Bolaji F Oyeyemi
@unilorin.edu.ng
Lecturer I, Department of Zoology/Faculty of Life Sciences
University of Ilorin
RESEARCH, TEACHING, or OTHER INTERESTS
Biochemistry, Genetics and Molecular Biology, Biochemistry, Genetics and Molecular Biology
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
S. Owoeye, S. M. Abegunde, B. F. Oyeyemi and Esther O. Isinkaye
Nupur Rani Agarwal, Garima Kachhawa, Bolaji Fatai Oyeyemi, and Neel Sarovar Bhavesh
Springer Science and Business Media LLC
Victor Omoboyede, Olugbenga Samson Onile, Bolaji Fatai Oyeyemi, Raphael Taiwo Aruleba, Adeyinka Ignatius Fadahunsi, Grace Ayomide Oke, Tolulope Adelonpe Onile, Ochapa Ibrahim, and Tayo Alex Adekiya
Springer Science and Business Media LLC
Nupur Rani Agrawal, Anupam Patra, Bolaji F. Oyeyemi, and Gajraj Singh Kushwaha
Elsevier
Olatunji A. Jimoh, Bolaji F. Oyeyemi, Wahab A. Oyeyemi, Simeon O. Ayodele, Hafsat O. Okin‐Aminu, Ayoola D. Ayodele, Tolulope O. Faniyi, and Chinwe Uchechi Nwachukwu
Wiley
AbstractA study was designed to evaluate the effect of Moringa oleifera, Phyllanthus amarus and Viscum album leaf meal as herbal inclusions to alleviate the detrimental outcomes of heat stress in weaned female rabbits. Forty (40) weaned rabbit does (527.99 ± 10.35 g; 28 days old) were randomly allotted to four dietary groups consisting of Diet 1(control diet; without leaf meal), Diets 2 (supplemented with 10% V. album); 3 (supplemented with 10% M. oleifera) and 4 (supplemented with 10% P. amarus) in an 84 days trial at the peak of heat stress in Southwest Nigeria. At the end of the trial, blood samples were collected to assess physiological responses and oxidative status of the rabbit does. The results obtained revealed that rabbit does were exposed to heat stress; rabbit does fed control diet had higher leucocyte and neutrophil/lymphocyte ratio compared to rabbit does fed on herbal inclusions. The herbal inclusions enhanced oxidative stability of rabbit does by lowering lipid peroxidation and enhancing antioxidant activities during heat stress conditions. Rabbit does fed control‐based diet had significantly higher heat shock protein 70, leptin and adiponectin compared to rabbit does on M. oleifera, P. amarus and V. album supplemented diets. The herbal inclusions tend to suppress proinflammatory cytokines in rabbit does during heat stress condition. In conclusion, the herbal inclusions suppress inflammation, adipokines and promotes oxidative stability of rabbit does exposed to heat stress conditions.
Glory Jesutomisin Ojo, Olugbenga Samson Onile, Abdul Onoruoiza Momoh, Bolaji Fatai Oyeyemi, Victor Omoboyede, Adeyinka Ignatius Fadahunsi, and Tolulope Onile
Elsevier BV
Bolaji Fatai Oyeyemi, Urvinder S. Kaur, Amit Paramraj, Chintamani, Ravi Tandon, Abhinav Kumar, and Neel Sarovar Bhavesh
Elsevier BV
Ziwei Han, Bolaji F. Oyeyemi, Jenny E. Zenobio, Omobayo A. Salawu, and Adeyemi S. Adeleye
Elsevier BV
Zainab Abdulmalik, Muftau Shittu, Sani Adamu, Suleiman Folorunsho Ambali, and Bolaji Fatai Oyeyemi
Elsevier BV
Nupur Rani Agarwal, Garima Kachhawa, Bolaji Fatai Oyeyemi, and Neel Sarovar Bhavesh
Elsevier BV
Olatunji Abubakar Jimoh, Bolaji Fatai Oyeyemi, and Wahab Adekunle Oyeyemi
Elsevier BV
Olatunji Abubakar Jimoh, Wahab Adekunle Oyeyemi, Hafsat Ololade Okin-Aminu, and Bolaji Fatai Oyeyemi
Elsevier BV
Olatunji Abubakar Jimoh, Micheal Olawale Akinola, Bolaji Fatai Oyeyemi, Wahab Adekunle Oyeyemi, Simeon Olugbenga Ayodele, Idowu Samuel Omoniyi, and Hafsat Ololade Okin-Aminu
Korean Society of Animal Science and Technology
Abstract Fruits with antioxidant enrichment can be an economically affordable supplement for mitigating oxidative damage prone spermatozoa membrane pathologies. Computer-assisted sperm analyzer and oxidative status were utilized to evaluate the impact of watermelon (Citrullus lanatus) fortification of dextrose saline as diluent for rooster semen and fertility response of hens inseminated. Watermelon juice and dextrose saline were used to formulate diluent of 7 treatments consisting of unextended semen (positive control), 10%, 20%, 30%, 40%, 50% and only dextrose saline (negative control) designated as Treatments 1–7. Pooled semen was obtained from fertile roosters and equilibrated with diluents at ratio 1:2 in the various treatments and were evaluated using computer software coupled microscope and seminal oxidative status assay. 168 laying hens randomly divided into 7 treatment of 8 replicates and 3 hen per replicate. Hen were everted, and semen (2 × 108 Spermatozoa) deposited intra-vagina and eggs collected over 8 weeks to assess fertility and hatchability of eggs laid. The result obtained revealed that watermelon-dextrose saline rooster semen diluent enhanced progressive motility, sperm kinetics and lowered non-progressive motility in T2–T6 compared to T7 over the 3 hours of evaluation. Watermelon addition to rooster semen diluent enhance the antioxidant capacity of rooster semen and lowered lipid peroxide generation. The percentage fertility was highest in T3 (81.01%) and T4 (81.24%) with lowest value obtained in T7 (73.46%). The hatchability of eggs set of hens inseminated with undiluted semen (71.46%) was lower than values for hens inseminated with watermelon inclusive extended semen (75.71%–80.39%). The optimal inclusion of 30%–40% watermelon in dextrose saline diluent enhance rooster semen kinetics, seminal oxidative stability and egg fertility.
Olugbenga S. Onile, Adeyinka I. Fadahunsi, Ameerah A. Adekunle, Bolaji F. Oyeyemi, and Chiaka I. Anumudu
PeerJ
Discovery of T and B memory cells capable of eliciting long-term immunity against schistosomiasisis is important for people in endemic areas. Changes in schistosomes environment due to developmental cycle, induces up-regulation of Heat Shock Proteins (HSPs) which assist the parasite in coping with the hostile conditions associated with its life cycle. This study therefore focused on exploring the role of HSPs in urogenital schistosomiasis to develop new multi-epitope subunit vaccine against the disease using immunoinformatic approaches. The designed subunit vaccine was subjected to in silico antigenicity, immunogenicity, allergenicity and physicochemical parameters analysis. A 3D structure of the vaccine construct was predicted, followed by disulphide engineering for stability, codon adaptation and in silico cloning for proper expression and molecular protein–protein docking of vaccine construct in the vector against toll-like receptor 4 receptor, respectively. Consequently, a 493 amino acid multi-epitope vaccine construct of antigenicity probability of 0.91 was designed. This was predicted to be stable, non-allergenic in nature and safe for human use.
Olugbenga S Onile, Glory J Ojo, Bolaji Fatai Oyeyemi, Gbenga O Agbowuro, and Adeyinka I Fadahunsi
Oxford University Press (OUP)
Abstract Approximately one-third of the world’s human population is estimated to have been exposed to the parasite Toxoplasma gondii. Its prevalence is reportedly high in Ethiopia (74.80%) and Zimbabwe (68.58%), and is 40.40% in Nigeria. The adverse effect of this parasite includes a serious congenital disease in the developing fetus of pregnant women. After several efforts to eliminate the disease, only one licensed vaccine ‘Toxovax’ has been used to avoid congenital infections in sheep. The vaccine has been adjudged expensive coupled with adverse effects and short shelf life. The potential of vaccine to likely revert to virulent strain is a major reason why it has not been found suitable for human use, hence the need for a vaccine that will induce T and B memory cells capable of eliciting longtime immunity against the infection. This study presents immunoinformatics approaches to design a T. gondii-oriented multiepitope subunit vaccine with focus on micronemal proteins for the vaccine construct. The designed vaccine was subjected to antigenicity, immunogenicity, allergenicity and physicochemical parameter analyses. A 657-amino acid multiepitope vaccine was designed with the antigenicity probability of 0.803. The vaccine construct was classified as stable, non-allergenic, and highly immunogenic, thereby indicating the safety of the vaccine construct for human use.
Urvinder Kaur S., Bolaji Fatai Oyeyemi, Anita Shet, Bindu Parachalil Gopalan, Himanshu D., Neel Sarovar Bhavesh, and Ravi Tandon
Public Library of Science (PLoS)
Background Perinatally HIV-infected children on anti-retroviral treatment (ART) are reported to have metabolic abnormalities such as dyslipidemia, lipodystrophy, and insulin resistance which potentially increase the risk of diabetes, kidney, liver and cardiovascular disease. Objective To elucidate HIV-mediated metabolic complications that sustain even during ART in perinatally HIV-infected children. Method We have carried out metabolic profiling of the plasma of treatment-naïve and ART-suppressed perinatally HIV-infected children and uninfected controls using 1H nuclear magnetic resonance (NMR) spectroscopy followed by statistical analysis and annotation. Result Validated multivariate analysis showed clear distinction among our study groups. Our results showed elevated levels of lactate, glucose, phosphoenolpyruvic acid, propionic acid, 2-ketobutyric acid and tricarboxylic acid (TCA) cycle metabolites in untreated HIV-infected children compared to uninfected controls. ART normalized the levels of several metabolites, however the level of lactate, phosphoenolpyruvic acid, oxoglutaric acid, oxaloacetic acid, myoinositol and glutamine remained upregulated despite ART in HIV-infected children. Pathway analysis revealed perturbed propanoate metabolism, amino acid metabolism, glycolysis and TCA cycle in untreated and ART-suppressed HIV-infected children. Conclusion Developing therapeutic strategies targeting metabolic abnormalities may be beneficial for preventing diabetes, cardiovascular disease or other associated complications in perinatally HIV-infected children.
Gajraj Singh Kushwaha, Bolaji Fatai Oyeyemi, and Neel Sarovar Bhavesh
Elsevier BV
F. Oyeyemi, J. Adebayo, Adekunle Wahab Oyeyemi, Iyabo Cecilia Adeola, Elizabeth Tope Ayanwole, Febisola Oluwatoyin Jegede and Ruth Oluwakemi Ogunsakin
Abass Toba Anifowoshe, Olubukola Abibat Owolodun, Kehinde Monica Akinseye, Oluyinka Ajibola Iyiola, and Bolaji Fatai Oyeyemi
Springer Science and Business Media LLC
Bolaji Fatai Oyeyemi, Charles Ayorinde Ologunde, Ayonposi Bukola Olaoye, and Nanfizat Abiket Alamukii
Hindawi Limited
Fat mass and obesity-associated (FTO) gene influences obesity but studies have shown that environmental/lifestyle variables like physical activity (PA), time spent sitting (TSS), and energy intake might mediate the effect. However, this is poorly understood in Nigeria due to scarce studies. We demystified association and interaction between FTO rs9939609, obesity, PA, TSS, and energy intake in Nigeria. FTO gene variant was genotyped by restriction fragment length polymorphism and gene sequencing analysis in 103 people with obesity and 98 controls. Anthropometrics and environmental variables were measured using standard procedures. Significant associations were found between FTO rs9939609 with obesity and environmental/lifestyle variables before and after adjusting for age. Carriers of allele A have significantly higher odds of being overweight/obese using BMI [0.191 (0.102–0.361), p<0.001] but this was attenuated by PA (p[interaction]=0.029); odds of being overweight reduced from 0.625 (0.181–2.159) to 0.082 (0.009–0.736) for low and high PA, respectively. Mediation analysis of total indirect effect also confirmed this by showing a simultaneous mediating role of total PA, energy intake, and TSS in the relationship between FTO and BMI (unstandardized-coefficient = 1.68; 95% CI: 1.26–2.22). This study shows a relationship between FTO and obesity phenotype and environmental/lifestyle factors might be an important modulator/mediator in the association.
O.A. Iyiola, F.B. Oyeyemi, U.A. Raheem, and F.O. Mark
Springer Science and Business Media LLC