyemi, HA Adejugbe
Bayero Journal of Medical Laboratory Science 9 (2), 129-139 2025

IMMUNO-OXIDATIVE AND HISTOLOGICAL EVALUATION OF VERNONIA AMYGDALINA AND AFRAMOMUM MELEGUETA ETHANOLIC LEAF EXTRACTS IN CADMIUM-INDUCED CARDIOPULMONARY TOXICITY IN RATS
AA Oyeleke, A Moronkeji, TD Adeniyi, CP Umeboro, AI Moronkeji, ...
FUOYE JOURNAL OF BIOMEDICAL RESEARCH 1 (2) 2024

Methanolic leaf extract of Vernonia amygdalina mitigates cadmium-induced oxidative stress in the liver and kidney of adult male Wistar rats
A Moronkeji, A Temidayo, A Benita, O Latifat
Egyptian Journal of Basic and Applied Sciences 11 (1), 469-478 2024

Evaluation of the combined extract of Rauwolfia vomitoria and Aframomum melegueta on the kidney and liver of adult male Wistar rats
TD Adeniyi, M Akinpelu, OO Akinlami, FO Alaga, MM Adenika
Sokoto Journal of Medical Laboratory Science 9 (2), 203-212 2024

Oxidative stress response to gasoline generator exhaust emission in adult male wistar rats
A Moronkeji, A Olayanju, TD Adeniyi, AD Atere, AI Moronkeji, MC Igunbor, ...
Environmental Analysis Health and Toxicology 39 (4), 54-63 2024

CYMBOPOGON CITRATUS: A MODULATOR OF TNF-Α AND IL-10 IN NSAID-INDUCED HEPATORENAL TOXICITY IN ADULT WISTAR RATS
A MORONKEJI, TD Adeniyi, A Oyeleke, CM Igunbor, JO AYENI, ...
Bulletin of Pharmaceutical Sciences Assiut University 47 (2), 1251-1262 2024

EFFECT OF ALCOHOL INTAKE AND CIGARETTE SMOKING ON LIPID PROFILE LEVELS AND SELECTED INFLAMMATORY BIOMARKERS.
GO Adunmo, TD Adeniyi, OA Olorunfemi, EO Adunmo, DA Stephen, ...
Era's Journal of Medical Research 11 (2) 2024

Attenuation of Cadmium Toxicity by Methanol Extracts of Rauvolfia vomitoria and Aframomum melegueta leaves
T Adeniyi, M Akinpelu, O Akinlami, MJ Kolawole, J Oloye, A Imoleayo
Folia Medica Indonesiana 60 (2), 94-102 2024

Mercury-induced oxidative stress and neuropathologic changes in the prefrontal cortex of Wistar rats.
G Adeniyi, T., Moronkeji, A., Oluwatunase, G., Adekomi, A., Adunmo
Nig. J. Neurosci. 15 (4), 97-104 2024

Histological and biochemical evaluation of the protective potential of ascorbate and alpha-tocopherol against cypermethrin-induced toxicity
T Adeniyi, A Moronkeji, A Fikayomi
J. Exp. Life Sci. Vol 14 (1) 2024

Effects of Pyrethroid Exposure on Testicular Histopathology and Biochemistry in Adult Male Wistar Rats: Evaluation of Ascorbic Acid and Alpha-Tocopherol Administration
T Adeniyi, A Moronkrji, D Eyovwerhuvu
Journal of Advanced Pharmacy Research 8 (1), 29-37 2024

Histological evaluation of the liver, kidney, and testes of adult male Wistar rats exposed to heavy metals-contaminated waterways
T Adeniyi, A Moronkeji, V Ekundina
Medical Laboratory Journal 17 (5), 4-8 2023

Phyllanthus amarus protects against potassium-dichromate pituitary toxicity via the oxidative pathway and improves the gonadotropins in male Wistar rats
KA Iteire, CA Adenodi, OM Olatuyi, RE Uwejigho, TD Adeniyi
Journal of Medical Science 92 (2), e834-e834 2023

Histopathological and biochemical effect of vitamin C and D on phosphine-induced hepatotoxicity in wistar rats
M Akinpelu, SM Gamade, F Akinbo, TD Adeniyi, AF Elizebeth, EI Obeagu
Asian Journal of Dental and Health Sciences 3 (2), 18-22 2023

Asian Journal of Dental and Health Sciences
M Akinpelu, SM Gamade, F Akinbo, TD Adeniyi, AF Elizebeth, EI Obeagu
Sciences 3 (2), 18-22 2023

Ascorbate and Alpha-Tocopherol Mitigate Toxic Pathological Changes in Adult Wistar Rats Exposed to Cypermethrin
TD Adeniyi, A Moronkeji, OF Ralph-Okhiria, N Wiqoyah, A Obi, ...
Folia Medica Indonesiana 59 (4), 391-399 2023

D-ribose-L-cysteine modulates paradoxical sleep deprivation-induced neurological impairments: anxiolytic and antioxidative study in rat model
T Abayomi, O Tokunbo, O Oroyemi, O Abayomi, O Osuntokun, B Falana, ...
Egyptian Journal of Basic and Applied Sciences 9 (1), 216-228 2022

Expression of CEA, CA125 and P16INK4A in the Normal Breast, Fibroadenoma and Invasive Adenocarcinomas of the Breast
V Ekundina, O Ayowole, P Awe, T Adeniyi, A Emmanuel-Omah, ...
AlQalam Journal of Medical and Applied Sciences, 78-88 2022

Effects of Anti-Sickling Polyherbal Mixture on Haematological Indices in Normal and Anaemia-Induced Rabbits
AO Olayanju, NI Kyesman, RB Jacob, TD Adeniyi, SS Enitan, AJ Olayanju
Asian Journal of Medicine and Health 19 (12), 15-26 2021

MOST CITED SCHOLAR PUBLICATIONS

Histological study of smoke extract of Tobacco nicotiana on the heart, liver, lungs, kidney, and testes of male Sprague-Dawley rats
AD Adedayo, AA Tijani, AA Musa, TD Adeniyi
Nigerian Medical Journal 52 (4), 217-222 2011
Citations: 39

Exposure to smoke extract of Datura stramonium leaf: Some of its effects on the heart, liver, lungs, kidneys and testes of male Sprague Dawley rats
DA Adekomi, AA Musa, AA Tijani, TD Adeniyi, B Usman
Journal of pharmacognosy and phytotherapy 3 (5), 67-75 2011
Citations: 25

Lead induces inflammation and neurodegenerative changes in the rat medial prefrontal cortex
AD Adedayo, AO Stephen, TA Adekilekun, AT Daniel
Anatomy 11 (2), 79-86 2017
Citations: 19

Some of the Effects of Aqueous Leaf Extracts of Cnidoscolus aconitifolius (Euphorbiaceae) on the Morphology and Histology of the Kidney and Liver of Sprague Dawley Rat
DA Adekomi, AA Tijani, TD Adeniyi, JO Olajide
The Tropical Journal Health Sciences 18, 9-15 2011
Citations: 10

Cyanide-induced hyperthyroidism in male Wistar rats
AT Daniel, TA Adekilekun, MAS Adewale, AT Adekemi
Nigerian Medical Journal 55 (3), 246-249 2014
Citations: 8

Histological and hepatic enzymes response of Oreochromis niloticus and Clarias anguillaris to pollution in Asa river, ilorin
SO Oladipo, T Adeniyi, A Anifowoshe
Journal of Life and Bio Sciences Research 1 (01), 16-21 2020
Citations: 6

Frequency of electronics waste generated heavy metals in urban waterways
TD Adeniyi, PU Achukwu, AA Abubakar
Int J Hum Cap Urb Manag 2 (2), 89-100 2017
Citations: 6

Datura metel is deleterious to the visual cortex of adult wistar rats
AA Tijani, DT Adeniyi, DA Adekomi
Advances in Applied Science Research 3 (2), 944-949 2012
Citations: 6

A comparative study of the lateral geniculate body of rat (Rattus Norvegicus), bat (Eidolon Helvum) and pangolin (Manis Tricuspis)
T Adeniyi, A Tijani, D Adekomi, T Abayomi
Global Journal of Health Science 4 (4), 118 2012
Citations: 5

Histomorphological staining of selected organs by iron-roselle nuclear technique and natural counterstains
SA Benard, TD Adeniyi, JK Bankole, JO Okoye
J Adv Med Res 28, 1-12 2018
Citations: 4

Heavy metals obtained from waterways induced neurodegeneration in the prefrontal cortex of Wistar rats
TD Adeniyi, PU Achukwu, AA Abubakar, AD Adekomi
Eur. j. anat 23 (1), 65-76 2019
Citations: 3

Lead contamination induces neurodegeneration in prefrontal cortex of Wistar rats
T Adeniyi, P Achukwu
Anatomy 12 (3), 128-134 2018
Citations: 3

Histochemical evaluation of the activities of glucose-6-phosphate dehydrogenase (G-6-PDH) and lactate dehydrogenase (LDH) in the visual relay centers of rat (Rattus norvegicus
TD Adeniyi, DA Adekomi, AA Tijani, AO Akinyinka
Journal of Cell and Animal Biology 6 (13), 188-191 2012
Citations: 3