Baskaran N
@niftem-t.ac.in
Assistant Professor / Academics and Human Resource Development
National Institute of Food Technology, Entrepreneurship and Management - Thanjavur (NIFTEM-T)
Dr. N. Baskaran is working as an Assistant Professor of Biochemistry at NIFTEM-Thanjavur, India. He completed his M.Phil & Ph.D degree from Annamalai University with prestigious University Grants Commission (UGC) fellowship. He worked as UGC-Post Doctoral Fellow for two years in School of Biological Sciences, Madurai Kamaraj University, Madurai. He has more than ten years of experience in Teaching & Research and also published several research papers in peer-reviewed National and International journals. His area of research interest includes Nutritional Biochemistry, Clinical Biochemistry, Biochemical & Molecular Cancer Chemoprevention, Nutraceuticals & Functional foods. He is serving as a reviewer in many National and International journals and also coordinated various programs such as Conferences, Workshops, Expos and Trainings.
EDUCATION
Ph.D Biochemistry (2009 - 2013), Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu, ndia.
M.Phil., Biochemistry (2008 - 2009), Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu, India.
M.Sc., Biochemistry (2006 - 2008) Meenakshi Ramasamy Arts and Science College, Thathanur, Bharathidhasan University, Thiruchirappalli, Tamilnadu, India.
B.Sc., Biochemistry (2002 - 2005) Government Arts College, Paramakudi, Madurai Kamaraj University, Tamilnadu, India.
RESEARCH INTERESTS
Nutritional Biochemistry, Clinical Biochemistry, Biochemical & Molecular Cancer Chemoprevention, Nutraceuticals & Functional foods
Scopus Publications
Scopus Publications
Bilna Joseph, Bhavadharani M, Nivetha S, Lavanya M, Jagan Mohan R, N Baskaran, and S Vignesh
Elsevier BV
E. Raja Rajeshwari, P. S. Sathanya, S. Vignesh, V. Chandrasekar, and N. Baskaran
Springer Science and Business Media LLC
Fathima Beevi Abdul Kareem, Arunkumar Elumalai, Arunkumar Anandharaj, Vignesh Sivanandham, and Baskaran Nagarethinam
Springer Science and Business Media LLC
Bilna Joseph, M. Bhavadharani, M. Lavanya, S. Nivetha, N. Baskaran, and S. Vignesh
Wiley
AbstractThis study investigates the expanding domain of functional beverages crafted from plant‐based milk alternatives. In this study, a total of eight different fermented drinks fortified with beneficial Chlorella sp. and probiotics including Lactobacillus rhamnosus (NCIM 5775) and Saccharomyces cerevisiae (Brewer's yeast) drinks were developed using barnyard millet as the base ingredient due to its rich protein and high‐fibre content in comparison with the other millets in the market. Results revealed that the protein content increases by 2% upon the addition of Chlorella sp., among bacterial samples, with Lactobacillus rhamnosus fermented Unflavoured drink (LRFFD) > Lactobacillus rhamnosus fermented flavoured drink > Lactobacillus rhamnosus fermented with Chlorella sp. > LRFM, and among yeast samples, with Saccharomyces cerevisiae fermented Unflavoured drink (SCFUFD) > Saccharomyces cerevisiae fermented with Chlorella sp. > Saccharomyces cerevisiae fermented flavoured drink (SCFFD) > SCFRM, indicating higher protein content than in typical fermented drink. Fat content was notably low across all samples. Ash and fibre content ranged from 0.23 to 0.27 g and 0.22 to 0.35 g, respectively, for both bacterial and yeast fermented drink. Millet is generally considered a carbohydrate‐rich grain. When fermented, some of the carbohydrates may be broken down by the fermentation process. So, the carbohydrate content was low in fermented millet drink when compared to the nonfermented drink. Energy values varied, with LRFFD and SCFFD containing the highest energy due to incorporation of Chlorella sp. and chocolate flavour. Both LAB and yeast‐fermented drinks demonstrated effective antioxidant activity, with higher total phenolic content, except for non‐Chlorella sp. beverages. GC‐MS analysis identified constituents like hexadecenoic acid and hydroxy methyl furfural (HMF) with anticarcinogenic and anti‐inflammatory properties. Additionally, these samples exhibited elevated antimicrobial activity against test strains. Sensory analysis indicated a preference of SCFFD and LRFFD sample for its good taste as it contains chocolate flavour and the overall acceptability of bacterial fermented beverage was higher compared to the yeast fermented drinks. Therefore, a fermented millet beverage was successfully obtained by the coculture of LAB and Saccharomyces cerevisiae incorporated with Chlorella sp. could increase the product's functional properties.
Addanki Mounika, Akalya Shanmugam, Tamminana Jeeviteswara Rao, V.R. Sinija, Ashish Rawson, and N. Baskaran
Elsevier BV
Lavanya M, Nivetha S, Baskaran N, and Vignesh S
Walter de Gruyter GmbH
Abstract The biofilm-forming pathogens with acquired antibiotic resistance and associated disease outbreaks are increasing worldwide, especially in the seafood industry. This study hypothesised that the bioengineered iron nanoparticles using the myrobalan (Terminalia chebula) extract (M-FeNPs) and its resin coating have an effective antibiofilm properties. 12 seafood waste-based biofilm-forming strains (SSS) were isolated from SS-316 metal coupon and screened for their antibiotic-resistant profile as per CLSI (2016) standards. M-FeNPs were characterised by UV, FTIR, etc. Over 50 % of SSS were resistant to Ciprofloxacin, Cefalexin and Penicillin-G. The antibiofilm activity of the M-FeNPs showed an excellent inhibition zone (16–24 mm), and the combination of M-FeNPs + Methicillin also showed better activity. in vitro antibiofilm study shows that upon adding M-FeNPs, biofilm formation was reduced from 1.425 g to 0.83 g at the end of the eighth day. The CLSM and SEM images indicated that the M-FeNPs are effective antibiofilm agents against biofilm strains.
Bhagwat Madhura, Kavitha Lakshmipathy, Chidanand D.V., C.K. Sunil, N. Baskaran, Ashish Rawson, and R. Dhivya
Elsevier BV
S. Kiriti Aaradhana, E. Arun Kumar, S. Vignesh, D.V. Chidanand, and N. Baskaran
Elsevier BV
Gayathri Rethinavelu, Lavanya Manoharan, Srinivasan Krishnamoorthy, N. Baskaran, and Vignesh Sivanandham
Elsevier BV
A.R. Basava Prasad, S. Vignesh, Arunkumar Elumalai, Arunkumar Anandharaj, D.V. Chidanand, and N. Baskaran
Elsevier BV
Praveen Kumar Dubey, K. Suresh Kumar, Ashish Rawson, Sugumar Anandakumar, N. Baskaran, and Suman Thamburaj
Wiley
AbstractThis study aimed to investigate the effect of PEF treatment (5, 20, and 35 kV/cm) on functional, physicochemical, and microbiological properties of rice and black gram fermented batter. The PEF treatment efficaciously inhibited the total bacterial, yeast, and mold count from 1 × 107 to 1.8 × 105 CFU/gm and 3.7 × 103 to 4.1 × 102 CFU/gm, respectively at 35 kV/cm. PEF treatment significantly improved protein solubility, reducing sugar, total phenolic content, and antioxidant activity in the fermented batter. Herschel–Bulkley model best described the change in apparent viscosity which significantly decreased in PEF treated samples. Further, FTIR analysis of the PEF treated sample exhibited an increase in the area of percentage in each functional group. The results of the study suggest that the potential of PEF treatment at 20 kV/cm enhanced bioactivity and bioavailability of protein, and carbohydrate content as well as impeded the microorganisms to avoid over‐fermentation.Practical applicationsPEF technology effectively inhibits or inactivates the microorganisms in rice and black gram fermented batter and is highly suitable to avoid over‐fermentation without major changes in the physicochemical properties of batter. Therefore, this study promotes inevitable scientific information that could further investigate the industrial production of fermented rice and black gram batter with targeted physicochemical properties through PEF treatment. This also creates new opportunities for food industries to strategically diversify microbial arrest aspects in the commercial fermented batter.
Najma Kalathil, Nirmal Thirunavookarasu, Kavitha Lakshmipathy, D.V. Chidanand, Mahendran Radhakrishnan, and N. Baskaran
Elsevier BV
Jenifer Periasamy, Srinivasan Krishnamoorthy, Baskaran Nagarethinam, and Vignesh Sivanandham
Springer Science and Business Media LLC
Srinivasan Krishnamoorthy, Arunkumar Anandharaj, N. Baskaran, Ashish Rawson, and S. Vignesh
CRC Press
Baskaran Nagarethinam, Dharani Gunaseelan, MohamedSharmila Banu Nagoor Ali, Abhishek Albert, Rajkumar Prabhakaran, and DanielLysias Beno
Medknow
Background: Boerhaavia diffusa is a medicinal herb with anti-inflammatory, antiproliferative, anticancer, and immunomodulatory properties, found across India. Aim and Objectives: The present study is designed to investigate the therapeutic potential for B. diffusa root extracts in oral cancer cell line. Materials and Methods: The aqueous and methanolic extracts of B. diffusa were prepared using Soxhlet apparatus. In order to determine the phytochemical constituents of B. diffusa, the extracts were subjected to gas chromatography-mass spectrometry analysis. The antioxidant potential of B. diffusa extracts was assessed by 2,2-Diphenyl-picrylhydrazyl, ferric ion-reducing antioxidant power, catalase and peroxidase assays. The effective concentration of B. diffusa root on cell viability was analyzed by [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay. The ability of B. diffusa root extracts to modify the cell-cycle phases was performed by FACS analysis. The apoptotic inducing potential of B. diffusa in oral cancer cells was confirmed by acridine orange-ethidium bromide and 4′,6-diamidino-2-phenylindole staining. The protein profile of apoptotic processes was validated by the Western blot analysis; docking studies were also performed. Results: We observed that antioxidant activity was higher in B. diffusa methanolic extract compared with aqueous extract. The results showed that the methanolic and aqueous extracts of B. diffusa exhibited significant cytotoxic effect with IC50 value of 36 μg/ml and 30 μg/ml, respectively. The apoptotic DNA fragmentation and the apoptotic inducing potential in KB oral cancer cell line were higher for the methanolic extract compared with the aqueous extract. These results were also confirmed by in-silico analysis. Conclusion: The results indicate that extracts obtained from the roots of B. diffusa inhibit the progression of oral cancer. These compounds of pharmacological importance can be either used alone or in combination with other drugs to treat oral cancer.
A.R. Basava Prasad, Anandharaj Arunkumar, S. Vignesh, D.V. Chidanand, and N. Baskaran
Elsevier BV
Subramani Yuvaraj, Sundrasen Sasikumar, Shanavas Syed Mohamed Puhari, Tharmarajan Ramprasath, Nagarethinam Baskaran, Varadaraj Vasudevan, and Govindan Sadasivam Selvam
Hindawi Limited
Chrysin (Chy) is known for various biological proprieties such as inhibitory effects on inflammation, cancer, oxidative stress, aging, and atherosclerosis. However, the hypolipidemic activity of Chy and its mechanistic action remains unclear in cardiovascular diseases (CVD). In this study, we focused on the hypolipidemic proprieties of Chy in hypercholesterolemia-induced atherosclerosis. Male Wistar rats (150-220 g) were divided into four groups as follows: Group I control was fed with standard laboratory chow. Rats in Group II were fed a high-fat diet (HFD) for 60 days. After 60 days of HFD, Group III rats received Chy (100 mg/kg body weight); Group IV rats received Atorvastatin (Atv; 10 mg/kg body weight) for 30 days. Biochemical studies showed Chy, Atv treatment decreased the activities of liver marker enzymes and the levels of Reactive Oxygen Species (ROS) and lipid profile. Gene expression analysis on nuclear factor erythroid 2-related factor 2 (Nrf2) and its regulated genes were significantly reduced in the intestine and increased in the aorta by Chy and Atv. Gut microbial species such as Bacteroidetes, Lactobacillus, Enterococcus, and Clostridium leptum copy numbers were significantly increased by Chy and Atv treatment. In addition, Chy and Atv modulated the expression of inflammatory genes including TLR4, TNFα, NLRP3, and IL-17 in the aorta and intestine compared with hypercholesterolemic control rats. Chy and Atv effectively increased the caspase-3 mRNA expression in the intestine, but these decreased in the aorta. The present study concludes that by reducing oxidative stress and increasing gut microbial colonization, Chy may provide an effective therapeutic approach for the prevention of hypercholesterolemia-mediated atherosclerosis. PRACTICAL APPLICATIONS: Our study focused on a therapeutic model representing the clinical presentation of atherosclerosis in humans. Statins are commonly used in the treatment of cardiovascular complications, patients with hypercholesterolemia face difficulties in the continuation of statin therapy. The reason for statin discontinuation has been associated with toxicological effects. It is necessary to investigate the potentiality of the natural compound as an alternative medicine to statin with fewer side effects. The main theme of our study is to compare the therapeutic potential of Chy and Atv. Chy is a natural bioflavonoid that could be considered as an alternative medicinal compound to statins and to avoid toxicity problems associated with statins. Chy is a bioflavonoid present in Passiflora caerulea (blue passion flower), Oroxylum indicum (Indian trumpet flower), Pelargonium crispum, propolis, and honey. Consuming Chy-rich foods will reduce hypercholesterolemia-mediated cardiovascular complications. Overall, the present studies provided a key to developing bioactive compounds-based foods for CVD patients.
C. S. Vidhya, M. Loganathan, S. Bhuvana, N. Baskaran, and R. Meenatchi
Informatics Publishing Limited
Cucurbita maxima belongs to the Cucurbitaceae family and has many traditional medicinal properties claimed that are used in food. The various parts of the Cucurbita maxima are reported to have versatile activities such as antimicrobial, antioxidant, anti-insecticidal, anti-inflammatory and anticancer properties. The current study was designed to evaluate the phytoconstituent profiles of C. maxima pulp, peel and seed extracts (aqueous and methanol) extracted at different temperatures (40 °C, 50 °C, 60 °C) and time (1 and 2 hr). For these extracts, qualitative and quantitative determination were performed, and the aqueous seed extract of C. maxima at 50 °C for 2 hours had higher phytoconstituents, which was further taken for the GCMS analysis. Furthermore, the top hit compounds from the GCMS such as Guanosine (CAS), 8,11,14-Eicosatrienoic acid, Farnesol and 13-Tetradecenal were docked against p53 Y220S mutant (6SI2), and Fibroblast growth factor receptor 1 protein (FGFR1) (4V05). The results revealed that Guanosine with p53 and 8,11,14-Eicosatrienoic acid with FGFR1 have good binding affinities of -7.2 and -6.3 kcal/mol respectively. Conclusively, the top compounds from the aqueous seed extract of C. maxima extracted at 50 °C for 2 hours have significant breast cancer activity and it has to be further taken to in vitro and in vivo studies in the future.
Nagarethinam Baskaran, Govindan Sadasivam Selvam, Subramani Yuvaraj, and Albert Abhishek
Springer Science and Business Media LLC
D. Palanimuthu, N. Baskaran, S. Silvan, D. Rajasekaran, and S. Manoharan
Springer Science and Business Media LLC
D Rajasekaran, S Manoharan, S Silvan, K Vasudevana, N Baskaran, and D Palanimuthu
African Journals Online (AJOL)
The present study has investigated the modulating effect of carnosic acid on the expression pattern of cell proliferative (proliferating cell nuclear antigen (PCNA) cyclin D1 and a transcription factor c-fos), apoptotic (p53, Bcl-2, Bax caspase -3 and 9), inflammatory (Nuclear factor kappa B (NFκB) and cyclooxygenase-2 (COX- 2) and angiogenic (vascular endothelial growth factor (VEGF) markers during 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Oral tumors were developed in the hamsters buccal pouches by painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. Hundred per cent tumour formation (well-differentiated squamous cell carcinoma) accompanied by deregulation in the above mentioned molecular markers was noticed in hamsters treated with DMBA alone (tumour bearing hamsters). Oral administration of carnosic acid at dose of 10mg/kg bw to hamsters treated with DMBA not only completely prevented the tumour formation, but also corrected the abnormalities in the expression pattern of molecular markers. The present study suggests that carnosic acid might have inhibited the tumour formation by exerting anti-cell-proliferative, anti-inflammatory, anti-angiogenic and apoptotic potential during DMBA-induced hamster buccal pouch carcinogenesis.