Dr.Umesh Laddi

Verified email at cittumkur.org

Professor and Head
Channabasaveshwar Institute of Technology, Gubbi, Tumkur, Karnataka, India



                                               

http://researchid.co/drumesh1969

I am a Professor and head of the department of Chemistry in an engineering college, in Karnataka. Have got 24 years of experience in teaching and research

EDUCATION

M.Sc., Ph.D., PGDIB

RESEARCH INTERESTS

Synthetic, heterocyclic, Pharmacological, Drug Intermediates, Speciality Chemicals, Nucleosides and Nucleotides

FUTURE PROJECTS

Nitrogen Hetero cycles of Pharmacological importance

Some 1,2,4-Triazoles and their derivatives will be prepared and tested for pharmacological properties


Applications Invited
Funds
16

Scopus Publications

272

Scholar Citations

10

Scholar h-index

10

Scholar i10-index

Scopus Publications

  • Synthesis and antimicrobial activity of some new 1, 3, 4-oxadiazoles, 1, 2, 4-triazoles and 1, 3, 4-thiadiazoles
    Indian Drugs, ISSN: 0019462X, Pages: 18-23, Published: June 2016

  • Some new 1,3,4-oxadiazoles as antimicrobial agents
    Indian Drugs, ISSN: 0019462X, Pages: 15-18, Published: February 2016

  • Synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives
    Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, ISSN: 03764699, Pages: 1176-1181, Published: August 2013

  • Synthesis and antimicrobial activities of some new 1, 3, 4-oxadiazoles
    Indian Drugs, ISSN: 0019462X, Pages: 38-44, Published: August 2012

  • Synthesis and pharmacological activities of some new 5-substituted-2- mercapto-1,3,4-oxadiazoles
    ShobhaR Desai, RajaniS Bennur, S Bennur, U Laddi, and PA Patil

    Indian Journal of Pharmaceutical Sciences, ISSN: 0250474X, eISSN: 19983743, Pages: 593-596, Published: September 2011 OMICS Publishing Group
    In this study, various 5-β-[(N-benzenesulphony/tosyl)-4-(un) substituted anilino]ethyl-2-mercapto-1,3,4-oxadiazole (4a-f), with sulphonamide moiety at the side chain have been synthesised. The structures of the newly synthesised compounds have been established on the basis of their spectral data and elemental analysis. All the compounds were screened for antimicrobial activities against Escherichia coli, Bacillus cirroflagellosus, Aspergillus niger. Colletotrichum capsici and antituberclosis activity against Mycobacterium tuberculosis H37Rv strain. Only two compounds 4b (73%) and 4e (54%), have shown moderate antituberculosis activity. All the compounds have shown moderate antiinflamatory activity and least ulcerogenecity. Most of the compounds have shown significant analgesic activity (64.20-120.72%) in comparison with the standard, Aspirin (49.39%) In the MES method, however only compound 4a, exhibited a protection of 33.33%, and others failed to protect.

  • Synthesis and antimicrobial activities of some new azetidin-2-ones and thiazolidin-4-ones
    S. Desai, U. Laddi, R. S. Bennur and S. Bennur

    Indian Journal of Pharmaceutical Sciences, ISSN: 0250474X, eISSN: 19983743, Pages: 478-482, Published: July 2011
    Various (4-substituted) phenyl-3-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]propionylamido-1,3-thiazolidine-4-ones (3a–x) and 1-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]-propionylamido-3-chloro-4-(4-substituted)phenyl-azetidin-2-ones (4a–x) have been synthesised by the cyclocondensation of Schiff bases (2a-x) with thioglycolic acid and chloroacetyl chloride, respectively. The structures of the newly synthesised compounds have been established on the basis of their spectral data and elemental analysis. All compounds were evaluated for antimicrobial activities against Escherichia coli, Bacillus cirroflagellosus, Aspergillus niger and Colletotrichum capsici. Most compounds investigated exhibited significant antifungal activity against Colletotrichum capsici, comparable to that of fluconazole, the standard used.

  • Synthesis and pharmacological activities of some new 3-Substituted-4-Amino- 5-Mercapto-1,2,4-Triazoles
    ShobhaR Desai, RajaniS Bennur, S Bennur, U Laddi, and PA Patil

    Indian Journal of Pharmaceutical Sciences, ISSN: 0250474X, eISSN: 19983743, Pages: 115-120, Published: January-February 2011 OMICS Publishing Group
    In this study, various 3-β-[(N-benzenesulphonyl/tosyl)-4-(un) substituted anilino]ethyl-4-amino-5-mercapto-4(H)-1,2,4-triazoles (5a–f), with biologically active ‘sulphonamide’ moiety as the side chain have been prepared. The structures of the newly synthesised compounds have been established on the basis of their spectral data and elemental analysis. All the compounds were evaluated for antimicrobial activities against Escherichia coli, Bacillus cirroflagellosus, Aspergillus niger and Colletotrichum capsici. Most of the compounds investigated exhibited significant antifungal activity against Colletotrichum capsici, even greater than fluconazole, the standard used. Only two compounds 3f (59%) and 5e (67%), have shown moderate antituberculosis activity. All the triazoles exhibited moderate degree of antiinflammatory activity and least ulcerogenecity. Most of the compounds have shown significant analgesic activity (81.02–120.72%) in comparison with aspirin (49.39%). In the MES method, only compound 3e exhibited a protection of 66.66%, whereas others exhibited minimum protection of (33.33%).

  • Some new 1,3,4-oxadiazoles as antimicrobial agents
    Indian Journal of Heterocyclic Chemistry, ISSN: 09711627, Pages: 319-322, Published: April 2002

  • Synthesis, antimicrobial and antituberculosis activities of N-bridged heterocycles
    Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, ISSN: 03764699, Pages: 828-833, Published: 2001

  • Some new 3-substituted-4-amino-5-mercapto-4(H)-1,2,4-triazoles as nonsteroidal antiinflammatory agents
    Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, ISSN: 03764699, Pages: 461-467, Published: 1998

  • Antiinflammatory activity of 3-substituted-4-amino-5- piperidino-4(h)- 1,2,4-triazoles
    Indian Drugs, ISSN: 0019462X, Pages: 509-513, Published: August 1998

  • Synthesis and biological activity of 2-(N,N-dialkyl amino/-piperidino/morpholino) methyl-7-halothiazolo (2,3-b) quinazolin-5-ones
    Indian Journal of Heterocyclic Chemistry, ISSN: 09711627, Pages: 39-42, Published: July 1997

  • Synthesis, antiinflammatory and biological activities of some new 2- mercapto-5-substituted-1,3,4-oxadiazoles
    Indian Drugs, ISSN: 0019462X, Pages: 666-673, Published: 1997

  • Synthesis and antimicrobial activity of 2-substituted-3H-thiazolo (2,3-b)-8-arylpyrazolo (4, 3-c) pyrimidin-5-ones
    Indian Journal of Heterocyclic Chemistry, ISSN: 09711627, Pages: 193-198, Published: 1996

  • Synthesis and biological activity of pyrazolopyrimidines
    Indian Journal of Heterocyclic Chemistry, ISSN: 09711627, Pages: 63-66, Published: 1996

  • Free radical elimination and oxidation of 1, 1, 1-trichloro-2, 2-bis(p-substituted phenyl)ethanes
    Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, ISSN: 03764699, Pages: 74-76, Published: January 1996

RECENT SCHOLAR PUBLICATIONS

  • SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW 1,3,4- OXADIAZOLES, 1,2,4-TRIAZOLES AND 1,3,4-THIADIAZOLES
    Laddi UV, Desai SR
    Indian Drugs 53 (6), 18-23 2016

  • SOME NEW 1,3,4-OXADIAZOLES AS ANTIMICROBIAL AGENTS
    Laddi. U. V.* and Desai S.
    INDIAN DRUGS 53 (02), 15-18 2016

  • Synthesis and antimicrobial activities of some new 1, 2, 4-triazole derivatives
    S Desai, U Laddi, R Bennur, S Bennur
    NISCAIR-CSIR, India 2013

  • Synthesis and Antimicrobial Activities of Some New 1, 3, 4-Oxadiazoles
    Shobha R Desai & UV.Laddi
    Indian Drugs. 49 (08), 38-44 2012

  • Synthesis and pharmacological activities of some new 5-substituted-2-mercapto-1, 3, 4-oxadiazoles
    SR Desai, U Laddi, RS Bennur, PA Patil, S Bennur
    Indian journal of pharmaceutical sciences 73 (5), 593 2011

  • Synthesis and antimicrobial activities of some new azetidin-2-ones and thiazolidin-4-ones
    SR Desai, UV Laddi, RS Bennur, SC Bennur
    Indian journal of pharmaceutical sciences 73 (4), 478 2011

  • Synthesis and Pharmacological activities of some new 5-substituted-2-mercapto-1,3,4-oxadizoles.
    PAPSCB Shobha R Desai, UV.Laddi, Rajani S Bennur
    Indian J. Pharm. Sci., , IJPS Online 73 ((5)), 593-596 2011

  • Synthesis and pharmacological activities of some new 3-Substituted-4-Amino-5-Mercapto-1, 2, 4-Triazoles
    SR Desai, U Laddi, RS Bennur, PA Patil, S Bennur
    Indian journal of pharmaceutical sciences 73 (1), 115 2011

  • Some new 1, 3, 4-oxadiazoles as antimicrobial agents
    UV Laddi, SR Desai, RS Bennur, SC Bennur
    Indian Journal of Heterocyclic Chemistry 11 (4), 319-322 2002

  • Synthesis, antimicrobial and antituberculosis activities of N-bridged heterocycles
    UV Laddi, MB Talawar, SR Desai, RS Bennur, SC Bennur
    NISCAIR-CSIR, India 2001

  • Some new 3-substituted-4-amino-5-mercapto-4 (H)-1, 2, 4-triazoles as nonsteroidal antiinflammatory agents
    UV Laddi, SR Desai, YS Somannavar, RS Bennur, SC Bennur
    INDIAN JOURNAL OF CHEMISTRY SECTION B 37, 461-467 1998

  • Nitrogen Heterocycles of Pharmacological Importance
    GDSB Umesh Laddi
    Karnataka University, Dharwad, Karnataka, India 1998

  • Synthesis, characterization and pharmacological evaluation of certain 3-substituted-4-amino- 5-mercapto-4(H)-1,2,4-triazoles.
    RSBSCB M.B.Talawar, Umesh Laddi
    Proceedings of National Conference on current trends in Chemistry., 10 1998

  • Antiinflammatory activity of 3-substituted-4-amino-5-piperidino-4 (H)-1, 2, 4-triazoles
    UV Laddi, MB Talawar, SR Desai, YS Somannavar, RS Bennur, ...
    Indian Drugs 35 (8), 509-513 1998

  • Synthesis, antiinflammatory and biological activities of some new 2-mercapto-5-substituted-1, 3, 4-oxadiazoles
    UV Laddi, SR Desai, YS Somannavar, RS Bennur, SC Bennur
    INDIAN DRUGS-BOMBAY- 34, 666-673 1997

  • Synthesis and biological activity of 2-(N, N-dialkyl amino/-piperidino/morpholino) methyl-7-halothiazolo (2, 3-b) quinazolin-5-ones
    SC Bennur, MB Talawar, UV Laddi, YS Somannavar, V Hariholimath, ...
    Indian Journal of Heterocyclic Chemistry 7 (1), 39-42 1997

  • Synthesis and biological activity of pyrazolopyrimidines
    VV Badiger, SC Bennur
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 6 (1), 63-66 1996

  • Synthesis and biological activity of pyrazolopyrimidines
    Badiger, VV and Bennur, SC
    Indian Journal of Heterocyclic Chemistry, CAN 125:328654 6, 63-66 6, 663 1996

  • Synthesis and biological activity of pyrazolo-pyrimidin derivatives
    VVBSCB H.M.Virupakshaiah, M.B.Talawar, U.V.Laddi, Y.S.Somannavar
    Indian J. Heterocyclic Chem., 7 (.), 63-66 1996

  • phenyl) ethanes
    SC Bennur, MB Talawarf, UV Laddi, F Nomej
    Indian Journal of Chemistry 35, 74-76 1996

MOST CITED SCHOLAR PUBLICATIONS

  • Some new 1, 3, 4-oxadiazoles as antimicrobial agents
    UV Laddi, SR Desai, RS Bennur, SC Bennur
    Indian Journal of Heterocyclic Chemistry 11 (4), 319-322 2002
    Citations: 75

  • Synthesis and Antimicrobial Activity of Bridgehead Nitrogen Heterocycles: Reactions of 3‐N‐Methyl/Ethyl (α‐Methyl) ethylmorpholino/Piperidino‐4‐amino‐5‐mercapto‐4 (H)‐1, 2, 4
    MC Hosur, MB Talawar, UV Laddi, RS Bennur, SC Bennur
    ChemInform 26 (44), no-no 1995
    Citations: 25

  • Synthesis, antimicrobial and antituberculosis activities of N-bridged heterocycles
    UV Laddi, MB Talawar, SR Desai, RS Bennur, SC Bennur
    NISCAIR-CSIR, India 2001
    Citations: 22

  • Synthesis and Biological-Activity of 1, 2, 4-Triazole Derivatives
    MB Talawar, UV Laddi, YS Somannavar, RS Bennur, SC Bennur
    Indian Journal of Heterocyclic Chemistry 4 (4), 297-300 1995
    Citations: 20

  • Synthesis and antimicrobial activities of some new 1, 2, 4-triazole derivatives
    S Desai, U Laddi, R Bennur, S Bennur
    NISCAIR-CSIR, India 2013
    Citations: 19

  • Synthesis and biological activity of pyrazolopyrimidines
    VV Badiger, SC Bennur
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 6 (1), 63-66 1996
    Citations: 18

  • Synthesis and pharmacological activities of some new 3-Substituted-4-Amino-5-Mercapto-1, 2, 4-Triazoles
    SR Desai, U Laddi, RS Bennur, PA Patil, S Bennur
    Indian journal of pharmaceutical sciences 73 (1), 115 2011
    Citations: 17

  • Synthesis and antimicrobial activities of some new 1,3,4-oxadiazoles
    M.C.Hosur, M.B.Talawar, U.V.Laddi, R.S.Bennur & S.C.Bennur
    Indian J. Heterocyclic Chem., 3, 237-42 1994
    Citations: 16

  • Antiinflammatory activity of 3-substituted-4-amino-5-piperidino-4 (H)-1, 2, 4-triazoles
    UV Laddi, MB Talawar, SR Desai, YS Somannavar, RS Bennur, ...
    Indian Drugs 35 (8), 509-513 1998
    Citations: 12

  • Synthesis, antiinflammatory and biological activities of some new 2-mercapto-5-substituted-1, 3, 4-oxadiazoles
    UV Laddi, SR Desai, YS Somannavar, RS Bennur, SC Bennur
    INDIAN DRUGS-BOMBAY- 34, 666-673 1997
    Citations: 12

  • Some new 3-substituted-4-amino-5-mercapto-4 (H)-1, 2, 4-triazoles as nonsteroidal antiinflammatory agents
    UV Laddi, SR Desai, YS Somannavar, RS Bennur, SC Bennur
    INDIAN JOURNAL OF CHEMISTRY SECTION B 37, 461-467 1998
    Citations: 9

  • Synthesis and antimicrobial activities of some new azetidin-2-ones and thiazolidin-4-ones
    SR Desai, UV Laddi, RS Bennur, SC Bennur
    Indian journal of pharmaceutical sciences 73 (4), 478 2011
    Citations: 6

  • Synthesis and biological activity of 2-(N, N-dialkyl amino/-piperidino/morpholino) methyl-7-halothiazolo (2, 3-b) quinazolin-5-ones
    SC Bennur, MB Talawar, UV Laddi, YS Somannavar, V Hariholimath, ...
    Indian Journal of Heterocyclic Chemistry 7 (1), 39-42 1997
    Citations: 6

  • Synthesis and anti-microbial activity of some new 1, 3, 4-oxadiazoles and 1, 2, 4-triazoles
    MB Talawar, UV Laddi, RS Bennur, SC Bennur
    Indian J. Heterocycl. Chem 4 (2), 111-116 1994
    Citations: 5

  • Synthesis and pharmacological activities of some new 5-substituted-2-mercapto-1, 3, 4-oxadiazoles
    SR Desai, U Laddi, RS Bennur, PA Patil, S Bennur
    Indian journal of pharmaceutical sciences 73 (5), 593 2011
    Citations: 4

  • Recent trends in antifungal agents and antifungal therapy
    MB Talwar, UV Laddi, YS Somannavar
    Indian J Heterocycl Chem 4, 297 1995
    Citations: 4

  • Synthesis and antimicrobial activity of 2-substituted-3H-thiazolo (2, 3-b)-8-arylpyrazolo (4, 3-c) pyrimidin-5-ones
    SC Bennur, MB Talawar, UV Laddi, YS Somannavar, VV Badiger, ...
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 5 (3), 193-198 1996
    Citations: 2

GRANT DETAILS

CSIR-SRF and University Minor projects

RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

New heterocycles

Industry, Institute, or Organisation Collaboration

Industry and Institute

INDUSTRY EXPERIENCE

Various R and Ds for 14 years

SOCIAL, ECONOMIC, or ACADEMIC BENEFITS

Publications in reputed journals, if interesting results are obtained will patent