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Indian Institute of Technology Bombay
Amreen has skills in nanomedicine formulation, nanoparticle synthesis and characterization, solid-phase peptide synthesis, nanofibers development and biomaterials, microneedle-based MEMS drug delivery device fabrication, nanotheranostics, 3D printing, small molecules and peptide screening, in-vitro analysis, etc. She has a teaching assistantship of more than 2 years in electron microscopy, with sound knowledge of sophisticated analytical instruments like high-performance liquid chromatography and two photon femtosecond lithography. Amreen has a good command of mammalian cell culture and has performed anticancer activity tests.
Amreen Khan is currently in her Ph.D. program working in biomedical applications wound healing and cancer theranostics nanomedicine at the Center for Research in Nanotechnology and Science, Indian Institute of Technology Bombay India. She works in collaboration with Biosciences and Bioengineering and the Chemical engineering department of IITB.
Potential approaches to enhance efficacy and reduce toxicity still remain unassured in many drug delivery systems especially in gene based. This has led to widen the pool of understanding extending insight towards the scope of modification and carrier interaction with acting moiety. CRISPR-Cas technology as gene editing tool has opened access to moderate and better control regulating central dogma of cell biology. Recent developments have shown major application in elucidating personalized genomic information, manipulation of gene and as emerging machinery to cure diseases by transforming therapies treating complex gene related disorders. However, trend has seen the need to deliver the active Cre recombinase successfully to targeted cell for achieving better genomic modification. We aim at revealing the immunomodulated nanobiomaterial plateform to cascade CRISPR-Cas improving effectiveness in targeted therapy.
Drug delivery systems have been drastically researched worldwide. Likewise, many novel drug delivery systems are being explored as technology is advancing. The study of localized stimuli-responsive drug delivery systems with nanoparticles tends to serve the purpose of theranostics administration in a single tool. To minimize the unwanted effect of damaging normal tissues, especially in the case of light-responsive theranostic, microneedle presents a promising mode for delivery of high-photon activated nanoparticles to the targeted tumor site. Incorporating the benefit of chemotherapy, we have designed an effective chemo-photo activated nanoparticle combined delivery system by microneedle. Surpassing the blood-brain barrier, opsonization, protein corona and external pathogens that block the path of cargo during oral or systemic (i.v.) delivery, we have strategized a novel method of localized delivery of theranostics.
Bioinspired sustained scaffolds involve well-defined morphological cues designed with unique physicochemical properties for a said medical application. The variations can be seen during the optimizing steps of sponge preparation. Here in this work, we have analyzed the effect of ion-based cross-linker calcium chloride added to polyvinyl alcohol/sodium alginate sponges containing natural origin green tea extract before and after the freeze-drying process. One set of PVA/sodium alginate/G.T. mixture was subjected to ionic concentrations of calcium ions and lyophilized. In another design, lyophilized PVA/sodium alginate/G.T. sponges were cross-linked with calcium chloride followed which was freeze-dried. The studies were conducted to assess the effect on morphology through SEM, mechanical strength, swelling and degradation rate at pH 7.4, and functional group analysis by FTIR. The release profile of green tea from the polymeric matrix performed in phosphate buffer at 37⁰C.
1. Khan, A., Dias, F., Neekhra, S., Singh, B., & Srivastava, R. (2021). Designing and Immunomodulating Multiresponsive Nanomaterial for Cancer Theranostics. Frontiers in Chemistry, 8. https://doi.org/10.3389/FCHEM.2020.631351/FULL
2. Khan, A., Jain, N. K., Gandhi, M., Prasad, R., & Srivastava, R. (2021). Photo-Triggered Nanomaterials for Cancer Theranostic Applications. Nano LIFE, 11(02), 2130004. https://doi.org/10.1142/S1793984421300041
3. Kiran, P., Debnath, S. K., Neekhra, S., Pawar, V., Khan, A., Dias, F., Pallod, S., & Srivastava, R. (2022). Designing nanoformulation for the nose-to-brain delivery in Parkinson’s disease: Advancements and barrier. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 14(1), e1768.https://doi.org/10.1002/WNAN.1768
4. Kiran, P., Khan, A., Neekhra, S., Kumar, P., Singh, B., Pallod, S., Dias, F., & Srivastava, R. (2022). Evolution Towards Theranostics: Basic Principles. BioSensing, Theranostics, and Medical Devices, 59–82. https://doi.org/10.1007/978-981-16-2782-8_3
5. Kiran, P., Khan, A., Neekhra, S., Pallod, S., & Srivastava, R. (2021). Nanohybrids as Protein-Polymer Conjugate Multimodal Therapeutics. Frontiers in Medical Technology, 27. https://doi.org/10.3389/FMEDT.2021.676025
6. Chakraborty, S., Prasad, R., Pandey, PK., Khan, A., Jain, NK., Valsami, JE., Srivastava, R., Misra, SK. (2022). Doxorubicin encapsulated hollow self-assembled CuS nanoparticles clusters for bio-responsive chemo-photo therapy. Material Letters, 327
Indian institute of Technology Gandhinagar
National Institute of Pharmaceutical education and research Hyderabad
Biocon research limited-Biologics International Regulatory affairs