Dr.Umesh Laddi

@cittumkur.org

Professor and Head
Channabasaveshwar Institute of Technology, Gubbi, Tumkur, Karnataka, India



                       

https://researchid.co/drumesh1969

After having served in various industries (R & Ds) , presently working as Professor and Head , Department of Chemistry in an Engineering College (since 2010), in Karnataka. Have got 24 years of experience in teaching and research. I did complete my doctorate degree in 'Synthetic organic chemistry' , from Karnataka University, Dharwad in 1996 as a regular schoar and CSIR-SRF (New Delhi) from 1993-1998.

EDUCATION

M.Sc., Ph.D., PGDIB

RESEARCH INTERESTS

Synthetic, heterocyclic, Pharmacological, Drug Intermediates, Speciality Chemicals, Nucleosides and Nucleotides

FUTURE PROJECTS

Nitrogen Hetero cycles of Pharmacological importance

Some 1,2,4-Triazoles and their derivatives will be prepared and tested for pharmacological properties


Applications Invited
Funds
17

Scopus Publications

291

Scholar Citations

10

Scholar h-index

10

Scholar i10-index

Scopus Publications

  • A Review on Emerging Impact of Antitubercular Activity of 1,2,4-Triazole Derivatives
    Vedavathi Rangaswamy and Umesh Laddi
    Bentham Science Publishers Ltd.
    Abstract: The present review aims to summarize the antitubercular profile of 1,2,4-triazole, one of the emerging entitled and most sought scaffold with a wide spectrum of biological and pharmacological activities. A systematic review of literature on ‘Heterocycles’, establishes the fact that 1,2,4-triazoles and their derivatives exhibit diverse activities. The 1,2,4-triazole core is found in therapeutically significant drugs and many new ones are in the pipeline. ‘Triazole pharmacophore’ has replaced the widely used ‘imidazole’ as ‘systemically integral azole’ by connecting synchronicity with serendipity. Triazoles are penetratingly studied as ‘diverse therapeutic agents’, due to the improved efficacy and reduced side effects. The extensive anthology of work carried out in the last two decades on 1,2,4-triazole moiety will provide imminent scope for the development of novel potential drugs having better efficacy selectivity and reduced toxicity.

  • Synthesis and antimicrobial activity of some new 1, 3, 4-oxadiazoles, 1, 2, 4-triazoles and 1, 3, 4-thiadiazoles


  • Some new 1,3,4-oxadiazoles as antimicrobial agents


  • Synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives


  • Synthesis and antimicrobial activities of some new 1, 3, 4-oxadiazoles


  • Synthesis and pharmacological activities of some new 5-substituted-2- mercapto-1,3,4-oxadiazoles
    ShobhaR Desai, RajaniS Bennur, S Bennur, U Laddi, and PA Patil
    OMICS Publishing Group
    In this study, various 5-β-[(N-benzenesulphony/tosyl)-4-(un) substituted anilino]ethyl-2-mercapto-1,3,4-oxadiazole (4a-f), with sulphonamide moiety at the side chain have been synthesised. The structures of the newly synthesised compounds have been established on the basis of their spectral data and elemental analysis. All the compounds were screened for antimicrobial activities against Escherichia coli, Bacillus cirroflagellosus, Aspergillus niger. Colletotrichum capsici and antituberclosis activity against Mycobacterium tuberculosis H37Rv strain. Only two compounds 4b (73%) and 4e (54%), have shown moderate antituberculosis activity. All the compounds have shown moderate antiinflamatory activity and least ulcerogenecity. Most of the compounds have shown significant analgesic activity (64.20-120.72%) in comparison with the standard, Aspirin (49.39%) In the MES method, however only compound 4a, exhibited a protection of 33.33%, and others failed to protect.

  • Synthesis and antimicrobial activities of some new azetidin-2-ones and thiazolidin-4-ones
    S. Desai, U. Laddi, R. S. Bennur and S. Bennur

    Various (4-substituted) phenyl-3-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]propionylamido-1,3-thiazolidine-4-ones (3a–x) and 1-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]-propionylamido-3-chloro-4-(4-substituted)phenyl-azetidin-2-ones (4a–x) have been synthesised by the cyclocondensation of Schiff bases (2a-x) with thioglycolic acid and chloroacetyl chloride, respectively. The structures of the newly synthesised compounds have been established on the basis of their spectral data and elemental analysis. All compounds were evaluated for antimicrobial activities against Escherichia coli, Bacillus cirroflagellosus, Aspergillus niger and Colletotrichum capsici. Most compounds investigated exhibited significant antifungal activity against Colletotrichum capsici, comparable to that of fluconazole, the standard used.

  • Synthesis and pharmacological activities of some new 3-Substituted-4-Amino- 5-Mercapto-1,2,4-Triazoles
    ShobhaR Desai, RajaniS Bennur, S Bennur, U Laddi, and PA Patil
    OMICS Publishing Group
    In this study, various 3-β-[(N-benzenesulphonyl/tosyl)-4-(un) substituted anilino]ethyl-4-amino-5-mercapto-4(H)-1,2,4-triazoles (5a–f), with biologically active ‘sulphonamide’ moiety as the side chain have been prepared. The structures of the newly synthesised compounds have been established on the basis of their spectral data and elemental analysis. All the compounds were evaluated for antimicrobial activities against Escherichia coli, Bacillus cirroflagellosus, Aspergillus niger and Colletotrichum capsici. Most of the compounds investigated exhibited significant antifungal activity against Colletotrichum capsici, even greater than fluconazole, the standard used. Only two compounds 3f (59%) and 5e (67%), have shown moderate antituberculosis activity. All the triazoles exhibited moderate degree of antiinflammatory activity and least ulcerogenecity. Most of the compounds have shown significant analgesic activity (81.02–120.72%) in comparison with aspirin (49.39%). In the MES method, only compound 3e exhibited a protection of 66.66%, whereas others exhibited minimum protection of (33.33%).

  • Some new 1,3,4-oxadiazoles as antimicrobial agents


  • Synthesis, antimicrobial and antituberculosis activities of N-bridged heterocycles


  • Some new 3-substituted-4-amino-5-mercapto-4(H)-1,2,4-triazoles as nonsteroidal antiinflammatory agents


  • Antiinflammatory activity of 3-substituted-4-amino-5- piperidino-4(h)- 1,2,4-triazoles


  • Synthesis and biological activity of 2-(N,N-dialkyl amino/-piperidino/morpholino) methyl-7-halothiazolo (2,3-b) quinazolin-5-ones


  • Synthesis, antiinflammatory and biological activities of some new 2- mercapto-5-substituted-1,3,4-oxadiazoles


  • Synthesis and antimicrobial activity of 2-substituted-3H-thiazolo (2,3-b)-8-arylpyrazolo (4, 3-c) pyrimidin-5-ones


  • Synthesis and biological activity of pyrazolopyrimidines


  • Free radical elimination and oxidation of 1, 1, 1-trichloro-2, 2-bis(p-substituted phenyl)ethanes


RECENT SCHOLAR PUBLICATIONS

  • A Review On Emerging Impact of Antitubercular Activity of 1,2,4-Triazole Derivatives,
    VR Umesh Laddi
    Anti-Infective Agents 22 (1), 1-16 2023

  • SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW 1,3,4- OXADIAZOLES, 1,2,4-TRIAZOLES AND 1,3,4-THIADIAZOLES
    Laddi UV, Desai SR
    Indian Drugs 53 (6), 18-23 2016

  • SOME NEW 1,3,4-OXADIAZOLES AS ANTIMICROBIAL AGENTS
    Laddi. U. V.* and Desai S.
    INDIAN DRUGS 53 (02), 15-18 2016

  • Synthesis and antimicrobial activities of some new 1, 2, 4-triazole derivatives
    S Desai, U Laddi, R Bennur, S Bennur
    NISCAIR-CSIR, India 2013

  • Synthesis and Antimicrobial Activities of Some New 1, 3, 4-Oxadiazoles
    Shobha R Desai & UV.Laddi
    Indian Drugs. 49 (08), 38-44 2012

  • Synthesis and pharmacological activities of some new 5-substituted-2-mercapto-1, 3, 4-oxadiazoles
    SR Desai, U Laddi, RS Bennur, PA Patil, S Bennur
    Indian Journal of Pharmaceutical Sciences 73 (5), 593 2011

  • Synthesis and antimicrobial activities of some new azetidin-2-ones and thiazolidin-4-ones
    SR Desai, UV Laddi, RS Bennur, SC Bennur
    Indian journal of pharmaceutical sciences 73 (4), 478 2011

  • Synthesis and Pharmacological activities of some new 5-substituted-2-mercapto-1,3,4-oxadizoles.
    PAPSCB Shobha R Desai, UV.Laddi, Rajani S Bennur
    Indian J. Pharm. Sci., , IJPS Online 73 ((5)), 593-596 2011

  • Synthesis and pharmacological activities of some new 3-Substituted-4-Amino-5-Mercapto-1, 2, 4-Triazoles
    SR Desai, U Laddi, RS Bennur, PA Patil, S Bennur
    Indian Journal of Pharmaceutical Sciences 73 (1), 115 2011

  • Some new 1, 3, 4-oxadiazoles as antimicrobial agents
    UV Laddi, SR Desai, RS Bennur, SC Bennur
    Indian Journal of Heterocyclic Chemistry 11 (4), 319-322 2002

  • Synthesis, antimicrobial and antituberculosis activities of N-bridged heterocycles
    UV Laddi, MB Talawar, SR Desai, RS Bennur, SC Bennur
    NISCAIR-CSIR, India 2001

  • SOME NEW 3-SUBSTITUTED-4-AMINO-5-MERCAPTO-4
    UV LADDI, SR DESAI, YS SOMANNAVAR, RS BENNUR, SC BENNUR
    Indian journal of chemistry. Sect. B: Organic chemistry, including medical 1998

  • Nitrogen Heterocycles of Pharmacological Importance
    GDSB Umesh Laddi
    Karnataka University, Dharwad, Karnataka, India 1998

  • Synthesis, characterization and pharmacological evaluation of certain 3-substituted-4-amino- 5-mercapto-4(H)-1,2,4-triazoles.
    RSBSCB M.B.Talawar, Umesh Laddi
    Proceedings of National Conference on current trends in Chemistry., 10 1998

  • Antiinflammatory activity of 3-substituted-4-amino-5-piperidino-4 (H)-1, 2, 4-triazoles
    UV Laddi, MB Talawar, SR Desai, YS Somannavar, RS Bennur, ...
    Indian Drugs 35 (8), 509-513 1998

  • Some new 3-substituted-4-amino-5-mercapto-4 (H)-1, 2, 4-triazoles as nonsteroidal antiinflammatory agents
    UV Laddi, SR Desai, YS Somannavar, RS Bennur, SC Bennur
    NISCAIR-CSIR, India 1998

  • Synthesis, antiinflammatory and biological activities of some new 2-mercapto-5-substituted-1, 3, 4-oxadiazoles
    UV Laddi, SR Desai, YS Somannavar, RS Bennur, SC Bennur
    INDIAN DRUGS-BOMBAY- 34, 666-673 1997

  • Synthesis and biological activity of 2-(N, N-dialkyl amino/-piperidino/morpholino) methyl-7-halothiazolo (2, 3-b) quinazolin-5-ones
    SC Bennur, MB Talawar, UV Laddi, YS Somannavar, V Hariholimath, ...
    Indian Journal of Heterocyclic Chemistry 7 (1), 39-42 1997

  • Synthesis and biological activity of pyrazolopyrimidines
    Badiger, VV and Bennur, SC
    Indian Journal of Heterocyclic Chemistry, CAN 125:328654 6, 63-66 6, 663 1996

  • Synthesis and biological activity of pyrazolo-pyrimidin derivatives
    VVBSCB H.M.Virupakshaiah, M.B.Talawar, U.V.Laddi, Y.S.Somannavar
    Indian J. Heterocyclic Chem., 7 (.), 63-66 1996

MOST CITED SCHOLAR PUBLICATIONS

  • Some new 1, 3, 4-oxadiazoles as antimicrobial agents
    UV Laddi, SR Desai, RS Bennur, SC Bennur
    Indian Journal of Heterocyclic Chemistry 11 (4), 319-322 2002
    Citations: 76

  • Synthesis and antimicrobial activity of bridgehead nitrogen-heterocycles: reactions of 3-N-methyl/ethyl/(alpha-methyl) ethylmorpholino/piperidino-4-amino-5-mercapto-4 (H)-1, 2
    MC Hosur, MB Talawar, UV Laddi, RS Bennur, SC Bennur
    Indian J Cheminform 26 (44), 707-712 1995
    Citations: 27

  • Synthesis, antimicrobial and antituberculosis activities of N-bridged heterocycles
    UV Laddi, MB Talawar, SR Desai, RS Bennur, SC Bennur
    NISCAIR-CSIR, India 2001
    Citations: 25

  • Synthesis and antimicrobial activities of some new 1, 2, 4-triazole derivatives
    S Desai, U Laddi, R Bennur, S Bennur
    NISCAIR-CSIR, India 2013
    Citations: 23

  • Synthesis and Biological-Activity of 1, 2, 4-Triazole Derivatives
    MB Talawar, UV Laddi, YS Somannavar, RS Bennur, S Bennur
    Indian Journal of Heterocyclic Chemistry 4, 297-300 1995
    Citations: 23

  • Synthesis and pharmacological activities of some new 3-Substituted-4-Amino-5-Mercapto-1, 2, 4-Triazoles
    SR Desai, U Laddi, RS Bennur, PA Patil, S Bennur
    Indian Journal of Pharmaceutical Sciences 73 (1), 115 2011
    Citations: 19

  • Synthesis and antimicrobial activities of some new 1,3,4-oxadiazoles
    M.C.Hosur, M.B.Talawar, U.V.Laddi, R.S.Bennur & S.C.Bennur
    Indian J. Heterocyclic Chem., 3, 237-42 1994
    Citations: 19

  • Antiinflammatory activity of 3-substituted-4-amino-5-piperidino-4 (H)-1, 2, 4-triazoles
    UV Laddi, MB Talawar, SR Desai, YS Somannavar, RS Bennur, ...
    Indian Drugs 35 (8), 509-513 1998
    Citations: 14

  • Synthesis, antiinflammatory and biological activities of some new 2-mercapto-5-substituted-1, 3, 4-oxadiazoles
    UV Laddi, SR Desai, YS Somannavar, RS Bennur, SC Bennur
    INDIAN DRUGS-BOMBAY- 34, 666-673 1997
    Citations: 13

  • Some new 3-substituted-4-amino-5-mercapto-4 (H)-1, 2, 4-triazoles as nonsteroidal antiinflammatory agents
    UV Laddi, SR Desai, YS Somannavar, RS Bennur, SC Bennur
    NISCAIR-CSIR, India 1998
    Citations: 10

  • Synthesis and antimicrobial activity of some new 1, 3, 4-oxadiazoles and 1, 2, 4-triazoles
    MB Talawar, UV Laddi, RS Bennur, SC Bennur
    Indian J. Heterocycl. Chem 4 (2), 111-116 1994
    Citations: 8

  • Synthesis and pharmacological activities of some new 5-substituted-2-mercapto-1, 3, 4-oxadiazoles
    SR Desai, U Laddi, RS Bennur, PA Patil, S Bennur
    Indian Journal of Pharmaceutical Sciences 73 (5), 593 2011
    Citations: 7

  • Synthesis and antimicrobial activities of some new azetidin-2-ones and thiazolidin-4-ones
    SR Desai, UV Laddi, RS Bennur, SC Bennur
    Indian journal of pharmaceutical sciences 73 (4), 478 2011
    Citations: 7

  • Synthesis and biological activity of 2-(N, N-dialkyl amino/-piperidino/morpholino) methyl-7-halothiazolo (2, 3-b) quinazolin-5-ones
    SC Bennur, MB Talawar, UV Laddi, YS Somannavar, V Hariholimath, ...
    Indian Journal of Heterocyclic Chemistry 7 (1), 39-42 1997
    Citations: 6

  • Synthesis of 2-(2, 5-dihydroxyphenylthio)-5-N-alkyl-1, 3, 4-oxadiazoles from properly substituted Chapter-8 References acid hydrazide in the presence of carbon disulphide and
    MC Hosur, MB Talawar, UV Laddi, RS Bennur, S Bennur
    Ind. J. Heterocycl. Chem 3, 237-242 1994
    Citations: 6

  • Recent Trends in Antifungal Agents and Antifungal Therapy
    MB Talwar, U Laddi, YS Somannavar
    Indian J. Heterocycles Chem 4, 297-312 1995
    Citations: 4

  • Synthesis and antimicrobial activity of 2-substituted-3H-thiazolo (2, 3-b)-8-arylpyrazolo (4, 3-c) pyrimidin-5-ones
    SC Bennur, MB Talawar, UV Laddi, YS Somannavar, VV Badiger, ...
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 5 (3), 193-198 1996
    Citations: 2

  • A Review On Emerging Impact of Antitubercular Activity of 1,2,4-Triazole Derivatives,
    VR Umesh Laddi
    Anti-Infective Agents 22 (1), 1-16 2023
    Citations: 1

  • phenyl) ethanes
    SC Bennur, MB Talawarf, UV Laddi, F Nomej
    Indian Journal of Chemistry 35, 74-76 1996
    Citations: 1

GRANT DETAILS

CSIR-SRF and University Minor projects

RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

New heterocycles

Industry, Institute, or Organisation Collaboration

Industry and Institute

INDUSTRY EXPERIENCE

Various R and Ds for 14 years

SOCIAL, ECONOMIC, or ACADEMIC BENEFITS

Publications in reputed journals, if interesting results are obtained will patent