Genotoxicity and Genomic Instability Induced by Micro- and Nanoplastics: A Comprehensive Multi-Taxa Mechanistic Review Abass Toba Anifowoshe, Bolaji Fatai Oyeyemi, Olufunke Adenike Opeyemi, Sandra Teniola Adebayo, Kehinde Mofesola Bankole, et al. Journal of Applied Toxicology, 2026 Micro‐ and nanoplastics (MNPs) are pervasive contaminants increasingly implicated in DNA damage and genomic instability across biological systems. This systematic review addresses two core questions: (1) How do MNPs induce genotoxic effects and/or genomic instability in invertebrates, vertebrates, and human cell lines? (2) Through which molecular mechanisms and cellular pathways do these particles exert genotoxic effects? To answer these questions, the review employs an analytical framework integrating mechanistic toxicology, comparative organismal evidence, and pathway‐level synthesis. Using PRISMA‐guided methods, data were compiled from studies assessing oxidative stress, DNA strand breaks, chromosomal alterations, and disruption of repair pathways. Across aquatic and terrestrial organisms, as well as human epithelial and fly model models, MNP exposure consistently activated oxidative stress pathways, impaired base‐excision and nucleotide‐excision repair, triggered inflammatory signaling (e.g., NF‐κB), and induced apoptosis or cell‐cycle arrest. The framework highlights converging mechanisms—including ROS overproduction, mitochondrial dysfunction, and direct nuclear interactions—that collectively compromise genome integrity. These` findings reveal a coherent pattern of genotoxicity across taxa and underscore the growing public‐health and ecological risks associated with rising MNP pollution. The review identifies critical knowledge gaps, particularly in chronic low‐dose exposures, polymer diversity, and environmentally aged particles, and calls for standardized mechanistic research to inform regulatory interventions.
Draft genomes of three Enterococcus species recovered from the gastrointestinal microbiota of healthy domestic rabbits (Oryctolagus cuniculus) Abimbola Olumide Adekanmbi, Oluwatosin Olubunmi Oladipo, Opeyemi U. Lawal, Valeria R. Parreira, Bolaji Fatai Oyeyemi, et al. Microbiology Resource Announcements, 2026 We report the draft genome sequences of three Enterococcus strains isolated from the gastrointestinal tract of domestic rabbits. These genomes contribute to expanding the representation of Enterococcus diversity in non-conventional hosts and provide resources for future comparative and functional genomics of gut-adapted Enterococci.
Exposure and Bioaccumulation of Mercury Impacted the Extent of Cellular Damage and Oxidative Stress in Local Chickens Around Ilesha Gold Mining Areas of Nigeria Bolaji F. Oyeyemi, Paul Ayodeji Awonegan, Adekunle Wahab Oyeyemi, Olatunji Abubakar Jimoh, John Babatope Owabumoye, et al. Environmental Toxicology, 2026 Mercury (Hg) is a well‐known global pollutant of environmental concern. Uncontrolled mining activities represent an avenue for its release and possible environmental contamination. Ilesha gold mining areas are characterized by extensive artisan and small‐scale gold mining (ASGM) activities. However, it is largely unknown to what extent Hg pollution has occurred as well as the environmental and ecological deterioration in the area. Here, we studied Hg in soil, sediments, water, chicken blood, liver, muscle (chest), and kidney. Oxidative stress, hepatorenal damage, heat shock response, cellular DNA damage, and mRNA levels of apoptosis‐related genes were analyzed using qPCR. All analyses were done in chickens from gold mining (GMA) and non‐gold mining areas (NGMA). This study reported that the levels of Hg in soil (range: 1.637 ± 0.237–1.796 ± 0.104 μg/g), sediment (range: 1.424 ± 0.046–1.450 ± 0.062 μg/g), and water (range: 1.255 ± 0.071–1.378 ± 0.145 μg/mL) in GMA far exceeded Hg levels in NGMA. This might imply the extent to which ASGM activities have contributed to the Hg contamination in the areas. Chickens from GMA exhibited significantly high Hg levels, with the largest proportion bioaccumulated in the kidney (range: 0.596 ± 0.057–0.605 ± 0.028 μg/g) and lowest proportion in blood (range: 0.215 ± 0.023–0.226 ± 0.043 μg/g), suggesting the health risks dwellers in the area are prone to. Cellular damage biomarkers were significantly elevated in the tissue of Hg‐exposed chickens from GMA compared to those from NGMA, demonstrating the significant health risks associated with Hg pollution and/or uptake in the areas.
Cellular stress and Inflammatory Responses in Mice Exposed to Aspergillus nigerus, Rhizopus oryzae, and Rhizopus delemar Latin American Journal of Pharmacy, 2023
Sexual dimorphism in ratio of second and fourth digits and its relationship with metabolic syndrome indices and cardiovascular risk factors Journal of Research in Medical Sciences, 2014
Functional and Genomic insights into probiotic Lactic Acid Bacteria isolated from the Gastrointestinal microbiota of domestic rabbits (Oryctolagus cuniculus) OO Oladipo, AO Adekanmbi, OU Lawal, VR Parreira, BF Oyeyemi, ... BMC microbiology 26, 478 , 2026 2026
Medicinal plants with antineoplastic potency and possible biomarkers for monitoring and diagnosing neoplastic disease HA Adekilekun, OD Omodamiro, NK Achi, BA Tijani, HA Oyewusi, ... Oncology and Translational Medicine 12 (2), 76-94 , 2026 2026
Antioxidants from Algae: Treasured Natural Compounds for Human Benefits HA Oyewusi, HA Adekilekun, AB Tijani, OO Oladipo, BF Oyeyemi Algae and Algal Metabolites: Emerging Applications, Trends and Prospects, 1-25 , 2026 2026
Exposure and Bioaccumulation of Mercury Impacted the Extent of Cellular Damage and Oxidative Stress in Local Chickens Around Ilesha Gold Mining Areas of Nigeria BF Oyeyemi, PA Awonegan, AW Oyeyemi, OA Jimoh, JB Owabumoye, ... Environmental Toxicology , 2026 2026
Techniques for Isolating and Culturing Algae OO Oladipo, HA Adekilekun, HA Oyewusi, BF Oyeyemi, AB Tijani Algae and Algal Metabolites: Emerging Applications, Trends and Prospects, 1-30 , 2026 2026
Draft genomes of three Enterococcus species recovered from the gastrointestinal microbiota of healthy domestic rabbits ( Oryctolagus cuniculus ) AO Adekanmbi, OO Oladipo, OU Lawal, VR Parreira, BF Oyeyemi, ... Microbiology Resource Announcements, e01162-25 , 2026 2026
Genotoxicity and Genomic Instability Induced by Micro‐and Nanoplastics: A Comprehensive Multi‐Taxa Mechanistic Review AT Anifowoshe, BF Oyeyemi, OA Opeyemi, ST Adebayo, KM Bankole, ... Journal of Applied Toxicology , 2026 2026
EVALUATION OF BIOACTIVE COMPOUNDS, IN-VITRO ANTIOXIDANT PROFILE AND ANTI-INFLAMMATORY PROPERTIES OF ETHANOLIC EXTRACTS OF ISOBERLINIA TOMENTOSA AH Adekilekun, OD Omodamiro, NK Achi, HA Oyewusi, RM Omodamiro, ... FUDMA JOURNAL OF SCIENCES 9 (12), 148-158 , 2025 2025 Citations: 1
NMR based human gut metabolomic profiling reveals altered metabolites associated with pulmonary and extra-pulmonary tuberculosis V Sharma, A Singh, S Sharma, M Gaur, AK Malaisamy, D Rawat, A Yadav, ... Metabolomics 22 (1), 1 , 2025 2025
Bacterial community structure and secondary metabolite insights from halophiles at Oniru Beach, Lagos AC Olaleye, HA Oyewusi, KA Akinyede, OO Oladipo, BF Oyeyemi Archives of Microbiology 207 (11), 299 , 2025 2025 Citations: 1
Reproductive Potential of Selenium on Aluminium Sulphate-Treated Prepubertal Male Wistar Rats AW Oyeyemi, WM Owonikoko, AO Akinola, BF Oyeyemi, OO Daramola, ... Nigerian Journal of Biochemistry and Molecular Biology 40 (1), 96-106 , 2025 2025
Hepato-renal toxicity of mercury bioaccumulation in cage-free chickens ( Gallus gallus domesticus ) from gold-producing areas of Zamfara State, Nigeria Z Abdulmalik, M Shittu, S Adamu, SF Ambali, BF Oyeyemi Environmental Sciences Europe 37 (1), 179 , 2025 2025 Citations: 2
Biochemical analyses of bio-wastes-based 45S5 bioglass-ceramics in male Wistar rats SS Owoeye, DO Folorunso, FO Aramide, BF Oyeyemi, SG Borisade, ... Sustainable Chemistry One World, 100140 , 2025 2025
Differentially regulated saliva proteome and metabolome: a way forward for risk-assessment of oral cancer among tobacco abusers BF Oyeyemi, S Dabral, A Paramaraj, S Srinivasan, GD Jhingan, D Kumar, ... Molecular Omics, https://doi.org/10.1039/D5MO00058K , 2025 2025 Citations: 1
Effect of Nigella sativa oil and organophosphate antidote, Pralidoxime-Chloride on blood pressure variables and cardiac apoptotic-related gene expression in dichlorvos-exposed … ST Shittu, FO Jibril, SA Shittu, A Imam, TA Jarikre, BF Oyeyemi, ... Journal of Applied Sciences & Environmental Management 29 (9) , 2025 2025 Citations: 1
Bacterial Diversity and Characterisation of Secondary Metabolite from Halophilic Bacterial Isolated from Popular Metropolitan Marine Oniru Beach, Lagos, Nigeria AC Olaleye, HA Oyewusi, KA Akinyede, OO Oladipo, BF Oyeyemi 2025
Emerging roles of noncoding RNA for biosynthesis of secondary metabolites in ethnomedicinal plants HA Oyewusi, OO Olubunmi, BA Tijani, BF Oyeyemi, HA Adekilekun Ethnomedicinal Plants for Drug Discovery: Current Developments, 369-383 , 2024 2024 Citations: 3
Preparation and characterization of ZnO modified solid state sintered 45S5 bioactive ceramics SS Owoeye, SM Abegunde, BF Oyeyemi, EO Isinkaye Hybrid Advances 6, 100251 , 2024 2024 Citations: 2
Urine Metabolomics Reveals Overlapping Metabolic Associations Between Preeclampsia and Gestational Diabetes NR Agarwal, G Kachhawa, BF Oyeyemi, NS Bhavesh Indian Journal of Clinical Biochemistry 39 (3), 356-364 , 2024 2024 Citations: 6
Esteroides y fertilidad de conejos alimentados con harina de hojas de Phyllanthus amarus como aditivo alimentario OA Jimoh, HO Okin-Aminu, BF Oyeyemi, UD Osayande, CU Nwachukwu, ... Archivos de zootecnia 73 (282), 72-76 , 2024 2024
MOST CITED SCHOLAR PUBLICATIONS
Gene frequencies of ABO and Rh blood groups in Nigeria: A review AT Anifowoshe, OA Owolodun, KM Akinseye, OA Iyiola, BF Oyeyemi Egyptian Journal of Medical human genetics 18 (3), 205-210 , 2017 2017 Citations: 101
Sexual dimorphism in ratio of second and fourth digits and its relationship with metabolic syndrome indices and cardiovascular risk factors BF Oyeyemi, OA Iyiola, AW Oyeyemi, KA Oricha, AT Anifowoshe, ... Journal of research in medical sciences: the official journal of Isfahan … , 2014 2014 Citations: 68
FTO gene associates and interacts with obesity risk, physical activity, energy intake, and time spent sitting: pilot study in a Nigerian population BF Oyeyemi, CA Ologunde, AB Olaoye, NA Alamukii Journal of obesity 2017 (1), 3245270 , 2017 2017 Citations: 44
Reproductive characteristics, semen quality, seminal oxidative status, steroid hormones, sperm production efficiency of rabbits fed herbal supplements AJ Olatunji, AO Wahab, OOA Hafsat, BF Oyeyemi. Theriogenology 168, 41-49 , 2021 2021 Citations: 34
Stringent response protein as a potential target to intervene persistent bacterial infection GS Kushwaha, BF Oyeyemi, NS Bhavesh Biochimie, DOI:10.1016/j.biochi.2019.07.006 , 2019 2019 Citations: 34
Development of multiepitope subunit protein vaccines against Toxoplasma gondii using an immunoinformatics approach OS Onile, GJ Ojo, BF Oyeyemi, GO Agbowuro, AI Fadahunsi NAR Genomics and Bioinformatics 2 (3), lqaa048 , 2020 2020 Citations: 28
Unravelling the anti-inflammatory mechanism of Allium cepa: an integration of network pharmacology and molecular docking approaches V Omoboyede, OS Onile, BF Oyeyemi, RT Aruleba, AI Fadahunsi, GA Oke, ... Molecular Diversity, 10.1007/s11030-023-10614-w , 2023 2023 Citations: 22
Plasma metabolomic study in perinatally HIV infected children using 1H NMR spectroscopy reveals perturbed metabolites that sustain during therapy T Kaur, S.U., Oyeyemi, B.F.,* Shet, A., Gopalan, B.P., Himanshu, D., Bhavesh ... Plos ONE 15 (8), e0238316 , 2020 2020 Citations: 22
Perfluorooctanoic acid dominates the molecular-level effects of a mixture of equal masses of perfluorooctanoic acid and perfluorooctane sulfonic acid in earthworm Z Han, BF Oyeyemi, JE Zenobio, OA Salawu, AS Adeleye Journal of Hazardous Materials 457, 131718 , 2023 2023 Citations: 21
Microbiome analysis of saliva from oral squamous cell carcinoma (OSCC) patients and tobacco abusers with potential biomarkers for oral cancer screening BF Oyeyemi, US Kaur, A Paramaraj, Chintamani, R Tandon, A Kumar, ... Heliyon, https://doi.org/10.1016/j.heliyon.2023.e , 2023 2023 Citations: 20
Histological changes, micronuclei induction and nuclear abnormalities in the peripheral erythrocytes of Clarias gariepinus (Burchell 1822) exposed to water sample from Apodu … A Anifowoshe, J Oyebanji, O Oladipo, F Oyeyemi, M Abdulrahim, ... Journal of Life and Bio Sciences Research 1 (01), 01-07 , 2020 2020 Citations: 19
Soursop juice enhanced seminal antioxidant defence and semen quality of rabbit bucks in extremely dry climatic condition of Southwestern Nigeria OA Jimoh, BF Oyeyemi, WA Oyeyemi Journal of thermal biology 100, 103034 , 2021 2021 Citations: 18
An immunoinformatics approach for the design of a multi-epitope subunit vaccine for urogenital schistosomiasis CA Olugbenga Samson Onile, Adeyinka I. Fadahunsi, Ameerah A. Adekunle ... PeerJ 8, e8795 , 2020 2020 Citations: 17
Frequency of twinning in Kwara State, North-Central Nigeria FOM Boalji F Oyeyemi, O.A Iyiola, U A Raheem Egyptian Journal of Medical Human Genetics Volume 14, Issue 1, January 2013 … , 2013 2013 Citations: 17
Physiochemical analyses and molecular characterization of heavy metal-resistant bacteria from Ilesha gold mining sites in Nigeria GJ Ojo, OS Onile, AO Momoh, BF Oyeyemi, V Omoboyede, AI Fadahunsi, ... Journal of Genetic Engineering and Biotechnology 21 (1), 172 , 2023 2023 Citations: 14
Potential of watermelon (Citrullus lanatus) to maintain oxidative stability of Rooster semen for Artificial Insemination A Jimoh, M Akinola, B Oyeyemi, W Oyeyemi, S Ayodele, I Omoniyi, ... Journal of Animal Science and Technology , 2020 2020 Citations: 11
Relationship between ratio of second and fourth digit and obesity traits among different ethnic groups in Ilorin, North Central Nigeria BF OYEYEMI, JO ADEBAYO, AT ANIFOWOSHE, OA IYIOLA Notulae Scientia Biologicae 8 (4), 396-400 , 2016 2016 Citations: 10
Assessment of blood mercury, immune response, heat shock and oxidative stress marker in free-ranging chicken (Gallus Gallus domesticus) from gold mining areas in Zamfara State … Z Abdulmalik, M Shittu, S Adamu, SF Ambali, BF Oyeyemi Journal of Hazardous Materials Advances 8, 100176 , 2022 2022 Citations: 9
Effects of Ascorbic Acid on Reproductive Functions of Male Wistar Rats Exposed to Nicotine TK Bolaji F oyeyemi, Wahab A oyeyemi, Sheu Shittu, R. Ajah Journal of African Association of Physiological Sciences 2 (2): 110-116 … , 2014 2014 Citations: 9
Metabolic profiling of serum and urine in preeclampsia and gestational diabetes in early pregnancy NR Agarwal, G Kachhawa, BF Oyeyemi, NS Bhavesh Medicine in Drug Discovery 16, 100143 , 2022 2022 Citations: 7